March 2025 Supplement Research Papers

• March 1

  • Malate or Not? Acute Effects of L-Citrulline Versus Citrulline Malate on Neuromuscular Performance in Young, Trained Adults: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial.

    • 2025-03-01
    • RCT · n = 21
    • International journal of sport nutrition and exercise metabolism 35(2)
    • • Juan J Martín-Olmedo
      • Sergio Miras-Moreno
      • Kevin Cuadra-Montes
      • Amador García-Ramos
      • Jonatan R Ruiz
      • Lucas Jurado-Fasoli

    • PubMed: 39662304
    • DOI: 10.1123/ijsnem.2024-0006

    9 Insights on

    • Improved Exertion and Emotional Perceptions
    • Improved Lower Limb Maximal Neuromuscular Performance
    • Improved Maximal Neuromuscular Performance
    • Improved Strength-Endurance Mean Velocity
    • Improved Emotional Perception
    • Reduced Exertion Perception
    • Improved Upper Limb Maximal Neuromuscular Performance
    • Improved Strength Endurance
    • Improved Ballistic Strength

    • High evidence

  • Post-Exercise Hypotension after Exercising in Hypoxia with and Without Tart Cherry Supplementation.

    • 2025-03-01
    • RCT
    • High altitude medicine & biology 26(1)
    • • Masahiro Horiuchi
      • Samuel J Oliver

    • PubMed: 39545270
    • DOI: 10.1089/ham.2024.0076

    2 Insights on

    • Reduced Mean Arterial Pressure
    • Improved Cardiac Baroreflex Sensitivity

    • High evidence

  • Exploring the Effects of a Calming Herbal Tea Blend on Perioperative Anxiety: A Randomized Clinical Trial.

    • 2025-03-01
    • RCT · n = 210
    • Journal of medicinal food 28(3)
    • • Victória Cosel Zampieri
      • Itamar Luís Gonçalves
      • Ana Luiza Lira
      • Jamile Zeni
      • Geciane Toniazzo Backes
      • André Keng Wei Hsu

    • PubMed: 39514279
    • DOI: 10.1089/jmf.2024.0170

    1 Insight on

    • Reduced Anxiety

    • High evidence
    • Large Human Trial
• March 2

  • Where Biology Meets Engineering: Scaling Up Microbial Nutraceuticals to Bridge Nutrition, Therapeutics, and Global Impact.

    • 2025-03-02
    • Review
    • Microorganisms 13(3)
    • • Ahmed M Elazzazy
      • Mohammed N Baeshen
      • Khalid M Alasmi
      • Shatha I Alqurashi
      • Said E Desouky
      • Sadat M R Khattab

    • PubMed: 40142459
    • DOI: 10.3390/microorganisms13030566

    1 Insight on

    • Improved Intestinal Function

    • Low evidence
• March 3

  • The Impact of Testosterone Therapy on the Vaginal Microbiota of Transgender Men and Nonbinary People: A Prospective Study.

    • 2025-03-03
    • Observational
    • The Journal of infectious diseases 232(3)
    • • Olivia T Van Gerwen
      • Kristal J Aaron
      • Emma Sophia Kay
      • Krishmita Siwakoti
      • Angela Pontius
      • Saralyn Richter
      • Z Alex Sherman
      • Keonte J Graves
      • Ashutosh Tamhane
      • Jacob H Elnaggar
      • Meng Luo
      • Evelyn Toh
      • David E Nelson
      • Nicholas J Van Wagoner
      • Christopher M Taylor
      • Christina A Muzny

    • PubMed: 40037329
    • DOI: 10.1093/infdis/jiaf114

    1 Insight on

    • No Human Health Outcome Reported

    • Low evidence

  • Lactobacillus reuteri protectis DSM 17938 at high doses versus placebo in children with acute gastroenteritis in a Pediatric Emergency Department.

    • 2025-03-03
    • RCT
    • Journal of pediatric gastroenterology and nutrition 80(5)
    • • Ricardo Iramain
      • Alfredo Jara
      • Jorge Ortiz
      • Laura Cardozo
      • Rocío Morinigo

    • PubMed: 40026275
    • DOI: 10.1002/jpn3.70026

    1 Insight on

    • Reduced Diarrhea Rate

    • High evidence

  • Therapeutic Value of Lactobacillus gasseri 345A in Chronic Constipation.

    • 2025-03-03
    • RCT · n = 40
    • Neurogastroenterology and motility 37(5)
    • • Stefan Roos
      • Atti-La Dahlgren
      • Yu-Kang Mao
      • Anton Pallin
      • Andrew M Stanisz
      • Paul Forsythe
      • Wolfgang Kunze
      • Per M Hellström

    • PubMed: 40033155
    • DOI: 10.1111/nmo.70012

    9 Insights on

    • Reduced Time Spent for Defecation
    • Reduced Abdominal Pain
    • Improved Sex Life
    • Improved Rectal Emptying
    • Improved Bowel Movement Frequency
    • Increased Complete Spontaneous Bowel Movements
    • Reduced Rescue Laxative Use
    • Improved Stool Consistency
    • Improved Intestinal Motility

    • High evidence

  • Lactobacillus plantae Expressing Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Single-Chain Antibody Can Inhibit PRRSV Replication and Change the Intestinal Flora Structure of Piglets.

    • 2025-03-03
    • International journal of molecular sciences 26(5)
    • • Tianming Niu
      • Tianqi Fan
      • Yingjie Wang
      • Kuipeng Gao
      • Jinhui Zhao
      • Ruyu Wang
      • Xiaolei Chen
      • Junhong Xing
      • Jingjing Qiu
      • Boshi Zou
      • Shuhui Fan
      • Shi Zhang
      • Qiong Wu
      • Guilian Yang
      • Nan Wang
      • Yan Zeng
      • Xin Cao
      • Yanlong Jiang
      • Jianzhong Wang
      • Haibin Huang
      • Wentao Yang
      • Chunwei Shi
      • Zhipeng Li
      • Chunfeng Wang

    • PubMed: 40076879
    • DOI: 10.3390/ijms26052257

    6 Insights on

    • Improved Immune Function
    • Reduced Disease Symptoms
    • Reduced Viral Infection
    • Reduced RSV Replication
    • Improved Clinical Protection Against Viral Challenge
    • Increased CD3+CD8+ Cell Counts

    • Low evidence
    • Rigorous Journal
    • Animal Study
• March 4

  • Coffee and tea consumption on the risk of osteoporosis: a meta-analysis.

    • 2025-03-04
    • Systematic Review · n = 838
    • Frontiers in nutrition 12
    • • Wopei Li
      • Yujiao Xie
      • Lei Jiang

    • PubMed: 40104819
    • DOI: 10.3389/fnut.2025.1559835

    1 Insight on

    • Reduced Osteoporosis Risk

    • High evidence

  • Effect of Daily Avocado Intake on Cardiovascular Health Assessed by Life's Essential 8: An Ancillary Study of HAT, a Randomized Controlled Trial.

