December 2024 Supplement Research Papers

• December 1

  • Effect of vitamin C and hawthorn beverage formula on blood pressure and oxidative stress in heat-exposed workers: a cluster-randomized controlled trial.

    • 2024-12-01
    • RCT
    • Asia Pacific journal of clinical nutrition 33(4)
    • • Wei Du
      • Shuhan Zhang
      • Jiajia Yang
      • Hongmin Fan

    • PubMed: 39209360
    • DOI: 10.6133/apjcn.202412_33(4).0005

    3 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Reduced 8-Isoprostane-Prostaglandin F2α Level

    • High evidence
• December 2

  • The Bacteriocins Produced by Lactic Acid Bacteria and the Promising Applications in Promoting Gastrointestinal Health.

    • 2024-12-02
    • Review
    • Foods (Basel, Switzerland) 13(23)
    • • Mohamedelfatieh Ismael
      • Mingxin Huang
      • Qingping Zhong

    • PubMed: 39682959
    • DOI: 10.3390/foods13233887

    2 Insights on

    • Improved Gastrointestinal Health
    • Alleviated Intestinal Disease

    • Low evidence

  • Evaluation of curcumin intake in reducing exercise-induced muscle damage in athletes: a systematic review.

    • 2024-12-02
    • Systematic Review
    • Journal of the International Society of Sports Nutrition 21(1)
    • • Popescu-Radu Daniel Vasile
      • Martinez-López Patricia
      • Massip-Salcedo Marta
      • Esquius Laura

    • PubMed: 39623590
    • DOI: 10.1080/15502783.2024.2434217

    3 Insights on

    • Increased Antioxidant Enzyme Levels
    • Reduced Inflammatory Markers
    • Reduced Muscle Soreness

    • High evidence

  • Effects of L-carnitine supplementation on lipid profile in adult patients under hemodialysis: a systematic review and meta-analysis of RCTs.

    • 2024-12-02
    • Systematic Review · n = 28
    • Frontiers in medicine 11
    • • Mehdi Karimi
      • Samira Pirzad
      • Seyed Morteza Ali Pourfaraji
      • Peyvand Parhizkar Roudsari
      • Niyousha Shirsalimi
      • Sajad Ahmadizad

    • PubMed: 39687901
    • DOI: 10.3389/fmed.2024.1454921

    6 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Body Mass Index
    • Reduced Total Cholesterol Levels
    • Reduced Low-Density Lipoprotein Level
    • Reduced Systolic Blood Pressure
    • Reduced Triglyceride Levels

    • High evidence
• December 3

  • Bacillus subtilis DE111 partially reverses endothelial dysfunction in western-diet fed mice.

    • 2024-12-03
    • Clinical Trial · n = 24
    • Beneficial microbes 16(3)
    • • B D Risk
      • E L Graham
      • M Zhang
      • Y Wei
      • G C Stark
      • G D Brown
      • C L Gentile
      • T L Weir

    • PubMed: 39631408
    • DOI: 10.1163/18762891-bja00052

    3 Insights on

    • Improved Vascular Endothelial Function
    • Improved Gut Barrier Function
    • No Change in Body Weight or Cardiometabolic Parameters

    • High evidence
    • Rigorous Journal
• December 4

  • The effects of L-theanine supplementation on the outcomes of patients with mental disorders: a systematic review.

    • 2024-12-04
    • Systematic Review
    • BMC psychiatry 24(1)
    • • Reza Moshfeghinia
      • Erfan Sanaei
      • Sara Mostafavi
      • Kasra Assadian
      • Ali Sanaei
      • Getinet Ayano

    • PubMed: 39633316
    • DOI: 10.1186/s12888-024-06285-y

    1 Insight on

    • Reduced Psychiatric Symptom

    • High evidence

  • Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis.

    • 2024-12-04
    • Systematic Review · n = 10
    • Frontiers in endocrinology 15
    • • Bingcong Peng
      • Weiwei Wang
      • Qingling Gu
      • Ping Wang
      • Weiping Teng
      • Zhongyan Shan

    • PubMed: 39698034
    • DOI: 10.3389/fendo.2024.1445878

    2 Insights on

    • Reduced Thyroid Peroxidase Antibody Level
    • Reduced Thyroglobulin Antibody Level

    • High evidence

  • Crocin Supplementation on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis.

    • 2024-12-04
    • Meta-Analysis
    • Phytotherapy research : PTR 39(1)
    • • Hossein Bahari
      • Mostafa Shahraki Jazinaki
      • Ladan Aghakhani
      • Mohammad Reza Amini
      • Zahra Noushzadeh
      • Rozita Khodashahi
      • Mahsa Malekahmadi

    • PubMed: 39632602
    • DOI: 10.1002/ptr.8380

    6 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Reduced C-Reactive Protein Levels
    • Increased Total Serum Antioxidant Capacity
    • Reduced Erythrocyte Sedimentation Rate
    • Reduced Malondialdehyde

    • High evidence
• December 5

  • Streptococcus salivarius Role as a Probiotic in Children's Health and Disease Prophylaxis-A Systematic Review.

    • 2024-12-05
    • Review
    • Life (Basel, Switzerland) 14(12)
    • • Flavia Cristina Al-Akel
      • Lacramioara Eliza Chiperi
      • Vas Krisztina Eszter
      • Anca Bacârea

    • PubMed: 39768321
    • DOI: 10.3390/life14121613

    3 Insights on

    • Reduced Incidence of Tooth Decay
    • Reduced Plaque
    • Reduced Black Stain

    • Low evidence

  • Efficacy of Lavender Essential Oil in Reducing Stress, Insomnia, and Anxiety in Pregnant Women: A Systematic Review.

    • 2024-12-05
    • Review · n = 413
    • Healthcare (Basel, Switzerland) 12(23)
    • • Eulàlia Vidal-García
      • Maria Vallhonrat-Bueno
      • Fabià Pla-Consuegra
      • Alícia Orta-Ramírez

    • PubMed: 39685078
    • DOI: 10.3390/healthcare12232456

    3 Insights on

    • Reduced Anxiety
    • Improved Sleep Quality
    • Reduced Stress

    • High evidence
• December 6

  • Probiotic Mixture Attenuates Colorectal Tumorigenesis in Murine AOM/DSS Model by Suppressing STAT3, Inducing Apoptotic p53 and Modulating Gut Microbiota.

    • 2024-12-06
    • Probiotics and antimicrobial proteins 17(4)
    • • Hoi Kit Matthew Leung
      • Emily Kwun Kwan Lo
      • Congjia Chen
      • Fangfei Zhang
      • Felicianna
      • Marsena Jasiel Ismaiah
      • Hani El-Nezami

    • PubMed: 39641861
    • DOI: 10.1007/s12602-024-10405-1

    3 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Proinflammatory Signaling
    • Reduced Colorectal Tumorigenesis

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Do Non-Prescription Products Help in Managing Androgenic Alopecia?

