January 2022 Supplement Research Papers

• January 1

  • The effect of multi-strain probiotics as feed additives on performance, immunity, expression of nutrient transporter genes and gut morphometry in broiler chickens

    • 2022-01-01
    • RCT · n = 256
    • Animal Bioscience 35(1)
    • • A. Biswas
      • K. Dev
      • P. K. Tyagi
      • A. Mandal

    • PubMed: 33677909
    • DOI: 10.5713/ab.20.0749

    3 Insights on

    • Improved Immune Response
    • Improved Gut Morphology
    • Improved Physical Performance

    • Low evidence
    • Animal Study

  • Effects of Urtica dioica on Metabolic Profiles in Type 2 Diabetes: A Systematic Review and Meta-analysis of Clinical Trials.

    • 2022-01-01
    • Meta-Analysis
    • Mini reviews in medicinal chemistry 22(3)
    • • Reza Tabrizi
      • Eghbal Sekhavati
      • Peyman Nowrouzi-Sohrabi
      • Shahla Rezaei
      • Parinaz Tabari
      • Salar Hafez Ghoran
      • Navid Jamali
      • Mohammad Jalali
      • Mahsa Moosavi
      • Ali-Asghar Kolahi
      • Deepti Bettampadi
      • Amirhossein Sahebkar
      • Saeid Safiri

    • PubMed: 34587883
    • DOI: 10.2174/1389557521666210929143112

    11 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Body Mass Index
    • Reduced Systolic Blood Pressure
    • Reduced Triglyceride Levels
    • Improved Insulin Levels
    • Reduced LDL Cholesterol
    • Reduced Hemoglobin A1c
    • Reduced Blood Cholesterol
    • Reduced C-Reactive Protein Levels
    • Reduced Fasting Blood Glucose Levels
    • Reduced HDL Cholesterol Level

    • High evidence

  • Effect of Evening Primrose Vaginal Capsule on Cervix Preparation and Duration of First Stage of Labor in Nulliparous Women Referred to Fatemieh Hospital in Hamadan, Iran: A Single-blind Randomized Controlled Trial.

    • 2022-01-01
    • RCT
    • Current drug research reviews 14(3)
    • • Arezoo Shayan
      • Seyedeh Zahra Masoumi
      • Farideh Kazemi
      • Mansoureh Refaee
      • Maryam Ahmadi
      • Hadis Sourinezhad
      • Minoo Hamoun

    • PubMed: 35440333
    • DOI: 10.2174/2589977514666220418091807

    4 Insights on

    • Improved Cervical Dilatation
    • Improved Cervical Effacement
    • Improved Bishop Score
    • Reduced Duration of First Stage of Labor

    • High evidence
• January 3

  • Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials.

    • 2022-01-03
    • Meta-Analysis
    • European journal of nutrition 61(4)
    • • Erand Llanaj
      • Gordana M Dejanovic
      • Ezra Valido
      • Arjola Bano
      • Magda Gamba
      • Lum Kastrati
      • Beatrice Minder
      • Stevan Stojic
      • Trudy Voortman
      • Pedro Marques-Vidal
      • Jivko Stoyanov
      • Brandon Metzger
      • Marija Glisic
      • Hua Kern
      • Taulant Muka

    • PubMed: 34977959
    • DOI: 10.1007/s00394-021-02763-1

    12 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Body Weight
    • Increased HDL Cholesterol Levels
    • Reduced LDL Cholesterol
    • Reduced Blood Glucose Levels
    • Reduced Blood Cholesterol
    • Reduced Apolipoprotein B Levels
    • Reduced Inflammatory Biomarker Level
    • Reduced Glycated Hemoglobin
    • Reduced Oxidative Stress Marker

    • High evidence
    • Rigorous Journal
• January 5

  • Phase I Study of High-Dose L-methylfolate in Combination with Temozolomide and Bevacizumab in Recurrent IDH wild-type High-Grade Glioma.

    • 2022-01-05
    • Clinical Trial
    • Cancer research communications 2(1)
    • • Lucas A Salas
      • Thomas G Stewart
      • Bret C Mobley
      • Chengwei Peng
      • Jing Liu
      • Sudan N Loganathan
      • Jialiang Wang
      • Yanjun Ma
      • Mitchell S Berger
      • Devin Absher
      • Yang Hu
      • Paul L Moots
      • Brock C Christensen
      • Stephen W Clark

    • PubMed: 35392283
    • DOI: 10.1158/2767-9764.crc-21-0088

    1 Insight on

    • Improved Overall Survival

    • Moderate evidence
• January 6

  • Decrease in Salivary Serotonin in Response to Probiotic Supplementation With Saccharomyces boulardii in Healthy Volunteers Under Psychological Stress: Secondary Analysis of a Randomized, Double-Blind, Placebo-Controlled Trial

    • 2022-01-06
    • RCT · n = 32
    • Frontiers in Endocrinology 12
    • • M. Karbownik
      • Joanna Kręczyńska
      • A. Wiktorowska-Owczarek
      • Paulina Kwarta
      • M. Cybula
      • N. Stilinović
      • T. Pietras
      • E. Kowalczyk

    • PubMed: 35069447
    • DOI: 10.3389/fendo.2021.800023

    1 Insight on

    • Reduced Salivary Serotonin Levels in Response to Stress

    • High evidence
• January 7

  • Lactiplantibacillus plantarum 22A-3-induced TGF-β1 secretion from intestinal epithelial cells stimulated CD103+ DC and Foxp3+ Treg differentiation and amelioration of colitis in mice.

