July 2022 Supplement Research Papers

• July 1

  • Comparison of L-Carnitine vs. Coq10 and Vitamin E for idiopathic male infertility: a randomized controlled trial.

    • 2022-07-01
    • RCT · n = 143
    • European review for medical and pharmacological sciences 26(13)
    • • L Ma
      • Y Sun

    • PubMed: 35856361
    • DOI: 10.26355/eurrev_202207_29194

    5 Insights on

    • Improved Sperm Morphology
    • Increased Testosterone Level
    • Improved Sperm Concentration
    • Improved Progressive Sperm Motility
    • Increased Luteinizing Hormone Level

    • High evidence
    • Large Human Trial

  • Effect of L-carnitine on quality of life in covert hepatic encephalopathy: a randomized, double-blind, placebo-controlled study.

    • 2022-07-01
    • RCT · n = 150
    • The Korean journal of internal medicine 37(4)
    • • Eileen L Yoon
      • Sang Bong Ahn
      • Dae Won Jun
      • Yong Kyun Cho
      • Do Seon Song
      • Jae Yoon Jeong
      • Hee Yeon Kim
      • Young Kul Jung
      • Myeong Jun Song
      • Sung Eun Kim
      • Hyoung Su Kim
      • Soung Won Jeong
      • Sang Gyune Kim
      • Tae Hee Lee

    • PubMed: 35526858
    • DOI: 10.3904/kjim.2021.338

    7 Insights on

    • Improved Quality of Life
    • Improved Cognitive Flexibility
    • Improved Inhibitory Control
    • Improved Psychometric Hepatic Encephalopathy Score
    • Improved Stroop Color Test
    • Improved Stroop Word Test
    • Reduced MELD Score

    • High evidence
    • Large Human Trial
• July 2

  • Exopolysaccharide from Lactobacillus rhamnosus ZFM231 alleviates DSS-induced colitis in mice by regulating gut microbiota.

    • 2022-07-02
    • Clinical Trial
    • Journal of the Science of Food and Agriculture 102(15)
    • • C. Wan
      • Wen-Wen Qian
      • W. Liu
      • X. Pi
      • Meng Tang
      • Xiao-Lin Wang
      • Q. Gu
      • Ping Li
      • Tao Zhou

    • PubMed: 35707876
    • DOI: 10.1002/jsfa.12070

    14 Insights on

    • Improved Gut Microbiota Diversity
    • Reduced Tumor Necrosis Factor Alpha
    • Increased Short-Chain Fatty Acid Levels
    • Reduced Body Weight
    • Reduced Tissue Damage from Colitis
    • Reduced Inflammation Levels
    • Improved Colonic Length
    • Improved Disease Activity Index Score
    • Increased Short-Chain Fatty Acid Production
    • Improved Colonic Health
    • Reduced Disease Activity Score
    • Reduced Pro-Inflammatory Factor TNF-α
    • Reduced Body Weight Loss
    • Restored Microbial Diversity

    • Low evidence
    • Rigorous Journal
    • Animal Study
• July 3

  • Beneficial effects of Ginkgo biloba leaf extract on inflammatory markers: A systematic review and meta-analysis of the clinical trials.

    • 2022-07-03
    • Meta-Analysis · n = 104
    • Phytotherapy research : PTR 36(9)
    • • Seyedeh Neda Mousavi
      • Mahboobe Hosseinikia
      • Esmaeil Yousefi Rad
      • Somayeh Saboori

    • PubMed: 35781715
    • DOI: 10.1002/ptr.7544

    3 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Reduced C-Reactive Protein Levels

    • High evidence

  • Effect of nutritional supports on malnutrition, cognition, function and biomarkers of Alzheimer's disease: a systematic review.

    • 2022-07-03
    • Systematic Review · n = 7,009
    • The International journal of neuroscience 133(12)
    • • Rümeysa Rabia Kocatürk
      • Arzu Temizyürek
      • Öznur Özge Özcan
      • Türker Tekin Ergüzel
      • Mesut Karahan
      • Muhsin Konuk
      • Nevzat Tarhan

    • PubMed: 35686376
    • DOI: 10.1080/00207454.2022.2079506

    8 Insights on

    • Improved Quality of Life
    • Promoted Weight Gain
    • Improved Malnutrition Status
    • Reduced Amyloid Precursor Protein Level
    • Reduced BACE1 Level
    • Reduced BACE1 mRNA Level
    • Improved Cognitive Prognosis
    • Improved Functional Prognosis

    • High evidence
• July 4

  • Lactiplantibacillus plantarum Postbiotics: Alternative of Antibiotic Growth Promoter to Ameliorate Gut Health in Broiler Chickens

    • 2022-07-04
    • RCT · n = 245
    • Frontiers in Veterinary Science 9
    • • H. Chang
      • T. Loh
      • H. Foo
      • E. Lim

    • PubMed: 35859810
    • DOI: 10.3389/fvets.2022.883324

    8 Insights on

    • Improved Intestinal Barrier Function
    • Improved Immune Response
    • Improved Growth Performance
    • Improved Gut Health
    • Enhanced Intestinal Mucin Production
    • Improved Gut Microbiota Balance
    • Improved Total Antioxidant Status
    • Improved Immunity Status

