January 2023 Supplement Research Papers

• January 1

  • Alterations in ileal transcriptomics during an intestinal barrier challenge in lactating Holstein cows fed a Saccharomyces cerevisiae fermentation product identify potential regulatory processes.

    • 2023-01-01
    • Clinical Trial · n = 5
    • Journal of animal science 101
    • • Qianming Jiang
      • Valentino Palombo
      • Danielle N Sherlock
      • Mario Vailati-Riboni
      • Mariasilvia D'Andrea
      • Ilkyu Yoon
      • Juan J Loor

    • PubMed: 37616596
    • DOI: 10.1093/jas/skad277

    4 Insights on

    • Reduced Proinflammatory Signaling
    • Reduced Intestinal Inflammation
    • Impaired Intestinal Barrier Function
    • Enhanced Antioxidant Metabolism

    • Low evidence
    • Animal Study

  • Assessment of a 50:50 Mixture of Two Bacillus subtilis Strains as Growth Promoters for Finishing Pigs: Productivity Improvement and Noxious Gas Reduction.

    • 2023-01-01
    • RCT
    • Journal of Animal Science 101
    • • Junho Song
      • Sook-Jung Jeong
      • Chai Bin Lim
      • Bongseok Kang
      • Sang Sik Oh
      • Gilly Yun
      • I. Kim
      • Yangrae Cho

    • PubMed: 37975179
    • DOI: 10.1093/jas/skad374

    3 Insights on

    • Increased Body Weight
    • Reduced Liver Toxicity
    • Reduced Noxious Gases in Fecal Matter

    • High evidence
• January 3

  • A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis.

    • 2023-01-03
    • Proceedings of the National Academy of Sciences of the United States of America 120(2)
    • • Yuqing Wang
      • Duolong Zhu
      • Laura C Ortiz-Velez
      • Jacob L Perry
      • Michael W Pennington
      • Joseph M Hyser
      • Robert A Britton
      • Christine Beeton

    • PubMed: 36595694
    • DOI: 10.1073/pnas.2211977120

    2 Insights on

    • Reduced Inflammation
    • Reduced T-Effector Memory Cell Activity

    • Low evidence

  • Biochemical and Genomic Characterization of Two New Strains of Lacticaseibacillus paracasei Isolated from the Traditional Corn-Based Beverage of South Africa, Mahewu, and Their Comparison with Strains Isolated from Kefir Grains

    • 2023-01-03
    • Foods 12(1)
    • • K. Moiseenko
      • A. V. Begunova
      • O. Savinova
      • O. Glazunova
      • I. V. Rozhkova
      • T. Fedorova

    • PubMed: 36613437
    • DOI: 10.3390/foods12010223

    4 Insights on

    • Increased Production of Bioactive Peptides with Angiotensin Converting Enzyme Inhibitory Activity
    • Increased Antioxidant Activity
    • Increased Antibacterial Activity
    • Reduced Angiotensin I-Converting Enzyme Activity

    • Low evidence
• January 4

  • When the microbiome helps the brain-current evidence.

    • 2023-01-04
    • Review
    • CNS neuroscience & therapeutics 29(S1)
    • • Jovana Drljača
      • Nataša Milošević
      • Maja Milanović
      • Ludovico Abenavoli
      • Nataša Milić

    • PubMed: 36601680
    • DOI: 10.1111/cns.14076

    1 Insight on

    • Improved Mental Health

    • Low evidence

  • Bifidobacterium longum subsp. infantis FJSYZ1M3 ameliorates DSS-induced colitis by maintaining the intestinal barrier, regulating inflammatory cytokines, and modifying gut microbiota.