    • 2024-12-06
    • Review · n = 13
    • Skin appendage disorders 11(3)
    • • Aditya K Gupta
      • Honglin Wang
      • Tong Wang
      • Mesbah Talukder

    • PubMed: 40475103
    • DOI: 10.1159/000542880

    1 Insight on

    • Improved Total Hair Density

    • Low evidence

  • Characterization of Physicochemical Properties, Bioactivities, and Sensory Attributes of Sea Buckthorn-Fava Bean Composite Instant Powder: Spray-Drying Versus Freeze-Drying Coupled with Carriers.

    • 2024-12-06
    • Foods (Basel, Switzerland) 13(23)
    • • Shi Li
      • Xizhe Fu
      • Jing Wen
      • Lin Jiang
      • Liheng Shao
      • Yinglin Du
      • Chunhui Shan

    • PubMed: 39683016
    • DOI: 10.3390/foods13233944

    2 Insights on

    • Improved Antioxidant Activity
    • Improved Glycemia

    • Low evidence
• December 9

  • Vitamin, antioxidant and micronutrient supplementation and the risk of developing incident autoimmune diseases: a systematic review and meta-analysis.

    • 2024-12-09
    • Meta-Analysis
    • Frontiers in immunology 15
    • • Chen Ee Low
      • Sean Loke
      • Nicole Shi Min Chew
      • Ainsley Ryan Yan Bin Lee
      • Sen Hee Tay

    • PubMed: 39717776
    • DOI: 10.3389/fimmu.2024.1453703

    1 Insight on

    • Reduced Autoimmune Disease Risk

    • High evidence

  • Phytochemicals in the treatment of patients with depression: a systemic review.

    • 2024-12-09
    • Systematic Review
    • Frontiers in psychiatry 15
    • • Natalia Picheta
      • Julia Piekarz
      • Karolina Daniłowska
      • Karol Mazur
      • Halina Piecewicz-Szczęsna
      • Agata Smoleń

    • PubMed: 39717381
    • DOI: 10.3389/fpsyt.2024.1509109

    3 Insights on

    • Increased Anti-Inflammatory Cytokine Levels
    • Reduced Depression Symptoms
    • Improved Mood

    • High evidence

  • Effect of Vitamin D3, Omega-3 Fatty Acids, and Exercise on Serum Sclerostin Levels and Bone Turnover Markers.

    • 2024-12-09
    • RCT · n = 1,848
    • The Journal of clinical endocrinology and metabolism 110(9)
    • • Elena Tsourdi
      • Stephanie Gängler
      • Melanie Kistler-Fischbacher
      • Martina Rauner
      • Bess Dawson-Hughes
      • E John Orav
      • Li-Tang Tsai
      • Wei Lang
      • John A Kanis
      • Robert Theiler
      • Andreas Egli
      • Heike A Bischoff-Ferrari
      • Lorenz C Hofbauer

    • PubMed: 39657964
    • DOI: 10.1210/clinem/dgae859

    3 Insights on

    • Reduced Serum Sclerostin Level
    • Reduced Procollagen Type 1 N Propeptide Level
    • Reduced C-terminal Telopeptide Level

    • High evidence
    • Large Human Trial

  • Microbiome-Based Therapeutics for Insomnia.

    • 2024-12-09
    • Review
    • International journal of molecular sciences 25(23)
    • • Chenyu Li
      • Sizhe Chen
      • Yun Wang
      • Qi Su

    • PubMed: 39684918
    • DOI: 10.3390/ijms252313208

    1 Insight on

    • Improved Sleep Quality

    • Moderate evidence
    • Rigorous Journal
• December 10

  • Effects of Probiotics on Neurodegenerative Disease-Related Symptoms and Systemic Inflammation: A Systematic Review.

    • 2024-12-10
    • Review
    • International journal of general medicine 17
    • • Fengya Zhu
      • Shao Yin
      • Yuan Wang
      • Yue Zhong
      • Qiang Ji
      • Jie Wu

    • PubMed: 39678681
    • DOI: 10.2147/ijgm.s499406

    7 Insights on

    • Improved Quality of Life
    • Improved Cognitive Function
    • Improved Mental Health
    • Reduced Inflammation
    • Increased Antioxidant Capacity
    • Improved Gastrointestinal Function
    • Improved Neurodegenerative Disease Symptoms

    • Low evidence
• December 11

  • Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population.

    • 2024-12-11
    • Systematic Review
    • Bone & joint research 13(12)
    • • Chenqi Xie
      • Jianbao Gong
      • Chenglong Zheng
      • Junwei Zhang
      • Jie Gao
      • Chunyan Tian
      • Xiaofei Guo
      • Shiyou Dai
      • Tianlin Gao

    • PubMed: 39657786
    • DOI: 10.1302/2046-3758.1312.bjr-2024-0053.r1

    9 Insights on

    • Increased Gamma-Carboxylated Osteocalcin Levels
    • Increased Lumbar Spine Bone Mineral Density
    • Decreased Uncarboxylated Osteocalcin Level
    • Increased Carboxylated Osteocalcin Ratio
    • Decreased Uncarboxylated to Total Osteocalcin Ratio
    • Unchanged Total Osteocalcin Level
    • Maintained Cross-Linked Telopeptide of Type 1 Collagen Level
    • Unchanged Bone Alkaline Phosphatase Level
    • Unchanged Procollagen I N-Terminal Propeptide Level

    • High evidence
• December 12

  • The cardiometabolic benefits of okra-based treatment in prediabetes and diabetes: a systematic review and meta-analysis of randomized controlled trials.

    • 2024-12-12
    • Systematic Review
    • Frontiers in nutrition 11
    • • Hossein Bahari
      • Mostafa Shahraki Jazinaki
      • Iman Rahnama
      • Ladan Aghakhani
      • Mohammad Reza Amini
      • Mahsa Malekahmadi

    • PubMed: 39726865
    • DOI: 10.3389/fnut.2024.1454286

    4 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Hemoglobin A1c
    • Reduced Blood Cholesterol
    • Reduced Fasting Blood Glucose Levels

    • High evidence

  • Ergogenic and Sympathomimetic Effects of Yohimbine: A Review.

    • 2024-12-12
    • Review
    • Neurology international 16(6)
    • • Sophia L Porrill
      • Rebecca R Rogers
      • Christopher G Ballmann

    • PubMed: 39728757
    • DOI: 10.3390/neurolint16060131

    5 Insights on

    • Improved Endurance
    • Increased Energy Levels
    • Improved Sprint Performance
    • Improved Resistance Exercise Performance
    • Decreased Fatigue

    • Low evidence

  • The Safety of Probiotics Intended for Use in Pregnant and Lactating Women: From a Desirable to a Required Task.

    • 2024-12-12
    • Review
    • Foods (Basel, Switzerland) 13(24)
    • • Leónides Fernández
      • Belén Orgaz
      • Juan M Rodríguez

    • PubMed: 39766967
    • DOI: 10.3390/foods13244024

    1 Insight on

    • Improved Gastrointestinal Tolerance

    • Low evidence

  • Crocus sativus (saffron) adjunct to risperidone for negative symptoms of schizophrenia: a randomized, double-blind, placebo-controlled trial.