    • Low evidence
    • Animal Study

  • Bifidobacterium infantis Promotes Foxp3 Expression in Colon Cells via PD-L1-Mediated Inhibition of the PI3K-Akt-mTOR Signaling Pathway

    • 2022-07-04
    • Frontiers in Immunology 13
    • • L. Zhou
      • Ying Xie
      • Yan Li

    • PubMed: 35860248
    • DOI: 10.3389/fimmu.2022.871705

    1 Insight on

    • Inhibited PI3K-Akt-mTOR Signaling

    • Low evidence
• July 5

  • Cinnamon as a Complementary Therapeutic Approach for Dysglycemia and Dyslipidemia Control in Type 2 Diabetes Mellitus and Its Molecular Mechanism of Action: A Review.

    • 2022-07-05
    • Review
    • Nutrients 14(13)
    • • Maria Leonor Silva
      • Maria Alexandra Bernardo
      • Jaipaul Singh
      • Maria Fernanda de Mesquita

    • PubMed: 35807953
    • DOI: 10.3390/nu14132773

    3 Insights on

    • Reduced Inflammation
    • Improved Blood Lipid Profile
    • Improved Glycemia

    • Moderate evidence
    • Rigorous Journal
• July 6

  • Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice

    • 2022-07-06
    • Frontiers in Immunology 13
    • • Jiayuan Cao
      • Qiqi Liu
      • Haining Hao
      • Yushan Bu
      • Xiaoying Tian
      • Ting Wang
      • H. Yi

    • PubMed: 35874662
    • DOI: 10.3389/fimmu.2022.940228

    3 Insights on

    • Reduced Uric Acid Levels
    • Improved Gut Microbiota Balance
    • Reduced Renal Inflammation

    • Low evidence

  • Beneficial Effect of Heat-Killed Lactiplantibacillus plantarum L-137 on Skin Functions in Healthy Participants: A Randomized, Placebo-Controlled, Double-Blind Study

    • 2022-07-06
    • RCT · n = 80
    • Frontiers in Medicine 9
    • • Rieko Yoshitake
      • Hiroko Nakai
      • Manato Ebina
      • K. Kawasaki
      • S. Murosaki
      • Y. Hirose

    • PubMed: 35872749
    • DOI: 10.3389/fmed.2022.912280

    4 Insights on

    • Improved Skin Hydration
    • Reduced Transepidermal Water Loss
    • Improved Dermatology Life Quality Index
    • Improved Skin Satisfaction

    • High evidence
• July 7

  • Effect of taurine administration on symptoms, severity, or clinical outcome of dilated cardiomyopathy and heart failure in humans: a systematic review.

    • 2022-07-07
    • Systematic Review · n = 250
    • Wellcome open research 7
    • • Kathryn A McGurk
      • Melpomeni Kasapi
      • James S Ware

    • PubMed: 35855073
    • DOI: 10.12688/wellcomeopenres.17505.3

    6 Insights on

    • Improved Diastolic Function
    • Improved Systolic Function
    • Improved Hemodynamic Parameter
    • Improved Ejection Fraction
    • Improved Exercise Capacity
    • Improved Stroke Volume

    • High evidence

  • Bifidobacterium longum BL-10 with Antioxidant Capacity Ameliorates Lipopolysaccharide-Induced Acute Liver Injury in Mice by the Nuclear Factor-κB Pathway.

    • 2022-07-07
    • Clinical Trial
    • Journal of Agricultural and Food Chemistry 70(28)
    • • Jiahuan Dong
      • Lijun Ping
      • Y. Meng
      • Kangyong Zhang
      • Hongwei Tang
      • Deyu Liu
      • Bailiang Li
      • G. Huo

    • PubMed: 35797025
    • DOI: 10.1021/acs.jafc.2c02950

    5 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Pro-Inflammatory Cytokines
    • Improved Antioxidant Capacity
    • Reduced Liver Function Indicators
    • Improved Acute Liver Injury

    • Low evidence
    • Animal Study
• July 8

  • Complementary and alternative medicine for glycemic control of diabetes mellitus: A systematic review.

    • 2022-07-08
    • Review
    • Journal of public health research 11(3)
    • • Erni Setiyorini
      • Mochammad Bagus Qomaruddin
      • Sony Wibisono
      • Titik Juwariah
      • Anggi Setyowati
      • Ning Arti Wulandari
      • Yeni Kartika Sari
      • Levi Tina Sari

    • PubMed: 35911428
    • DOI: 10.1177/22799036221106582

    1 Insight on

    • Reduced Blood Glucose Levels

    • Low evidence

  • Saccharomyces boulardii Allows Partial Patients to Avoid Reusing Bismuth Quadruple for Helicobacter pylori Rescue Therapy: A Single-Center Randomized Controlled Study.