    • 2022-01-07
    • Clinical Trial
    • Food & Function 12(17)
    • • Jarukan Lamubol
      • Nobuaki Ohto
      • Hiroshige Kuwahara
      • M. Mizuno

    • PubMed: 34282811
    • DOI: 10.1039/d1fo00990g

    11 Insights on

    • Increased Interleukin-10 Levels
    • Increased Regulatory T-Cells
    • Reduced Ulcerative Colitis Symptoms
    • Improved Colitis Symptoms
    • Increased Transforming Growth Factor-β Levels
    • Increased Regulatory T Cell Populations
    • Increased CD103+ Dendritic Cell Count
    • Enhanced Anti-Inflammatory Cytokine Secretion
    • Increased Serum IL-10 Levels
    • Increased Anti-Inflammatory Cytokines in the Small Intestine
    • Increased Treg Population in the Small Intestine

    • Low evidence
    • Animal Study

  • Protective Effect of Lactobacillus sporogenes against Arsenic-Induced Hematological Alterations in Male Albino Wistar Rats.

    • 2022-01-07
    • n = 36
    • Biological trace element research 200(11)
    • • Swathi Bora
      • M Lakshman
      • D Madhuri
      • B Kalakumar
      • M Udayakumar

    • PubMed: 34993908
    • DOI: 10.1007/s12011-021-03055-9

    1 Insight on

    • Reduced Toxicity

    • Low evidence
    • Animal Study
• January 10

  • Bifidobacterium animalis subsp. lactis BB-12 Has Effect Against Obesity by Regulating Gut Microbiota in Two Phases in Human Microbiota-Associated Rats

    • 2022-01-10
    • Clinical Trial
    • Frontiers in Nutrition 8
    • • Kemin Mao
      • Jie Gao
      • Xianghong Wang
      • Xiyu Li
      • S. Geng
      • Tuo Zhang
      • F. A. Sadiq
      • Yaxin Sang

    • PubMed: 35083265
    • DOI: 10.3389/fnut.2021.811619

    13 Insights on

    • Increased Protective Fecal Bifidobacterial Diversity
    • Improved Gut Microbiota Composition
    • Reduced Body Weight
    • Suppressed Transition to Obesity
    • Reduced Dysbiosis
    • Reduced Obesity
    • Improved Abundance of Beneficial Bacteria
    • Improved Gut Microbiome Composition
    • Increased Beneficial Gut Bacteria
    • Prevention of Obesity Transition
    • Maintained Prevotella-Dominant Gut Microbiota
    • Improved Obesity Metrics
    • Reduced Risk of Obesity

    • Low evidence
    • Animal Study
• January 11

  • Probiotic improves symptomatic and viral clearance in Covid19 outpatients: a randomized, quadruple-blinded, placebo-controlled trial

    • 2022-01-11
    • RCT · n = 300
    • Gut Microbes 14(1)
    • • P. Gutiérrez-Castrellón
      • Tania Gandara-Martí
      • A. T. Abreu y Abreu
      • Cesar D. Nieto-Rufino
      • E. López-Orduña
      • I. Jiménez-Escobar
      • C. Jiménez-Gutiérrez
      • G. López-Velázquez
      • Jordi Espadaler Mazo

    • PubMed: 35014600
    • DOI: 10.1080/19490976.2021.2018899

    1 Insight on

    • Reduced Viral Load

    • High evidence
    • Large Human Trial
    • Highly Cited
    • Rigorous Journal
• January 12

  • Antimicrobial Bacillus: Metabolites and Their Mode of Action.

    • 2022-01-12
    • Review
    • Antibiotics (Basel, Switzerland) 11(1)
    • • Charlie Tran
      • Ian E Cock
      • Xiaojing Chen
      • Yunjiang Feng

    • PubMed: 35052965
    • DOI: 10.3390/antibiotics11010088

    1 Insight on

    • Improved Gastrointestinal Health

    • Low evidence

  • Herbal Medicines-Are They Effective and Safe during Pregnancy?

    • 2022-01-12
    • Review
    • Pharmaceutics 14(1)
    • • Beata Sarecka-Hujar
      • Beata Szulc-Musioł

    • PubMed: 35057067
    • DOI: 10.3390/pharmaceutics14010171

    1 Insight on

    • Relieved Hyperemesis Gravidarum

    • Low evidence

  • Probiotic Properties of Bifidobacterium longum KABP042 and Pediococcus pentosaceus KABP041 Show Potential to Counteract Functional Gastrointestinal Disorders in an Observational Pilot Trial in Infants

    • 2022-01-12
    • Clinical Trial · n = 36
    • Frontiers in Microbiology 12
    • • E. Astó
      • P. Huedo
      • Tatiana Altadill
      • M. Aguiló García
      • M. Sticco
      • Marta Perez
      • Jordi Espadaler Mazo

    • PubMed: 35095783
    • DOI: 10.3389/fmicb.2021.741391

    2 Insights on

    • Reduced FGID Severity
    • Reduced Severity of Gastrointestinal Disorders

    • High evidence
• January 13

  • Lactiplantibacillus plantarum AR113 Exhibit Accelerated Liver Regeneration by Regulating Gut Microbiota and Plasma Glycerophospholipid

    • 2022-01-13
    • Clinical Trial
    • Frontiers in Microbiology 12
    • • C. Xie
      • Zhoumei Zhang
      • Manyi Yang
      • Changliang Cao
      • Yingjun Zhou
      • Zuohua Zhu
      • Wenbing Gong
      • Chao Xu
      • Li Yan
      • Zhenxiu Hu
      • Lian-zhong Ai
      • Yuande Peng

    • PubMed: 35154031
    • DOI: 10.3389/fmicb.2021.800470

    5 Insights on

    • Improved Gut Microbiome Composition
    • Altered Plasma Metabolite Levels
    • Improved Liver Regeneration
    • Changed Plasma Glycerophospholipid Levels
    • Reduced Serum Glycerophospholipid Levels

    • Low evidence
    • Animal Study
• January 15

  • Emerging Links between Microbiome Composition and Skin Immunology in Diaper Dermatitis: A Narrative Review.

