May 2025 Supplement Research Papers

• May 1

  • The effect of aromatherapy intervention with Bergamot and Grapefruit essential oils on premenstrual syndrome and menstrual symptoms: a randomized controlled trial.

    • 2025-05-01
    • RCT · n = 30
    • BMC complementary medicine and therapies 25(1)
    • • Esra Özer
      • Şerife İrem Döner
      • Hafize Dağ Tüzmen

    • PubMed: 40312670
    • DOI: 10.1186/s12906-025-04857-3

    7 Insights on

    • Reduced Pain
    • Reduced Irritability
    • Reduced Premenstrual Syndrome Scale Score
    • Reduced Depressive Affect
    • Reduced Depressive Thoughts
    • Reduced Appetite Changes
    • Reduced Menstrual Symptom Questionnaire Score

    • High evidence
• May 2

  • Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    • 2025-05-02
    • Meta-Analysis
    • Nutrition reviews 83(10)
    • • Edward R Payne
      • Magaly Aceves-Martins
      • Joy Dubost
      • Arno Greyling
      • Baukje de Roos

    • PubMed: 40314930
    • DOI: 10.1093/nutrit/nuaf054

    1 Insight on

    • Improved Choice Reaction Time

    • High evidence
• May 3

  • Gut Microbiota and Exercise: Probiotics to Modify the Composition and Roles of the Gut Microbiota in the Context of 3P Medicine.

    • 2025-05-03
    • Review
    • Microbial ecology 88(1)
    • • Yongfu Liu
      • Yuting Hu
      • Baolei Ma
      • Zijun Wang
      • Bowen Wei

    • PubMed: 40319213
    • DOI: 10.1007/s00248-025-02529-w

    2 Insights on

    • Improved Exercise Performance
    • Reduced Fatigue

    • Low evidence

  • A strain of Lactobacillus plantarum from piglet intestines enhances the anti-PoRV effect via the STING-IFN-I pathway.

    • 2025-05-03
    • BMC veterinary research 21(1)
    • • Anqi Sun
      • Xin Shan
      • Ruihan Liu
      • Zhengxu Tang
      • Jingshu Huang
      • Shihan Zhang
      • Lihong Bian
      • Yumeng Shi
      • Zixuan Liu
      • Jingtao Hu
      • Chunfeng Wang

    • PubMed: 40319282
    • DOI: 10.1186/s12917-025-04766-0

    3 Insights on

    • Improved Antiviral Immune Response
    • Reduced Rotavirus Infection Severity
    • Improved Intestinal Barrier

    • Low evidence
    • Animal Study
• May 4

  • Effects of taurine supplementation on cognitive function: a systematic review and meta-analysis of randomised controlled trials.

    • 2025-05-04
    • Meta-Analysis · n = 402
    • International journal of food sciences and nutrition 76(4)
    • • Qinglong Cao
      • Zizheng Nie
      • Yingying Liu
      • Jiaoyang Xu
      • Liangjing Chen
      • Shufen Han

    • PubMed: 40320621
    • DOI: 10.1080/09637486.2025.2499044

    2 Insights on

    • Improved Cognitive Function
    • Improved Cognitive Performance

    • High evidence
• May 5

  • Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, Placebo-Controlled Trial.

    • 2025-05-05
    • RCT
    • Molecular nutrition & food research 69(17)
    • • Reeta Ala-Jaakkola
      • Sofia D Forssten
      • Jing Cheng
      • Flavie Griffon
      • Isabelle Metreau
      • Yves Sturm
      • Jean-Michel Lecerf
      • Yves Donazzolo
      • Jouni Junnila
      • Anders Nordlund
      • Ashley Hibberd
      • Arthur C Ouwehand
      • Alvin Ibarra

    • PubMed: 40320938
    • DOI: 10.1002/mnfr.70081

    16 Insights on

    • Improved Bowel Movement Frequency
    • Reduced Straining
    • Improved Stool Consistency
    • Reduced Flatulence
    • Reduced Abdominal Pain
    • Improved Tolerability
    • Improved Safety Profile
    • Improved Functional Constipation
    • Reduced Severity of Gastrointestinal Disorders
    • Increased Frequency of Complete Spontaneous Bowel Movements
    • Adverse Events
    • Improved PAC-QoL Score
    • Improved PAC-SYM Score
    • Reduced Use of Rescue Medication
    • Increased Fecal Moisture Content
    • Reduced Fecal Calprotectin Level

    • High evidence

  • Efficacy of Olive Leaf Extract in Improving Blood Pressure in Pre-Hypertensive and Hypertensive Individuals: A Systematic Review and Meta-Analysis.

    • 2025-05-05
    • Review · n = 248
    • Phytotherapy research : PTR 39(6)
    • • Rebeca Lachovicz
      • Vera Ferro-Lebres
      • Juliana Almeida-de-Souza
      • José Alberto Pereira

    • PubMed: 40325976
    • DOI: 10.1002/ptr.8509

    2 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure

    • High evidence
• May 6

  • Administration of Bifidobacterium animalis Subsp. lactis BLa80 and Lactobacillus acidophilus LA85 Improved Hyperglycemia and Modulated Gut Microbiota in Type 2 Diabetic Mice.