    • 2023-01-04
    • Clinical Trial
    • Food & Function 14(1)
    • • Mingjie Li
      • Jiuhong Ding
      • C. Stanton
      • R. Ross
      • Jianxin Zhao
      • Bo Yang
      • Wei Chen

    • PubMed: 36511157
    • DOI: 10.1039/d2fo03263e

    11 Insights on

    • Improved Gut Microbiota
    • Improved Intestinal Barrier Function
    • Reduced Disease Activity
    • Enhanced Tight Junction Integrity
    • Reduced Tissue Damage from Colitis
    • Reduced Inflammation Levels
    • Reduced Disease Activity Index (DAI) Levels
    • Reduced Disease Activity in Colitis
    • Regulated Inflammatory Cytokines
    • Restored Mucus Layer Integrity
    • Reduced Epithelial Cell Apoptosis

    • Low evidence
    • Animal Study
• January 5

  • Fermented Supernatants of Lactobacillus plantarum GKM3 and Bifidobacterium lactis GKK2 Protect against Protein Glycation and Inhibit Glycated Protein Ligation.

    • 2023-01-05
    • Nutrients 15(2)
    • • Shih-Wei Lin
      • Chi-Hao Wu
      • Ya-Chien Jao
      • You-Shan Tsai
      • Yen-Lien Chen
      • Chin-Chu Chen
      • Tony J Fang
      • Chi-Fai Chau

    • PubMed: 36678147
    • DOI: 10.3390/nu15020277

    1 Insight on

    • Reduced Protein Glycation

    • Low evidence
    • Rigorous Journal

  • Assessing the Safety and Probiotic Characteristics of Lacticaseibacillus rhamnosus X253 via Complete Genome and Phenotype Analysis

    • 2023-01-05
    • Microorganisms 11(1)
    • • Lei Zhao
      • Yinan Zhang
      • Yang Liu
      • J. Zhong
      • Dong-Hua Zhang

    • PubMed: 36677432
    • DOI: 10.3390/microorganisms11010140

    4 Insights on

    • Improved Adherence Ability
    • Improved Antioxidant Levels
    • Enhanced Bile Salt Resistance
    • Unchanged Lactose Utilization

    • Low evidence

  • Lacticaseibacillus rhamnosus Hao9 exerts antidiabetic effects by regulating gut microbiome, glucagon metabolism, and insulin levels in type 2 diabetic mice

    • 2023-01-05
    • Clinical Trial
    • Frontiers in Nutrition 9
    • • Mei Han
      • Wenyan Liao
      • Yao Dong
      • C. Bai
      • Zhonghui Gai

    • PubMed: 36687673
    • DOI: 10.3389/fnut.2022.1081778

    6 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Pro-Inflammatory Cytokines
    • Reduced Fasting Blood Sugar Levels
    • Reduced Insulin Levels
    • Improved Gut Microbiome Composition
    • Improved Liver Antioxidant Capacity

    • Low evidence
    • Animal Study
• January 6

  • Lactobacillus acidophilus (LA) Fermenting Astragalus Polysaccharides (APS) Improves Calcium Absorption and Osteoporosis by Altering Gut Microbiota

    • 2023-01-06
    • Clinical Trial
    • Foods 12(2)
    • • Junhua Zhou
      • Jing Cheng
      • Liu Liu
      • Jianming Luo
      • Xichun Peng

    • PubMed: 36673366
    • DOI: 10.3390/foods12020275

    9 Insights on

    • Improved Calcium Absorption
    • Restored Normal Microbiota
    • Improved Bone Mass Density
    • Improved Bone Microarchitecture
    • Reduced Osteoclast Differentiation Markers
    • Increased Osteoblast Differentiation Marker
    • Restored Relative Abundance of Specific Bacteria
    • Enhanced Osteoblast Differentiation
    • Enhanced Active Metabolite Levels

    • Low evidence
    • Animal Study
• January 7

  • Herbal Medicines for Rhinosinusitis: A Systematic Review and Network Meta-analysis.

    • 2023-01-07
    • Systematic Review
    • Current allergy and asthma reports 23(2)
    • • Minh Phuoc Hoang
      • Kachorn Seresirikachorn
      • Wirach Chitsuthipakorn
      • Kornkiat Snidvongs

    • PubMed: 36609950
    • DOI: 10.1007/s11882-022-01060-z

    3 Insights on

    • Improved Health-related Quality of Life
    • Improved Symptom Score
    • Improved Symptom Control

    • High evidence
• January 9

  • Lactobacillus plantarum ZJUIDS14 alleviates non-alcoholic fatty liver disease in mice in association with modulation in the gut microbiota