    • 2022-01-15
    • Review
    • Children (Basel, Switzerland) 9(1)
    • • Tjaša Hertiš Petek
      • Maya Petek
      • Tadej Petek
      • Nataša Marčun Varda

    • PubMed: 35053737
    • DOI: 10.3390/children9010112

    4 Insights on

    • Improved Skin Barrier Function
    • Reduced Inflammation
    • Improved Skin Health
    • Reduced Skin Inflammation

    • Low evidence

  • Bifidobacterium lactis CCT 7858 Improves Gastrointestinal Symptoms by Antibiotics Treatment: a Double-Blind, Randomized, Placebo-Controlled Trial.

    • 2022-01-15
    • RCT · n = 104
    • Probiotics and antimicrobial proteins 15(3)
    • • Monique Michels
      • Emily Córneo
      • Luana Cucker
      • Carla Sasso Simon
      • Gabriel Fernandes Alves de Jesus
      • Carolina Michels
      • Kristian Madeira
      • Ana Paula Voytena
      • Marina Rossetto
      • Fernanda Ramlov
      • Danusa de Castro Damásio
      • Felipe Dal-Pizzol

    • PubMed: 35031969
    • DOI: 10.1007/s12602-021-09900-6

    3 Insights on

    • Reduced Antibiotic-Associated Diarrhea
    • Improved Gastrointestinal Symptoms
    • Reduced Abdominal Distension

    • High evidence
    • Large Human Trial
• January 17

  • Red Yeast Rice for Hyperlipidemia: A Meta-Analysis of 15 High-Quality Randomized Controlled Trials.

    • 2022-01-17
    • Review · n = 12
    • Frontiers in pharmacology 12
    • • Pengfan Li
      • Qi Wang
      • Kanjun Chen
      • Shihui Zou
      • Shi Shu
      • Chanchan Lu
      • Shiyun Wang
      • Yunqin Jiang
      • Chunxiang Fan
      • Yue Luo

    • PubMed: 35111069
    • DOI: 10.3389/fphar.2021.819482

    5 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Increased HDL Cholesterol Levels
    • Reduced Blood Cholesterol
    • Reduced Apolipoprotein B Levels

    • Low evidence

  • The Probiotics in Pediatric Asthma Management (PROPAM) Study in the Primary Care Setting: A Randomized, Controlled, Double-Blind Trial with Ligilactobacillus salivarius LS01 (DSM 22775) and Bifidobacterium breve B632 (DSM 24706)

    • 2022-01-17
    • RCT · n = 422
    • Journal of Immunology Research 2022
    • • L. Drago
      • Luigi Cioffi
      • M. Giuliano
      • M. Pane
      • A. Amoruso
      • I. Schiavetti
      • G. Reid
      • G. Ciprandi
      • PROPAM Study Group

    • PubMed: 35083341
    • DOI: 10.1155/2022/3837418

    2 Insights on

    • Reduced Asthma Exacerbations
    • Reduced Pediatric Exacerbations

    • High evidence
    • Large Human Trial

  • Randomized control trial on the efficacy of Limosilactobacillus reuteri ATCC PTA 4659 in reducing inflammatory markers in acute uncomplicated diverticulitis

    • 2022-01-17
    • RCT · n = 119
    • European Journal of Gastroenterology & Hepatology 34(5)
    • • V. Ojetti
      • A. Saviano
      • M. Brigida
      • C. Petruzziello
      • Martina Caronna
      • G.D.B. Gayani
      • F. Franceschi

    • PubMed: 35045564
    • DOI: 10.1097/MEG.0000000000002342

    2 Insights on

    • Reduced Hospitalization Duration
    • Reduced Inflammatory Response

    • High evidence
    • Rigorous Journal

  • A Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Efficacy and Safety of Lactiplantibacillus plantarum CJLP243 in Patients with Functional Diarrhea and High Fecal Calprotectin Levels

    • 2022-01-17
    • RCT · n = 24
    • Nutrients 14(2)
    • • Minah H. Jung
      • Susie Jung
      • Nam-Kyu Kim
      • H. Ahn
      • H. Yun
      • Kyu-Nam Kim

    • PubMed: 35057571
    • DOI: 10.3390/nu14020389

    4 Insights on

    • Improved Gut Microbiota Diversity
    • Reduced Fecal Calprotectin Levels
    • Improved Functional Diarrhea Symptoms
    • Increased Leuconostoc Levels

    • High evidence
• January 19

  • Lactobacillus paracasei modulates the gut microbiota and improves inflammation in type 2 diabetic rats.