    • 2025-05-06
    • Probiotics and antimicrobial proteins 18(1)
    • • Mingming Zhu
      • Lvzhu Yang
      • LuYao Li
      • Yuyuan Bai
      • Bin Zhao

    • PubMed: 40327313
    • DOI: 10.1007/s12602-025-10567-6

    5 Insights on

    • Improved Gut Microbiota Composition
    • Improved Lipid Metabolism
    • Reduced Inflammation
    • Improved Glycemia
    • Improved Tissue Pathology

    • Low evidence
    • Rigorous Journal
    • Animal Study
• May 7

  • Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics.

    • 2025-05-07
    • Review
    • Microorganisms 13(5)
    • • Valentina Origüela
      • Alvaro Lopez-Zaplana

    • PubMed: 40431257
    • DOI: 10.3390/microorganisms13051084

    7 Insights on

    • Improved Immune Function
    • Reduced Allergic Symptoms
    • Improved Atopic Dermatitis Symptoms
    • Improved Atopic Dermatitis
    • Reduced Respiratory Infections
    • Reduced Severity of Allergic Rhinitis Symptoms
    • Improved Allergic Symptoms

    • Low evidence

  • The Neurological Sequelae of Vitamin B12 Deficiency: A Systematic Review and Randomized Controlled Trial.

    • 2025-05-07
    • Review
    • Cureus 17(5)
    • • Abir Abdalaal Hamza Ali
      • Fatima H A Mohamed
      • Samir Hago
      • Israa Fathelrahman Elsadig Elgali
      • Hager Elsir Sherfeldin Mohammed
      • Rania G Mirghani

    • PubMed: 40486314
    • DOI: 10.7759/cureus.83668

    2 Insights on

    • Improved Neuropathy Symptom Score
    • Improved Neurological Symptoms

    • Low evidence
• May 8

  • Exploring the bioactive landscape: peptides and non-peptides from the human microbiota.

    • 2025-05-08
    • Review
    • NPJ biofilms and microbiomes 11(1)
    • • Abdul Bari Shah
      • Hyeonjae Cho
      • Sang Hee Shim

    • PubMed: 40341751
    • DOI: 10.1038/s41522-025-00713-x

    3 Insights on

    • Reduced Colitis Severity
    • Reduced Gastrointestinal Infections
    • Reduced Pathogen Colonization

    • Low evidence

  • Probiotics and mediterranean diet for breast cancer management and prevention?

    • 2025-05-08
    • Review
    • Cell stress 9
    • • Ehssan A Sharif-Askari
      • Khadija M Atoui
      • Ali K Mteyrek
      • Lama M Fawaz

    • PubMed: 40417456
    • DOI: 10.15698/cst2025.05.303

    2 Insights on

    • Improved Gut Microbiota Composition
    • Supportive Effect in Breast Cancer Management

    • Low evidence

  • The Effect of Probiotics on Preterm Birth Rates in Pregnant Women After a Threatened Preterm Birth Episode (The PROPEV Trial).

    • 2025-05-08
    • RCT · n = 200
    • Biomedicines 13(5)
    • • Ester Del Barco
      • Leidy-Alejandra G Molano
      • Mireia Vargas
      • Marta Miserachs
      • Linda Puerto
      • Carmen Garrido-Giménez
      • Zaida Soler
      • Begoña Muñoz
      • Laia Pratcorona
      • Sonia Rimbaut
      • Mercè Vidal
      • Marta Dalmau
      • Alba Casellas
      • Elena Carreras
      • Chaysavanh Manichanh
      • Maria Goya

    • PubMed: 40426968
    • DOI: 10.3390/biomedicines13051141

    5 Insights on

    • Reduced Preterm Births
    • Reduced Morbidity Rate
    • Reduced Preterm Birth Rate
    • Spontaneous Preterm Birth
    • Changed Vaginal Microbiota Composition

    • High evidence
• May 9

  • Next-Generation Wound Care: A Scoping Review on Probiotic, Prebiotic, Synbiotic, and Postbiotic Cutaneous Formulations.

    • 2025-05-09
    • Review
    • Pharmaceuticals (Basel, Switzerland) 18(5)
    • • Patrícia Machado
      • Felipe Neme Ribeiro
      • Fernanda Cristina Wroblevski Giublin
      • Naomi Gerzvolf Mieres
      • Fernanda Stumpf Tonin
      • Roberto Pontarolo
      • Marcel Henrique Marcondes Sari
      • Raul Edison Luna Lazo
      • Luana Mota Ferreira

    • PubMed: 40430523
    • DOI: 10.3390/ph18050704

    1 Insight on

    • Improved Wound Healing

    • Low evidence

  • Secondary Metabolites from Bacillus spp. probiotics as potential treatments for multidrug-resistant pathogens: A comprehensive review.

    • 2025-05-09
    • Review
    • Current research in microbial sciences 8
    • • George Michael Nicolas

    • PubMed: 40337641
    • DOI: 10.1016/j.crmicr.2025.100392

    2 Insights on

    • Reduced Pathogen Growth
    • Reduced Pathogen Activity

    • Low evidence

  • The dynamic linkage between covid-19 and nutrition: a review from a probiotics perspective using machine learning and bibliometric analysis.