    • 2024-12-12
    • RCT
    • International clinical psychopharmacology 40(6)
    • • Siamand Mazhar
      • Ahmad Shamabadi
      • Kimia Kazemzadeh
      • Mohammad Aidin Farahvash
      • Atiye Heidari Dalfard
      • Bita Fallahpour
      • Mohammad-Reza Khodaei Ardakani
      • Shahin Akhondzadeh

    • PubMed: 39661337
    • DOI: 10.1097/yic.0000000000000575

    6 Insights on

    • Reduced Depression
    • Reduced Negative Symptoms
    • Reduced Total PANSS Score
    • Reduced Extrapyramidal Symptoms
    • Reduced General Psychopathology
    • Improved Negative Symptom Response Rate

    • High evidence
• December 13

  • Microbiome Differences in Colorectal Cancer Patients and Healthy Individuals: Implications for Vaccine Antigen Discovery.

    • 2024-12-13
    • Review
    • ImmunoTargets and therapy 13
    • • Gordon C Ibeanu
      • Adekunle B Rowaiye
      • Joy C Okoli
      • Daniel U Eze

    • PubMed: 39698218
    • DOI: 10.2147/itt.s486731

    1 Insight on

    • Identified Colorectal Cancer Vaccine Antigen Candidates

    • Low evidence

  • Hotspots and development trends of gut microbiota in atopic dermatitis: A bibliometric analysis from 1988 to 2024.

    • 2024-12-13
    • Review
    • Medicine 103(50)
    • • Fang Liu
      • Haipeng Zhang
      • Lina Fan
      • Qi Yu
      • Siqiao Wang

    • PubMed: 39686442
    • DOI: 10.1097/md.0000000000040931

    3 Insights on

    • Improved Gut Microbiota
    • Improved Atopic Dermatitis Symptoms
    • Modulated Gut Microbiota

    • Low evidence
• December 15

  • The Effect of Carnosine Supplementation on Musculoskeletal Health in Adults with Prediabetes and Type 2 Diabetes: A Secondary Analysis of a Randomized Controlled Trial.

    • 2024-12-15
    • RCT · n = 49
    • Nutrients 16(24)
    • • Saeede Saadati
      • Paul Jansons
      • David Scott
      • Maximilian de Courten
      • Aya Mousa
      • Jack Feehan
      • Jakub Mesinovic
      • Barbora de Courten

    • PubMed: 39770949
    • DOI: 10.3390/nu16244328

    10 Insights on

    • Reduced Visceral Fat
    • Reduced Body Fat Percentage
    • Increased Bone Mineral Density
    • Improved Handgrip Strength
    • Increased Appendicular Lean Mass
    • Improved Upper Limb Relative Strength
    • Increased Cortical Volumetric Bone Mineral Density
    • Increased Proximal Tibial Cortical Volumetric Bone Mineral Density
    • Improved Strain Index
    • Improved Stress-Strain Index

    • High evidence
    • Rigorous Journal

  • Therapeutic Potential of a Natural Blend of Aronia melancarpa, Lonicera caerulea, and Echinacea purpurea Extracts in Treating Upper Respiratory Tract Infections: Preliminary Clinical and In Vitro Immunomodulatory Insights.

    • 2024-12-15
    • RCT · n = 61
    • International journal of molecular sciences 25(24)
    • • Katarzyna Zima
      • Marta Sochocka
      • Michał Ochnik
      • Barbara Khaidakov
      • Krzysztof Lemke
      • Paulina Kowalczyk

    • PubMed: 39769201
    • DOI: 10.3390/ijms252413436

    2 Insights on

    • Reduced Incidence of Upper Respiratory Tract Infections
    • Reduced Throat Symptom

    • High evidence
    • Rigorous Journal
• December 16

  • Probiotics as an adjunctive therapy in periodontitis treatment-reality or illusion-a clinical perspective.

    • 2024-12-16
    • Review
    • NPJ biofilms and microbiomes 10(1)
    • • Lamyae Baddouri
      • Matthias Hannig

    • PubMed: 39681550
    • DOI: 10.1038/s41522-024-00614-5

    1 Insight on

    • Improved Periodontal Health

    • Low evidence

  • A review on the effect of green tea extract against obesity.

    • 2024-12-16
    • Review
    • Food science and biotechnology 34(8)
    • • Hyeonji Lee
      • Heeju Kim
      • Sanguine Byun

    • PubMed: 40151607
    • DOI: 10.1007/s10068-024-01778-8

    6 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Body Weight
    • Reduced Obesity
    • Reduced Body Fat Percentage
    • Reduced Obesity-Related Metabolic Disorder

    • Low evidence
• December 17

  • Salidroside: An Overview of Its Promising Potential and Diverse Applications.

    • 2024-12-17
    • Review
    • Pharmaceuticals (Basel, Switzerland) 17(12)
    • • Keke Liang
      • Shuhe Ma
      • Kai Luo
      • Renjie Wang
      • Chenrong Xiao
      • Xianxie Zhang
      • Yue Gao
      • Maoxing Li

    • PubMed: 39770545
    • DOI: 10.3390/ph17121703

    3 Insights on

    • Reduced Inflammation
    • Reduced Fatigue
    • Improved Hypoxia Resistance

    • Low evidence

  • The mortality of Bombyx mori larvae challenged by BmNPV is reduced when supplemented with Lactobacillus acidophilus bacteria.

    • 2024-12-17
    • Clinical Trial
    • BMC research notes 17(1)
    • • Siripuk Suraporn
      • Vallaya Suthikhum
      • Olle Terenius

    • PubMed: 39690411
    • DOI: 10.1186/s13104-024-07019-9

    3 Insights on

    • Improved Survival
    • Improved Growth and Economic Traits
    • Improved Growth and Economic Silk Production Measures

    • Low evidence
    • Animal Study

  • Clinical and Biochemical Efficacies of Green and White Tea Extract Mouthwashes in the Management of Plaque-Induced Gingivitis.

    • 2024-12-17
    • RCT · n = 112
    • International journal of dental hygiene 23(3)
    • • Oguz Kose
      • Yagmur Sarac Gul
      • Ahmet Altin
      • Semih Alperen Bostan
      • Ozlem Faiz
      • Kerimali Akyildiz
      • Adnan Yilmaz

    • PubMed: 39686858
    • DOI: 10.1111/idh.12890

    4 Insights on

    • Reduced Interleukin-1β Levels
    • Improved Gingival Index
    • Reduced Matrix Metalloproteinase-8 Level
    • Reduced Tooth Discoloration

    • High evidence
    • Large Human Trial
• December 18

  • Efficacy and safety evaluation of Boswellia serrata and Curcuma longa extract combination in the management of chronic lower back pain: A randomised, double-blind, placebo-controlled clinical study.