    • 2022-01-19
    • Clinical Trial
    • Food & Function 12(15)
    • • Zhu Zeng
      • Xiaoxuan Guo
      • Jinlan Zhang
      • Qipeng Yuan
      • Shangwu Chen

    • PubMed: 34113945
    • DOI: 10.1039/d1fo00515d

    12 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Reduced Inflammatory Response
    • Reduced Inflammation Levels
    • Increased Beneficial Gut Microbiota
    • Reduced Plasma Lipopolysaccharide Levels
    • Improved Gut Microbiome Composition
    • Reduced Inflammation via Gut Microbiota
    • Reduced Inflammation
    • Enhanced Intestinal Integrity
    • Improved Inflammatory Status
    • Improved Gut Barrier Function

    • Low evidence
    • Animal Study

  • Efficacy and Safety of Lactobacillus plantarum K50 on Lipids in Koreans With Obesity: A Randomized, Double-Blind Controlled Clinical Trial

    • 2022-01-19
    • RCT · n = 81
    • Frontiers in Endocrinology 12
    • • M. Sohn
      • G. Na
      • Jaeryang Chu
      • Hyunchae Joung
      • Byung-Kook Kim
      • Soo Lim

    • PubMed: 35126309
    • DOI: 10.3389/fendo.2021.790046

    4 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Triglyceride Levels
    • Reduced Blood Leptin Levels
    • Disrupted Gut Microbiota Distribution

    • High evidence

  • Pediococcus pentosaceus PP04 improves high-fat diet-induced liver injury by the modulation of gut inflammation and intestinal microbiota in C57BL/6N mice.

    • 2022-01-19
    • Clinical Trial
    • Food & Function 12(15)
    • • Yu Wang
      • Yuan Tian
      • N. Zhang
      • Xia Li
      • Xiujuan Wang
      • Weili Wang
      • Jun Zhang
      • Chunhong Piao
      • Yuhua Wang
      • Jingsheng Liu

    • PubMed: 34126631
    • DOI: 10.1039/d1fo00857a

    3 Insights on

    • Improved Intestinal Function
    • Improved Liver Function
    • Improved Intestinal Flora Balance

    • Low evidence
    • Animal Study

  • Probiotic Lacticaseibacillus rhamnosus GG Increased Longevity and Resistance Against Foodborne Pathogens in Caenorhabditis elegans by Regulating MicroRNA miR-34

    • 2022-01-19
    • Clinical Trial
    • Frontiers in Cellular and Infection Microbiology 11
    • • B. Yun
      • S. Ryu
      • Minkyoung Kang
      • Juyeon Lee
      • Jiseon Yoo
      • Younghoon Kim
      • Sangnam Oh

    • PubMed: 35127565
    • DOI: 10.3389/fcimb.2021.819328

    4 Insights on

    • Extended Lifespan
    • Reduced Susceptibility to Foodborne Pathogens
    • Enhanced Innate Immune Response
    • Improved Resistance to Foodborne Pathogens

    • Low evidence
    • Animal Study

  • An optimized culture medium to isolate Lactobacillus fermentum strains from the human intestinal tract.

    • 2022-01-19
    • Food & Function 12(15)
    • • Yan Zhao
      • Leilei Yu
      • F. Tian
      • Jianxin Zhao
      • Hao Zhang
      • Wei Chen
      • Q. Zhai

    • PubMed: 34105590
    • DOI: 10.1039/d1fo00209k

    1 Insight on

    • Increased Antioxidant Activity

    • Low evidence
• January 20

  • Interventions on Microbiota: Where Do We Stand on a Gut-Brain Link in Autism? A Systematic Review.

    • 2022-01-20
    • Systematic Review · n = 1,769
    • Nutrients 14(3)
    • • Margherita Prosperi
      • Elisa Santocchi
      • Letizia Guiducci
      • Jacopo Frinzi
      • Maria Aurora Morales
      • Raffaella Tancredi
      • Filippo Muratori
      • Sara Calderoni

    • PubMed: 35276821
    • DOI: 10.3390/nu14030462

    3 Insights on

    • Improved Gastrointestinal Symptoms
    • Unclear / Not Reported in Provided Abstract
    • Improved Autism Spectrum Disorder Symptoms

    • High evidence
    • Rigorous Journal
• January 21

  • How Microbes Affect Depression: Underlying Mechanisms via the Gut-Brain Axis and the Modulating Role of Probiotics.

    • 2022-01-21
    • Review
    • International journal of molecular sciences 23(3)
    • • Kazunori Suda
      • Kazunori Matsuda

    • PubMed: 35163104
    • DOI: 10.3390/ijms23031172

    2 Insights on

    • Reduced Depression Symptoms
    • Improved Depressive Symptoms

    • Moderate evidence
    • Rigorous Journal
• January 24

  • Lactobacillus plantarum DP189 Reduces α-SYN Aggravation in MPTP-Induced Parkinson's Disease Mice via Regulating Oxidative Damage, Inflammation, and Gut Microbiota Disorder.

    • 2022-01-24
    • Clinical Trial
    • Journal of Agricultural and Food Chemistry 70(4)
    • • Lei Wang
      • Zijian Zhao
      • Lei Zhao
      • Yujuan Zhao
      • Ge Yang
      • Chao Wang
      • Lei Gao
      • Chunhua Niu
      • Shengyu Li

    • PubMed: 35067061
    • DOI: 10.1021/acs.jafc.1c07711

    16 Insights on

    • Increased Anti-Inflammatory Cytokine Levels
    • Reduced Hepatic Oxidative Stress
    • Reduced Dysbiosis
    • Reduced Inflammatory Response
    • Elevated Antioxidant Levels
    • Reduced Neuroinflammation
    • Reduced Inflammation Levels
    • Reduced Alpha-Synuclein Accumulation
    • Delayed Neurodegeneration
    • Improved Gut Microbiome Composition
    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Enhanced Antioxidant Activity
    • Reduced Oxidative Damage
    • Modulated Gut Microbiota
    • Reduced α-Synuclein Levels

    • Low evidence
    • Animal Study
• January 25

  • Streptococcus thermophilus extends lifespan through activation of DAF-16-mediated antioxidant pathway in Caenorhabditis elegans