    • 2023-01-09
    • Clinical Trial
    • Frontiers in Nutrition 9
    • • Feiwei Cao
      • Qinchao Ding
      • Hui Zhuge
      • Shanglei Lai
      • K-J Chang
      • Chunyan Le
      • Guorong Yang
      • T. Valencak
      • Songtao Li
      • Daxi Ren

    • PubMed: 36698477
    • DOI: 10.3389/fnut.2022.1071284

    8 Insights on

    • Improved Insulin Sensitivity
    • Improved Intestinal Barrier Function
    • Reduced Liver Damage
    • Reduced Hepatic Steatosis
    • Improved Intestinal Flora Balance
    • Increased AMPK Activation
    • Improved Mitochondrial Function
    • Reduced Ileum Inflammation

    • Low evidence
    • Animal Study

  • Lacticaseibacillus rhamnosus CA15 (DSM 33960) strain as a new driver in restoring the normal vaginal microbiota: A randomized, double-blind, placebo-controlled clinical trial

    • 2023-01-09
    • RCT · n = 60
    • Frontiers in Surgery 9
    • • A. Rapisarda
      • A. Pino
      • Raffaela Luisa Grimaldi
      • C. Caggia
      • C. Randazzo
      • A. Cianci

    • PubMed: 36700035
    • DOI: 10.3389/fsurg.2022.1075612

    7 Insights on

    • Improved Quality of Life
    • Reduced Potential Pathogenic Bacteria
    • Improved Vaginal Microbiota Balance
    • Reduced Vaginal Pathogens
    • Reduced Potential Pathogens
    • Increased Vaginal Lactobacilli
    • Improved Perceived Physical Health

    • High evidence
• January 10

  • Supplementation with Whey Protein, but Not Pea Protein, Reduces Muscle Damage Following Long-Distance Walking in Older Adults.

    • 2023-01-10
    • RCT · n = 15
    • Nutrients 15(2)
    • • Marcia Spoelder
      • Lotte Koopmans
      • Yvonne A W Hartman
      • Coen C W G Bongers
      • Merle C A Schoofs
      • Thijs M H Eijsvogels
      • Maria T E Hopman

    • PubMed: 36678213
    • DOI: 10.3390/nu15020342

    1 Insight on

    • Reduced Muscle Damage

    • High evidence
    • Rigorous Journal

  • Antiviral effects of Pediococcus acidilactici isolated from Tibetan mushroom and comparative genomic analysis

    • 2023-01-10
    • Frontiers in Microbiology 13
    • • Tianming Niu
      • Yuxin Jiang
      • Shuhui Fan
      • Guilian Yang
      • C. Shi
      • L. Ye
      • Chunfeng Wang

    • PubMed: 36704546
    • DOI: 10.3389/fmicb.2022.1069981

    2 Insights on

    • Reduced Viral Load
    • Reduced Viral Infection

    • Low evidence
• January 12

  • The probiotic and immunomodulation effects of Limosilactobacillus reuteri RGW1 isolated from calf feces

    • 2023-01-12
    • Frontiers in Cellular and Infection Microbiology 12
    • • Kailang Huang
      • Weibing Shi
      • Bin Yang
      • Jiakun Wang

    • PubMed: 36710979
    • DOI: 10.3389/fcimb.2022.1086861

    3 Insights on

    • Increased Interleukin-10 Levels
    • Improved Intestinal Function
    • Reduced TNF-α Levels

    • Low evidence
• January 13

  • In vitro and in silico assessment of probiotic and functional properties of Bacillus subtilis DE111®

    • 2023-01-13
    • Frontiers in Microbiology 13
    • • S. Mazhar
      • E. Khokhlova
      • J. Colom
      • A. Simon
      • J. Deaton
      • K. Rea

    • PubMed: 36713219
    • DOI: 10.3389/fmicb.2022.1101144

    11 Insights on

    • Improved Immune Function
    • Improved Gut Health
    • Enhanced Immune Function
    • Improved Digestive Health
    • Increased SCFA Production
    • Healthy Gut Microbiome
    • Increased Antioxidant Potential
    • Improved Gut Microbiome Health
    • Increased Antimicrobial Resistance
    • Enhanced Gut Microbiome Health
    • Enhanced Metabolic Processing of Dietary Molecules

    • Low evidence
• January 16

  • Exploring the Bioactive Mycocompounds (Fungal Compounds) of Selected Medicinal Mushrooms and Their Potentials against HPV Infection and Associated Cancer in Humans.

