December 2024 Supplement Research Papers

• December 2

  • The Bacteriocins Produced by Lactic Acid Bacteria and the Promising Applications in Promoting Gastrointestinal Health.

    • 2024-12-02
    • Review
    • Foods (Basel, Switzerland) 13(23)
    • • Mohamedelfatieh Ismael
      • Mingxin Huang
      • Qingping Zhong

    • PubMed: 39682959
    • DOI: 10.3390/foods13233887

    2 Insights on

    • Improved Gastrointestinal Health
    • Alleviated Intestinal Disease

    • Low evidence

  • Effects of L-carnitine supplementation on lipid profile in adult patients under hemodialysis: a systematic review and meta-analysis of RCTs.

    • 2024-12-02
    • Systematic Review · n = 28
    • Frontiers in medicine 11
    • • Mehdi Karimi
      • Samira Pirzad
      • Seyed Morteza Ali Pourfaraji
      • Peyvand Parhizkar Roudsari
      • Niyousha Shirsalimi
      • Sajad Ahmadizad

    • PubMed: 39687901
    • DOI: 10.3389/fmed.2024.1454921

    6 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Body Mass Index
    • Reduced Total Cholesterol Levels
    • Reduced Low-Density Lipoprotein Level
    • Reduced Systolic Blood Pressure
    • Reduced Triglyceride Levels

    • High evidence
• December 3

  • Bacillus subtilis DE111 partially reverses endothelial dysfunction in western-diet fed mice.

    • 2024-12-03
    • Clinical Trial · n = 24
    • Beneficial microbes 16(3)
    • • B D Risk
      • E L Graham
      • M Zhang
      • Y Wei
      • G C Stark
      • G D Brown
      • C L Gentile
      • T L Weir

    • PubMed: 39631408
    • DOI: 10.1163/18762891-bja00052

    3 Insights on

    • Improved Vascular Endothelial Function
    • Improved Gut Barrier Function
    • No Change in Body Weight or Cardiometabolic Parameters

    • High evidence
    • Rigorous Journal
• December 4

  • Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis.

    • 2024-12-04
    • Systematic Review · n = 10
    • Frontiers in endocrinology 15
    • • Bingcong Peng
      • Weiwei Wang
      • Qingling Gu
      • Ping Wang
      • Weiping Teng
      • Zhongyan Shan

    • PubMed: 39698034
    • DOI: 10.3389/fendo.2024.1445878

    2 Insights on

    • Reduced Thyroid Peroxidase Autoantibody Level
    • Reduced Thyroglobulin Autoantibody Level

    • High evidence
• December 5

  • Streptococcus salivarius Role as a Probiotic in Children's Health and Disease Prophylaxis-A Systematic Review.

    • 2024-12-05
    • Review
    • Life (Basel, Switzerland) 14(12)
    • • Flavia Cristina Al-Akel
      • Lacramioara Eliza Chiperi
      • Vas Krisztina Eszter
      • Anca Bacârea

    • PubMed: 39768321
    • DOI: 10.3390/life14121613

    3 Insights on

    • Reduced Incidence of Tooth Decay
    • Reduced Plaque
    • Reduced Black Stain

    • Low evidence
• December 6

  • Probiotic Mixture Attenuates Colorectal Tumorigenesis in Murine AOM/DSS Model by Suppressing STAT3, Inducing Apoptotic p53 and Modulating Gut Microbiota.

    • 2024-12-06
    • Probiotics and antimicrobial proteins 17(4)
    • • Hoi Kit Matthew Leung
      • Emily Kwun Kwan Lo
      • Congjia Chen
      • Fangfei Zhang
      • Felicianna
      • Marsena Jasiel Ismaiah
      • Hani El-Nezami

    • PubMed: 39641861
    • DOI: 10.1007/s12602-024-10405-1

    3 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Proinflammatory Signaling
    • Reduced Colorectal Tumorigenesis

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Do Non-Prescription Products Help in Managing Androgenic Alopecia?

    • 2024-12-06
    • Review · n = 13
    • Skin appendage disorders 11(3)
    • • Aditya K Gupta
      • Honglin Wang
      • Tong Wang
      • Mesbah Talukder

    • PubMed: 40475103
    • DOI: 10.1159/000542880

    1 Insight on

    • Improved Total Hair Density

    • Low evidence

  • Characterization of Physicochemical Properties, Bioactivities, and Sensory Attributes of Sea Buckthorn-Fava Bean Composite Instant Powder: Spray-Drying Versus Freeze-Drying Coupled with Carriers.