    • 2022-07-08
    • RCT · n = 50
    • Frontiers in cellular and infection microbiology 12
    • • Peng Qu
      • Xiaoming Liu
      • Xiujuan Xia
      • Xiaoran Xie
      • Ju Luo
      • Sha Cheng
      • Jingshu Chi
      • Peng Liu
      • Huan Li
      • Wenfang Zhao
      • Huihao Yang
      • Canxia Xu

    • PubMed: 35880079
    • DOI: 10.3389/fcimb.2022.903002

    1 Insight on

    • Reduced Helicobacter Pylori Infection

    • High evidence
• July 9

  • Lactobacillus salivarius UCC118™ Dampens Inflammation and Promotes Microbiota Recovery to Provide Therapeutic Benefit in a DSS-Induced Colitis Model

    • 2022-07-09
    • Clinical Trial
    • Microorganisms 10(7)
    • • N. Iyer
      • Michelle A Williams
      • A. O’Callaghan
      • E. Dempsey
      • R. Cabrera-Rubio
      • Mathilde Raverdeau
      • F. Crispie
      • P. Cotter
      • S. Corr

    • PubMed: 35889102
    • DOI: 10.3390/microorganisms10071383

    11 Insights on

    • Reduced Colitis Severity
    • Increased Interleukin-10 Levels
    • Improved Recovery From Colitis
    • Reduced Dysbiosis
    • Accelerated Colitis Recovery
    • Increased Anti-Inflammatory Cytokine IL-10
    • Improved Gut Microbiome Recovery
    • Enhanced Inflammation Resolution
    • Recovered Microbiome-associated Dysbiosis
    • Restored Gut Microbiota
    • Promoted Recovery from Colitis-Associated Dysbiosis

    • Low evidence
    • Rigorous Journal
    • Animal Study
• July 10

  • The Phagocytosis of Lacticaseibacillus casei and Its Immunomodulatory Properties on Human Monocyte-Derived Dendritic Cells Depend on the Expression of Lc-p75, a Bacterial Peptidoglycan Hydrolase

    • 2022-07-10
    • International Journal of Molecular Sciences 23(14)
    • • M. Tóth
      • Szabolcs Muzsai
      • Krzysztof Regulski
      • Tímea Szendi-Szatmári
      • Zsolt Czimmerer
      • E. Rajnavölgyi
      • M. Chapot-Chartier
      • A. Bácsi

    • PubMed: 35886967
    • DOI: 10.3390/ijms23147620

    1 Insight on

    • Enhanced Phagocytosis by Monocyte-Derived Dendritic Cells

    • Low evidence
• July 11

  • A Review on the Antidiabetic Properties of Moringa oleifera Extracts: Focusing on Oxidative Stress and Inflammation as Main Therapeutic Targets.

    • 2022-07-11
    • Review
    • Frontiers in pharmacology 13
    • • Fikile T Mthiyane
      • Phiwayinkosi V Dludla
      • Khanyisani Ziqubu
      • Sinenhlanhla X H Mthembu
      • Ndivhuwo Muvhulawa
      • Nokulunga Hlengwa
      • Bongani B Nkambule
      • Sithandiwe E Mazibuko-Mbeje

    • PubMed: 35899107
    • DOI: 10.3389/fphar.2022.940572

    1 Insight on

    • Reduced Postprandial Glucose

    • Low evidence

  • Effects of the Probiotic, Lactobacillus delbrueckii subsp. bulgaricus, as a Substitute for Antibiotics on the Gastrointestinal Tract Microbiota and Metabolomics Profile of Female Growing-Finishing Pigs

    • 2022-07-11
    • RCT · n = 42
    • Animals 12(14)
    • • Jiayuan Mo
      • Yujie Lu
      • Shan Jiang
      • Gang Yan
      • Tianqi Xing
      • Di Xu
      • Yao He
      • Bingkun Xie
      • G. Lan
      • Baojian Chen
      • Jing Liang

    • PubMed: 35883325
    • DOI: 10.3390/ani12141778

    10 Insights on

    • Increased Fecal Lactobacilli
    • Improved Gastrointestinal Health
    • Improved Average Daily Gain
    • Improved Growth Performance
    • Increased Valerate Concentration
    • Altered Pyridoxine Concentration
    • Increased Levels of Beneficial Metabolites
    • Reduced Lithocholic Acid Concentration
    • Regulated Gastrointestinal Function
    • Enhanced Metabolite Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study
• July 12

  • Protein Sources Alternative to Meat: State of the Art and Involvement of Fermentation.