    • 2024-12-18
    • RCT · n = 45
    • Explore (New York, N.Y.) 21(1)
    • • Anuradha Majumdar
      • Mungara Anjaneya Venkata Vara Prasad
      • Satish Reddy Gandavarapu
      • Kalakata Sudhir Kumar Reddy
      • Varun Sureja
      • Dharmeshkumar Kheni
      • Vishal Dubey

    • PubMed: 39700654
    • DOI: 10.1016/j.explore.2024.103099

    9 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Improved Quality of Life
    • Reduced Pain
    • Reduced High-Sensitivity C-Reactive Protein Level
    • Improved Physician Global Assessment
    • Improved Patient Global Assessment
    • Reduced Disability
    • Reduced Unpleasantness

    • High evidence

  • Effect of Dietary Supplementation with Lutein, Zeaxanthin, and Elderberries on Dry Eye Disease (DED) and Immunity: A Randomized Controlled Trial.

    • 2024-12-18
    • RCT
    • Nutrients 16(24)
    • • Kok Ming Goh
      • Eugenie Sin Sing Tan
      • Crystale Siew Ying Lim
      • Pui Yee Tan
      • Sayantan Biswas
      • Li Ann Lew
      • Chung Keat Tan

    • PubMed: 39770987
    • DOI: 10.3390/nu16244366

    2 Insights on

    • Reduced Dry Eye Symptom
    • Improved Visual Comfort

    • High evidence
    • Rigorous Journal
• December 19

  • 7 days of L-citrulline supplementation does not improve running performance in the heat whilst in a hypohydrated state.

    • 2024-12-19
    • RCT
    • European journal of applied physiology 125(5)
    • • Thomas G Cable
      • Mark P Funnell
      • Kirsty M Reynolds
      • Ella F Hudson
      • Heather Z Macrae
      • Drusus A Johnson
      • Lee Taylor
      • Liam M Heaney
      • Stephen A Mears
      • Stephen J Bailey
      • Lewis J James

    • PubMed: 39699639
    • DOI: 10.1007/s00421-024-05671-4

    6 Insights on

    • Reduced Flatulence
    • Reduced Heart Rate
    • Improved Running Performance
    • Reduced Core Temperature
    • Improved Hydration Status
    • Reduced Gastrointestinal Damage

    • High evidence
• December 20

  • Comparing the Effects of Collagen Hydrolysate and Dairy Protein on Recovery from Eccentric Exercise: A Double Blind, Placebo-Controlled Study.

    • 2024-12-20
    • RCT
    • Nutrients 16(24)
    • • Rachel Barclay
      • Jane Coad
      • Katie Schraders
      • Matthew J Barnes

    • PubMed: 39771010
    • DOI: 10.3390/nu16244389

    8 Insights on

    • Reduced Interleukin-6 Levels
    • Reduced Creatine Kinase Level
    • Reduced High-Sensitivity C-Reactive Protein Level
    • Reduced Delayed-Onset Muscle Soreness
    • Improved Countermovement Jump Height
    • Improved Isometric Midthigh Pull Force
    • Improved Maximal Voluntary Isometric Contraction Force
    • Improved Running Economy

    • High evidence
    • Rigorous Journal

  • Changes in Human Colonic Microbiota Promoted by Synbiotic Açai Juice Composed of Gluco-Oligosaccharides, Dextran, and Bifidobacterium breve NRRL B-41408.

    • 2024-12-20
    • Foods (Basel, Switzerland) 13(24)
    • • Bianca Mara Reges
      • Francisca Andréa da Silva Oliveira
      • Thatyane Vidal Fonteles
      • Sueli Rodrigues

    • PubMed: 39767062
    • DOI: 10.3390/foods13244121

    3 Insights on

    • Improved Gut Microbiota Diversity
    • Increased Short-Chain Fatty Acid Production
    • Increased Propionic Acid Production

    • Low evidence
• December 22

  • Clinical Trials Conducted on Herbal Remedies for the Treatment of Melasma: A Scoping Review.

    • 2024-12-22
    • Systematic Review · n = 21
    • Journal of cosmetic dermatology 24(2)
    • • Mohammad Mahdi Parvizi
      • Maryam Hekmat
      • Nahid Yousefi
      • Rojan Javaheri
      • Arman Mehrzadeh
      • Nasrin Saki

    • PubMed: 39710951
    • DOI: 10.1111/jocd.16741

    1 Insight on

    • Reduced Melasma Severity

    • High evidence
• December 23

  • Efficacy of iron replacement in pulmonary hypertension: A systematic review.

    • 2024-12-23
    • Systematic Review
    • Nutrition and health 31(2)
    • • Tejaswini Baral
      • Pravachana Malakapogu
      • Zuha Shyma
      • Shilia Jacob Kurian
      • Ruby Benson
      • Mohan K Manu
      • Debasis Bagchi
      • Sonal Sekhar Miraj

    • PubMed: 39711168
    • DOI: 10.1177/02601060241303814

    4 Insights on

    • Improved Iron Levels
    • Improved Six-Minute Walk Distance
    • Improved Peak Oxygen Intake
    • Improved Anaerobic Threshold

    • High evidence
• December 24

  • Gut Dysbiosis and Adult Atopic Dermatitis: A Systematic Review.

    • 2024-12-24
    • Review
    • Journal of clinical medicine 14(1)
    • • Kevin Díez-Madueño
      • Pablo de la Cueva Dobao
      • Isabel Torres-Rojas
      • Marta Fernández-Gosende
      • Claudio Hidalgo-Cantabrana
      • Pablo Coto-Segura

    • PubMed: 39797102
    • DOI: 10.3390/jcm14010019

    1 Insight on

    • Improved Atopic Dermatitis Management

    • Low evidence

  • Health-Promoting and Functional Properties of Fermented Milk Beverages with Probiotic Bacteria in the Prevention of Civilization Diseases.

    • 2024-12-24
    • Review
    • Nutrients 17(1)
    • • Milena Alicja Stachelska
      • Piotr Karpiński
      • Bartosz Kruszewski

    • PubMed: 39796443
    • DOI: 10.3390/nu17010009

    7 Insights on

    • Improved Immune Function
    • Reduced Obesity
    • Reduced Constipation
    • Reduced Lactose Intolerance Symptoms
    • Reduced Cancer Risk
    • Reduced Diabetes Incidence
    • Reduced Intestinal Pathogens

    • Moderate evidence
    • Rigorous Journal
• December 25

  • Akkermansia muciniphila: A Potential Target for the Prevention of Diabetes.

    • 2024-12-25
    • Review
    • Foods (Basel, Switzerland) 14(1)
    • • Kairu He
      • Feiyu An
      • Henan Zhang
      • Danli Yan
      • Tong Li
      • Junrui Wu
      • Rina Wu

    • PubMed: 39796314
    • DOI: 10.3390/foods14010023

    1 Insight on

    • Improved Glycemia

    • Low evidence
• December 26

  • Effects of Different Dietary Supplements on Swimming Performance: A Systematic Review and Network Meta-Analysis.