    • 2024-12-06
    • Foods (Basel, Switzerland) 13(23)
    • • Shi Li
      • Xizhe Fu
      • Jing Wen
      • Lin Jiang
      • Liheng Shao
      • Yinglin Du
      • Chunhui Shan

    • PubMed: 39683016
    • DOI: 10.3390/foods13233944

    2 Insights on

    • Improved Antioxidant Activity
    • Improved Glycemia

    • Low evidence
• December 9

  • Effect of Vitamin D3, Omega-3 Fatty Acids, and Exercise on Serum Sclerostin Levels and Bone Turnover Markers.

    • 2024-12-09
    • RCT · n = 1,848
    • The Journal of clinical endocrinology and metabolism 110(9)
    • • Elena Tsourdi
      • Stephanie Gängler
      • Melanie Kistler-Fischbacher
      • Martina Rauner
      • Bess Dawson-Hughes
      • E John Orav
      • Li-Tang Tsai
      • Wei Lang
      • John A Kanis
      • Robert Theiler
      • Andreas Egli
      • Heike A Bischoff-Ferrari
      • Lorenz C Hofbauer

    • PubMed: 39657964
    • DOI: 10.1210/clinem/dgae859

    3 Insights on

    • Reduced Serum Sclerostin Level
    • Reduced Procollagen Type 1 N Propeptide Level
    • Reduced C-terminal Telopeptide Level

    • High evidence
    • Large Human Trial

  • Microbiome-Based Therapeutics for Insomnia.

    • 2024-12-09
    • Review
    • International journal of molecular sciences 25(23)
    • • Chenyu Li
      • Sizhe Chen
      • Yun Wang
      • Qi Su

    • PubMed: 39684918
    • DOI: 10.3390/ijms252313208

    1 Insight on

    • Improved Sleep Quality

    • Moderate evidence
    • Rigorous Journal
• December 10

  • Effects of Probiotics on Neurodegenerative Disease-Related Symptoms and Systemic Inflammation: A Systematic Review.

    • 2024-12-10
    • Review
    • International journal of general medicine 17
    • • Fengya Zhu
      • Shao Yin
      • Yuan Wang
      • Yue Zhong
      • Qiang Ji
      • Jie Wu

    • PubMed: 39678681
    • DOI: 10.2147/ijgm.s499406

    7 Insights on

    • Improved Quality of Life
    • Improved Cognitive Function
    • Improved Mental Health
    • Reduced Inflammation
    • Increased Antioxidant Capacity
    • Improved Gastrointestinal Function
    • Improved Neurodegenerative Disease Symptoms

    • Low evidence
• December 11

  • Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population.

    • 2024-12-11
    • Systematic Review
    • Bone & joint research 13(12)
    • • Chenqi Xie
      • Jianbao Gong
      • Chenglong Zheng
      • Junwei Zhang
      • Jie Gao
      • Chunyan Tian
      • Xiaofei Guo
      • Shiyou Dai
      • Tianlin Gao

    • PubMed: 39657786
    • DOI: 10.1302/2046-3758.1312.bjr-2024-0053.r1

    9 Insights on

    • Increased Lumbar Spine Bone Mineral Density
    • Increased Carboxylated Osteocalcin Level
    • Decreased Uncarboxylated Osteocalcin Level
    • Increased Carboxylated Osteocalcin Ratio
    • Decreased Uncarboxylated to Total Osteocalcin Ratio
    • Unchanged Total Osteocalcin Level
    • Maintained Cross-Linked Telopeptide of Type 1 Collagen Level
    • Unchanged Bone Alkaline Phosphatase Level
    • Unchanged Procollagen I N-Terminal Propeptide Level

    • High evidence
• December 12

  • Ergogenic and Sympathomimetic Effects of Yohimbine: A Review.

    • 2024-12-12
    • Review
    • Neurology international 16(6)
    • • Sophia L Porrill
      • Rebecca R Rogers
      • Christopher G Ballmann

    • PubMed: 39728757
    • DOI: 10.3390/neurolint16060131

    5 Insights on

    • Improved Endurance
    • Increased Energy Levels
    • Improved Sprint Performance
    • Improved Resistance Exercise Performance
    • Decreased Fatigue

    • Low evidence

  • The cardiometabolic benefits of okra-based treatment in prediabetes and diabetes: a systematic review and meta-analysis of randomized controlled trials.