    • 2025-03-04
    • RCT · n = 969
    • Journal of the American Heart Association 14(5)
    • • Janhavi J Damani
      • Penny M Kris-Etherton
      • Alice H Lichtenstein
      • Nirupa R Matthan
      • Joan Sabaté
      • Zhaoping Li
      • David Reboussin
      • Kristina S Petersen

    • PubMed: 39968784
    • DOI: 10.1161/jaha.124.039130

    4 Insights on

    • Improved Diet Quality
    • Improved Life's Essential 8 Score
    • Improved Blood Lipid Profile
    • Improved Sleep Health

    • High evidence
    • Large Human Trial
• March 5

  • Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis.

    • 2025-03-05
    • Meta-Analysis
    • BMC complementary medicine and therapies 25(1)
    • • Samar A Amer
      • Dina Essam Abo-Elnour
      • Abdallah Abbas
      • Abdelrahman Salah Abdelrahman
      • Hossam-Eldin Mohamed Hamdy
      • Samar Kenawy
      • Menna M Sarhan
      • Omar Hany Mohamed
      • Mohamed Yousif Elnaghy
      • Mohammed Baker
      • Rawan Medhat El-Gayar
      • Omnia Samy El-Sayed
      • Moamen Mostafa Asla

    • PubMed: 40045266
    • DOI: 10.1186/s12906-025-04809-x

    3 Insights on

    • Reduced Pulse Rate
    • Reduced Systolic Blood Pressure
    • Reduced Diastolic Blood Pressure

    • High evidence

  • Research in etiology of Floppy Kid Syndrome.

    • 2025-03-05
    • Observational
    • Frontiers in veterinary science 12
    • • Cheng Cheng
      • Yan Zheng
      • Xin Wang
      • Jianping Tao
      • Darong Cheng

    • PubMed: 40110433
    • DOI: 10.3389/fvets.2025.1557951

    2 Insights on

    • Reduced Pathogen Growth
    • Reduced Dysbiosis

    • Low evidence

  • Impact of Vitamin D3 on Postorthodontic Treatment Stability: A Randomized Controlled Trial.

    • 2025-03-05
    • RCT
    • The journal of contemporary dental practice 25(12)
    • • Thrivikhraman Kothandaraman
      • Prema Anbarasu
      • Sp Saravana Dinesh
      • Saravana Kumar Subramanian
      • Gabriel Eisenhuth
      • Sebastian Eisenhuth
      • Claudia Eisenhuth

    • PubMed: 40079995
    • DOI: 10.5005/jp-journals-10024-3795

    4 Insights on

    • Reduced Inter-canine Width
    • Reduced Orthodontic Relapse
    • Reduced Arch Perimeter Change
    • Reduced Intermolar Width Change

    • High evidence

  • Efficacy of ginkgo biloba extract in the treatment of idiopathic pulmonary fibrosis: a systematic review and meta-analysis of randomized controlled trials.

    • 2025-03-05
    • Review · n = 1,043
    • Frontiers in pharmacology 16
    • • Xuxin Sun
      • Ling Peng
      • Wenchao Xiao
      • Keying Li
      • Sheng Chen

    • PubMed: 40110130
    • DOI: 10.3389/fphar.2025.1524505

    11 Insights on

    • Reduced Hyaluronan Level
    • Reduced Carbon Dioxide Partial Pressure
    • Reduced Interleukin-4 Levels
    • Reduced Laminin Level
    • Improved Forced Expiratory Volume in One Second
    • Improved Arterial Oxygen Saturation
    • Improved Arterial Oxygen Partial Pressure
    • Improved Six-Minute Walk Test
    • Improved Maximum Voluntary Ventilation
    • Improved Treatment Response Rate
    • Improved Forced Vital Capacity

    • High evidence
• March 6

  • Microbial-Derived Antioxidants in Intestinal Inflammation: A Systematic Review of Their Therapeutic Potential.

    • 2025-03-06
    • Review
    • Antioxidants (Basel, Switzerland) 14(3)
    • • María José García Mansilla
      • María Jesús Rodríguez Sojo
      • Andreea Roxana Lista
      • Ciskey Vanessa Ayala Mosqueda
      • Antonio Jesús Ruiz Malagón
      • Ailec Ho Plagaro
      • Julio Gálvez
      • Alba Rodríguez Nogales
      • María José Rodríguez Sánchez

    • PubMed: 40227262
    • DOI: 10.3390/antiox14030321

    1 Insight on

    • Reduced Intestinal Inflammation

    • Low evidence

  • Effectiveness of acupoint injection combined with specific electromagnetic spectrum irradiation and acupuncture on peripheral facial paralysis.

    • 2025-03-06
    • RCT · n = 85
    • Neurological research 47(5)
    • • Meihua Sun
      • Mingli Ge
      • Qinglin Shen

    • PubMed: 40050238
    • DOI: 10.1080/01616412.2025.2476515

    7 Insights on

    • Improved Portmann Score
    • Reduced Interleukin-1β Levels
    • Shortened Cure Time
    • Improved House-Brackmann Grade
    • Improved Cure Rate
    • Reduced Tumor Necrosis Factor-alpha Level
    • Reduced Interleukin-6 Levels

    • High evidence

  • Cardioprotective Effect of Nigella sativa in Pediatric Patients with Type 1 Diabetes Mellitus: A Randomized Controlled Study.

    • 2025-03-06
    • RCT · n = 30
    • Paediatric drugs 27(4)
    • • Dalia El-Afify
      • Doaa El Amrousy

    • PubMed: 40048139
    • DOI: 10.1007/s40272-025-00687-5

    9 Insights on

    • Improved Left Ventricular E'/A' Ratio
    • Reduced Low-Density Lipoprotein Level
    • Reduced Malondialdehyde Level
    • Reduced Nitric Oxide Level
    • Reduced Troponin I Level
    • Reduced Transforming Growth Factor Beta Levels
    • Reduced Tumor Necrosis Factor Alpha
    • Improved Left Ventricular Global Longitudinal Strain
    • Reduced Total Cholesterol Levels

    • High evidence
• March 7

  • Quercetins efficacy on bone and inflammatory markers, body composition, and physical function in postmenopausal women.

    • 2025-03-07
    • RCT
    • Journal of bone and mineral metabolism 43(3)
    • • Alyssa R Bailly
      • Garrett M Hester
      • Michaela G Alesi
      • Robert J Buresh
      • Yuri Feito
      • Christine M Mermier
      • Jeremy B Ducharme
      • Trisha A VanDusseldorp

    • PubMed: 40053115
    • DOI: 10.1007/s00774-025-01592-0

    9 Insights on

    • Increased Osteocalcin Level
    • Increased Procollagen Type I N-terminal Propeptide Level
    • Reduced Tumor Necrosis Factor Alpha
    • Reduced C-Reactive Protein Levels
    • Increased Type I Collagen Cross-linked C-terminal Telopeptide
    • Improved Body Composition
    • Improved Timed Up and Go
    • Improved Handgrip Strength
    • Reduced Interleukin-6 Levels

    • High evidence

  • Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients.