    • 2022-07-12
    • Review
    • Foods (Basel, Switzerland) 11(14)
    • • Mariagrazia Molfetta
      • Etiele G Morais
      • Luisa Barreira
      • Giovanni Luigi Bruno
      • Francesco Porcelli
      • Eric Dugat-Bony
      • Pascal Bonnarme
      • Fabio Minervini

    • PubMed: 35885308
    • DOI: 10.3390/foods11142065

    1 Insight on

    • Improved Nutritional Quality

    • Low evidence

  • Coix Seed-Based Milk Fermented With Limosilactobacillus reuteri Improves Lipid Metabolism and Gut Microbiota in Mice Fed With a High-Fat Diet

    • 2022-07-12
    • Clinical Trial
    • Frontiers in Nutrition 9
    • • Zhoujie Yang
      • Xiaoli Zhu
      • Anyan Wen
      • Jin Ran
      • Likang Qin
      • Yi Zhu

    • PubMed: 35903451
    • DOI: 10.3389/fnut.2022.921255

    10 Insights on

    • Reduced Body Weight
    • Reduced Hepatic Oxidative Stress
    • Increased Beneficial Gut Microbiota
    • Increased HDL Cholesterol Levels
    • Reduced LDL Cholesterol
    • Reduced Hepatic Fat Accumulation
    • Reduced Serum Total Cholesterol Levels
    • Reduced Lipid Synthesis
    • Improved Gut Microbiota Structure
    • Reduced Harmful Gut Bacteria

    • Low evidence
    • Animal Study
• July 13

  • N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations.

    • 2022-07-13
    • Review
    • Amino acids 54(9)
    • • Dimitrios Tsikas
      • Marie Mikuteit

    • PubMed: 35829920
    • DOI: 10.1007/s00726-022-03185-x

    5 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-1β Levels
    • Reduced C-Reactive Protein Levels
    • Reduced Malondialdehyde Level
    • Reduced Nitric Oxide Level

    • Low evidence

  • Sustainable Green Synthesis of Yttrium Oxide (Y2O3) Nanoparticles Using Lantana camara Leaf Extracts: Physicochemical Characterization, Photocatalytic Degradation, Antibacterial, and Anticancer Potency.

    • 2022-07-13
    • Nanomaterials (Basel, Switzerland) 12(14)
    • • Rajakumar Govindasamy
      • Mydhili Govindarasu
      • Salman S Alharthi
      • Preeyanghaa Mani
      • Neppolian Bernaurdshaw
      • Thandapani Gomathi
      • Mohammad Azam Ansari
      • Mohammad N Alomary
      • Banan Atwah
      • M Shaheer Malik
      • V Devi Rajeswari
      • Kaliaperumal Rekha
      • Saleh A Ahmed
      • Muthu Thiruvengadam

    • PubMed: 35889617
    • DOI: 10.3390/nano12142393

    1 Insight on

    • Reduced Bacterial Load

    • Low evidence

  • Effect of vitamin B6 on pain, disease severity, and psychological profile of fibromyalgia patients; a randomized, double-blinded clinical trial.

    • 2022-07-13
    • RCT · n = 90
    • BMC musculoskeletal disorders 23(1)
    • • Banafsheh Ghavidel-Parsa
      • Arvin Naeimi
      • Faeze Gharibpoor
      • Nazila Sattari
      • Atefeh Jafari
      • Irandokht Shenavar Masooleh
      • Ali Montazeri

    • PubMed: 35831850
    • DOI: 10.1186/s12891-022-05637-7

    3 Insights on

    • Reduced Anxiety
    • Reduced Pain
    • Improved Fibromyalgia Impact

    • High evidence
• July 14

  • Probiotics: Protecting Our Health from the Gut.

    • 2022-07-14
    • Review
    • Microorganisms 10(7)
    • • Gael Urait Varela-Trinidad
      • Carolina Domínguez-Díaz
      • Karla Solórzano-Castanedo
      • Liliana Íñiguez-Gutiérrez
      • Teresita de Jesús Hernández-Flores
      • Mary Fafutis-Morris

    • PubMed: 35889147
    • DOI: 10.3390/microorganisms10071428

    5 Insights on

    • Reduced Blood Pressure
    • Improved Skin Hydration
    • Reduced Body Fat
    • Reduced Fat Accumulation
    • Improved Tolerance

    • Low evidence

  • Efficacy of dietary supplements targeting gut microbiota in the prevention and treatment of gestational diabetes mellitus.

    • 2022-07-14
    • Review
    • Frontiers in microbiology 13
    • • Jiayang Wan
      • Jingmei Ma

    • PubMed: 35910625
    • DOI: 10.3389/fmicb.2022.927883

    2 Insights on

    • Modulated Gut Microbiota
    • Reduced Prevalence of Gestational Diabetes Mellitus

    • Low evidence

  • Lactobacillus fermentum CECT5716 Alleviates the Inflammatory Response in Asthma by Regulating TLR2/TLR4 Expression

    • 2022-07-14
    • Clinical Trial
    • Frontiers in Nutrition 9
    • • Weifang Wang
      • Yunfeng Li
      • G. Han
      • Aimin Li
      • X. Kong

    • PubMed: 35911120
    • DOI: 10.3389/fnut.2022.931427

    5 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Inflammatory Response
    • Reduced Airway Inflammation
    • Improved Airway Mucosa Condition
    • Reduced Pulmonary Fibrosis

    • Low evidence
    • Animal Study
• July 15

  • The Health Benefits of Egg Protein.