    • 2022-01-25
    • Clinical Trial
    • Journal of Clinical Biochemistry and Nutrition 70(1)
    • • Natsumi Desaka
      • Chinatsu Ota
      • Hitomi Nishikawa
      • K. Yasuda
      • N. Ishii
      • T. Bito
      • Yukio Kishinaga
      • Y. Naito
      • Yasuki Higashimura

    • PubMed: 35068675
    • DOI: 10.3164/jcbn.21-56

    9 Insights on

    • Reduced Hepatic Oxidative Stress
    • Increased Antioxidant Activity
    • Increased Lifespan
    • Extended Lifespan
    • Reduced Lipofuscin Accumulation
    • Maintained Vigorous Locomotion
    • Maintained Growth Curve
    • Unchanged Offspring Number
    • Maintained Physical Activity Level

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • New Wild-Type Lacticaseibacillus rhamnosus Strains as Candidates to Manage Type 1 Diabetes

    • 2022-01-25
    • Microorganisms 10(2)
    • • Grigorios Nelios
      • Valentini Santarmaki
      • Chrysoula Pavlatou
      • D. Dimitrellou
      • Y. Kourkoutas

    • PubMed: 35208726
    • DOI: 10.3390/microorganisms10020272

    3 Insights on

    • Reduced α-Glucosidase Activity
    • Reduced Pathogen Growth
    • Maintained Gut Homeostasis

    • Low evidence
    • Rigorous Journal

  • Genome Sequence and Assessment of Safety and Potential Probiotic Traits of Lactobacillus johnsonii CNCM I-4884

    • 2022-01-25
    • Microorganisms 10(2)
    • • Anne-Sophie Boucard
      • I. Florent
      • B. Polack
      • P. Langella
      • L. Bermúdez-Humarán

    • PubMed: 35208728
    • DOI: 10.3390/microorganisms10020273

    1 Insight on

    • Reduced Giardia intestinalis Infection

    • Low evidence
    • Rigorous Journal
• January 26

  • The Lactobacillus as a Probiotic: Focusing on Liver Diseases.

    • 2022-01-26
    • Review
    • Microorganisms 10(2)
    • • Jin-Ju Jeong
      • Hee Jin Park
      • Min Gi Cha
      • Eunju Park
      • Sung-Min Won
      • Raja Ganesan
      • Haripriya Gupta
      • Yoseph Asmelash Gebru
      • Satya Priya Sharma
      • Su Been Lee
      • Goo Hyun Kwon
      • Min Kyo Jeong
      • Byeong Hyun Min
      • Ji Ye Hyun
      • Jung A Eom
      • Sang Jun Yoon
      • Mi Ran Choi
      • Dong Joon Kim
      • Ki Tae Suk

    • PubMed: 35208742
    • DOI: 10.3390/microorganisms10020288

    1 Insight on

    • Improved Liver Disease Biomarkers

    • Low evidence

  • The Effect of Polyphenols on Working and Episodic Memory in Non-pathological and Pathological Aging: A Systematic Review and Meta-Analysis.

    • 2022-01-26
    • Systematic Review · n = 20
    • Frontiers in nutrition 8
    • • Karin de Vries
      • Evelyn Medawar
      • Aniko Korosi
      • A Veronica Witte

    • PubMed: 35155509
    • DOI: 10.3389/fnut.2021.720756

    2 Insights on

    • Improved Working Memory
    • Improved Episodic Memory

    • High evidence

  • Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions

    • 2022-01-26
    • RCT
    • Microorganisms 10(2)
    • • X. Ang
      • U. Mageswaran
      • Y. Chung
      • Boon-Kiat Lee
      • S. Azhar
      • N. S. Roslan
      • Ili Saufian
      • N. Mustaffa
      • E. Kalam
      • A. Ibrahim
      • Normala Abdul Wahid
      • Z. Deris
      • C. Oon
      • W. F. Adnan
      • S. Sany
      • M. Liong

    • PubMed: 35208739
    • DOI: 10.3390/microorganisms10020285

    2 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Candida albicans Abundance in Cervicovaginal Region

    • High evidence
    • Rigorous Journal

  • In silico, in vitro and in vivo safety evaluation of Limosilactobacillus reuteri strains ATCC PTA-126787 & ATCC PTA-126788 for potential probiotic applications

    • 2022-01-26
    • PLOS ONE 17(1)
    • • Dharanesh Gangaiah
      • S. Mane
      • N. Tawari
      • Nallakannu Lakshmanan
      • Valerie Ryan
      • Alyssa Volland
      • D. Susanti
      • M. Patel
      • Abraham Abouzeid
      • E. Helmes
      • Arvind Kumar

    • PubMed: 35081129
    • DOI: 10.1371/journal.pone.0262663

    1 Insight on

    • Absence of Adverse Health Effects

    • Low evidence
    • Rigorous Journal
• January 27

  • Exopolysaccharides produced by Lactobacillus rhamnosus GG alleviate hydrogen peroxide-induced intestinal oxidative damage and apoptosis through the Keap1/Nrf2 and Bax/Bcl-2 pathways in vitro.