    • 2025-03-07
    • RCT · n = 163
    • Journal of translational medicine 23(1)
    • • Huai Heng Loh
      • Siow Phing Tay
      • Ai Jiun Koa
      • Mei Ching Yong
      • Asri Said
      • Chee Shee Chai
      • Natasya Marliana Abdul Malik
      • Anselm Ting Su
      • Bonnie Bao Chee Tang
      • Florence Hui Sieng Tan
      • Norlela Sukor

    • PubMed: 40055713
    • DOI: 10.1186/s12967-025-06312-w

    18 Insights on

    • Reduced Steatotic Liver Disease Grade
    • Reduced hsCRP Level
    • Improved Heart Rate Variability
    • Reduced Body Weight
    • Reduced Body Mass Index
    • Improved Epworth Sleepiness Scale
    • Improved Metabolic Parameters
    • Improved Blood Lipid Profile
    • Reduced Hemoglobin A1c
    • Improved Quality of Life Score
    • Improved Flow-Mediated Dilatation
    • Improved Quality of Life
    • Reduced Aldosterone Level
    • Reduced Uric Acid Levels
    • Improved Epworth Sleepiness Scale Score
    • Reduced Nocturnal Heart Rate
    • Reduced Waist Circumference
    • Reduced Renin Level

    • High evidence
    • Large Human Trial

  • The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises Under Resting and Mental Fatigue Conditions: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial.

    • 2025-03-07
    • RCT
    • Nutrients 17(6)
    • • Daniel Marcos-Frutos
      • Žiga Leban
      • Zhaoqian Li
      • Xing Zhang
      • Paula M Lara
      • Carlos Alix-Fages
      • Pablo Jiménez-Martínez
      • Nadia Zebboudji
      • Annabelle Caillet
      • Beatriz Redondo
      • Jesús Vera
      • Danica Janicijevic
      • Amador García-Ramos

    • PubMed: 40289957
    • DOI: 10.3390/nu17060940

    6 Insights on

    • Increased Bench Pull Velocity
    • Improved Strength Performance
    • Increased Bench Press Repetition
    • Improved Visuo-Cognitive Processing
    • Reduced Perceived Exertion
    • Reduced Mental Fatigue

    • High evidence
    • Rigorous Journal

  • Unraveling the role of the gut microbiome in pregnancy disorders: insights and implications.

    • 2025-03-07
    • Review
    • Frontiers in cellular and infection microbiology 15
    • • Yupei Xie
      • Qian Chen
      • Dan Shan
      • Xiongfei Pan
      • Yayi Hu

    • PubMed: 40125520
    • DOI: 10.3389/fcimb.2025.1521754

    1 Insight on

    • Reduced Pregnancy Disorder Risk

    • Low evidence

  • Effect of Nigella sativa-L supplementation on glycemia in adolescent polycystic ovarian syndrome: secondary analysis of a randomized controlled trial study.

    • 2025-03-07
    • RCT
    • Journal of ovarian research 18(1)
    • • Azamsadat Mahmoudian
      • Akram Ashouri
      • Fatemeh Mohammadzadeh
      • Roghaieh Rahmani Bilandi
      • Sareh Dashti
      • Narjes Bahri

    • PubMed: 40055705
    • DOI: 10.1186/s13048-025-01634-1

    3 Insights on

    • Reduced Two-Hour Postprandial Glucose
    • Improved Fasting Plasma Glucose
    • Reduced Postprandial Glucose

    • High evidence
• March 8

  • Evaluating the anti-inflammatory and antioxidant efficacy of complementary and alternative medicines (CAM) used for management of inflammatory bowel disease: a comprehensive review.

    • 2025-03-08
    • Review
    • Redox report : communications in free radical research 30(1)
    • • Sia Shin
      • Siqi Chen
      • Kangzhe Xie
      • Suehad Abou Duhun
      • Tamara Ortiz-Cerda

    • PubMed: 40056427
    • DOI: 10.1080/13510002.2025.2471737

    3 Insights on

    • Reduced Inflammation
    • Improved Total Antioxidant Status
    • Improved Gut Microbiota

    • Low evidence
• March 10

  • Effective probiotic regimens for bacterial vaginosis treatment and recurrence prevention: A systematic review.

    • 2025-03-10
    • Systematic Review
    • Narra J 5(1)
    • • Udjianto Udjianto
      • Noorhamdani A Sirat
      • Bambang Rahardjo
      • Lilik Zuhriyah

    • PubMed: 40352249
    • DOI: 10.52225/narra.v5i1.1671

    3 Insights on

    • Improved Symptoms of Bacterial Vaginosis
    • Improved Vaginal pH
    • Reduced Recurrence of Bacterial Vaginosis

    • High evidence
• March 11

  • Impact of Dietary Supplements on Clinical Outcomes and Quality of Life in Patients with Breast Cancer: A Systematic Review.

    • 2025-03-11
    • Systematic Review · n = 45
    • Nutrients 17(6)
    • • Luca Scafuri
      • Carlo Buonerba
      • Oriana Strianese
      • Evandro de Azambuja
      • Michela Palleschi
      • Vittorio Riccio
      • Vincenzo Marotta
      • Concetta Scocca
      • Giovanni Riccio
      • Carla Errico
      • Grazia Arpino
      • Giuseppe Di Lorenzo

    • PubMed: 40290044
    • DOI: 10.3390/nu17060981

    7 Insights on

    • Improved Quality of Life
    • Improved Tumor Response
    • Reduced Disease Progression Biomarker
    • Improved Overall Survival
    • Improved Liver Function
    • Reduced Hepatotoxicity
    • Improved Disease-Free Survival

    • High evidence
    • Rigorous Journal

  • Efficacy and safety of gastrodin in preventing postoperative delirium following cardiac surgery: a randomized placebo controlled clinical trial.

    • 2025-03-11
    • RCT
    • Critical care (London, England) 29(1)
    • • Yun-Xiao Bai
      • Hui-Liang Wu
      • Wan-Li Xie
      • Xia Li
      • Jing-Jing Han
      • Jie Liu
      • Shi-Qiang Chen
      • Ping Yin
      • Nian-Guo Dong
      • Qing-Ping Wu

    • PubMed: 40069830
    • DOI: 10.1186/s13054-025-05331-9

    3 Insights on

    • Improved Hospital Discharge
    • Reduced Postoperative Delirium Incidence
    • Reduced Postoperative Cognitive Dysfunction Incidence

    • High evidence

  • Pharmacokinetic and pharmacodynamic assessment of oral nicotinamide in the NEAT clinical trial for early Alzheimer's disease.

    • 2025-03-11
    • RCT · n = 23
    • Alzheimer's research & therapy 17(1)
    • • Gabriel L Ketron
      • Felix Grun
      • Joshua D Grill
      • Howard H Feldman
      • Robert A Rissman
      • Gregory J Brewer

    • PubMed: 40069789
    • DOI: 10.1186/s13195-025-01693-y

    1 Insight on

    • Reduced pTau231 Level

    • High evidence

  • Cardiometabolic Effects of Nigella sativa in Postmenopausal Women with Hypertension: A Prospective, Observational, Pilot Study.