    • 2024-12-26
    • Systematic Review
    • Nutrients 17(1)
    • • Dongxiang Huang
      • Xiaobing Wang
      • Hideki Takagi
      • Shiwei Mo
      • Zhongzheng Wang
      • Daniel Hung-Kay Chow
      • Bo Huang

    • PubMed: 39796467
    • DOI: 10.3390/nu17010033

    4 Insights on

    • Reduced Blood Lactate
    • Reduced Heart Rate
    • Reduced Body Mass
    • Reduced Swimming Time

    • High evidence
    • Rigorous Journal

  • Efficacy of Bacillus clausii UBBC-07 and Bacillus coagulans Unique IS-2 in Mitigating Pulmonary Parameters in Patients With Moderate COVID-19 Symptoms.

    • 2024-12-26
    • RCT · n = 56
    • Cureus 16(12)
    • • Mehdi Ali Mirza
      • Rajiv Kumar Bandaru
      • Ushasree T

    • PubMed: 39866999
    • DOI: 10.7759/cureus.76436

    5 Insights on

    • Reduced Interleukin-6 Levels
    • Reduced C-Reactive Protein Levels
    • Reduced Lactate Dehydrogenase Level
    • Reduced Ferritin Level
    • Reduced D-Dimer Level

    • High evidence
• December 27

  • Health benefits, antimicrobial activities, and potential applications of probiotics: A review.

    • 2024-12-27
    • Review
    • Medicine 103(52)
    • • Amin Sepehr
      • Seyedeh Tina Miri
      • Shadi Aghamohammad
      • Nazanin Rahimirad
      • Mahnaz Milani
      • Mohammad-Reza Pourshafie
      • Mahdi Rohani

    • PubMed: 39969286
    • DOI: 10.1097/md.0000000000032412

    4 Insights on

    • Improved Gut Microbiota Balance
    • Modulated Immune Response
    • Reduced Risk of Chronic Inflammatory Diseases
    • Reduced Risk of Infection

    • Low evidence

  • Effect of Long-Term Taurine Supplementation on the Lipid and Glycaemic Profile in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis.

    • 2024-12-27
    • Meta-Analysis
    • Nutrients 17(1)
    • • Qin Sun
      • Jieping Wang
      • Huanyu Wang
      • Hanhan Yu
      • Kang Wan
      • Fuyi Ma
      • Ru Wang

    • PubMed: 39796489
    • DOI: 10.3390/nu17010055

    7 Insights on

    • Improved Insulin Sensitivity
    • Reduced Body Mass Index
    • Reduced Triglyceride Levels
    • Reduced Insulin Levels
    • Reduced Hemoglobin A1c
    • Reduced Blood Cholesterol
    • Reduced Fasting Blood Glucose Levels

    • High evidence
    • Rigorous Journal

  • Local Application of Honey for Postoperative Pain Management and Associated Outcomes Following Tonsillectomy in Children: A Systematic Review and Meta-Analysis.

    • 2024-12-27
    • Meta-Analysis · n = 710
    • Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 50(3)
    • • Seyed Javad Hosseini
      • Seyed Reza Hosseini
      • Amirreza Jamshidbeigi
      • Gholam Reza Mahmoodi-Shan
      • Fatemeh Hajiabadi
      • Masoud Abdollahi
      • Mahbobeh Firooz

    • PubMed: 39730193
    • DOI: 10.1111/coa.14276

    4 Insights on

    • Reduced Pain Intensity
    • Reduced Pain Relief Time
    • Reduced Analgesic Consumption
    • Reduced Nighttime Awakenings

    • High evidence
• December 28

  • Effects of specific symbiotic supplements on anthropometric measurements, glycaemic control, and lipid profiles among individuals with type 2 diabetes mellitus in two teaching hospitals in Baghdad/Iraq: a double-blinded, randomised placebo-controlled trial.

    • 2024-12-28
    • RCT
    • BMC nutrition 10(1)
    • • Sarah Hayder Ali Zalzala
      • Ban Abdul-Ridha Salman Al-Hashimi
      • Zahraa Hayder Ali Zalzala
      • Khalid Saeed Fahad

    • PubMed: 39732694
    • DOI: 10.1186/s40795-024-00976-1

    7 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Blood HbA1c Levels
    • Improved Body Mass Index
    • Reduced Fasting Blood Glucose Levels
    • Improved Fasting Glucose Levels
    • Increased High-Density Lipoprotein Cholesterol

    • High evidence

  • Beneficial Effects of Pomegranate Extracts for Benign Gynecologic Disorders.

    • 2024-12-28
    • Review
    • Reproductive sciences (Thousand Oaks, Calif.) 32(3)
    • • Samya El Sayed
      • Valeria I Macri
      • Bhuchitra Singh
      • James H Segars
      • Md Soriful Islam

    • PubMed: 39733205
    • DOI: 10.1007/s43032-024-01776-5

    5 Insights on

    • Improved Quality of Life
    • Improved Cardiovascular Health
    • Reduced Testosterone Level
    • Reduced Oxidative Stress Biomarker Level
    • Reduced Inflammation Biomarker Level

    • Low evidence
• December 29

  • Effect of Ginseng Supplementation on Exercise Endurance as a Support for Cardiovascular Disease Management: A Systematic Review and Meta-Analysis.

    • 2024-12-29
    • Review
    • Antioxidants (Basel, Switzerland) 14(1)
    • • Angelika Szymańska
      • Anna Nowak
      • Anna Lipert
      • Ewa Kochan

    • PubMed: 39857366
    • DOI: 10.3390/antiox14010032

    2 Insights on

    • Increased Exercise Time to Exhaustion
    • Increased VO2 Max

    • Low evidence
• December 30

  • The Impact of Lactobacillus reuteri on Oral and Systemic Health: A Comprehensive Review of Recent Research.

    • 2024-12-30
    • Review
    • Microorganisms 13(1)
    • • Zihui Liu
      • Qing Cao
      • Wenqing Wang
      • Bowen Wang
      • Yilun Yang
      • Cory J Xian
      • Tiejun Li
      • Yuankun Zhai

    • PubMed: 39858814
    • DOI: 10.3390/microorganisms13010045

    2 Insights on

    • Improved Oral Health
    • Improved Systemic Health

    • Low evidence

  • Rice Bran Consumption Improves Lipid Profiles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    • 2024-12-30
    • Meta-Analysis · n = 572
    • Nutrients 17(1)
    • • Soo-Yeon Park
      • Yehyeon Kim
      • Min Ju Park
      • Ji Yeon Kim

    • PubMed: 39796546
    • DOI: 10.3390/nu17010114

    3 Insights on

    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol
    • Reduced Blood Cholesterol

    • High evidence
    • Rigorous Journal
• December 31

  • Exploring Gut Microbiota Imbalance in Irritable Bowel Syndrome: Potential Therapeutic Effects of Probiotics and Their Metabolites.