    • 2022-07-15
    • Review
    • Nutrients 14(14)
    • • Michael J Puglisi
      • Maria Luz Fernandez

    • PubMed: 35889862
    • DOI: 10.3390/nu14142904

    10 Insights on

    • Reduced Body Weight
    • Reduced Blood Pressure
    • Reduced Cancer Risk
    • Reduced Infection Rate
    • Reduced Malnutrition
    • Increased Height
    • Reduced Kwashiorkor
    • Improved Skeletal Muscle Health
    • Reduced Sarcopenia
    • Reduced Caloric Intake

    • Moderate evidence
    • Rigorous Journal

  • The Role of Psychobiotics in Supporting the Treatment of Disturbances in the Functioning of the Nervous System-A Systematic Review.

    • 2022-07-15
    • Systematic Review
    • International journal of molecular sciences 23(14)
    • • Krzysztof Skowron
      • Anna Budzyńska
      • Natalia Wiktorczyk-Kapischke
      • Karolina Chomacka
      • Katarzyna Grudlewska-Buda
      • Monika Wilk
      • Ewa Wałecka-Zacharska
      • Małgorzata Andrzejewska
      • Eugenia Gospodarek-Komkowska

    • PubMed: 35887166
    • DOI: 10.3390/ijms23147820

    1 Insight on

    • Improved Depressive Symptoms

    • High evidence
    • Rigorous Journal

  • Reuterin Isolated from Lactobacillus reuteri Indonesian Strain Affected Interleukin-8 and Human Beta Defensin-2 on Pathogens Induced-HaCat Cells

    • 2022-07-15
    • Tropical Life Sciences Research 33(2)
    • • A. Widyarman
      • B. Bachtiar
      • Endang Winiati Bahctiar

    • PubMed: 35966270
    • DOI: 10.21315/tlsr2022.33.2.5

    4 Insights on

    • Reduced Inflammatory Response
    • Reduced Inflammation Levels
    • Enhanced Antimicrobial Peptide Levels
    • Increased Expression of Human Beta Defensin-2

    • Low evidence
• July 19

  • High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.

    • 2022-07-19
    • RCT · n = 307
    • Human psychopharmacology 37(6)
    • • David T Field
      • Rebekah O Cracknell
      • Jessica R Eastwood
      • Peter Scarfe
      • Claire M Williams
      • Ying Zheng
      • Teresa Tavassoli

    • PubMed: 35851507
    • DOI: 10.1002/hup.2852

    5 Insights on

    • Reduced Depression Symptoms
    • Reduced Anxiety
    • Improved Visual Surround Suppression
    • Reduced Binocular Rivalry Reversal Rate
    • Improved Tactile Sensitivity

    • High evidence
    • Large Human Trial

  • Probiotic Lactobacillus rhamnosus GR-1 supplementation attenuates Pb-induced learning and memory deficits by reshaping the gut microbiota

    • 2022-07-19
    • Clinical Trial
    • Frontiers in Nutrition 9
    • • Xiaozhen Gu
      • Nanxi Bi
      • Tiandong Wang
      • Chengqing Huang
      • Rongrong Wang
      • Yi Xu
      • Hui-Li Wang

    • PubMed: 35928850
    • DOI: 10.3389/fnut.2022.934118

    6 Insights on

    • Improved Gut Microbiota Diversity
    • Reduced Neurotoxicity
    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Inflammation
    • Improved Gut Permeability
    • Improved Gut Barrier Function

    • Low evidence
    • Animal Study

  • Akkermansia muciniphila Enhances Egg Quality and the Lipid Profile of Egg Yolk by Improving Lipid Metabolism

    • 2022-07-19
    • RCT · n = 220
    • Frontiers in Microbiology 13
    • • Fuxiao Wei
      • Xinyue Yang
      • Meihong Zhang
      • Chang Xu
      • Yongfei Hu
      • Dan Liu

    • PubMed: 35928144
    • DOI: 10.3389/fmicb.2022.927245

    10 Insights on

    • Reduced Visceral Fat
    • Reduced Body Weight
    • Reduced Serum Total Cholesterol Levels
    • Improved Lipid Levels
    • Reduced Yolk Cholesterol Content
    • Reduced Liver Cholesterol Levels
    • Enhanced Eggshell Thickness
    • Reduced Serum Lipid Levels
    • Reduced Liver Lipid Content
    • Reduced Cholesterol Synthesis

    • Low evidence
    • Animal Study

  • Clinical Application of Traditional Chinese Medicine Therapy for Type 2 Diabetes Mellitus: An Evidence Map.

    • 2022-07-19
    • Review
    • Evidence-based complementary and alternative medicine : eCAM 2022
    • • Ying Wang
      • Zelei Dai
      • Qin Wang
      • Ying He
      • Yalan Peng
      • Miaomiao Wu
      • Haiqi Song
      • Long Ma
      • Yonggang Zhang
      • Nian Li

    • PubMed: 35911140
    • DOI: 10.1155/2022/2755332

    6 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Reduced Hemoglobin A1c
    • Reduced Blood Cholesterol
    • Reduced Fasting Blood Glucose Levels
    • Reduced Postprandial Blood Glucose

    • Low evidence
• July 20

  • The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials.