    • 2025-05-09
    • Review
    • Frontiers in nutrition 12
    • • Christos Stefanis
      • Christina Tsigalou
      • Ioanna Bezirtzoglou
      • Gregoria Mitropoulou
      • Chrysoula Voidarou
      • Elisavet Stavropoulou

    • PubMed: 40416372
    • DOI: 10.3389/fnut.2025.1575130

    1 Insight on

    • Reduced COVID-19 Immune Support Needs

    • Low evidence
• May 12

  • Pre-sleep casein ingestion with probiotic strains improves anaerobic power and lower-body-specific strength and power performance in soccer players.

    • 2025-05-12
    • RCT
    • Journal of the International Society of Sports Nutrition 22(1)
    • • Reza Sadeghi
      • Mohammad Hemmatinafar
      • Fereshteh Eftekhari
      • Babak Imanian
      • Negar Koureshfard

    • PubMed: 40353739
    • DOI: 10.1080/15502783.2025.2505184

    5 Insights on

    • Improved Muscle Endurance
    • Improved Anaerobic Power
    • Improved Lower-Body Strength and Power
    • Improved Isokinetic Strength
    • Improved Rate of Force Development

    • High evidence

  • Can soy isoflavones in combination with soy protein change serum levels of C-reactive protein among patients with chronic inflammatory diseases? A systematic review and meta-analysis on randomized controlled trials.

    • 2025-05-12
    • Meta-Analysis
    • Journal of health, population, and nutrition 44(1)
    • • Ali Gholami
      • Bahareh Amirkalali
      • Mitra Hariri

    • PubMed: 40355968
    • DOI: 10.1186/s41043-025-00902-6

    1 Insight on

    • Reduced C-Reactive Protein Levels

    • High evidence
• May 13

  • Tribulus terrestris for management of patients with erectile dysfunction: a systematic review and meta-analysis of randomized trials.

    • 2025-05-13
    • Meta-Analysis
    • International journal of impotence research 38(1)
    • • Sally Suharyani
      • Bella Amanda
      • Jesselyn Angellee
      • William William
      • Timotius Ivan Hariyanto
      • Reny I'tishom

    • PubMed: 40360723
    • DOI: 10.1038/s41443-025-01086-7

    3 Insights on

    • Improved Erectile Function
    • No Change in Total Testosterone Level
    • Unchanged Adverse Event Incidence

    • High evidence
• May 15

  • Probiotic Lactobacillus Species Modulate Immune Responses During Vaginal Epithelial Cell Colonization.

    • 2025-05-15
    • The Journal of infectious diseases 232(3)
    • • Marisa Valentine
      • Diletta Rosati
      • Axel Dietschmann
      • Tim B Schille
      • Mihai G Netea
      • Bernhard Hube
      • Mark S Gresnigt

    • PubMed: 40372982
    • DOI: 10.1093/infdis/jiaf221

    3 Insights on

    • Increased Pro-inflammatory Cytokine Production
    • Reduced Vaginal Epithelial Cell Damage
    • Altered Neutrophil Fungicidal Function

    • Low evidence
• May 16

  • Effect of Magnesium Supplements on Improving Glucose Control, Blood Pressure and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A systematic review and meta-analysis.

    • 2025-05-16
    • Meta-Analysis · n = 345
    • Sultan Qaboos University medical journal 25(1)
    • • Nasiba Al Maqrashi
      • Salim Al Busaidi
      • Sara Al-Rasbi
      • Abdullah M Al Alawi
      • Juhaina S Al-Maqbali

    • PubMed: 40641714
    • DOI: 10.18295/2075-0528.2848

    3 Insights on

    • Reduced Diastolic Blood Pressure
    • Improved Blood Lipid Profile
    • Reduced Fasting Blood Glucose

    • High evidence

  • Wild Hops in Breadmaking Among Bulgarians: From History to Modern Perspectives and Future Potentials.

    • 2025-05-16
    • Review
    • Foods (Basel, Switzerland) 14(10)
    • • Anely Nedelcheva
      • Dauro Mattia Zocchi
      • Naji Sulaiman
      • Renata Sõukand
      • Andrea Pieroni
      • Antonella Pasqualone

    • PubMed: 40428547
    • DOI: 10.3390/foods14101767

    1 Insight on

    • Improved Antimicrobial Production

    • Low evidence
• May 17

  • Evidence-Based Human Clinical Trials on Antidiabetic Herbal Remedies Commonly Used in the Middle East.

    • 2025-05-17
    • Review
    • Sultan Qaboos University medical journal 25(1)
    • • Shihab Al-Makhmari
      • Abir Al-Aufi
      • Saleh Al-Kindi
      • Maha Alriyami
      • Hussein Sakr
      • Mohamed-Rachid Boulassel
      • Khalid M Abu Khadra
      • Rahma Al-Haddabi
      • Ammar Boudaka
      • Jumana Saleh

    • PubMed: 40641727
    • DOI: 10.18295/2075-0528.2852

    5 Insights on

    • Improved Insulin Sensitivity
    • Reduced Blood Lipid Levels
    • Improved Blood Lipid Profile
    • Reduced Blood Glucose Level
    • Regulated Carbohydrate Metabolism Enzyme Level

    • Low evidence
• May 18

  • Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial.