    • 2024-12-31
    • Review
    • Nutrients 17(1)
    • • María José García Mansilla
      • María Jesús Rodríguez Sojo
      • Andrea Roxana Lista
      • Ciskey Vanessa Ayala Mosqueda
      • Antonio Jesús Ruiz Malagón
      • Julio Gálvez
      • Alba Rodríguez Nogales
      • María José Rodríguez Sánchez

    • PubMed: 39796588
    • DOI: 10.3390/nu17010155

    2 Insights on

    • Improved Irritable Bowel Syndrome Symptoms
    • Reduced Irritable Bowel Syndrome Symptoms

    • Moderate evidence
    • Rigorous Journal

  • Engineered Bacillus subtilis as Oral Probiotics To Enhance Clearance of Blood Lactate.

    • 2024-12-31
    • ACS synthetic biology 14(1)
    • • Mengdi Yang
      • Noah Hutchinson
      • Ningyuan Ye
      • Hania Timek
      • Maria Jennings
      • Jianing Yin
      • Ming Guan
      • Zongqi Wang
      • Peiru Chen
      • Shaobo Yang
      • Justin D Crane
      • Ke Zhang
      • Xuesong He
      • Jiahe Li

    • PubMed: 39739838
    • DOI: 10.1021/acssynbio.4c00399

    1 Insight on

    • Reduced Lactate Levels

    • Low evidence
    • Animal Study

  • Dileucine ingestion, but not leucine, increases lower body strength and performance following resistance training: A double-blind, randomized, placebo-controlled trial.

    • 2024-12-31
    • RCT
    • PloS one 19(12)
    • • Anthony M Hagele
      • Joesi M Krieger
      • Connor J Gaige
      • Kevin F Holley
      • Kristen N Gross
      • Joshua M Iannotti
      • Leah E Allen
      • Paige J Sutton
      • Logan S Orr
      • Petey W Mumford
      • Martin Purpura
      • Ralf Jager
      • Chad M Kerksick

    • PubMed: 39739679
    • DOI: 10.1371/journal.pone.0312997

    9 Insights on

    • Improved Body Composition
    • Increased Lower-Body Strength
    • Improved Anaerobic Capacity
    • Increased Lower Body Muscular Endurance
    • Increased Upper Body Strength
    • Increased Upper Body Muscular Endurance
    • Improved Countermovement Jump Height
    • Increased Maximal Voluntary Contraction
    • Improved Countermovement Jump

    • High evidence

  • Dietary interventions to reduce heavy metal exposure in antepartum and postpartum women: a systematic review.

    • 2024-12-31
    • Systematic Review
    • Women's health nursing (Seoul, Korea) 30(4)
    • • Su Ji Heo
      • Nalae Moon
      • Ju Hee Kim

    • PubMed: 39756471
    • DOI: 10.4069/whn.2024.12.16

    1 Insight on

    • Reduced Heavy Metal Level in Blood

    • High evidence
• Undated – 26 supplement studies

  • Exploring the relationship between Faecalibacterium duncaniae and Escherichia coli in inflammatory bowel disease (IBD): Insights and implications.

    • 2024-12
    • Review
    • Computational and structural biotechnology journal 23
    • • Alejandro Cabezas-Cruz
      • Luis G Bermúdez-Humarán

    • PubMed: 38094217
    • DOI: 10.1016/j.csbj.2023.11.027

    1 Insight on

    • Modulated Gut Microbiota

    • Low evidence

  • The role of nutritional factors in transitioning between early, mid, and late stages of age-related macular degeneration: prospective longitudinal analysis.

    • 2024-12
    • Observational
    • The American journal of clinical nutrition 120(6)
    • • Johanna M Seddon
      • Dikha De
      • Bernard Rosner

    • PubMed: 39181206
    • DOI: 10.1016/j.ajcnut.2024.08.019

    1 Insight on

    • Reduced Incidence of Age-Related Macular Degeneration Progression

    • Low evidence

  • The impact of chia seeds on diabetes, blood pressure, lipid profile, and obesity indicators: Systematic review and meta-regression analysis of 14 randomized controlled trials.

    • 2024-12
    • Meta-Analysis · n = 835
    • Prostaglandins & other lipid mediators 175
    • • Hawal Lateef Fateh
      • Dyari H Ahmed
      • Maryam Sharifi Najafabadi
      • Jalal Moludi

    • PubMed: 39299649
    • DOI: 10.1016/j.prostaglandins.2024.106907

    4 Insights on

    • Reduced Systolic Blood Pressure
    • Reduced Body Weight
    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol

    • High evidence

  • "Protective effects of artichoke extract and Bifidobacterium longum on male infertility in diabetic rats".

    • 2024-12
    • RCT
    • Biochemistry and biophysics reports 40
    • • Zahra Ansari
      • Mohammad Hasan Maleki
      • Fatemeh Roohy
      • Zahra Ebrahimi
      • Mesbah Shams
      • Pooneh Mokaram
      • Zahra Zamanzadeh
      • Zahra Hosseinzadeh
      • Farhad Koohpeyma
      • Sanaz Dastghaib

    • PubMed: 39386078
    • DOI: 10.1016/j.bbrep.2024.101834

    1 Insight on

    • Improved Fertility

    • High evidence

  • Extensive genomic characterization, pre-clinical probiotic evaluation, and safety analysis of Bifidobacterium longum subsp. longum BL21 isolated from infant feces.

    • 2024-12
    • Microbial pathogenesis 197
    • • Yao Dong
      • Yinan Zhang
      • Fei Xu
      • Kang Zou

    • PubMed: 39505088
    • DOI: 10.1016/j.micpath.2024.107100

    2 Insights on

    • Reduced Toxicity
    • Enhanced Gastrointestinal Stress Resistance

    • Low evidence

  • The impact of N-acetylcysteine on lactate, biomarkers of oxidative stress, immune response, and muscle damage: A systematic review and meta-analysis.

    • 2024-12
    • Meta-Analysis · n = 20
    • Journal of cellular and molecular medicine 28(23)
    • • Marcin Sadowski
      • Emilia Zawieja
      • Agata Chmurzynska

    • PubMed: 39632267
    • DOI: 10.1111/jcmm.70198

    8 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Reduced Lactate Levels
    • Reduced Muscle Soreness
    • Reduced Thiobarbituric Acid-Reactive Substance Levels
    • Reduced Creatine Kinase Level
    • Increased Glutathione Level
    • Reduced Glutathione Disulfide Level

    • High evidence

  • Effects of Vitamin D3 Combined with Folic Acid on Domain and Specific Cognitive Function among Patients with Mild Cognitive Impairment: A Randomized Clinical Trial.

    • 2024-12
    • RCT · n = 402
    • The journal of prevention of Alzheimer's disease 11(6)
    • • W Liu
      • D Zheng
      • X Li
      • T Wang
      • L Wang
      • L Hao
      • M Ju
      • W Feng
      • Z Guo
      • X Sun
      • H Yu
      • Z Qin
      • R Xiao

    • PubMed: 39559875
    • DOI: 10.14283/jpad.2024.165

    1 Insight on

    • Improved Overall Cognitive Function

    • High evidence
    • Large Human Trial

  • Vitis Vinifera Seed Extract Versus Micronized Purified Flavonoid Fraction for Patients with Chronic Venous Disease: A Randomized Noninferiority Trial.