    • 2023-01-16
    • Review
    • Life (Basel, Switzerland) 13(1)
    • • Tomas Rokos
      • Terezia Pribulova
      • Erik Kozubik
      • Kamil Biringer
      • Veronika Holubekova
      • Erik Kudela

    • PubMed: 36676192
    • DOI: 10.3390/life13010244

    1 Insight on

    • Improved HPV Clearance

    • Low evidence
• January 17

  • Screening and Characterization of Pediococcus acidilactici LC-9-1 toward Selection as a Potential Probiotic for Poultry with Antibacterial and Antioxidative Properties

    • 2023-01-17
    • Clinical Trial
    • Antioxidants 12(2)
    • • Chong Li
      • Shaolong Wang
      • Si Chen
      • Xiaoying Wang
      • Xuejuan Deng
      • Guohua Liu
      • Wenhuan Chang
      • Y. Beckers
      • Huiyi Cai

    • PubMed: 36829774
    • DOI: 10.3390/antiox12020215

    11 Insights on

    • Improved Gut Microbiota Diversity
    • Reduced Abdominal Fat
    • Improved Growth Performance
    • Reduced Pathogen Infection
    • Improved Antioxidant Function
    • Improved Abundance of Beneficial Bacteria
    • Increased Beneficial Gut Bacteria
    • Improved Intestinal Immunity
    • Improved Intestinal Innate Immunity
    • Reduced Opportunistic Pathogens
    • Improved Community Diversity of Intestinal Microbiota

    • Low evidence
    • Animal Study
• January 18

  • Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis.

    • 2023-01-18
    • Meta-Analysis
    • Frontiers in bioscience (Landmark edition) 28(1)
    • • Kaoshik Sureshkumar
      • Mahesh Durairaj
      • Kaviya Srinivasan
      • Khang Wen Goh
      • Krishna Undela
      • Vijayakumar Thangavel Mahalingam
      • Chrismawan Ardianto
      • Long Chiau Ming
      • Rajanandh Muhasaparur Ganesan

    • PubMed: 36722274
    • DOI: 10.31083/j.fbl2801018

    5 Insights on

    • Improved Delayed Memory
    • Reduced Hemoglobin A1c
    • Reduced Fasting Blood Glucose
    • Worsened Alzheimer's Disease Assessment Scale
    • Worsened Depression Score

    • High evidence

  • Immunomodulatory and Antioxidant Properties of a Novel Potential Probiotic Bacillus clausii CSI08

    • 2023-01-18
    • Microorganisms 11(2)
    • • E. Khokhlova
      • J. Colom
      • A. Simon
      • S. Mazhar
      • Guillermo Garcia-Lainez
      • S. Llopis
      • Núria González
      • María Enrique-López
      • Beatriz Alvarez
      • P. Martorell
      • M. Tortajada
      • J. Deaton
      • K. Rea

    • PubMed: 36838205
    • DOI: 10.3390/microorganisms11020240

    5 Insights on

    • Improved Immunomodulation
    • Improved Intestinal Cell Adhesion
    • Activated Immune Response
    • Improved Cytoprotection During Oxidative Stress
    • Suppressed Pathogenic Growth

    • Low evidence
• January 19

  • Limosilactobacillus reuteri DSM 17938-Containing Infant Formulas and the Associations with Gastrointestinal Tolerance: A Cross-Sectional Observational Study

    • 2023-01-19
    • Observational · n = 1,731
    • Nutrients 15(3)
    • • L. Lavalle
      • N. Sauvageot
      • C. Cercamondi
      • I. Janković
      • D. Egli
      • Y. Vandenplas