    • 2025-05-18
    • RCT · n = 35
    • Nutrients 17(10)
    • • Lucrezia Laterza
      • Cesare Cremon
      • Gaetano Coppola
      • Carlo Romano Settanni
      • Rossella Maresca
      • Martina Strazzeri
      • Eleonora Durini
      • Valentina Petito
      • Franco Scaldaferri
      • Giorgio Gargari
      • Diego Mora
      • Elnaz Vojoudi Yazdi
      • Chiara Marangelo
      • Gianluca Ianiro
      • Lorenza Putignani
      • Maria Raffaella Barbaro
      • Giovanni Marasco
      • Giovanni Barbara
      • Antonio Gasbarrini

    • PubMed: 40431448
    • DOI: 10.3390/nu17101708

    4 Insights on

    • Improved Bowel Movement Frequency
    • Increased Short-Chain Fatty Acid Production
    • Improved Gut Barrier Function
    • Reduced Zonulin Level

    • High evidence
    • Rigorous Journal

  • The Effect of Dietary Supplements on Male Infertility in Terms of Pregnancy, Live Birth, and Sperm Parameters: A Systematic Review and Meta-Analysis.

    • 2025-05-18
    • Meta-Analysis
    • Nutrients 17(10)
    • • Mette Peters Michaelsen
      • Michelle Poulsen
      • Anne Ahrendt Bjerregaard
      • Maria Borgstrøm
      • Lotte Kraglund Poulsen
      • Maria Bach Chortsen
      • Sahra Gatten Henriksen
      • Ulrik Schiøler Kesmodel

    • PubMed: 40431450
    • DOI: 10.3390/nu17101710

    3 Insights on

    • Improved Sperm Motility
    • Improved Sperm Concentration
    • Improved Sperm Quality

    • High evidence
    • Rigorous Journal

  • Hypoglycemic, Antioxidant Activities, and Probiotic Characteristics of Lacticaseibacillus rhamnosus LBUX2302 Isolated from Stool Samples of Neonates.

    • 2025-05-18
    • Life (Basel, Switzerland) 15(5)
    • • Pedro A Reyes-Castillo
      • Ana Laura Esquivel-Campos
      • Edgar Torres-Maravilla
      • Eduardo Zúñiga-León
      • Felipe Mendoza-Pérez
      • Rosa González-Vázquez
      • María Guadalupe Córdova-Espinoza
      • María Angélica Gutiérrez-Nava
      • Raquel González-Vázquez
      • Lino Mayorga-Reyes

    • PubMed: 40430230
    • DOI: 10.3390/life15050804

    3 Insights on

    • Increased Antioxidant Activity
    • Improved Gut Health
    • Reduced Enzyme Activity

    • Low evidence
• May 19

  • Impact of Lactiplantibacillus plantarum on the fermentation quality, nutritional enhancement, and microbial dynamics of whole plant soybean silage.

    • 2025-05-19
    • Frontiers in microbiology 16
    • • He Meng
      • Yuwen Xu
      • Lin Wang
      • Jianping Wang
      • Bing Wang
      • Huimin Wu
      • Donghui Hou
      • Sui Wang
      • Xiaohong Tong
      • Yan Jiang
      • Shaodong Wang

    • PubMed: 40458705
    • DOI: 10.3389/fmicb.2025.1565951

    2 Insights on

    • Improved Microbial Community Composition
    • Enhanced Lysine Biosynthesis

    • Low evidence

  • Randomized trial: Peppermint oil (menthol) pharmacokinetics in children and effects on gut motility in children with functional abdominal pain: 540 mg vs. 900 mg dose comparison.

    • 2025-05-19
    • RCT
    • British journal of clinical pharmacology 91(9)
    • • Robert J Shulman
      • Bruno P Chumpitazi
      • Daniel Gonzalez
      • Uttam Garg
      • Salma Musaad
      • Jiali Wen
      • Gregory L Kearns

    • PubMed: 40390282
    • DOI: 10.1002/bcp.70097

    2 Insights on

    • Reduced Colonic Contraction Frequency
    • Reduced Whole Gut Contraction Frequency

    • High evidence
• May 21

  • Unravelling the gut-brain connection: a systematic review of migraine and the gut microbiome.

    • 2025-05-21
    • Systematic Review
    • The journal of headache and pain 26(1)
    • • Caroline W Mugo
      • Ella Church
      • Richard D Horniblow
      • Susan P Mollan
      • Hannah Botfield
      • Lisa J Hill
      • Alexandra J Sinclair
      • Olivia Grech

    • PubMed: 40399789
    • DOI: 10.1186/s10194-025-02039-7

    4 Insights on

    • Reduced Painkiller Consumption
    • Reduced Migraine Severity
    • Reduced Migraine Frequency
    • Reduced Migraine Duration

    • High evidence

  • ILSI Europe perspective review: site-specific microbiota changes during pregnancy associated with biological consequences and clinical outcomes: opportunities for probiotic interventions.

    • 2025-05-21
    • Review
    • Gut microbes 17(1)
    • • Eduard Flores Ventura
      • Jonathan A Lane
      • Sondra Turjeman
      • Nikoletta Vidra
      • Gisela Adrienne Weiss
      • Gabriele Gross
      • Ching-Yu Chang
      • Omry Koren

    • PubMed: 40397816
    • DOI: 10.1080/19490976.2025.2501186

    7 Insights on

    • Reduced Constipation
    • Reduced Anxiety
    • Reduced Preterm Births
    • Improved Vaginal Microbiota Balance
    • Reduced Preterm Birth Rate
    • Improved Maternal Constipation
    • No Clear Effect on Depression

    • Low evidence
• May 22

  • The Effect of Probiotic Supplementation on Cytokine Modulation in Athletes After a Bout of Exercise: A Systematic Review and Meta-Analysis.