    • 2024-12-12
    • Systematic Review
    • Frontiers in nutrition 11
    • • Hossein Bahari
      • Mostafa Shahraki Jazinaki
      • Iman Rahnama
      • Ladan Aghakhani
      • Mohammad Reza Amini
      • Mahsa Malekahmadi

    • PubMed: 39726865
    • DOI: 10.3389/fnut.2024.1454286

    4 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Hemoglobin A1c
    • Reduced Fasting Blood Glucose Levels
    • Reduced Total Cholesterol

    • High evidence

  • The Safety of Probiotics Intended for Use in Pregnant and Lactating Women: From a Desirable to a Required Task.

    • 2024-12-12
    • Review
    • Foods (Basel, Switzerland) 13(24)
    • • Leónides Fernández
      • Belén Orgaz
      • Juan M Rodríguez

    • PubMed: 39766967
    • DOI: 10.3390/foods13244024

    1 Insight on

    • Improved Gastrointestinal Tolerance

    • Low evidence
• December 13

  • Microbiome Differences in Colorectal Cancer Patients and Healthy Individuals: Implications for Vaccine Antigen Discovery.

    • 2024-12-13
    • Review
    • ImmunoTargets and therapy 13
    • • Gordon C Ibeanu
      • Adekunle B Rowaiye
      • Joy C Okoli
      • Daniel U Eze

    • PubMed: 39698218
    • DOI: 10.2147/itt.s486731

    1 Insight on

    • Identified Colorectal Cancer Vaccine Antigen Candidates

    • Low evidence

  • Hotspots and development trends of gut microbiota in atopic dermatitis: A bibliometric analysis from 1988 to 2024.

    • 2024-12-13
    • Review
    • Medicine 103(50)
    • • Fang Liu
      • Haipeng Zhang
      • Lina Fan
      • Qi Yu
      • Siqiao Wang

    • PubMed: 39686442
    • DOI: 10.1097/md.0000000000040931

    3 Insights on

    • Improved Gut Microbiota
    • Improved Atopic Dermatitis Symptoms
    • Modulated Gut Microbiota

    • Low evidence
• December 15

  • The Effect of Carnosine Supplementation on Musculoskeletal Health in Adults with Prediabetes and Type 2 Diabetes: A Secondary Analysis of a Randomized Controlled Trial.

    • 2024-12-15
    • RCT · n = 49
    • Nutrients 16(24)
    • • Saeede Saadati
      • Paul Jansons
      • David Scott
      • Maximilian de Courten
      • Aya Mousa
      • Jack Feehan
      • Jakub Mesinovic
      • Barbora de Courten

    • PubMed: 39770949
    • DOI: 10.3390/nu16244328

    10 Insights on

    • Reduced Visceral Fat
    • Reduced Body Fat Percentage
    • Increased Bone Mineral Density
    • Increased Appendicular Lean Mass
    • Improved Hand Grip Strength
    • Improved Upper Limb Relative Strength
    • Increased Cortical Volumetric Bone Mineral Density
    • Increased Proximal Tibial Cortical Volumetric Bone Mineral Density
    • Improved Strain Index
    • Improved Stress-Strain Index

    • High evidence
    • Rigorous Journal

  • Therapeutic Potential of a Natural Blend of Aronia melancarpa, Lonicera caerulea, and Echinacea purpurea Extracts in Treating Upper Respiratory Tract Infections: Preliminary Clinical and In Vitro Immunomodulatory Insights.

    • 2024-12-15
    • RCT · n = 61
    • International journal of molecular sciences 25(24)
    • • Katarzyna Zima
      • Marta Sochocka
      • Michał Ochnik
      • Barbara Khaidakov
      • Krzysztof Lemke
      • Paulina Kowalczyk

    • PubMed: 39769201
    • DOI: 10.3390/ijms252413436

    2 Insights on

    • Reduced Incidence of Upper Respiratory Tract Infections
    • Reduced Throat Symptom

    • High evidence
    • Rigorous Journal
• December 16

  • Probiotics as an adjunctive therapy in periodontitis treatment-reality or illusion-a clinical perspective.