    • 2022-07-20
    • Meta-Analysis
    • Phytotherapy research : PTR 36(10)
    • • Trias Mahmudiono
      • Saade Abdalkareem Jasim
      • Yasir Salam Karim
      • Dmitry Olegovich Bokov
      • Walid Kamal Abdelbasset
      • Kholmurod S Akhmedov
      • Ghulam Yasin
      • Lakshmi Thangavelu
      • Yasser Fakri Mustafa
      • Shehla Shoukat
      • Mazin A A Najm
      • Mohammad Amraei

    • PubMed: 35859037
    • DOI: 10.1002/ptr.7566

    2 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure

    • High evidence

  • Spore Powder of Paecilomyces hepiali Shapes Gut Microbiota to Relieve Exercise-Induced Fatigue in Mice

    • 2022-07-20
    • Clinical Trial
    • Nutrients 14(14)
    • • Tianyue Guan
      • Shuoshuo Li
      • Qijie Guan
      • Jin-song Shi
      • Zhen-Ming Lu
      • Zhenghong Xu
      • Yan Geng

    • PubMed: 35889929
    • DOI: 10.3390/nu14142973

    6 Insights on

    • Improved Gut Microbiota Composition
    • Increased Exercise Endurance
    • Reduced Exercise-Induced Biochemical Markers
    • Improved Muscle Integrity
    • Reduced Fatigue
    • Improved Fatigue

    • Low evidence
    • Animal Study

  • Lactobacillus salivarius SNK-6 Activates Intestinal Mucosal Immune System by Regulating Cecal Microbial Community Structure in Laying Hens

    • 2022-07-20
    • RCT · n = 384
    • Microorganisms 10(7)
    • • Yuchen Liu
      • Lianhong Li
      • H. Yan
      • Z. Ning
      • Zhong Wang

    • PubMed: 35889188
    • DOI: 10.3390/microorganisms10071469

    2 Insights on

    • Improved Immune Response
    • Altered Microbial Composition

    • Low evidence
    • Rigorous Journal
    • Animal Study
• July 21

  • Beneficial Shifts in Gut Microbiota by Lacticaseibacillus rhamnosus R0011 and Lactobacillus helveticus R0052 in Alcoholic Hepatitis

    • 2022-07-21
    • RCT · n = 89
    • Microorganisms 10(7)
    • • Haripriya Gupta
      • Sung Hun Kim
      • Seul Ki Kim
      • Sang Hak Han
      • H. Kwon
      • K. Suk

    • PubMed: 35889193
    • DOI: 10.3390/microorganisms10071474

    16 Insights on

    • Improved Gut Microbiota
    • Reduced Aminotransferase Levels
    • Reduced Endotoxin Levels
    • Improved Liver Function
    • Reduced Gram-Negative Bacteria Count
    • Reduced Plasma Lipopolysaccharide Levels
    • Improved Child-Pugh Scores
    • Restored Normal Microbiota
    • Reduced Gamma-Glutamyl Transferase Levels
    • Reduced Proportion of Proteobacteria
    • Reduced Proportion of Fusobacteria
    • Reduced Gram-Negative Bacteria Levels
    • Reduced Serum Alanine Aminotransferase Levels
    • Reduced Alanine Aminotransferase Level
    • Reduced Lipopolysaccharide Level
    • Reduced Gamma-glutamyltranspeptidase Level

    • High evidence
    • Rigorous Journal

  • Lactococcus lactis subsp. cremoris C60 induces macrophages activation that enhances CD4+ T cell-based adaptive immunity

    • 2022-07-21
    • Clinical Trial
    • Bioscience of Microbiota, Food and Health 41(3)
    • • Suguru Saito
      • A. Okuno
      • N. Kakizaki
      • T. Maekawa
      • N. Tsuji

    • PubMed: 35854694
    • DOI: 10.12938/bmfh.2021-057

    1 Insight on

    • Enhanced T Cell Activation

    • Low evidence
    • Rigorous Journal
    • Animal Study
• July 22

  • Safety Assessment of One Lactiplantibacillus plantarum Isolated from the Traditional Chinese Fermented Vegetables—Jiangshui

    • 2022-07-22
    • Clinical Trial
    • Foods 11(15)
    • • Dexin Ou
      • N. Ling
      • Xihao Wang
      • Y. Zou
      • Jingjing Dong
      • Danfeng Zhang
      • Yizhong Shen
      • Y. Ye

    • PubMed: 35892762
    • DOI: 10.3390/foods11152177

    2 Insights on

    • Increased Antibiotic Susceptibility
    • No Mortality or Toxicity

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Effect of Oral Administration of Lactiplantibacillus plantarum SNK12 on Temporary Stress in Adults: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study

    • 2022-07-22
    • RCT
    • International Journal of Environmental Research and Public Health 19(15)
    • • Takumi Watanabe
      • Kyoko Hayashi
      • T. Takara
      • T. Teratani
      • J. Kitayama
      • T. Kawahara