    • 2025-03-11
    • Observational · n = 52
    • Nutrients 17(6)
    • • Barbara Pala
      • Giulia Nardoianni
      • Paola Gualtieri
      • Giulia Frank
      • Marco Alfonso Perrone
      • Laura Di Renzo
      • Giuliano Tocci

    • PubMed: 40338252
    • DOI: 10.3390/nu17060985

    7 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Heart Rate
    • Improved Blood Lipid Profile
    • Reduced Body Weight
    • Reduced Systolic Blood Pressure
    • Reduced Body Mass Index
    • Improved Climacteric Symptom

    • High evidence
    • Rigorous Journal

  • Antioxidants for the management of oral leukoplakia: A systematic review of randomized controlled trials.

    • 2025-03-11
    • Review · n = 1,147
    • Journal of oral biology and craniofacial research 15(3)
    • • Divya Gopinath
      • Sara Ibrahim Waki
      • Kwok Fu Cheah
      • Swagatika Panda

    • PubMed: 40144648
    • DOI: 10.1016/j.jobcr.2025.03.001

    1 Insight on

    • Reduced Lesion Size

    • High evidence
• March 12

  • Effectiveness of Probiotics, Prebiotics, and Symbiotic Supplementation in Cystic Fibrosis Patients: A Systematic Review and Meta-Analysis of Clinical Trials.

    • 2025-03-12
    • Meta-Analysis
    • Medicina (Kaunas, Lithuania) 61(3)
    • • Freiser Eceomo Cruz Mosquera
      • Claudia Lorena Perlaza
      • Anisbed Naranjo Rojas
      • Saray Murillo Rios
      • Alejandra Carrero Gallego
      • Sara Isabel Fischersworring
      • Juan Sebastián Rodríguez
      • Yamil Liscano

    • PubMed: 40142300
    • DOI: 10.3390/medicina61030489

    6 Insights on

    • Improved Quality of Life
    • Reduced Hospitalization Rate
    • Reduced Faecal Calprotectin
    • Reduced Pro-Inflammatory Cytokines
    • Improved Lung Function
    • Reduced Exacerbation Frequency

    • High evidence

  • Effects of Guarana and Green Tea Consumption on Students' Intellectual Performances.

    • 2025-03-12
    • Clinical Trial
    • Nutrients 17(6)
    • • Valentina Amaritei
      • Petronela-Elena Buruiana
      • Roxana Filip
      • Florin Filip
      • Ancuta Veronica Lupaescu
      • Monica Iavorschi
      • Roxana-Elena Gheorghita

    • PubMed: 40290036
    • DOI: 10.3390/nu17061000

    1 Insight on

    • Improved Memory Function

    • High evidence
    • Rigorous Journal

  • Evaluating the efficacy of N-acetylcysteine in diminishing the duration and frequency of rotavirus-induced gastroenteritis: a preliminary randomized, placebo-controlled, double-blind clinical trial.

    • 2025-03-12
    • RCT · n = 71
    • BMC pediatrics 25(1)
    • • Behrooz Heydari
      • Majid Aflatonian
      • Mina Bagherizadeh
      • Farahnaz Hoseinzade
      • Fatemeh Saghafi

    • PubMed: 40069676
    • DOI: 10.1186/s12887-025-05534-7

    2 Insights on

    • Improved Bowel Movement Frequency
    • Reduced Diarrhea Rate

    • High evidence
• March 13

  • Multidisciplinary Integrative Medicine Approach for Cancer Patients: A Multicenter Retrospective Study.

    • 2025-03-13
    • Clinical Trial · n = 54
    • Nutrients 17(6)
    • • Massimiliano Berretta
      • Vincenzo Quagliariello
      • Alessandro Ottaiano
      • Mariachiara Santorsola
      • Raffaele Di Francia
      • Patrizia Carroccio
      • Nicola Maurea
      • Oreste Claudio Buonomo
      • Gaetano Facchini
      • Giordana Di Mauro
      • Monica Montopoli
      • Enrica Toscano
      • Claudia Gelsomino
      • Antonio Picone
      • Tindara Franchina
      • Paola Muscolino
      • Alessia Bignucolo
      • Gianluca Vanni
      • Giuliana Ciappina
      • Liliana Montella

    • PubMed: 40290037
    • DOI: 10.3390/nu17061012

    2 Insights on

    • Improved Quality of Life
    • Reduced Fatigue

    • High evidence
    • Rigorous Journal

  • Effect of Combined Vitamin C and Thiamine Therapy on Myocardial and Inflammatory Markers in Cardiac Surgery: A Randomized Controlled Clinical Trial.

    • 2025-03-13
    • RCT · n = 64
    • Nutrients 17(6)
    • • Mantana Saetang
      • Wirat Wasinwong
      • Maliwan Oofuvong
      • Jutarat Tanasansutthiporn
      • Laortip Rattanapittayaporn
      • Sutthasinee Petsakul
      • Pongsanae Duangpakdee
      • Puripong Rodneam
      • Parin Boonthum
      • Supphamongkhon Khunakanan
      • Chaitong Churuangsuk
      • Wilaiwan Sriwimol
      • Amphan Chantarokon
      • Kanjana Nuanjun
      • Dararat Yongsata

    • PubMed: 40290059
    • DOI: 10.3390/nu17061006

    7 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Interleukin-6 Levels
    • Reduced Postoperative Arrhythmia
    • Improved Hemodynamic Stability
    • Reduced Duration of Dobutamine Use
    • Improved Left Ventricular Ejection Fraction
    • Reduced Dobutamine Duration

    • High evidence
    • Rigorous Journal

  • The effects of concurrent alpha-linolenic acid, L-carnitine supplementation on clinical symptoms, mental health, and quality of life in women with migraine: a randomized, triple-blind, placebo-controlled trial.

    • 2025-03-13
    • RCT · n = 80
    • Nutrition journal 24(1)
    • • Sahar Golpour-Hamedani
      • Mohammad Bagherniya
      • Fariborz Khorvash
      • Awat Feizi
      • Manoj Sharma
      • Gholamreza Askari

    • PubMed: 40082970
    • DOI: 10.1186/s12937-025-01107-7

    7 Insights on

    • Reduced Anxiety
    • Improved Migraine-Specific Quality of Life
    • Reduced Depression Symptoms
    • Reduced Migraine Duration
    • Reduced Headache Impact Score
    • Reduced Migraine Frequency
    • Reduced Migraine Severity

    • High evidence
• March 14

  • Dietary Nitrate Supplementation and Exercise Performance: An Umbrella Review of 20 Published Systematic Reviews with Meta-analyses.