    • 2024-12-16
    • Review
    • NPJ biofilms and microbiomes 10(1)
    • • Lamyae Baddouri
      • Matthias Hannig

    • PubMed: 39681550
    • DOI: 10.1038/s41522-024-00614-5

    1 Insight on

    • Improved Periodontal Health

    • Low evidence
• December 17

  • Salidroside: An Overview of Its Promising Potential and Diverse Applications.

    • 2024-12-17
    • Review
    • Pharmaceuticals (Basel, Switzerland) 17(12)
    • • Keke Liang
      • Shuhe Ma
      • Kai Luo
      • Renjie Wang
      • Chenrong Xiao
      • Xianxie Zhang
      • Yue Gao
      • Maoxing Li

    • PubMed: 39770545
    • DOI: 10.3390/ph17121703

    3 Insights on

    • Reduced Inflammation
    • Reduced Fatigue
    • Improved Hypoxia Resistance

    • Low evidence

  • The mortality of Bombyx mori larvae challenged by BmNPV is reduced when supplemented with Lactobacillus acidophilus bacteria.

    • 2024-12-17
    • Clinical Trial
    • BMC research notes 17(1)
    • • Siripuk Suraporn
      • Vallaya Suthikhum
      • Olle Terenius

    • PubMed: 39690411
    • DOI: 10.1186/s13104-024-07019-9

    3 Insights on

    • Improved Survival
    • Improved Growth and Economic Traits
    • Improved Growth and Economic Silk Production Measures

    • Low evidence
    • Animal Study
• December 18

  • Effect of Dietary Supplementation with Lutein, Zeaxanthin, and Elderberries on Dry Eye Disease (DED) and Immunity: A Randomized Controlled Trial.

    • 2024-12-18
    • RCT
    • Nutrients 16(24)
    • • Kok Ming Goh
      • Eugenie Sin Sing Tan
      • Crystale Siew Ying Lim
      • Pui Yee Tan
      • Sayantan Biswas
      • Li Ann Lew
      • Chung Keat Tan

    • PubMed: 39770987
    • DOI: 10.3390/nu16244366

    2 Insights on

    • Reduced Dry Eye Symptom
    • Improved Visual Comfort

    • High evidence
    • Rigorous Journal
• December 20

  • Changes in Human Colonic Microbiota Promoted by Synbiotic Açai Juice Composed of Gluco-Oligosaccharides, Dextran, and Bifidobacterium breve NRRL B-41408.

    • 2024-12-20
    • Foods (Basel, Switzerland) 13(24)
    • • Bianca Mara Reges
      • Francisca Andréa da Silva Oliveira
      • Thatyane Vidal Fonteles
      • Sueli Rodrigues

    • PubMed: 39767062
    • DOI: 10.3390/foods13244121

    3 Insights on

    • Improved Gut Microbiota Diversity
    • Increased Short-Chain Fatty Acid Production
    • Increased Propionic Acid Production

    • Low evidence
• December 22

  • Clinical Trials Conducted on Herbal Remedies for the Treatment of Melasma: A Scoping Review.

    • 2024-12-22
    • Systematic Review · n = 21
    • Journal of cosmetic dermatology 24(2)
    • • Mohammad Mahdi Parvizi
      • Maryam Hekmat
      • Nahid Yousefi
      • Rojan Javaheri
      • Arman Mehrzadeh
      • Nasrin Saki

    • PubMed: 39710951
    • DOI: 10.1111/jocd.16741

    1 Insight on

    • Reduced Melasma Severity

    • High evidence
• December 24

  • Health-Promoting and Functional Properties of Fermented Milk Beverages with Probiotic Bacteria in the Prevention of Civilization Diseases.

    • 2024-12-24
    • Review
    • Nutrients 17(1)
    • • Milena Alicja Stachelska
      • Piotr Karpiński
      • Bartosz Kruszewski

    • PubMed: 39796443
    • DOI: 10.3390/nu17010009

    7 Insights on

    • Improved Immune Function
    • Reduced Obesity
    • Reduced Constipation
    • Reduced Lactose Intolerance Symptoms
    • Reduced Cancer Risk
    • Reduced Diabetes Incidence
    • Reduced Intestinal Pathogens

    • Moderate evidence
    • Rigorous Journal
• December 25

  • Akkermansia muciniphila: A Potential Target for the Prevention of Diabetes.