    • PubMed: 35897310
    • DOI: 10.3390/ijerph19158936

    4 Insights on

    • Reduced Salivary Cortisol Levels Under Stress
    • Reduced Total Mood Disturbance
    • Reduced Confusion and Bewilderment
    • Improved Autonomic Balance

    • High evidence
    • Rigorous Journal
• July 23

  • A Pilot Study: Favorable Effects of Clostridium butyricum on Intestinal Microbiota for Adjuvant Therapy of Lung Cancer

    • 2022-07-23
    • RCT
    • Cancers 14(15)
    • • J. Cong
      • Chuantao Zhang
      • Siyu Zhou
      • Jingjuan Zhu
      • Chengwei Liang

    • PubMed: 35892858
    • DOI: 10.3390/cancers14153599

    3 Insights on

    • Reduced Incidence of Adverse Events
    • Improved Progression-free Survival
    • Improved Overall Survival

    • High evidence
    • Rigorous Journal
• July 24

  • Efficacy of nigella sativa oil on endothelial function and atherogenic indices in patients with coronary artery diseases: A randomized, double-blind, placebo-control clinical trial.

    • 2022-07-24
    • RCT
    • Phytotherapy research : PTR 36(12)
    • • Omid Mohammad Tavakoli-Rouzbehani
      • Mohsen Abbasnezhad
      • Sorayya Kheirouri
      • Mohammad Alizadeh

    • PubMed: 35871718
    • DOI: 10.1002/ptr.7568

    4 Insights on

    • Increased Total Serum Antioxidant Capacity
    • Reduced Vascular Cell Adhesion Molecule-1 Level
    • Reduced Malondialdehyde Level
    • Reduced Intercellular Adhesion Molecule-1 Level

    • High evidence
• July 25

  • A Systematic Review on the Effect of Nutraceuticals on Antidepressant-Induced Sexual Dysfunctions: From Basic Principles to Clinical Applications.

    • 2022-07-25
    • Review · n = 10
    • Current issues in molecular biology 44(8)
    • • Carmen Concerto
      • Alessandro Rodolico
      • Valeria Meo
      • Donatella Chiappetta
      • Marina Bonelli
      • Ludovico Mineo
      • Giulia Saitta
      • Sebastiano Stuto
      • Maria Salvina Signorelli
      • Antonino Petralia
      • Giuseppe Lanza
      • Eugenio Aguglia

    • PubMed: 35892716
    • DOI: 10.3390/cimb44080230

    1 Insight on

    • Improved Antidepressant-Induced Sexual Dysfunction

    • Low evidence
• July 26

  • Association between Cervical Microbiota and HPV: Could This Be the Key to Complete Cervical Cancer Eradication?

    • 2022-07-26
    • Review
    • Biology 11(8)
    • • Eliano Cascardi
      • Gerardo Cazzato
      • Antonella Daniele
      • Erica Silvestris
      • Gennaro Cormio
      • Giovanni Di Vagno
      • Antonio Malvasi
      • Vera Loizzi
      • Salvatore Scacco
      • Vincenzo Pinto
      • Ettore Cicinelli
      • Eugenio Maiorano
      • Giuseppe Ingravallo
      • Leonardo Resta
      • Carla Minoia
      • Miriam Dellino

    • PubMed: 35892970
    • DOI: 10.3390/biology11081114

    2 Insights on

    • Reduced Dysbiosis
    • Reduced HPV-Related Cervical Lesions

    • Low evidence

  • Vitamin K and vascular calcification in chronic kidney disease: An update of current evidence.

    • 2022-07-26
    • Review
    • Tzu chi medical journal 35(1)
    • • Yu-Li Lin
      • Bang-Gee Hsu

    • PubMed: 36866348
    • DOI: 10.4103/tcmj.tcmj_100_22

    1 Insight on

    • Reduced Vascular Calcification Progression

    • Low evidence

  • Effect of vitamin K2 administration on depression status in patients with polycystic ovary syndrome: a randomized clinical trial.

    • 2022-07-26
    • RCT · n = 42
    • BMC women's health 22(1)
    • • Firoozeh Tarkesh
      • Bahia Namavar Jahromi
      • Najmeh Hejazi
      • Golazin Hoseini

    • PubMed: 35883082
    • DOI: 10.1186/s12905-022-01825-8

    1 Insight on

    • Improved Depression Status

    • High evidence
• July 27

  • Amino acid utilization allows intestinal dominance of Lactobacillus amylovorus.

    • 2022-07-27
    • The ISME journal 16(11)
    • • Yujia Jing
      • Chunlong Mu
      • Huisong Wang
      • Junhua Shen
      • Erwin G Zoetendal
      • Weiyun Zhu

    • PubMed: 35896730
    • DOI: 10.1038/s41396-022-01287-8

    1 Insight on

    • Increased Intestinal Lactobacillus amylovorus Dominance

    • Low evidence
    • Animal Study
• July 28

  • The role of probiotics in vaginal health.