    • 2025-05-22
    • Systematic Review · n = 19
    • Sports medicine - open 11(1)
    • • Diego Aparicio-Pascual
      • Vicente Javier Clemente-Suárez
      • José Francisco Tornero-Aguilera
      • Alejandro Rubio-Zarapuz

    • PubMed: 40402402
    • DOI: 10.1186/s40798-025-00860-7

    2 Insights on

    • Increased Interleukin-10 Levels
    • Increased Anti-Inflammatory Cytokine IL-10

    • High evidence

  • Probiotics improve intestinal ischemia-reperfusion injury: a systematic review and meta-analysis.

    • 2025-05-22
    • Systematic Review · n = 12
    • Frontiers in medicine 12
    • • Zicen Zhao
      • Yuxuan Wu
      • Yufang Leng
      • Liya Chang
      • Yu Wang
      • Dongbin Li
      • Yang Xing

    • PubMed: 40486191
    • DOI: 10.3389/fmed.2025.1546650

    4 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Reduced Intestinal Ischemia-Reperfusion Injury

    • High evidence

  • Microbial dynamics and Pseudomonas natural product production in milk and dairy products.

    • 2025-05-22
    • Review
    • Natural product reports 42(5)
    • • Ina Wasmuth
      • Christina Warinner
      • Pierre Stallforth

    • PubMed: 40028703
    • DOI: 10.1039/d4np00074a

    2 Insights on

    • Improved Gut Microbiota Diversity
    • Improved Gastrointestinal Health

    • Low evidence
• May 23

  • A narrative review of research advances in gut microbiota and microecological agents in children with attention deficit hyperactivity disorder (ADHD).

    • 2025-05-23
    • Review
    • Frontiers in psychiatry 16
    • • Yang Liu
      • Panpan Zhang
      • Hao Sun

    • PubMed: 40485937
    • DOI: 10.3389/fpsyt.2025.1588135

    1 Insight on

    • Improved ADHD-Related Symptoms

    • Low evidence

  • Effectiveness of amino acid supplementation in preventing acute kidney injury following cardiac surgery: A systematic review and meta-analysis of randomized controlled trials.

    • 2025-05-23
    • Meta-Analysis
    • Acta anaesthesiologica Scandinavica 69(6)
    • • Mir Wajid Majeed
      • Emma Finnegan
      • Mariano Gallo Ruelas
      • Lucca Moreira Lopes
      • Bruno Branco Righetto
      • Issa Salha
      • Daniel Delgado
      • Melissa Chacón Quirós
      • Assaina Tatiana Jaquissone Tomo
      • Raheel Ahmad
      • Suhaib Andrabi
      • Samer Abujaber

    • PubMed: 40411139
    • DOI: 10.1111/aas.70037

    1 Insight on

    • Reduced Acute Kidney Injury Incidence

    • High evidence
• May 24

  • Milk sialyl-oligosaccharides mediate the early colonization of gut commensal microbes in piglets.

    • 2025-05-24
    • Microbiome 13(1)
    • • Ryoga Hashimoto
      • Keita Nishiyama
      • Fu Namai
      • Kasumi Suzuki
      • Taiga Sakuma
      • Itsuko Fukuda
      • Yuta Sugiyama
      • Kenji Okano
      • Takafumi Shanoh
      • Eita Toyoshi
      • Ryusuke Ohgi
      • Sudeb Saha
      • Sae Tsuchida
      • Eri Nishiyama
      • Takao Mukai
      • Mutsumi Furukawa
      • Tomonori Nochi
      • Julio Villena
      • Wakako Ikeda-Ohtsubo
      • Gou Yoshioka
      • Eri Nakazaki
      • Yoshihito Suda
      • Haruki Kitazawa

    • PubMed: 40413516
    • DOI: 10.1186/s40168-025-02129-3

    3 Insights on

    • Reduced Abundance of Enterobacteriaceae Species
    • Reduced Escherichia coli Growth
    • Improved Gut Microbiota Colonization

    • Low evidence
    • Rigorous Journal
    • Animal Study
• May 25

  • Antimicrobial properties and toxicity challenges of chlorine dioxide used in alternative medicine.

    • 2025-05-25
    • Scientific reports 15(1)
    • • Ruth Dudek-Wicher
      • Malwina Brożyna
      • Justyna Paleczny
      • Beata Mączyńska
      • Bartłomiej Dudek
      • Paweł Migdał
      • Arleta Dołowacka-Jóźwiak
      • Jędrzej Fischer
      • Adam Junka

    • PubMed: 40414916
    • DOI: 10.1038/s41598-025-01852-z

    1 Insight on

    • Increased Cytotoxicity and Mucosal Damage Risk

    • Low evidence
    • Rigorous Journal

  • The Impact of Flaxseed (Linum usitatissimum L.) Oil Supplementation on Human Health: A Human-Centric Evidence-Graded Approach.