    • 2024-12-25
    • Review
    • Foods (Basel, Switzerland) 14(1)
    • • Kairu He
      • Feiyu An
      • Henan Zhang
      • Danli Yan
      • Tong Li
      • Junrui Wu
      • Rina Wu

    • PubMed: 39796314
    • DOI: 10.3390/foods14010023

    1 Insight on

    • Improved Glycemia

    • Low evidence
• December 26

  • Effects of Different Dietary Supplements on Swimming Performance: A Systematic Review and Network Meta-Analysis.

    • 2024-12-26
    • Systematic Review
    • Nutrients 17(1)
    • • Dongxiang Huang
      • Xiaobing Wang
      • Hideki Takagi
      • Shiwei Mo
      • Zhongzheng Wang
      • Daniel Hung-Kay Chow
      • Bo Huang

    • PubMed: 39796467
    • DOI: 10.3390/nu17010033

    4 Insights on

    • Reduced Heart Rate
    • Reduced Body Mass
    • Reduced Blood Lactate Level
    • Reduced Swimming Time

    • High evidence
    • Rigorous Journal

  • Efficacy of Bacillus clausii UBBC-07 and Bacillus coagulans Unique IS-2 in Mitigating Pulmonary Parameters in Patients With Moderate COVID-19 Symptoms.

    • 2024-12-26
    • RCT · n = 56
    • Cureus 16(12)
    • • Mehdi Ali Mirza
      • Rajiv Kumar Bandaru
      • Ushasree T

    • PubMed: 39866999
    • DOI: 10.7759/cureus.76436

    5 Insights on

    • Reduced Interleukin-6 Levels
    • Reduced C-Reactive Protein Levels
    • Reduced Lactate Dehydrogenase Level
    • Reduced Ferritin Level
    • Reduced D-Dimer Level

    • High evidence
• December 27

  • Health benefits, antimicrobial activities, and potential applications of probiotics: A review.

    • 2024-12-27
    • Review
    • Medicine 103(52)
    • • Amin Sepehr
      • Seyedeh Tina Miri
      • Shadi Aghamohammad
      • Nazanin Rahimirad
      • Mahnaz Milani
      • Mohammad-Reza Pourshafie
      • Mahdi Rohani

    • PubMed: 39969286
    • DOI: 10.1097/md.0000000000032412

    4 Insights on

    • Improved Gut Microbiota Balance
    • Modulated Immune Response
    • Reduced Risk of Chronic Inflammatory Diseases
    • Reduced Risk of Infection

    • Low evidence

  • Effect of Long-Term Taurine Supplementation on the Lipid and Glycaemic Profile in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis.

    • 2024-12-27
    • Meta-Analysis
    • Nutrients 17(1)
    • • Qin Sun
      • Jieping Wang
      • Huanyu Wang
      • Hanhan Yu
      • Kang Wan
      • Fuyi Ma
      • Ru Wang

    • PubMed: 39796489
    • DOI: 10.3390/nu17010055

    7 Insights on

    • Improved Insulin Sensitivity
    • Reduced Body Mass Index
    • Reduced Triglyceride Levels
    • Reduced Insulin Levels
    • Reduced Hemoglobin A1c
    • Reduced Fasting Blood Glucose Levels
    • Reduced Total Cholesterol

    • High evidence
    • Rigorous Journal
• December 28

  • Effects of specific symbiotic supplements on anthropometric measurements, glycaemic control, and lipid profiles among individuals with type 2 diabetes mellitus in two teaching hospitals in Baghdad/Iraq: a double-blinded, randomised placebo-controlled trial.

    • 2024-12-28
    • RCT
    • BMC nutrition 10(1)
    • • Sarah Hayder Ali Zalzala
      • Ban Abdul-Ridha Salman Al-Hashimi
      • Zahraa Hayder Ali Zalzala
      • Khalid Saeed Fahad

    • PubMed: 39732694
    • DOI: 10.1186/s40795-024-00976-1

    7 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Blood HbA1c Levels
    • Improved Body Mass Index
    • Reduced Fasting Blood Glucose Levels
    • Improved Fasting Glucose Levels
    • Increased High-Density Lipoprotein Cholesterol

    • High evidence
• December 30

  • The Impact of Lactobacillus reuteri on Oral and Systemic Health: A Comprehensive Review of Recent Research.