    • 2024-12
    • RCT · n = 303
    • Annals of vascular surgery 109
    • • Suh Min Kim
      • Jin Hyun Joh
      • In Mok Jung
      • Mi Jin Kim
      • Sang Su Lee
      • Hong Pil Hwang
      • Jin Mo Kang
      • Hyuk Jae Jung
      • Shin-Seok Yang
      • Seung-Kee Min
      • Young Sun Yoo
      • Jun Gyo Gwon
      • Hyung Sub Park
      • Taeseung Lee

    • PubMed: 39009117
    • DOI: 10.1016/j.avsg.2024.06.011

    4 Insights on

    • Improved Quality of Life
    • Reduced Pain
    • Reduced Venous Clinical Severity Score
    • Reduced Leg Circumference

    • High evidence
    • Large Human Trial

  • Feasibility of Fish Oil Supplementation on Headache Symptoms and Blood Lipids in Migraine Patients.

    • 2024-12
    • RCT · n = 47
    • Brain and behavior 14(12)
    • • En-Ling Yeh
      • Chun-Pai Yang
      • Shu-Wen Lin
      • Hsueh-Fang Wang

    • PubMed: 39643480
    • DOI: 10.1002/brb3.70149

    6 Insights on

    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol
    • Reduced Blood Cholesterol
    • Reduced Headache Duration
    • Reduced Headache Frequency
    • Reduced Headache Pain Intensity

    • High evidence

  • Synbiotic combination of 2'-fucosyllactose and Bifidobacterium mitigates neurodevelopmental disorders and ASD-like behaviors induced by valproic acid.

    • 2025
    • Food & function 16(7)
    • • Ying He
      • Bo Zhang
      • Yu Xin
      • Wenxiu Wang
      • Xue Wang
      • Zhuo Liu
      • Yongbo She
      • Rui Guo
      • Gengjie Jia
      • Shan Wu
      • Zhigang Liu

    • PubMed: 40165714
    • DOI: 10.1039/d4fo06234e

    6 Insights on

    • Reduced Neuroinflammation
    • Increased Short-Chain Fatty Acid Production
    • Improved Gut Integrity
    • Improved Behavioral Health
    • Reduced Gut Inflammation
    • Reduced Repetitive Behaviors

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Efficacy of vitamin C supplementation during pregnancy in the prevention of preterm birth: a systematic review and meta-analysis.

    • 2025
    • Meta-Analysis · n = 567
    • Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia 47
    • • Ana Gabriela Alves Pereira
      • Gabriela Oliveira Gonçalves Molino
      • Ana Clara Felix de Farias Santos
      • Maírla Marina Ferreira Dias
      • Nicole Dos Santos Pimenta
      • Nicole Dos Santos Pimenta
      • Pedro Henrique Costa Matos da Silva

    • PubMed: 40584396
    • DOI: 10.61622/rbgo/2025rbgo1

    6 Insights on

    • Reduced Preterm Births
    • Increased Birth Weight
    • Increased Gestational Age
    • Reduced Neonatal Death
    • Reduced NICU Admission
    • Reduced Pre-Term Premature Rupture of Membranes

    • High evidence

  • The effect of crocetin (a saffron carotenoid) supplementation on antioxidant and inflammatory indexes and serum leptin concentration in patients with coronary artery disease.

    • 2025
    • RCT
    • Food & function 16(11)
    • • Faezeh Moeini Badi
      • S Zahra Bathaie
      • Fatemeh Borazjani
      • Seyed Ahmad Hosseini
      • Mohammad Ali Sheikhi
      • Sheikh Mohammed Shariful Islam
      • Kambiz Ahmadi Angali
      • Mohammadreza Taban Sadeghi
      • Parisa Rahimi

    • PubMed: 40400479
    • DOI: 10.1039/d4fo03396e

    6 Insights on

    • Reduced Leptin Levels
    • Reduced Malondialdehyde Level
    • Improved Superoxide Dismutase Activity
    • Reduced Hs-CRP Level
    • Improved Atherogenic Index of Plasma
    • Improved Catalase Activity

    • High evidence
    • Rigorous Journal

  • Adherence to oral zinc supplementation in the management of acute diarrhoeal disease among under-5 children: A systematic review and meta-analysis.

    • 2025
    • Meta-Analysis · n = 10
    • Epidemiology and infection 153
    • • Somen Kumar Pradhan
      • Swagatika Pati
      • Pritimayee Sethy
      • Harshita Rajesh Dhusiya
      • Ashutosh Panda
      • Debasish Pandit
      • Jaya Singh Kshatri
      • Jaya Singh Kshatri
      • Srikanta Kanungo
      • Sanghamitra Pati

    • PubMed: 41178278
    • DOI: 10.1017/s0950268825100733

    1 Insight on

    • Improved Zinc Supplementation Adherence

    • High evidence

  • Astaxanthin supplement improves clinical outcomes, quality of life, and inflammatory factors in patients with rheumatoid arthritis: a randomized clinical trial.

    • 2025
    • RCT · n = 60
    • Food & function 16(14)
    • • Ani Grigorian
      • Ali Tabatabaeyan
      • Mansour Salesi
      • Awat Feizi
      • Ali-Reza Ahmadi
      • Marzieh Kafeshani

    • PubMed: 40569081
    • DOI: 10.1039/d5fo00949a

    1 Insight on

    • Improved Quality of Life

    • High evidence
    • Rigorous Journal

  • Substituting animal protein with black soymilk reduces advanced glycation end product level and improves gut microbiota composition in obese prediabetic individuals: a randomized crossover intervention trial.

    • 2025
    • RCT
    • Food & function 16(1)
    • • Yu-Ho Chang
      • Pei-Ni Lee
      • Cheng-Hsu Chen
      • Hsin-Yi Yang
      • Chi-Hao Wu
      • Jia-Yau Doong
      • Wan-Ju Yeh

    • PubMed: 39651546
    • DOI: 10.1039/d4fo04717f

    5 Insights on

    • Improved Gut Microbiota
    • Reduced Oxidative Stress
    • Reduced Dietary Advanced Glycation End Product Intake
    • Reduced Advanced Glycation End Product Level
    • Reduced Glycative Stress Marker Level

    • High evidence
    • Rigorous Journal

  • Quinoa is more effective than other whole grains in the management of impaired glucose tolerance: a randomized controlled trial.