    • 2025-05-25
    • Review
    • Nutrients 17(11)
    • • Ying Nie
      • Yuchen Wang
      • Ju Hui
      • Danqing Shao
      • Ran Chen
      • Qianchun Deng
      • Yashu Chen
      • Xiangyu Wang
      • Dazhou Zhu

    • PubMed: 40507062
    • DOI: 10.3390/nu17111791

    7 Insights on

    • Reduced Waist Circumference
    • Reduced Pro-Inflammatory Cytokines
    • Reduced Blood Pressure
    • Improved Blood Lipid Profile
    • Improved Mood
    • Reduced Insulin Sensitivity
    • Improved Cognition

    • Moderate evidence
    • Rigorous Journal
• May 26

  • COVID-19 clinical outcomes and N-acetylcysteine (CoViNAC study): a GRADE compliant meta-analysis of randomized controlled trials with molecular docking and dynamics simulation studies with Mpro of SARS-CoV-2.

    • 2025-05-26
    • Meta-Analysis · n = 1,125
    • Cellular and molecular biology (Noisy-le-Grand, France) 71(5)
    • • Seshadri Reddy Varikasuvu
      • Munikumar Manne
      • Subodh Kumar
      • Shiv Kumar Mudgal
      • Vikash Raj
      • Saurabh Varshney
      • Pratima Gupta
      • Ashoo Grover
      • Chanchal Goyal
      • Vanita Lal
      • Harminder Singh
      • Mona Lisa
      • Saransh Workshop Members

    • PubMed: 40418545
    • DOI: 10.14715/cmb/2025.71.5.13

    2 Insights on

    • Reduced Mortality Risk
    • Improved Recovery Rate

    • High evidence
• May 27

  • Exploring the Potential of Novel Animal-Origin Probiotics as Key Players in One Health: Opportunities and Challenges.

    • 2025-05-27
    • Review
    • International journal of molecular sciences 26(11)
    • • Zofia Gorzelanna
      • Aleksandra Mamrot
      • Daria Będkowska
      • Joanna Bubak
      • Marta Miszczak

    • PubMed: 40507953
    • DOI: 10.3390/ijms26115143

    8 Insights on

    • Improved Gastrointestinal Health
    • Improved Gut Health
    • Improved Gut Microbiota Balance
    • Improved Digestive Health
    • Reduced Inflammation
    • Improved General Health
    • Reduced Risk of Infection
    • Improved Health Outcomes

    • Moderate evidence
    • Rigorous Journal

  • Impact of Vitamin B1 and Vitamin B2 Supplementation on Anxiety, Stress, and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial.

    • 2025-05-27
    • RCT · n = 43
    • Nutrients 17(11)
    • • Yingxuan Tao
      • Murong Wu
      • Boyao Su
      • Heng Lin
      • Qianzi Li
      • Tian Zhong
      • Ying Xiao
      • Xi Yu

    • PubMed: 40507089
    • DOI: 10.3390/nu17111821

    2 Insights on

    • Improved Sleep Quality
    • Reduced Perceived Stress

    • High evidence
    • Rigorous Journal
• May 28

  • Circadian Disruption and Sleep Disorders in Astronauts: A Review of Multi-Disciplinary Interventions for Long-Duration Space Missions.

    • 2025-05-28
    • Review
    • International journal of molecular sciences 26(11)
    • • Hongjie Zong
      • Yifei Fei
      • Ningang Liu

    • PubMed: 40507991
    • DOI: 10.3390/ijms26115179

    2 Insights on

    • Improved Sleep Quality
    • Reduced Circadian Sleep Disturbance

    • Moderate evidence
    • Rigorous Journal

  • Adjunctive use of Streptococcus salivarius M18 probiotic in the treatment of periodontitis: a randomized controlled trial.

    • 2025-05-28
    • RCT · n = 55
    • 3 Biotech 15(6)
    • • Wei-Ju Chen
      • Lavanya Ajay Sharma
      • Peng Shao
      • Tia Griffith
      • Robert Love
      • Rohit Jain
      • John Hale
      • Ajay Sharma

    • PubMed: 40443548
    • DOI: 10.1007/s13205-025-04363-w

    7 Insights on

    • Improved Periodontal Health
    • Reduced Bleeding on Probing (BOP)
    • Reduced Periodontal Pathogen Burden
    • Reduced Plaque Index
    • Improved Periodontal Clinical Parameters
    • Reduced Pocket Probing Depth
    • Reduced Clinical Attachment Loss

    • High evidence

  • Effects of berry consumption on cardiometabolic risk factors in patients with metabolic syndrome: a systematic review and meta-analysis of randomised controlled trials.

    • 2025-05-28
    • Meta-Analysis · n = 50
    • International journal of food sciences and nutrition 76(5)
    • • Mohammad Amin Mohammadi
      • Ali Ebrahimi Dabagh
      • Shirin Hassanizadeh
      • Gholamreza Askari
      • Mohammad Bagherniya
      • Amirhossein Sahebkar

    • PubMed: 40436036
    • DOI: 10.1080/09637486.2025.2510358

    5 Insights on

    • Reduced Interleukin-6 Levels
    • Reduced Triglyceride Levels
    • Reduced Blood Glucose Levels
    • Reduced C-Reactive Protein Levels
    • Increased High-Density Lipoprotein Cholesterol

    • High evidence

  • Bifidobacterium animalis subsp. lactis modulates early-life immune response and gut metabolism.