    • 2025-03-14
    • Meta-Analysis
    • Sports medicine (Auckland, N.Z.) 55(5)
    • • Eric Tsz-Chun Poon
      • Jason Chun-Kit Iu
      • Wesley Man-Kuk Sum
      • Po-San Wong
      • Kenneth Ka-Hei Lo
      • Ajmol Ali
      • Stephen F Burns
      • Eric T Trexler

    • PubMed: 40085422
    • DOI: 10.1007/s40279-025-02194-6

    5 Insights on

    • Reduced Time to Peak Power Output
    • Improved Muscular Endurance
    • Improved Total Distance Covered
    • Improved Time to Exhaustion
    • Improved Peak Power Output

    • High evidence

  • Heavy Metal-Gut Microbiota Interactions: Probiotics Modulation and Biosensors Detection.

    • 2025-03-14
    • Review
    • Biosensors 15(3)
    • • Liliana Anchidin-Norocel
      • Oana C Iatcu
      • Andrei Lobiuc
      • Mihai Covasa

    • PubMed: 40136985
    • DOI: 10.3390/bios15030188

    2 Insights on

    • Improved Gut Microbiota Balance
    • Enhanced Detoxification

    • Low evidence

  • Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology.

    • 2025-03-14
    • Review
    • Nutrients 17(6)
    • • Ioanna Aggeletopoulou
      • Georgios Geramoutsos
      • Ploutarchos Pastras
      • Christos Triantos

    • PubMed: 40290087
    • DOI: 10.3390/nu17061028

    4 Insights on

    • Improved Quality of Life
    • Reduced Flatulence
    • Reduced Constipation
    • Reduced Abdominal Pain

    • Moderate evidence
    • Rigorous Journal

  • Anti-inflammatory and antimicrobial efficacy of coconut oil for periodontal pathogens: a triple-blind randomized clinical trial.

    • 2025-03-14
    • RCT · n = 30
    • Clinical oral investigations 29(4)
    • • Simón Pardiñas López
      • Mónica E García-Caro
      • Juan A Vallejo
      • Pablo Aja-Macaya
      • Kelly Conde-Pérez
      • Paula Nión-Cabeza
      • Ismael Khouly
      • Germán Bou
      • Ana Isabel Rodríguez Cendal
      • Silvia Díaz-Prado
      • Margarita Poza

    • PubMed: 40085302
    • DOI: 10.1007/s00784-025-06267-8

    5 Insights on

    • Improved Subgingival Microbial Dysbiosis Index
    • Reduced Pathogenic Bacterial Family Level
    • Reduced Pathogenic Bacterial Species Level
    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels

    • High evidence
• March 15

  • A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum BB 536 Counteracts the Increase in Permeability Induced by the Mucosal Mediators of Irritable Bowel Syndrome by Acting on Zonula Occludens 1.

    • 2025-03-15
    • n = 28
    • International journal of molecular sciences 26(6)
    • • Maria Raffaella Barbaro
      • Francesca Bianco
      • Cesare Cremon
      • Giovanni Marasco
      • Vincenzo Stanghellini
      • Giovanni Barbara

    • PubMed: 40141298
    • DOI: 10.3390/ijms26062656

    1 Insight on

    • Improved Intestinal Barrier Function

    • Low evidence
• March 17

  • Recovery of Strength After Exercise-Induced Muscle Damage in Vegetarians Consuming the Upper and Lower Ends of Protein Recommendations for Athletes.

    • 2025-03-17
    • RCT
    • Nutrients 17(6)
    • • Nicole Presti
      • Todd C Rideout
      • Jennifer L Temple
      • Brian Bratta
      • David Hostler

    • PubMed: 40292443
    • DOI: 10.3390/nu17061046

    6 Insights on

    • Improved Concentric Strength
    • Improved Vertical Jump
    • Improved Isometric Strength
    • Reduced Muscle Soreness
    • Improved Pressure Pain Threshold
    • Reduced Soreness

    • High evidence
    • Rigorous Journal
• March 18

  • Current Approaches in Cosmeceuticals: Peptides, Biotics and Marine Biopolymers.

    • 2025-03-18
    • Review
    • Polymers 17(6)
    • • Ulya Badilli
      • Ozge Inal

    • PubMed: 40292641
    • DOI: 10.3390/polym17060798

    2 Insights on

    • Improved Skin Barrier Function
    • Reduced Signs of Aging

    • Low evidence

  • BEETter AGING: Short-Term Dietary Nitrate Supplementation Enhances Muscle Contractile Properties in Older But Not in Young Adults.

    • 2025-03-18
    • RCT
    • Medicine and science in sports and exercise 57(8)
    • • Letizia Rasica
      • Marta Colosio
      • Alessandra Ferri
      • Giovanni Baldassarre
      • Chris Easton
      • Mia Burleigh
      • Gianluca Vernillo
      • Roberto Bottinelli
      • Mauro Marzorati
      • Simone Porcelli

    • PubMed: 40098056
    • DOI: 10.1249/mss.0000000000003708

    7 Insights on

    • Reduced Double Twitch Area Under the Curve
    • Reduced Half Relaxation Time
    • Improved Force Production
    • Improved Maximal Voluntary Isometric Contraction
    • Improved Potentiated Single Twitch Force
    • Improved Double Twitch Force at 100 Hz
    • Increased Time to Exhaustion

    • High evidence

  • Efficacy of flaxseed in reducing blood pressure among patients with cardiovascular risk factors: A systematic review and meta-analysis of parallel randomized controlled trials.

    • 2025-03-18
    • Review
    • Journal of cardiovascular and thoracic research 17(1)
    • • Refli Hasan
      • Raed Obaid Saleh
      • Rana H Raheema
      • Hanen Mahmod Hulail
      • Irfan Ahmad
      • Deepak Nathiya
      • Parjinder Kaur

    • PubMed: 40365516
    • DOI: 10.34172/jcvtr.025.33280

    2 Insights on

    • Reduced Systolic Blood Pressure
    • Reduced Diastolic Blood Pressure

    • Low evidence
• March 20

  • The Genomic Characteristics of Potential Probiotics: Two Streptococcus salivarius Isolates from a Healthy Individual in China.

    • 2025-03-20
    • Microorganisms 13(3)
    • • Mingyue Sun
      • Qian Li
      • Feiran Zhang
      • Ding Yao
      • Wenhua Huang
      • Qingyu Lv
      • Hua Jiang
      • Decong Kong
      • Yuhao Ren
      • Shaolong Chen
      • Yongqiang Jiang
      • Peng Liu

    • PubMed: 40142586
    • DOI: 10.3390/microorganisms13030694

    3 Insights on

    • Increased Expression of Antimicrobial Peptide Genes
    • Reduced Pathogen Growth
    • Reduced Oral Pathogen Growth

    • Low evidence
• March 21

  • The impact of prebiotics, probiotics and synbiotics on the prevention and treatment of atopic dermatitis in children: an umbrella meta-analysis.