    • 2025
    • RCT · n = 207
    • Food & function 16(2)
    • • Lu Huang
      • Xiaoli Li
      • Mingxi Zou
      • Hongli Zeng
      • Shixin Wu
      • Yuchan Liang
      • Dongjiang Wang
      • Yan Yang
      • Zhenyang Qiu
      • Quan Zhou

    • PubMed: 39784492
    • DOI: 10.1039/d4fo04557b

    9 Insights on

    • Improved Insulin Sensitivity
    • Reduced Insulin Levels
    • Reduced Postprandial Glucose
    • Increased Time in Range
    • Improved Normal Glucose Tolerance Conversion Rate
    • Reduced Blood Glucose Level
    • Reduced Diabetes Mellitus Development
    • Reduced Glycated Hemoglobin Level
    • Reduced Glycemic Variability

    • High evidence
    • Large Human Trial
    • Rigorous Journal

  • Effects of green tea supplementation on antioxidant status and inflammatory markers in adults: a grade-assessed systematic review and dose-response meta-analysis of randomised controlled trials.

    • 2025
    • Meta-Analysis
    • Journal of nutritional science 14
    • • Mohammad Jafar Dehzad
      • Hamid Ghalandari
      • Mehran Nouri
      • Maede Makhtoomi
      • Moein Askarpour

    • PubMed: 40160899
    • DOI: 10.1017/jns.2025.13

    8 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Improved Antioxidant Capacity
    • Reduced C-Reactive Protein Levels
    • Reduced Malondialdehyde
    • Improved Superoxide Dismutase Level
    • Reduced Interleukin-1 Beta Level
    • Improved Glutathione Peroxidase Level

    • High evidence

  • Saccharomyces boulardii supplementation does not affect anaerobic power gain induced by short-term sprint interval training in physically active individuals.

    • 2025
    • RCT · n = 8
    • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 58
    • • A S R Hudson
      • A M T Lisboa
      • P V R Andrade
      • R S Bruzzi
      • Y A T Martins
      • D D Soares
      • F S Martins
      • S P Wanner

    • PubMed: 40136227
    • DOI: 10.1590/1414-431x2025e14196

    1 Insight on

    • Improved Anaerobic Power

    • High evidence

  • The Effect of Oral Nutritional Supplements in Improving the Condition of Children with Diarrhea: A Systematic Review.

    • 2025
    • Review
    • Pediatric gastroenterology, hepatology & nutrition 28(5)
    • • Kamiar Mahmoudifar
      • Mehrara Hashempoor
      • Fateme Asadi Touranlou
      • Mitra Rezaie

    • PubMed: 41001439
    • DOI: 10.5223/pghn.2025.28.5.267

    1 Insight on

    • Reduced Duration of Diarrhea

    • Low evidence

  • Comparative efficacy and tolerability of nutraceuticals for depressive disorder: A systematic review and network meta-analysis.

    • 2025
    • Systematic Review · n = 437
    • Psychological medicine 55
    • • Ying-Chih Cheng
      • Wei-Lieh Huang
      • Wen-Yin Chen
      • Yu-Chen Huang
      • Po-Hsiu Kuo
      • Yu-Kang Tu

    • PubMed: 40314175
    • DOI: 10.1017/s0033291725000996

    3 Insights on

    • Improved Depressive Symptoms
    • Improved Response Rate
    • Improved Remission

    • High evidence

  • A pilot and feasibility analysis of serum TMAO and choline in a randomized sample from the COSMOS trial.

    • 2025
    • RCT · n = 40
    • Food & function 16(22)
    • • Irene Sánchez Gavilán
      • Sidong Li
      • Michael G Sweet
      • Juanita G Ratliff
      • Pamela M Rist
      • Eunjung Kim
      • JoAnn E Manson
      • Howard D Sesso
      • Andrew P Neilson

    • PubMed: 41127993
    • DOI: 10.1039/d5fo02596f

    2 Insights on

    • Reduced TMAO Levels
    • Increased Choline Level

    • High evidence
    • Rigorous Journal

  • Cocoa flavanols alleviate early diastolic dysfunction by decreasing left atrial volume in a randomized double blinded trial in healthy older individuals.

    • 2025
    • RCT
    • Food & function 16(22)
    • • Dragos Andrei Duse
      • Michael Gröne
      • Niklas Ophoff
      • Nicolas Kramser
      • Hendrik Schweers
      • Javier Ottaviani
      • Hagen Schroeter
      • Christine Quast
      • Florian Bönner
      • Christian Heiss
      • Roberto Sansone
      • Christian Jung
      • Malte Kelm
      • Ralf Erkens

    • PubMed: 41143317
    • DOI: 10.1039/d5fo02589c

    6 Insights on

    • Reduced Systolic Blood Pressure
    • Reduced Left Atrial Maximal Volume
    • Reduced Left Ventricular End-Diastolic Volume
    • Improved Myocardial Strain
    • Improved Myocardial Strain Rate
    • Improved Systolic Function

    • High evidence
    • Rigorous Journal

  • Meta-analysis of the efficacy and safety of L-carnitine and N-acetylcysteine monotherapy for male idiopathic infertility.

    • 2025
    • Meta-Analysis
    • Revista internacional de andrologia 23(1)
    • • Xiaohong Ma
      • Yingying Yang
      • Shiguo Liu
      • Yuanshan Cui
      • Jitao Wu

    • PubMed: 40350672
    • DOI: 10.22514/j.androl.2025.004

    6 Insights on

    • Increased Serum Testosterone Levels
    • Increased Sperm Motility
    • Increased Sperm Concentration
    • Increased Normal Sperm Morphology
    • Increased Ejaculation Volume
    • Increased Other Serum Hormone Level

    • High evidence

  • Efficacy of vitamin E from dietary, circulation system, and supplementation on chronic obstructive pulmonary disease (COPD): a systematic review and meta-analysis.

    • 2025
    • Meta-Analysis · n = 425
    • Food & function 16(22)
    • • Peixuan Tian
      • Hui Xia
      • Bihuan Hu
      • Yu Yang
      • Da Pan
      • Wang Liao
      • Shaokang Wang
      • Guiju Sun
      • Jing Sui

    • PubMed: 41099347
    • DOI: 10.1039/d5fo03814f

    2 Insights on

    • Reduced Chronic Obstructive Pulmonary Disease Onset Risk
    • Reduced Mortality from COPD

    • High evidence
    • Rigorous Journal

  • Effectiveness of ginger supplementation in alleviating hyperemesis gravidarum: a systematic review and meta-analysis.

    • 2025
    • Review
    • American journal of translational research 17(3)
    • • Pei Gao
      • Beibei Chen
      • Luyao Wang

    • PubMed: 40226035
    • DOI: 10.62347/txkv6669

    2 Insights on

    • Reduced Vomiting Frequency
    • Reduced Nausea and Vomiting

    • Low evidence

  • Effects of Fish Oil Supplementation on Serum C-Reactive Protein Levels in Trained Individuals: A Systematic Review of Clinical Trials.

    • 2025
    • Review
    • Clinical nutrition research 14(2)
    • • Parivash Shekarchizadeh-Esfahani
      • Leili Khaghani
      • Jahangir Karimian

    • PubMed: 40386658
    • DOI: 10.7762/cnr.2025.14.2.139

    1 Insight on

    • Reduced C-Reactive Protein Levels

    • Low evidence