    • 2025-05-28
    • Animal models and experimental medicine 8(6)
    • • Haoming Du
      • Yiran Cai
      • Lulu Shen
      • Yuxing Zheng
      • Lingling Zhao
      • Ruibiao Hu
      • Shan Jiang
      • Jiajia Yuan
      • Chengming Hu
      • Qi Deng
      • Jiaoyan Huang
      • Jingbo Hu
      • Yuexiang Wang
      • Jing Tan
      • Jiahui Chen
      • Feitong Liu
      • Yuanyuan Duan
      • Haitao Niu

    • PubMed: 40437776
    • DOI: 10.1002/ame2.70034

    2 Insights on

    • Improved Immune Organ Development
    • Increased Levels of Beneficial Metabolites

    • Low evidence
    • Animal Study

  • The Effect of Probiotics on Health in Pregnancy and Infants: A Randomized, Double-Blind, Placebo-Controlled Trial.

    • 2025-05-28
    • RCT
    • Nutrients 17(11)
    • • Sylvie Binda
      • Mélanie Chow-Shi-Yée
      • Saly El Salti
      • Noémie Auclair-Ouellet
      • Marie-Laure Oula
      • Thomas Carton
      • Sébastien Leuillet
      • Diego Tomassi
      • Robert Hemmings
      • Isaac-Jacques Kadoch

    • PubMed: 40507094
    • DOI: 10.3390/nu17111825

    7 Insights on

    • Increased Beneficial Gut Microbiota
    • Improved Gut Microbiome Composition
    • Reduced Duration of Infectious Diseases
    • Reduced Respiratory Infections in Infants
    • Increased Beneficial Gut Microbiota Abundance
    • Reduced Infection Frequency
    • Reduced Infant Infections

    • High evidence
    • Rigorous Journal

  • Folate Production by Streptococcus thermophilus IDCC 2201 and Its Impact on Human Gut Microbiota.

    • 2025-05-28
    • Journal of microbiology and biotechnology 35
    • • Eoun Ho Nam
      • Minjee Lee
      • Donggyu Kim
      • Young Hoon Jung
      • Jungwoo Yang
      • Minhye Shin

    • PubMed: 40443239
    • DOI: 10.4014/jmb.2502.02045

    2 Insights on

    • Increased Gut Microbial Growth
    • Increased Folate Production

    • Low evidence
• May 30

  • Fruit and Vegetable Juices as Functional Carriers for Probiotic Delivery: Microbiological, Nutritional, and Sensory Perspectives.

    • 2025-05-30
    • Review
    • Microorganisms 13(6)
    • • Renata Žvirdauskienė
      • Vesta Jonikė
      • Loreta Bašinskienė
      • Dalia Čižeikienė

    • PubMed: 40572160
    • DOI: 10.3390/microorganisms13061272

    3 Insights on

    • Reduced Allergic Symptoms
    • Improved Immune Modulation
    • Improved Gut Barrier Function

    • Low evidence

  • Vitamin C in Allergy Mechanisms and for Managing Allergic Diseases: A Narrative Review.

    • 2025-05-30
    • Review
    • Children (Basel, Switzerland) 12(6)
    • • Chiara Trincianti
      • Matteo Naso
      • Maria Angela Tosca
      • Giorgio Ciprandi

    • PubMed: 40564676
    • DOI: 10.3390/children12060718

    5 Insights on

    • Reduced Oxidative Stress Marker
    • Improved Lung Function
    • Decreased Airway Inflammation
    • Reduced Asthma Prevalence
    • Reduced Asthma Severity

    • Low evidence

  • Assessment of the effect of routine-dose vitamin D3 supplementation in Chinese women of childbearing age with vitamin D insufficiency.

    • 2025-05-30
    • RCT · n = 44
    • European journal of nutrition 64(5)
    • • Xiaoyun Shan
      • Wenxuan Wu
      • Jingxin Yang
      • Yang Cao
      • Yuting Li
      • Yichun Hu
      • Rui Wang
      • Lichen Yang

    • PubMed: 40445221
    • DOI: 10.1007/s00394-025-03723-9

    4 Insights on

    • Reduced Uric Acid Levels
    • Increased 25-Hydroxyvitamin D Concentration
    • Increased Bioavailable 25-Hydroxyvitamin D Level
    • Reduced Bone Turnover Marker Level

    • High evidence
    • Rigorous Journal

  • Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 Supplementation: An Exploratory, Randomized, Placebo-Controlled Trial of Endocannabinoid and Inflammatory Responses in Female Dancers.

    • 2025-05-30
    • Clinical Trial
    • Microorganisms 13(6)
    • • Jakub Wiącek
      • Karolina Skonieczna-Żydecka
      • Igor Łoniewski
      • Chariklia K Deli
      • Ioannis G Fatouros
      • Athanasios Z Jamurtas
      • Dominika Moszczyńska
      • Joanna Karolkiewicz

    • PubMed: 40572172
    • DOI: 10.3390/microorganisms13061284

    1 Insight on

    • No Significant Change in Endocannabinoid or Inflammatory Biomarkers

    • Moderate evidence
• Undated – 11 supplement studies

  • Efficacy and safety of Hibiscus sabdariffa in cardiometabolic health: An overview of reviews and updated dose-response meta-analysis.