    • 2022-01-27
    • Food & Function 12(20)
    • • Jinze Li
      • Qiuke Li
      • Nan Gao
      • Zhihua Wang
      • Feng Li
      • Jianping Li
      • A. Shan

    • PubMed: 34664577
    • DOI: 10.1039/d1fo00277e

    3 Insights on

    • Increased Antioxidant Activity
    • Reduced Intestinal Oxidative Damage
    • Improved Cell Survival Rates

    • Low evidence

  • Effect of Bacillus subtilis C-3102 Spores as a Probiotic Feed Supplement on Growth Performance, Nutrient Digestibility, Diarrhea Score, Intestinal Microbiota, and Excreta Odor Contents in Weanling Piglets

    • 2022-01-27
    • RCT · n = 150
    • Animals 12(3)
    • • Jing Hu
      • I. Kim

    • PubMed: 35158640
    • DOI: 10.3390/ani12030316

    3 Insights on

    • Improved Body Weight
    • Reduced Diarrhea Symptoms
    • Improved Nutrient Digestibility

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Impact of Infectious Disease after Lactococcus lactis Strain Plasma Intake in Vietnamese Schoolchildren: A Randomized, Placebo-Controlled, Double-Blind Study

    • 2022-01-27
    • RCT
    • Nutrients 14(3)
    • • N. Thu
      • Truong Tuyet Mai
      • T. Trang
      • N. A. Tuan
      • Tran Chau Quyen
      • Nguyen Lien Hanh
      • Nguyên huu Hoàn
      • Bui Thi Huong Lan
      • Phung Thi Hau
      • Ha Huy Tue
      • T. V. Dung
      • R. Tsuji
      • Yuta Watanabe
      • Naoki Yamamoto
      • O. Kanauchi

    • PubMed: 35276914
    • DOI: 10.3390/nu14030552

    8 Insights on

    • Reduced Duration of Diarrhea
    • Reduced Diarrhea Rate
    • Reduced Upper Respiratory Infections
    • Reduced Fever Days
    • Improved General Well-Being
    • Reduced School Absenteeism Due to Infectious Diseases
    • Increased Fever-Free Days
    • Reduced Days with Diarrhea

    • High evidence
• January 28

  • Multifunctional Probiotic and Functional Properties of Lactiplantibacillus plantarum LRCC5314, Isolated from Kimchi

    • 2022-01-28
    • Journal of Microbiology and Biotechnology 32(1)
    • • Seokmin Yoon
      • H. Cho
      • YoHan Nam
      • Mi-ri Park
      • Ahyoung Lim
      • Jong-Hwa Kim
      • Jaewoong Park
      • Wonyong Kim

    • PubMed: 34750286
    • DOI: 10.4014/jmb.2109.09025

    11 Insights on

    • Reduced Stress Hormone Levels
    • Reduced Inflammatory Response
    • Improved Blood Glucose Levels
    • Reduced Inflammation Levels
    • Improved Gut Health
    • Reduced Adipogenesis
    • Reduced Inflammation
    • Reduced Enzyme Activity
    • Reduced Cortisol Levels
    • Improved Survival Capacity
    • Reduced Postprandial Glucose

    • Low evidence
• January 29

  • Probiotic activity traits in vitro and production of antimicrobial peptides by Lactobacillaceae isolates from pulque using Lactobacillus acidophilus NCFM as control.

    • 2022-01-29
    • Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] 53(2)
    • • Yesica Ruíz-Ramírez
      • Paula Cecilia Guadarrama-Mendoza
      • Adelfo Escalante
      • Martha Giles-Gómez
      • Rogelio Valadez-Blanco

    • PubMed: 35094300
    • DOI: 10.1007/s42770-022-00684-7

    2 Insights on

    • Increased Resistance to Gastric Juices
    • Increased Probiotic Activity

    • Low evidence

  • In Vitro Probiotic Modulation of the Intestinal Microbiota and 2'Fucosyllactose Consumption in Fecal Cultures from Infants at Two Months of Age.

    • 2022-01-29
    • Microorganisms 10(2)
    • • Alicja M Nogacka
      • Silvia Arboleya
      • Naghmeh Nikpoor
      • Jeremie Auger
      • Nuria Salazar
      • Isabel Cuesta
      • Jorge R Alvarez-Buylla
      • Laura Mantecón
      • Gonzalo Solís
      • Miguel Gueimonde
      • Thomas A Tompkins
      • Clara G de Los Reyes-Gavilán

    • PubMed: 35208773
    • DOI: 10.3390/microorganisms10020318

    1 Insight on

    • Improved 2'-Fucosyllactose Degradation

    • Low evidence
• January 30

  • Effect of Probiotics on Psychiatric Symptoms and Central Nervous System Functions in Human Health and Disease: A Systematic Review and Meta-Analysis.

    • 2022-01-30
    • Meta-Analysis
    • Nutrients 14(3)
    • • Charlotte Le Morvan de Sequeira
      • Charlotte Hengstberger
      • Paul Enck
      • Isabelle Mack

    • PubMed: 35276981
    • DOI: 10.3390/nu14030621

    3 Insights on

    • Reduced Psychological Distress
    • Reduced Depression Symptoms
    • Improved Central Nervous System Function

    • High evidence
    • Rigorous Journal
• January 31

  • Alleviation of cognitive impairment by gut microbiota lipopolysaccharide production-suppressing Lactobacillus plantarum and Bifidobacterium longum in mice.

    • 2022-01-31
    • Clinical Trial
    • Food & Function 12(21)
    • • Dong-Yun Lee
      • Yoon-Jung Shin
      • Jeon-Kyung Kim
      • H. Jang
      • Min-Kyung Joo
      • Dong-Hyun Kim

    • PubMed: 34608923
    • DOI: 10.1039/d1fo02167b

    2 Insights on

    • Improved Cognitive Function
    • Reduced Neuroinflammation

    • Low evidence
    • Animal Study

  • Traditional East Asian Herbal Medicine Treatment for Alzheimer's Disease: A Systematic Review and Meta-Analysis.