    • 2024-12-30
    • Review
    • Microorganisms 13(1)
    • • Zihui Liu
      • Qing Cao
      • Wenqing Wang
      • Bowen Wang
      • Yilun Yang
      • Cory J Xian
      • Tiejun Li
      • Yuankun Zhai

    • PubMed: 39858814
    • DOI: 10.3390/microorganisms13010045

    2 Insights on

    • Improved Oral Health
    • Improved Systemic Health

    • Low evidence

  • Rice Bran Consumption Improves Lipid Profiles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    • 2024-12-30
    • Meta-Analysis · n = 572
    • Nutrients 17(1)
    • • Soo-Yeon Park
      • Yehyeon Kim
      • Min Ju Park
      • Ji Yeon Kim

    • PubMed: 39796546
    • DOI: 10.3390/nu17010114

    3 Insights on

    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol
    • Reduced Total Cholesterol

    • High evidence
    • Rigorous Journal
• December 31

  • Exploring Gut Microbiota Imbalance in Irritable Bowel Syndrome: Potential Therapeutic Effects of Probiotics and Their Metabolites.

    • 2024-12-31
    • Review
    • Nutrients 17(1)
    • • María José García Mansilla
      • María Jesús Rodríguez Sojo
      • Andrea Roxana Lista
      • Ciskey Vanessa Ayala Mosqueda
      • Antonio Jesús Ruiz Malagón
      • Julio Gálvez
      • Alba Rodríguez Nogales
      • María José Rodríguez Sánchez

    • PubMed: 39796588
    • DOI: 10.3390/nu17010155

    2 Insights on

    • Improved Irritable Bowel Syndrome Symptoms
    • Reduced Irritable Bowel Syndrome Symptoms

    • Moderate evidence
    • Rigorous Journal

  • Engineered Bacillus subtilis as Oral Probiotics To Enhance Clearance of Blood Lactate.

    • 2024-12-31
    • ACS synthetic biology 14(1)
    • • Mengdi Yang
      • Noah Hutchinson
      • Ningyuan Ye
      • Hania Timek
      • Maria Jennings
      • Jianing Yin
      • Ming Guan
      • Zongqi Wang
      • Peiru Chen
      • Shaobo Yang
      • Justin D Crane
      • Ke Zhang
      • Xuesong He
      • Jiahe Li

    • PubMed: 39739838
    • DOI: 10.1021/acssynbio.4c00399

    1 Insight on

    • Reduced Lactate Levels

    • Low evidence
    • Animal Study

  • Dileucine ingestion, but not leucine, increases lower body strength and performance following resistance training: A double-blind, randomized, placebo-controlled trial.

    • 2024-12-31
    • RCT
    • PloS one 19(12)
    • • Anthony M Hagele
      • Joesi M Krieger
      • Connor J Gaige
      • Kevin F Holley
      • Kristen N Gross
      • Joshua M Iannotti
      • Leah E Allen
      • Paige J Sutton
      • Logan S Orr
      • Petey W Mumford
      • Martin Purpura
      • Ralf Jager
      • Chad M Kerksick

    • PubMed: 39739679
    • DOI: 10.1371/journal.pone.0312997

    9 Insights on

    • Improved Body Composition
    • Increased Lower-Body Strength
    • Improved Anaerobic Capacity
    • Increased Lower Body Muscular Endurance
    • Increased Upper Body Strength
    • Increased Upper Body Muscular Endurance
    • Improved Countermovement Jump Height
    • Increased Maximal Voluntary Contraction
    • Improved Countermovement Jump

    • High evidence
• Undated – 14 supplement studies

  • Exploring the relationship between Faecalibacterium duncaniae and Escherichia coli in inflammatory bowel disease (IBD): Insights and implications.

    • 2024-12
    • Review
    • Computational and structural biotechnology journal 23
    • • Alejandro Cabezas-Cruz
      • Luis G Bermúdez-Humarán

    • PubMed: 38094217
    • DOI: 10.1016/j.csbj.2023.11.027

    1 Insight on

    • Modulated Gut Microbiota

    • Low evidence

  • Extensive genomic characterization, pre-clinical probiotic evaluation, and safety analysis of Bifidobacterium longum subsp. longum BL21 isolated from infant feces.

    • 2024-12
    • Microbial pathogenesis 197
    • • Yao Dong
      • Yinan Zhang
      • Fei Xu
      • Kang Zou

    • PubMed: 39505088
    • DOI: 10.1016/j.micpath.2024.107100

    2 Insights on

    • Reduced Toxicity
    • Enhanced Gastrointestinal Stress Resistance

    • Low evidence

  • "Protective effects of artichoke extract and Bifidobacterium longum on male infertility in diabetic rats".