    • PubMed: 36771237
    • DOI: 10.3390/nu15030530

    14 Insights on

    • Reduced Vomiting Frequency
    • Reduced Abdominal Pain
    • Reduced Crying Duration
    • Improved Gastrointestinal Tolerance
    • Reduced Difficulty in Defecation
    • Reduced Hard Stool Incidence
    • Reduced Physician-Confirmed Colic
    • Reduced Volume of Infant Spit-Up
    • Reduced Fussiness from Spitting-Up or Vomiting
    • Reduced Crying Time
    • Reduced Colic
    • Reduced Difficulty in Passing Stools
    • Reduced Hard Stool
    • Reduced Spit-Up Volume

    • High evidence
• January 24

  • Release of HMGB1 and Toll-like Receptors 2, 4, and 9 Signaling Are Modulated by Bifidobacterium animalis subsp. lactis BB-12 and Salmonella Typhimurium in a Gnotobiotic Piglet Model of Preterm Infants.

    • 2023-01-24
    • International journal of molecular sciences 24(3)
    • • Igor Splichal
      • Sharon M Donovan
      • Zdislava Kindlova
      • Zbynek Stranak
      • Vera Neuzil Bunesova
      • Marek Sinkora
      • Katerina Polakova
      • Barbora Valaskova
      • Alla Splichalova

    • PubMed: 36768650
    • DOI: 10.3390/ijms24032329

    3 Insights on

    • Reduced Inflammation
    • Reduced Inflammatory Response to Inflammatory Stimulus
    • Preserved Colon Goblet Cell Density

    • Low evidence
    • Rigorous Journal

  • Effects of Heat-Killed Lactobacillus plantarum L-137 Supplementation on Growth Performance, Blood Profiles, Intestinal Morphology, and Immune Gene Expression in Pigs

    • 2023-01-24
    • n = 100
    • Veterinary Sciences 10(2)
    • • W. Tartrakoon
      • Rangsun Charoensook
      • T. Incharoen
      • S. Numthuam
      • Thitima Pechrkong
      • S. Onoda
      • Gaku Shoji
      • B. Brenig

    • PubMed: 36851391
    • DOI: 10.3390/vetsci10020087

    3 Insights on

    • Improved Immune Response
    • Improved Growth Performance
    • Increased Platelet Count

    • Moderate evidence

  • Effects of Clostridium butyricum on growth performance, meat quality, and intestinal health of broilers

    • 2023-01-24
    • RCT · n = 800
    • Frontiers in Veterinary Science 10
    • • Zhen Li
      • Lingbo Long
      • X. Jin
      • Yang Li
      • Qiong Wu
      • Xingyong Chen
      • Z. Geng
      • Cheng Zhang

    • PubMed: 36761883
    • DOI: 10.3389/fvets.2023.1107798

    2 Insights on

    • Increased Serum Antioxidant Levels
    • Improved Health Markers

    • Low evidence
    • Animal Study
• January 28

  • Safety and Effects of Lactobacillus paracasei TISTR 2593 Supplementation on Improving Cholesterol Metabolism and Atherosclerosis-Related Parameters in Subjects with Hypercholesterolemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

    • 2023-01-28
    • RCT · n = 50
    • Nutrients 15(3)
    • • Jurairat Khongrum
      • P. Yingthongchai
      • K. Boonyapranai
      • Wachira Wongtanasarasin
      • Paitoon Aobchecy
      • Suriya Tateing
      • A. Prachansuwan
      • Jaruwan Sitdhipol
      • K. Niwasabutra
      • Punnathon Thaveethaptaikul
      • P. Phapugrangkul
      • Pennapa Chonpathompikunlert

    • PubMed: 36771367
    • DOI: 10.3390/nu15030661

    15 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Hepatic Oxidative Stress
    • Reduced Inflammatory Response
    • Reduced Inflammation Levels
    • Reduced Serum Cholesterol Levels
    • Increased Adiponectin Levels
    • Reduced Serum Malondialdehyde Levels
    • Increased Apolipoprotein E Levels
    • Reduced Low-Density Lipoprotein Cholesterol
    • No Change in Serum Triglycerides
    • No Improvement in Total Cholesterol
    • No Change in HDL Cholesterol
    • Unchanged Total Bile Acids Levels
    • Unchanged Monocyte Chemoattractant Protein-1 Levels

    • High evidence
• January 30

  • Antimicrobial Resistance and Recent Alternatives to Antibiotics for the Control of Bacterial Pathogens with an Emphasis on Foodborne Pathogens.