    • 2022-01-31
    • Review
    • Pharmaceuticals (Basel, Switzerland) 15(2)
    • • JiEun Lee
      • Seungwon Kwon
      • Chul Jin
      • Seung-Yeon Cho
      • Seong-Uk Park
      • Woo-Sang Jung
      • Sang-Kwan Moon
      • Jung-Mi Park
      • Chang-Nam Ko
      • Ki-Ho Cho

    • PubMed: 35215287
    • DOI: 10.3390/ph15020174

    2 Insights on

    • Improved Mini-Mental State Examination Score
    • Improved Alzheimer Disease Assessment Scale-Cognitive Subscale Score

    • Low evidence

  • The synergy of dietary supplements Lactobacillus salivarius LI01 and Bifidobacterium longum TC01 in alleviating liver failure in rats treated with D-galactosamine.

    • 2022-01-31
    • Clinical Trial
    • Food & Function 12(20)
    • • Aoxiang Zhuge
      • Shengjie Li
      • Yin Yuan
      • Bo Li
      • Lanjuan Li

    • PubMed: 34546256
    • DOI: 10.1039/d1fo01807h

    4 Insights on

    • Improved Gut Microbiota
    • Improved Intestinal Barrier Function
    • Reduced Pro-Inflammatory Cytokines
    • Reduced Liver Damage

    • Low evidence
    • Animal Study
• Undated – 14 supplement studies

  • Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives.

    • 2022-01
    • Review
    • Oxidative medicine and cellular longevity 2022(1)
    • • Prabhakar Semwal
      • Sakshi Painuli
      • Tareq Abu-Izneid
      • Abdur Rauf
      • Anshu Sharma
      • Sevgi Durna Daştan
      • Manoj Kumar
      • Mohammed M Alshehri
      • Yasaman Taheri
      • Rajib Das
      • Saikat Mitra
      • Talha Bin Emran
      • Javad Sharifi-Rad
      • Daniela Calina
      • William C Cho

    • PubMed: 35677108
    • DOI: 10.1155/2022/1035441

    2 Insights on

    • Improved Cognitive Function
    • Improved Menopause Symptom

    • Low evidence

  • Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions.

    • 2022-01
    • Review
    • Journal of evidence-based integrative medicine 27
    • • Tomas Koltai
      • Larry Fliegel

    • PubMed: 35018864
    • DOI: 10.1177/2515690x211068826

    1 Insight on

    • Reduced Hepatitis C Progression

    • Low evidence

  • The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.

    • 2022-01
    • RCT · n = 149
    • The American journal of clinical nutrition 115(1)
    • • Jamie W Bellinge
      • Roslyn J Francis
      • Sing C Lee
      • Nicola P Bondonno
      • Marc Sim
      • Joshua R Lewis
      • Gerald F Watts
      • Carl J Schultz

    • PubMed: 34637494
    • DOI: 10.1093/ajcn/nqab306

    1 Insight on

    • Reduced Arterial Calcifying Lesion Development

    • High evidence
    • Large Human Trial

  • Complete genome analysis of Lactobacillus fermentum YLF016 and its probiotic characteristics.

    • 2022-01
    • Microbial Pathogenesis 162
    • • Li-hong Zhang
      • Hong-Bo Ma
      • M. F. Kulyar
      • Huachun Pan
      • Kewei Li
      • Aoyun Li
      • Q. Mo
      • Yaping Wang
      • Hailong Dong
      • Yuhua Bao
      • Jia-kui Li

    • PubMed: 34597776
    • DOI: 10.1016/j.micpath.2021.105212

    5 Insights on

    • Increased Antioxidant Activity
    • Increased Gastric Survival Rate
    • Enhanced Intestinal Epithelial Cell Adhesion
    • Increased Antibacterial Activity Against Pathogens
    • Reduced Virulence Factors

    • Low evidence

  • Effect of Berberine Hydrochloride on the Diversity of Intestinal Flora in Parkinson's Disease Patients.

    • 2022-01
    • RCT
    • Contrast media & molecular imaging 2022(1)
    • • Jiaojiao Li
      • Pin Meng
      • Jianyu Zhang
      • Mingli He

    • PubMed: 35685661
    • DOI: 10.1155/2022/8381870

    3 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Increased Interleukin 8 Levels

    • High evidence

  • Lactobacillus salivarius HHuMin-U Activates Innate Immune Defense against Norovirus Infection through TBK1-IRF3 and NF-κB Signaling Pathways.

    • 2022-01
    • Research (Washington, D.C.) 2022
    • • Da Hyun Kim
      • Minju Jeong
      • Jae Hwan Kim
      • Joe Eun Son
      • John J Y Lee
      • Sang-Jun Park
      • Juyeon Lee
      • Minwoo Kim
      • Jong-Won Oh
      • Myeong Soo Park
      • Sanguine Byun

    • PubMed: 39290965
    • DOI: 10.34133/research.0007

    5 Insights on

    • Enhanced Innate Immune Response
    • Improved Antiviral Immune Response
    • Reduced Viral Infection
    • Reduced Norovirus Multiplication
    • Increased Intestinal IFN-beta Levels

    • Low evidence

  • The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: A systematic review and meta-analysis of controlled trials with duration- and dose-response analysis.

    • 2022-01
    • Meta-Analysis
    • Pharmacological research 175
    • • Sahar Foshati
      • Fatemeh Nouripour
      • Erfan Sadeghi
      • Reza Amani

    • PubMed: 34798267
    • DOI: 10.1016/j.phrs.2021.105905

    4 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Reduced Heart Rate
    • Reduced Flow-Mediated Dilation

    • High evidence

  • Beneficial effects of a combination of Clostridium cochlearium and Lactobacillus acidophilus on body weight gain, insulin sensitivity, and gut microbiota in high-fat diet-induced obese mice.