    • 2024-12
    • RCT
    • Biochemistry and biophysics reports 40
    • • Zahra Ansari
      • Mohammad Hasan Maleki
      • Fatemeh Roohy
      • Zahra Ebrahimi
      • Mesbah Shams
      • Pooneh Mokaram
      • Zahra Zamanzadeh
      • Zahra Hosseinzadeh
      • Farhad Koohpeyma
      • Sanaz Dastghaib

    • PubMed: 39386078
    • DOI: 10.1016/j.bbrep.2024.101834

    1 Insight on

    • Improved Fertility

    • High evidence

  • Vitis Vinifera Seed Extract Versus Micronized Purified Flavonoid Fraction for Patients with Chronic Venous Disease: A Randomized Noninferiority Trial.

    • 2024-12
    • RCT · n = 303
    • Annals of vascular surgery 109
    • • Suh Min Kim
      • Jin Hyun Joh
      • In Mok Jung
      • Mi Jin Kim
      • Sang Su Lee
      • Hong Pil Hwang
      • Jin Mo Kang
      • Hyuk Jae Jung
      • Shin-Seok Yang
      • Seung-Kee Min
      • Young Sun Yoo
      • Jun Gyo Gwon
      • Hyung Sub Park
      • Taeseung Lee

    • PubMed: 39009117
    • DOI: 10.1016/j.avsg.2024.06.011

    4 Insights on

    • Improved Quality of Life
    • Reduced Pain
    • Reduced Venous Clinical Severity Score
    • Reduced Leg Circumference

    • High evidence
    • Large Human Trial

  • Feasibility of Fish Oil Supplementation on Headache Symptoms and Blood Lipids in Migraine Patients.

    • 2024-12
    • RCT · n = 47
    • Brain and behavior 14(12)
    • • En-Ling Yeh
      • Chun-Pai Yang
      • Shu-Wen Lin
      • Hsueh-Fang Wang

    • PubMed: 39643480
    • DOI: 10.1002/brb3.70149

    6 Insights on

    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol
    • Reduced Total Cholesterol
    • Reduced Headache Duration
    • Reduced Headache Frequency
    • Reduced Headache Pain Intensity

    • High evidence

  • Synbiotic combination of 2'-fucosyllactose and Bifidobacterium mitigates neurodevelopmental disorders and ASD-like behaviors induced by valproic acid.

    • 2025
    • Food & function 16(7)
    • • Ying He
      • Bo Zhang
      • Yu Xin
      • Wenxiu Wang
      • Xue Wang
      • Zhuo Liu
      • Yongbo She
      • Rui Guo
      • Gengjie Jia
      • Shan Wu
      • Zhigang Liu

    • PubMed: 40165714
    • DOI: 10.1039/d4fo06234e

    6 Insights on

    • Reduced Neuroinflammation
    • Increased Short-Chain Fatty Acid Production
    • Improved Gut Integrity
    • Improved Behavioral Health
    • Reduced Gut Inflammation
    • Reduced Repetitive Behaviors

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Substituting animal protein with black soymilk reduces advanced glycation end product level and improves gut microbiota composition in obese prediabetic individuals: a randomized crossover intervention trial.

    • 2025
    • RCT
    • Food & function 16(1)
    • • Yu-Ho Chang
      • Pei-Ni Lee
      • Cheng-Hsu Chen
      • Hsin-Yi Yang
      • Chi-Hao Wu
      • Jia-Yau Doong
      • Wan-Ju Yeh

    • PubMed: 39651546
    • DOI: 10.1039/d4fo04717f

    5 Insights on

    • Improved Gut Microbiota
    • Reduced Oxidative Stress
    • Reduced Dietary Advanced Glycation End Product Intake
    • Reduced Advanced Glycation End Product Level
    • Reduced Glycative Stress Marker Level

    • High evidence
    • Rigorous Journal

  • Astaxanthin supplement improves clinical outcomes, quality of life, and inflammatory factors in patients with rheumatoid arthritis: a randomized clinical trial.