    • 2023-01-30
    • Review
    • Antibiotics (Basel, Switzerland) 12(2)
    • • Yosra A Helmy
      • Khaled Taha-Abdelaziz
      • Hanan Abd El-Halim Hawwas
      • Soumya Ghosh
      • Samar Sami AlKafaas
      • Mohamed M M Moawad
      • Essa M Saied
      • Issmat I Kassem
      • Asmaa M M Mawad

    • PubMed: 36830185
    • DOI: 10.3390/antibiotics12020274

    1 Insight on

    • Improved Gastrointestinal Function

    • Low evidence
• January 31

  • The effects of pyridoxine (vitamin B6) supplementation in nausea and vomiting during pregnancy: a systematic review and meta-analysis.

    • 2023-01-31
    • Meta-Analysis
    • Archives of gynecology and obstetrics 308(4)
    • • Ranil Jayawardena
      • Shahana Majeed
      • Piumika Sooriyaarachchi
      • Udara Abeywarne
      • Probhodana Ranaweera

    • PubMed: 36719452
    • DOI: 10.1007/s00404-023-06925-w

    1 Insight on

    • Reduced Nausea and Vomiting Severity

    • High evidence

  • Evaluation of the Immunomodulatory Effects of a Probiotics and Natural Extract-Based Formulation in Bacterial-Induced Prostatitis.

    • 2023-01-31
    • Life (Basel, Switzerland) 13(2)
    • • Stefania Murzilli
      • Vincenzo Mirone
      • Marta Micheletto
      • Erik Tedesco
      • Giovanni Di Maira
      • Federico Benetti
      • Arianna Vanelli

    • PubMed: 36836748
    • DOI: 10.3390/life13020389

    1 Insight on

    • Reduced Prostate Inflammation

    • Low evidence
• Undated – 4 supplement studies

  • Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease.

    • 2023-01
    • Review
    • Clinical science (London, England : 1979) 137(1)
    • • Justine Gillard
      • Isabelle A Leclercq

    • PubMed: 36601783
    • DOI: 10.1042/cs20220697

    1 Insight on

    • Improved Gut Health

    • Low evidence

  • Decreasing the Adverse Effects in Pelvic Radiation Therapy: A Randomized Controlled Trial Evaluating the Use of Probiotics.

    • 2023-01
    • RCT
    • Advances in radiation oncology 8(1)
    • • Irini Lazou Ahrén
      • Maria Bjurberg
      • Gunnar Steineck
      • Karin Bergmark
      • Bengt Jeppsson

    • PubMed: 36483069
    • DOI: 10.1016/j.adro.2022.101089

    3 Insights on

    • Reduced Abdominal Pain
    • Reduced Gastrointestinal Toxicity
    • Reduced Days with Defecation Urgency

    • High evidence

  • Dietary Saccharomyces cerevisiae improves intestinal flora structure and barrier function of Pekin ducks.

    • 2023-01
    • RCT · n = 180
    • Poultry science 102(1)
    • • Wenwen Gao
      • Keying An
      • Peng Li
      • Lei Li
      • Zhaofei Xia

    • PubMed: 36436368
    • DOI: 10.1016/j.psj.2022.101940

    3 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Increased Ileum Length

    • Low evidence
    • Animal Study

  • Impacts of feeding a Saccharomyces cerevisiae fermentation product on productive performance, and metabolic and immunological responses during a feed-restriction challenge of mid-lactation dairy cows.

    • 2023-01
    • RCT
    • Journal of Dairy Science 106(1)
    • • T. Marins
      • F.A. Gutierrez Oviedo
      • M. Costa
      • Y.-C. Chen
      • H. Goodnight
      • M. Garrick
      • D. Hurley
      • J. Bernard
      • I. Yoon
      • S. Tao

    • PubMed: 36460513
    • DOI: 10.3168/jds.2022-22522

    3 Insights on

    • Improved Milk Fat Production
    • Improved Granulocyte Oxidative Burst
    • Increased Glucose Utilization During Feed Restriction

    • High evidence
    • Rigorous Journal