    • 2025-03-21
    • Systematic Review · n = 150
    • Frontiers in pediatrics 13
    • • Lifeng Wang
      • Lijuan Xu

    • PubMed: 40191649
    • DOI: 10.3389/fped.2025.1498965

    4 Insights on

    • No Significant Reduction in Atopic Dermatitis Severity
    • Reduced SCORAD Score
    • Reduced Incidence of Atopic Dermatitis
    • Reduced Atopic Dermatitis Severity

    • High evidence

  • Bifidobacterium lactis ameliorates AOM/DSS-induced inflammation, dysbiosis, and colonic precancerous lesions.

    • 2025-03-21
    • Applied microbiology and biotechnology 109(1)
    • • Yi-Lin Chan
      • Jun-Cheng Liao
      • Tsung-Lin Li
      • Chang-Jer Wu
      • Yi-Han Chiu

    • PubMed: 40116950
    • DOI: 10.1007/s00253-025-13445-x

    5 Insights on

    • Improved Gut Microbiome Composition
    • Reduced Intestinal Inflammation
    • Reduced Abnormal Colonic Lesions
    • Improved Gut Microbiota Composition
    • Reduced Inflammation

    • Low evidence
    • Animal Study
• March 22

  • Potent Antimicrobial Activity of Aspergillus oryzae Fermentate Against Toxigenic Strains of Clostridioides difficile.

    • 2025-03-22
    • Antibiotics (Basel, Switzerland) 14(4)
    • • Ahmad Alshannaq
      • Morgan Henning
      • Jonah Dixon
      • Colleen Riley
      • Dasol Choi
      • Jae-Hyuk Yu
      • Nasia Safdar

    • PubMed: 40298462
    • DOI: 10.3390/antibiotics14040333

    2 Insights on

    • Disrupted Bacterial Cell Membranes
    • Reduced Clostridium Difficile Growth

    • Low evidence
• March 24

  • Plasma nitrate, dietary nitrate, blood pressure, and vascular health biomarkers: a GRADE-Assessed systematic review and dose-response meta-analysis of randomized controlled trials.

    • 2025-03-24
    • Meta-Analysis · n = 1,823
    • Nutrition journal 24(1)
    • • Mostafa Norouzzadeh
      • Minoo Hasan Rashedi
      • Shadi Ghaemi
      • Niloufar Saber
      • Artemiss Mirdar Harijani
      • Hamzeh Habibi
      • Soroush Mostafavi
      • Fatemeh Sarv
      • Hossein Farhadnejad
      • Farshad Teymoori
      • Mohsen Khaleghian
      • Parvin Mirmiran

    • PubMed: 40128734
    • DOI: 10.1186/s12937-025-01114-8

    5 Insights on

    • Reduced Pulse Wave Velocity
    • Improved Flow-Mediated Dilation
    • Reduced Augmentation Index
    • Reduced Systolic Blood Pressure
    • Reduced Diastolic Blood Pressure

    • High evidence

  • Unlocking the potential of antioxidant supplementation with n-acetylcysteine to improve seminal parameters and analysis of its safety: a systematic review and meta-analysis of randomized controlled trials.

    • 2025-03-24
    • Meta-Analysis
    • Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 97(1)
    • • Syarif Syarif
      • Moh Anfasa Giffari Makkaraka
      • Ahmad Taufik Fadillah Zainal
      • Ponco Birowo
      • Widi Atmoko

    • PubMed: 40126496
    • DOI: 10.4081/aiua.2025.13750

    4 Insights on

    • Improved Total Sperm Motility
    • Improved Sperm Morphology
    • Improved Sperm Volume
    • Improved Sperm Concentration

    • High evidence

  • Expert Opinion: Place in Therapy of Probiotics in Infertility and Recurrent Implantation Failure.

    • 2025-03-24
    • Review
    • Cureus 17(3)
    • • Ameet Patki
      • Sujata Kar
      • Nayana Patel
      • Kundan Ingale
      • Kanthi Bansal
      • Poornima Durga

    • PubMed: 40271314
    • DOI: 10.7759/cureus.81067

    2 Insights on

    • Improved Reproductive Health
    • Reduced Recurrent Implantation Failure

    • Low evidence
• March 25

  • Assessing the combined effects of Black Cohosh, Soy Isoflavones, and SDG Lignans on menopausal symptoms: a randomized, double-blind, placebo-controlled clinical trial.

    • 2025-03-25
    • RCT · n = 90
    • European journal of nutrition 64(3)
    • • Evgeny Pokushalov
      • A Ponomarenko
      • C Garcia
      • L Kasimova
      • I Pak
      • E Shrainer
      • A Romanova
      • D Kudlay
      • M Johnson
      • R Miller

    • PubMed: 40131516
    • DOI: 10.1007/s00394-025-03588-y

    6 Insights on

    • Reduced Follicle Stimulating Hormone
    • Reduced Depression Severity
    • Increased Estradiol Level
    • Reduced Urogenital Symptom Score
    • Reduced Psychological Score
    • Reduced Somatic Symptom Score

    • High evidence
    • Rigorous Journal

  • Optimizing chronic kidney disease management: The potential of a multi-strain probiotic formulation.

    • 2025-03-25
    • Review
    • World journal of nephrology 14(1)
    • • Deodatta Chafekar

    • PubMed: 40134645
    • DOI: 10.5527/wjn.v14.i1.101515

    6 Insights on

    • Reduced Blood Glucose Levels
    • Reduced Blood Pressure
    • Improved Gut Microbiota Balance
    • Reduced Inflammation
    • Improved Immune-Related Symptoms
    • Improved Gastrointestinal Symptoms

    • Low evidence

  • A Review of the Clinical and Epidemiologic Evidence Relevant to the Impact of Postdiagnosis Isoflavone Intake on Breast Cancer Outcomes.

    • 2025-03-25
    • Review
    • Current nutrition reports 14(1)
    • • Mark Messina
      • Sarah Nechuta

    • PubMed: 40131602
    • DOI: 10.1007/s13668-025-00640-5

    4 Insights on

    • Reduced Breast Cell Proliferation
    • Reduced Mammographic Density
    • Reduced Breast Cancer Recurrence
    • Reduced Breast Cancer Mortality

    • Low evidence

  • Effect of honey-ginger mouthwash on oral mucositis in patients undergoing chemotherapy.

    • 2025-03-25
    • RCT · n = 70
    • Journal of immunoassay & immunochemistry 46(3)
    • • Fatemeh Sadat Razavi
      • Hania Zokaee
      • Mojtaba Sehat
      • Mohsen Taghizadeh
      • Hossein Motedayyen
      • Elaheh Ghasemzadeh Hoseini

    • PubMed: 40134126
    • DOI: 10.1080/15321819.2025.2484645

    2 Insights on

    • Reduced Pain Intensity
    • Reduced Oral Mucositis Severity

    • High evidence
• March 26

  • Impact of Acute and Sub-Acute Gluten Exposure on Gastrointestinal Symptoms and Psychological Responses in Non-Coeliac Gluten Sensitivity: A Randomised Crossover Study.