    • 2025
    • RCT · n = 60
    • Food & function 16(14)
    • • Ani Grigorian
      • Ali Tabatabaeyan
      • Mansour Salesi
      • Awat Feizi
      • Ali-Reza Ahmadi
      • Marzieh Kafeshani

    • PubMed: 40569081
    • DOI: 10.1039/d5fo00949a

    1 Insight on

    • Improved Quality of Life

    • High evidence
    • Rigorous Journal

  • Comparative efficacy and tolerability of nutraceuticals for depressive disorder: A systematic review and network meta-analysis.

    • 2025
    • Systematic Review · n = 437
    • Psychological medicine 55
    • • Ying-Chih Cheng
      • Wei-Lieh Huang
      • Wen-Yin Chen
      • Yu-Chen Huang
      • Po-Hsiu Kuo
      • Yu-Kang Tu

    • PubMed: 40314175
    • DOI: 10.1017/s0033291725000996

    3 Insights on

    • Improved Depressive Symptoms
    • Improved Remission
    • Improved Response

    • High evidence

  • A pilot and feasibility analysis of serum TMAO and choline in a randomized sample from the COSMOS trial.

    • 2025
    • RCT · n = 40
    • Food & function 16(22)
    • • Irene Sánchez Gavilán
      • Sidong Li
      • Michael G Sweet
      • Juanita G Ratliff
      • Pamela M Rist
      • Eunjung Kim
      • JoAnn E Manson
      • Howard D Sesso
      • Andrew P Neilson

    • PubMed: 41127993
    • DOI: 10.1039/d5fo02596f

    2 Insights on

    • Reduced TMAO Level
    • Increased Choline Level

    • High evidence
    • Rigorous Journal

  • Meta-analysis of the efficacy and safety of L-carnitine and N-acetylcysteine monotherapy for male idiopathic infertility.

    • 2025
    • Meta-Analysis
    • Revista internacional de andrologia 23(1)
    • • Xiaohong Ma
      • Yingying Yang
      • Shiguo Liu
      • Yuanshan Cui
      • Jitao Wu

    • PubMed: 40350672
    • DOI: 10.22514/j.androl.2025.004

    6 Insights on

    • Increased Sperm Motility
    • Increased Sperm Concentration
    • Increased Normal Sperm Morphology
    • Increased Serum Testosterone Level
    • Increased Ejaculation Volume
    • Increased Other Serum Hormone Level

    • High evidence

  • Cocoa flavanols alleviate early diastolic dysfunction by decreasing left atrial volume in a randomized double blinded trial in healthy older individuals.

    • 2025
    • RCT
    • Food & function 16(22)
    • • Dragos Andrei Duse
      • Michael Gröne
      • Niklas Ophoff
      • Nicolas Kramser
      • Hendrik Schweers
      • Javier Ottaviani
      • Hagen Schroeter
      • Christine Quast
      • Florian Bönner
      • Christian Heiss
      • Roberto Sansone
      • Christian Jung
      • Malte Kelm
      • Ralf Erkens

    • PubMed: 41143317
    • DOI: 10.1039/d5fo02589c

    6 Insights on

    • Reduced Systolic Blood Pressure
    • Reduced Left Atrial Maximal Volume
    • Reduced Left Ventricular End-Diastolic Volume
    • Improved Myocardial Strain
    • Improved Myocardial Strain Rate
    • Improved Systolic Function

    • High evidence
    • Rigorous Journal

  • Efficacy of vitamin E from dietary, circulation system, and supplementation on chronic obstructive pulmonary disease (COPD): a systematic review and meta-analysis.

    • 2025
    • Meta-Analysis · n = 425
    • Food & function 16(22)
    • • Peixuan Tian
      • Hui Xia
      • Bihuan Hu
      • Yu Yang
      • Da Pan
      • Wang Liao
      • Shaokang Wang
      • Guiju Sun
      • Jing Sui

    • PubMed: 41099347
    • DOI: 10.1039/d5fo03814f

    2 Insights on

    • Reduced Chronic Obstructive Pulmonary Disease Onset Risk
    • Reduced Mortality from COPD

    • High evidence
    • Rigorous Journal

  • Effectiveness of ginger supplementation in alleviating hyperemesis gravidarum: a systematic review and meta-analysis.

    • 2025
    • Review
    • American journal of translational research 17(3)
    • • Pei Gao
      • Beibei Chen
      • Luyao Wang

    • PubMed: 40226035
    • DOI: 10.62347/txkv6669

    1 Insight on

    • Reduced Nausea and Vomiting

    • Low evidence