    • 2022-01
    • RCT · n = 36
    • Nutrition 93
    • • Fei Yang
      • Wenjun Zhu
      • Paba Edirisuriya
      • Qing Ai
      • Kai Nie
      • Xiang Ji
      • Yong Li
      • K. Zhou

    • PubMed: 34507264
    • DOI: 10.1016/j.nut.2021.111439

    5 Insights on

    • Improved Insulin Sensitivity
    • Improved Gut Microbiota Diversity
    • Reduced Body Weight
    • Reduced Obesity-Related Microbial Taxa
    • Reduced Obesity-Related Taxa

    • Low evidence
    • Animal Study

  • Effects of Pro/Prebiotics Alone over Pro/Prebiotics Combined with Conventional Antibiotic Therapy to Treat Bacterial Vaginosis: A Systematic Review.

    • 2022-01
    • Systematic Review
    • International journal of clinical practice 2022(1)
    • • Roghayeh Afifirad
      • Amir Darb Emamie
      • Rezvan Golmoradi Zadeh
      • Parisa Asadollahi
      • Roya Ghanavati
      • Atieh Darbandi

    • PubMed: 35685517
    • DOI: 10.1155/2022/4774783

    5 Insights on

    • Increased Cure Rate of Bacterial Vaginosis
    • Reduced Vaginal Colonization of Pathogenic Bacteria
    • Improved Clinical Outcomes
    • Reduced Vaginal Group B Streptococcus Colonization
    • Adverse Events

    • High evidence

  • Efficacy of Hibiscus sabdariffa on Reducing Blood Pressure in Patients With Mild-to-Moderate Hypertension: A Systematic Review and Meta-Analysis of Published Randomized Controlled Trials.

    • 2022-01
    • Meta-Analysis · n = 1,205
    • Journal of cardiovascular pharmacology 79(1)
    • • Mohamed Abdelmonem
      • Mahmoud Ahmed Ebada
      • Sherein Diab
      • Mariam Mohamed Ahmed
      • Mohamed Sayed Zaazouee
      • Tarek Mohamed Essa
      • Zainab Salah ElBaz
      • Hazem S Ghaith
      • Walid Shaban Abdella
      • Mohamed Ebada
      • Ahmed Negida

    • PubMed: 34694241
    • DOI: 10.1097/fjc.0000000000001161

    2 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure

    • High evidence

  • Clinical Evidence of Acetyl-L-Carnitine Efficacy in the Treatment of Acute Ischemic Stroke: A Pilot Clinical Trial.

    • 2022-01
    • RCT
    • Oxidative medicine and cellular longevity 2022(1)
    • • Mehrdokht Mazdeh
      • Parnaz Abolfathi
      • Maryam Sabetghadam
      • Younes Mohammadi
      • Maryam Mehrpooya

    • PubMed: 35936217
    • DOI: 10.1155/2022/2493053

    10 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Increased Antioxidant Enzyme Levels
    • Increased Superoxide Dismutase Levels
    • Increased Total Serum Antioxidant Capacity
    • Reduced Soluble Intercellular Adhesion Molecule-1 Level
    • Improved Modified Rankin Scale Score
    • Reduced Stroke Scale Score
    • Reduced Neuron-Specific Enolase Level
    • Increased Total L-Carnitine Level

    • High evidence

  • Effect of Medicinal Plants and Natural Products on Liver Enzymes in Non-alcoholic Fatty Liver Patients in Iran: A Systematic Review and Meta-Analysis.

    • 2022-01
    • Review · n = 1,298
    • International journal of preventive medicine 13(1)
    • • Moloud Fakhri
      • Hafez Fakheri
      • Mohammad Azadbakht
      • Mahmood Moosazadeh
      • Seyde Sedighe Yousefi

    • PubMed: 35958359
    • DOI: 10.4103/ijpvm.ijpvm_313_20

    4 Insights on

    • Reduced Gamma-Glutamyl Transferase Levels
    • Reduced Alanine Aminotransferase Level
    • Reduced Alkaline Phosphatase Level
    • Reduced Aspartate Aminotransferase Level

    • High evidence

  • L-citrulline Enriched Fermented Milk with Lactobacillus helveticus Attenuates Dextran Sulfate Sodium (DSS) Induced Colitis in Mice.

    • 2022-01
    • RCT · n = 6
    • The Journal of Nutritional Biochemistry 99
    • • Sze Wing Ho
      • H. El‐Nezami
      • H. Corke
      • C. Ho
      • N. Shah

    • PubMed: 34587540
    • DOI: 10.1016/j.jnutbio.2021.108858

    12 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Pro-Inflammatory Cytokines
    • Reduced Body Weight
    • Reduced Disease Activity
    • Reduced Histological Scores
    • Reduced Interleukin-4 Production
    • Improved Survival Rate
    • Reduced Colonic Permeability
    • Reduced Inflammation Levels
    • Improved Disease Activity Index Score
    • Reduced Disease Activity Index (DAI) Levels
    • Reduced Colonic Damage

    • Low evidence
    • Animal Study

  • The supplementation of L-carnitine in septic shock patients: Systematic review and meta-analysis.

    • 2022-01
    • Meta-Analysis · n = 275
    • Clinics (Sao Paulo, Brazil) 77
    • • Gabriel Voltani Guedes
      • Marcos Ferreira Minicucci
      • Suzana Erico Tanni

    • PubMed: 36327640
    • DOI: 10.1016/j.clinsp.2022.100124

    1 Insight on

    • Reduced Mortality Rate

    • High evidence