    • 2025-03-26
    • RCT · n = 16
    • United European gastroenterology journal 13(7)
    • • Julie Iven
      • Annelies Geeraerts
      • Tim Vanuytsel
      • Jan Tack
      • Lukas Van Oudenhove
      • Jessica R Biesiekierski

    • PubMed: 40138597
    • DOI: 10.1002/ueg2.70014

    12 Insights on

    • Reduced Intestinal Permeability
    • Improved Intestinal Epithelial Permeability
    • Reduced Fatigue Score
    • Improved Cortisol Awakening Response
    • Reduced Negative Affect Score
    • Improved Positive Affect Score
    • Reduced Flatulence
    • Reduced High-Sensitive C-Reactive Protein Level
    • Improved Positive Affect
    • Reduced Bloating Score
    • Reduced Tension Score
    • Reduced Abdominal Pain

    • High evidence

  • Comparative efficacy of Mucuna pruriens and conventional levodopa in Parkinson's disease: a randomized controlled trial on pharmacokinetics and clinical perspectives from Asia.

    • 2025-03-26
    • RCT · n = 11
    • Journal of neural transmission (Vienna, Austria : 1996) 132(11)
    • • Thanatat Boonmongkol
      • Onanong Phokaewvarangkul
      • Sornkanok Vimolmangkang
      • Thitima Wattanavijitkul
      • Virunya Komenkul
      • Roongroj Bhidayasiri

    • PubMed: 40137945
    • DOI: 10.1007/s00702-025-02914-2

    1 Insight on

    • Extended ON State Without Dyskinesia

    • High evidence

  • Long-read, multi-amplicon sequencing to explore genetic diversity associated with starch degrading phenotypes in amylolytic Lactobacillaceae.

    • 2025-03-26
    • Frontiers in microbiology 16
    • • Sandra A Olivier
      • Michelle K Bull
      • John P Bowman
      • Tom Ross
      • Belinda Chapman

    • PubMed: 40207158
    • DOI: 10.3389/fmicb.2025.1548052

    1 Insight on

    • Improved Starch Degradation Potential

    • Low evidence

  • Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome - a randomized placebo-controlled clinical trial.

    • 2025-03-26
    • RCT
    • BMC complementary medicine and therapies 25(1)
    • • Arezoo Maleki-Hajiagha
      • Faraz Mojab
      • Fardin Amidi
      • Leila Amini

    • PubMed: 40141012
    • DOI: 10.1186/s12906-025-04858-2

    6 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Reduced Malondialdehyde Level
    • Improved Antioxidant Capacity
    • Increased HDL Cholesterol Levels
    • Reduced Total Cholesterol Levels

    • High evidence
• March 27

  • Strain-Specific Therapeutic Potential of Lactiplantibacillus plantarum: A Systematic Scoping Review.

    • 2025-03-27
    • Systematic Review
    • Nutrients 17(7)
    • • Oranut Chatsirisakul
      • Natasha Leenabanchong
      • Yada Siripaopradit
      • Chun-Wei Chang
      • Patsakorn Buhngamongkol
      • Krit Pongpirul

    • PubMed: 40218922
    • DOI: 10.3390/nu17071165

    4 Insights on

    • Improved Immune Function
    • Enhanced Oral Health
    • Reduced Inflammation
    • Improved Gastrointestinal Symptoms

    • High evidence
    • Rigorous Journal

  • Effect of probiotics on necrotizing enterocolitis in preterm infants: a network meta-analysis of randomized controlled trials.

    • 2025-03-27
    • Systematic Review · n = 661
    • BMC pediatrics 25(1)
    • • Yu Dai
      • Qinlei Yu
      • Fan Zhang
      • Ke Ma
      • Xiangyun Yan
      • Wenjuan Chen
      • Xiaohui Chen
      • Shushu Li
      • Shuping Han

    • PubMed: 40140789
    • DOI: 10.1186/s12887-025-05469-z

    6 Insights on

    • Reduced Length of Hospitalization
    • No Change in Sepsis Risk
    • Reduced Incidence of Necrotizing Enterocolitis
    • Reduced Time to Full Enteral Feeding
    • Reduced Length of Hospital Stay
    • Reduced All-Cause Mortality

    • High evidence

  • Effects of natural extracts in cognitive function of healthy adults: a systematic review and network meta-analysis.

    • 2025-03-27
    • Systematic Review
    • Frontiers in pharmacology 16
    • • Zhi-Yuan Wang
      • Ya-Lu Deng
      • Ting-Yuan Zhou
      • Yi Liu
      • Yu Cao

    • PubMed: 40213691
    • DOI: 10.3389/fphar.2025.1573034

    3 Insights on

    • Improved Cognitive Function
    • Improved Memory Function
    • Improved Cognitive Flexibility

    • High evidence

  • Effect of bovine colostrum supplementation on gut health of children: A systematic review.

    • 2025-03-27
    • Systematic Review
    • Journal of pediatric gastroenterology and nutrition 80(6)
    • • Deshna Oswal
      • Mubashir Angolkar
      • N S Mahantashetti
      • Pooja Dhagavkar
      • Shivani Haritay
      • Madan Godbole

    • PubMed: 40150801
    • DOI: 10.1002/jpn3.70033

    2 Insights on

    • Reduced Duration of Diarrheal Infection
    • Reduced Diarrhea Rate

    • High evidence

  • Distinct Effects of Wheat and Black Bean Consumption on Postprandial Vascular Responses in People with Arterial Stiffness: A Pilot Randomized Cross-Over Study.

    • 2025-03-27
    • RCT · n = 9
    • Nutrients 17(7)
    • • Peter Zahradka
      • Danielle Perera
      • Jordan Charney
      • Carla G Taylor

    • PubMed: 40218917
    • DOI: 10.3390/nu17071159

    1 Insight on

    • Increased Systolic Blood Pressure

    • High evidence
    • Rigorous Journal
• March 28

  • Lactobacillus acidophilus LA85 reverses experimental diabetic sensory neuropathy by restoring redox homeostasis in the spinal cord.

    • 2025-03-28
    • Clinical Trial
    • Beneficial microbes 16(5)
    • • Max Denisson Maurı́cio Viana
      • Sthefane Silva Santos
      • Mariana Bastos de Souza
      • Luı́za Carolina França Opretzka
      • Dhara Leite Lopes
      • Milena Botelho Pereira Soares
      • Cristiane Flora Villarreal

    • PubMed: 40312038
    • DOI: 10.1163/18762891-bja00069

    3 Insights on

    • Improved Redox Homeostasis
    • Reduced Neuroinflammation
    • Reduced Diabetic Neuropathic Pain

    • Low evidence
    • Rigorous Journal
    • Animal Study
• Undated – 11 supplement studies

  • Review on the Function, Substrate Affinity, and Potential Application of Bile Salt Hydrolase Originated from Probiotic Strains of Lactobacillus, Bifidobacterium, and Enterococcus.