    • 2022-07-28
    • Review
    • Frontiers in cellular and infection microbiology 12
    • • Zhaojun Mei
      • Dandan Li

    • PubMed: 35967876
    • DOI: 10.3389/fcimb.2022.963868

    9 Insights on

    • Improved Immune Function
    • Reduced Pathogen Growth
    • Improved Vaginal Microbiota Balance
    • Reduced Vaginal Colonization of Pathogenic Bacteria
    • Improved Vaginal Health
    • Reduced Pathogen Colonization
    • Improved Vaginal Microbiota
    • Reduced Cancer Progression
    • Enhanced Vaginal Immune Defense

    • Low evidence

  • Stepwise establishment of functional microbial groups in the infant gut between 6 months and 2 years: A prospective cohort study

    • 2022-07-28
    • Observational · n = 40
    • Frontiers in Nutrition 9
    • • V. T. Pham
      • A. Greppi
      • C. Chassard
      • C. Braegger
      • C. Lacroix

    • PubMed: 35967780
    • DOI: 10.3389/fnut.2022.948131

    1 Insight on

    • Increased Fecal Butyrate Levels

    • Moderate evidence

  • Effects of Saccharomyces boulardii Supplementation on Nutritional Status, Fecal Parameters, Microbiota, and Mycobiota in Breeding Adult Dogs

    • 2022-07-28
    • RCT · n = 25
    • Veterinary Sciences 9(8)
    • • G. Meineri
      • E. Martello
      • David Atuahene
      • S. Miretti
      • B. Stefanon
      • Misa Sandri
      • I. Biasato
      • M. R. Corvaglia
      • I. Ferrocino
      • L. Cocolin

    • PubMed: 36006304
    • DOI: 10.3390/vetsci9080389

    2 Insights on

    • Reduced Fecal Calprotectin Immunoglobulin A
    • Reduced Fecal Cortisol Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study
• July 29

  • The potential of pumpkin seed oil as a functional food-A comprehensive review of chemical composition, health benefits, and safety.

    • 2022-07-29
    • Review
    • Comprehensive reviews in food science and food safety 21(5)
    • • Dunja Šamec
      • Monica Rosa Loizzo
      • Olga Gortzi
      • İrem Tatlı Çankaya
      • Rosa Tundis
      • İpek Suntar
      • Samira Shirooie
      • Gokhan Zengin
      • Hari Prasad Devkota
      • Patricia Reboredo-Rodríguez
      • Sherif T S Hassan
      • Azadeh Manayi
      • Hamid Reza Khayat Kashani
      • Seyed Mohammad Nabavi

    • PubMed: 35904246
    • DOI: 10.1111/1541-4337.13013

    2 Insights on

    • Improved Cardiovascular Function
    • Improved Sex Hormone Balance

    • Low evidence
• July 30

  • Effect of Dietary Fiber (Oat Bran) Supplement in Heart Rate Lowering in Patients with Hypertension: A Randomized DASH-Diet-Controlled Clinical Trial.

    • 2022-07-30
    • RCT
    • Nutrients 14(15)
    • • Yang Ju
      • Chenglin Zhang
      • Zhirong Zhang
      • Hongying Zhu
      • Yuanyuan Liu
      • Ting Liu
      • Omorogieva Ojo
      • Jingbo Qiu
      • Xiaohua Wang

    • PubMed: 35956324
    • DOI: 10.3390/nu14153148

    5 Insights on

    • Reduced Maximum Heart Rate
    • Reduced Average Heart Rate
    • Reduced Day-Time Average Heart Rate
    • Reduced Daytime Minimum Heart Rate
    • Reduced Daytime Maximum Heart Rate

    • High evidence
    • Rigorous Journal

  • Heat-Killed Lactococcus lactis subsp. cremoris H61 Altered the Iron Status of Young Women: A Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group Comparative Study

    • 2022-07-30
    • RCT
    • Nutrients 14(15)
    • • Mizuki Takaragawa
      • K. Sakuraba
      • Yoshio Suzuki

    • PubMed: 35956320
    • DOI: 10.3390/nu14153144

    2 Insights on

    • Improved Iron Levels
    • Elevated Ferric Iron Levels

    • High evidence
• Undated – 1 supplement study

  • Assessment of the efficacy of a feed additive consisting of Limosilactobacillus reuteri (formerly Lactobacillus reuteri) DSM 32203 for dogs (NBF LANES)

    • 2022-07
    • EFSA Journal 20(7)
    • • V. Bampidis
      • G. Azimonti
      • M. Bastos
      • Henrik Christensen
      • B. Dusemund
      • Mojca Fašmon Durjava
      • M. Kouba
      • M. López-Alonso
      • Secundino López Puente
      • F. Marcon
      • B. Mayo
      • A. Pechová
      • M. Petkova
      • F. Ramos
      • Yolanda Sanz
      • R. Villa
      • R. Woutersen
      • G. Martelli
      • M. Anguita
      • Rosella Brozzi
      • J. Galobart
      • J. Ortuño
      • J. Revez

    • PubMed: 35865118
    • DOI: 10.2903/j.efsa.2022.7436

    2 Insights on

    • Improved Stool Consistency
    • Increased Constipation Risk

    • Low evidence