    • 2025-03
    • Review
    • Food science of animal resources 45(2)
    • • Mo Hyeon Kang
      • Arxel G Elnar
      • Geun-Bae Kim

    • PubMed: 40093624
    • DOI: 10.5851/kosfa.2025.e1

    1 Insight on

    • Reduced Blood Cholesterol

    • Low evidence

  • Bifidobacterium longum subsp. longum XZ01 delays the progression of colon cancer in mice through the interaction between the microbial spatial distribution and tumour immunity.

    • 2025-03
    • International immunopharmacology 150
    • • Ying Chen
      • Jinyun Wu
      • Kaiwei Cai
      • Xiaoyi Xiao
      • Ye Chen
      • Xingyuan Zhang
      • Song Deng
      • Chaoying Pei
      • Yanlong Chen
      • Zhiyong Xie
      • Pei Li
      • Qiongfeng Liao

    • PubMed: 39955918
    • DOI: 10.1016/j.intimp.2025.114283

    1 Insight on

    • Reduced Cancer Progression

    • Low evidence

  • NapBiome trial: Targeting gut microbiota to improve sleep rhythm and developmental and behavioural outcomes in early childhood in a birth cohort in Switzerland - a study protocol.

    • 2025-03
    • RCT
    • BMJ open 15(3)
    • • Petra Zimmermann
      • Salome Kurth
      • Stamatios Giannoukos
      • Martin Stocker
      • Nicholas A Bokulich

    • PubMed: 40032396
    • DOI: 10.1136/bmjopen-2024-092938

    2 Insights on

    • Improved Neurodevelopmental Outcome
    • Improved Sleep

    • High evidence

  • Carnosine supplementation improves cognitive outcomes in younger participants of the NEAT trial.

    • 2025-03
    • RCT · n = 299
    • Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 22(2)
    • • Timothy E O'Toole
      • Alok R Amraotkar
      • Hong Gao
      • Clara G Sears
      • Shesh N Rai
      • Mathias Basner
      • Aruni Bhatnagar

    • PubMed: 39919936
    • DOI: 10.1016/j.neurot.2025.e00541

    4 Insights on

    • Improved Speed Score
    • Improved Delayed Memory
    • Improved Attention Span
    • Improved Cognitive Speed

    • High evidence
    • Large Human Trial

  • Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers.

    • 2025-03
    • RCT · n = 17
    • The Journal of nutrition 155(3)
    • • Alaa T Alhasani
      • Amisha A Modasia
      • Mohamed Anodiyil
      • Maura Corsetti
      • Abdulsalam I Aliyu
      • Colin Crooks
      • Luca Marciani
      • Joshua Reid
      • Gleb E Yakubov
      • Moira Taylor
      • Amanda Avery
      • Hannah Harris
      • Frederick J Warren
      • Robin C Spiller

    • PubMed: 39732438
    • DOI: 10.1016/j.tjnut.2024.12.017

    2 Insights on

    • Reduced Breath Hydrogen
    • Reduced Breath Hydrogen Level

    • High evidence

  • Reduction of postoperative ileus in gastrointestinal surgery: systematic review and meta-analysis.

    • 2025-03
    • Meta-Analysis · n = 4,647
    • Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 29(3)
    • • Doris Sarmiento-Altamirano
      • Daniel Arce-Jara
      • Pablo Balarezo-Guerrero
      • Rafael Valdivieso-Espinoza

    • PubMed: 39788451
    • DOI: 10.1016/j.gassur.2025.101960

    2 Insights on

    • Reduced Time to First Flatus
    • Reduced Time to First Stool

    • High evidence

  • The effect of a 14-day Gymnema sylvestre intervention to reduce sugar intake in people self-identifying with a sweet tooth.

    • 2025-03
    • RCT
    • Appetite 207
    • • Hsiao Wh
      • Kruger R
      • Diako C
      • Nelson I
      • Stice E
      • Ali A

    • PubMed: 39855349
    • DOI: 10.1016/j.appet.2025.107871

    4 Insights on

    • Reduced Sugar Craving
    • Reduced Chocolate Craving
    • Reduced Chocolate Pleasantness Rating
    • Reduced Sugar-Sweetened Beverage Intake

    • High evidence

  • Cardioprotective effect of crocin in patients with breast cancer receiving anthracycline-based chemotherapy: A randomized, double-blind, placebo-controlled study.

    • 2025-03
    • RCT · n = 200
    • Pharmacological research 213
    • • Xinye Li
      • Xin Su
      • Wanping Liang
      • Li Wang
      • Chao Yuan
      • Juping Xu
      • Yijun Zhang
      • Yan Liu
      • Ning Ma
      • Fan Yang
      • Yiyuan Yang
      • Liyuan Tao
      • Shipeng Sun
      • Hongcai Shang
      • Yanwei Xing

    • PubMed: 39889867
    • DOI: 10.1016/j.phrs.2025.107630

    3 Insights on

    • Reduced NT-proBNP Level
    • Reduced Heart Rate
    • Reduced Decline in Left Ventricular Ejection Fraction

    • High evidence
    • Large Human Trial

  • Acute Effect of Honey-sweetened Coffee on Blood Pressure, Heart Rate and Blood Glucose Level in Healthy Female Subjects.

    • 2025-03
    • RCT · n = 10
    • Cardiovascular & hematological disorders drug targets 25(1)
    • • Esther Oluwasola Aluko
      • Etiemem Emmanuel Effiong
      • Titilope Helen Olatunbosun
      • Grace Edet Bassey

    • PubMed: 39757598
    • DOI: 10.2174/011871529x348787241217103918

    5 Insights on

    • Reduced Heart Rate
    • Reduced Systolic Blood Pressure
    • Reduced Mean Arterial Pressure
    • Reduced Diastolic Blood Pressure
    • Reduced Fasting Blood Glucose Levels

    • High evidence

  • An Observational Study on the Association Between Nutritional Intake and Mental Health Among Older Adults in Rural Areas.

    • 2025-03
    • Observational · n = 465
    • Nursing & health sciences 27(1)
    • • Kyeongmin Jang

    • PubMed: 40101703
    • DOI: 10.1111/nhs.70080

    2 Insights on

    • Reduced Anxiety
    • Reduced Depression Symptoms

    • High evidence

  • The effect of saffron supplementation on liver and kidney function, blood glucose and pressure in patients with diabetes and prediabetes: A grade assessed systematic review and meta-analysis of randomized controlled trials.

    • 2025-03
    • Meta-Analysis
    • Prostaglandins & other lipid mediators 177
    • • Jia-Wei Zhang
      • Qing Zhao
      • Zhe Li
      • Qian Liu
      • Sha-Sha Zang
      • Sha Liu

    • PubMed: 39818282
    • DOI: 10.1016/j.prostaglandins.2025.106949

    7 Insights on

    • Reduced Aspartate Aminotransferase Level
    • Reduced Alanine Aminotransferase Level
    • Reduced Systolic Blood Pressure
    • Reduced Diastolic Blood Pressure
    • Reduced Creatinine Level
    • Reduced Blood Urea Nitrogen Levels
    • Reduced Fasting Blood Glucose Levels

    • High evidence