    • 2025-05
    • Meta-Analysis · n = 1,797
    • Complementary therapies in medicine 89
    • • Mostafa Norouzzadeh
      • Minoo Hasan Rashedi
      • Mohammad Hesam Azizi
      • Farshad Teymoori
      • Zohreh Maghsoomi
      • Farzad Shidfar

    • PubMed: 39870328
    • DOI: 10.1016/j.ctim.2025.103135

    6 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Low-Density Lipoprotein Level
    • Reduced Systolic Blood Pressure
    • Increased HDL Cholesterol Levels
    • Reduced Fasting Blood Glucose Levels
    • Reduced Total Cholesterol

    • High evidence

  • Regulation of intestinal health by Lactobacillus rhamnosus GG during fasting-induced molting in laying hens.

    • 2025-05
    • RCT · n = 288
    • Poultry science 104(5)
    • • Zhixuan Luo
      • Yujie Gong
      • Qiang Li
      • Mengyan Zhang
      • Jun Zhang
      • Hao Zhang
      • Qingduo Zeng
      • Yidan Zhu
      • Yujie Guo
      • Donghua Li
      • Yadong Tian
      • Xiangtao Kang
      • Ruirui Jiang

    • PubMed: 40120246
    • DOI: 10.1016/j.psj.2025.105057

    4 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Reduced Intestinal Inflammation
    • Increased Short-Chain Fatty Acid Production

    • Low evidence
    • Animal Study

  • Nutraceuticals: using food to enhance brain health by modulating postnatal neurogenesis in animal models and patient populations.

    • 2025-05
    • Review
    • Stem cells translational medicine 14(5)
    • • Jun Ong
      • Qingqing Wu
      • Kazunori Sasaki
      • Hiroko Isoda
      • Francis G Szele

    • PubMed: 40387786
    • DOI: 10.1093/stcltm/szaf006

    2 Insights on

    • Improved Cognitive Function
    • Increased Neurogenesis

    • Low evidence

  • Bitter gourd (Momordica charantia L.) supplementation for twelve weeks improves biomarkers of glucose homeostasis in a prediabetic population.

    • 2025-05
    • RCT · n = 38
    • Journal of ethnopharmacology 347
    • • Jurriaan J Mes
      • Maartje van den Belt
      • Sandra van der Haar
      • Els Oosterink
      • Teus Luijendijk
      • Koen Manusama
      • Lotte van Dam
      • Tessa de Bie
      • Renger Witkamp
      • Diederik Esser

    • PubMed: 40199408
    • DOI: 10.1016/j.jep.2025.119756

    3 Insights on

    • Improved Insulin Sensitivity
    • Reduced Insulin Levels
    • Improved Fasting Plasma Glucose

    • High evidence

  • The key quorum sensing gene luxS in Lactobacillus acidophilus CICC 6074 and Lactobacillus helveticus R0052 mediates organic acid production and promotes protein hydrolysis in yogurt.

    • 2025-05
    • Journal of dairy science 108(5)
    • • Ruitong Zhang
      • Zihang Shi
      • Xiankang Fan
      • Tao Zhang
      • Maolin Tu
      • Zhen Wu
      • Xiaoqun Zeng
      • Weichen Bao
      • Bo Chen
      • Daodong Pan

    • PubMed: 40216233
    • DOI: 10.3168/jds.2025-26323

    1 Insight on

    • Increased Organic Acid Production

    • Low evidence
    • Rigorous Journal

  • Effects of Spirulina Supplementation on C-Reactive Protein (CRP): A Systematic Review and Dose-Response Meta-Analysis.

    • 2025-05
    • Review · n = 283
    • Food science & nutrition 13(5)
    • • Mostafa Shahraki Jazinaki
      • Mohammad Rashidmayvan
      • Pegah Rahbarinejad
      • Mohammad Reza Shadmand Foumani Moghadam
      • Naseh Pahlavani

    • PubMed: 40330210
    • DOI: 10.1002/fsn3.70196

    1 Insight on

    • Reduced C-Reactive Protein Levels

    • High evidence

  • Role of Antioxidants in Melasma: A Systematic Review.

    • 2025-05
    • Review
    • Indian journal of dermatology 70(3)
    • • Rashmi Sarkar
      • Anjali Sahu

    • PubMed: 40487500
    • DOI: 10.4103/ijd.ijd_473_24

    1 Insight on

    • Reduced Melasma Severity

    • Low evidence

  • Extraction Processes, Bioaccessibility, Antioxidant Capacity, and Potential Prebiotic Effect of Co-Product Extracts From Fruits of the Spondias Genus.

    • 2025-05
    • Journal of food science 90(5)
    • • Ivania Samara Dos Santos Silva Morais
      • Lucas Monteiro Bezerra Pinheiro
      • Fernanda Pereira Santos
      • Marcos Dos Santos Lima
      • Karina Maria Olbrich Dos Santos
      • Carolina Lima Cavalcanti de Albuquerque
      • Haissa Roberta Cardarelli

    • PubMed: 40331749
    • DOI: 10.1111/1750-3841.70260

    1 Insight on

    • Reduced Faecal pH

    • Low evidence
    • Rigorous Journal

  • Complete Immunophenotypic Reversal of Chronic Lymphocytic Leukaemia With High Dose Parenteral Methylcobalamin: A Case Report and Brief Review of Cobalamin in Cancer.

    • 2025-05
    • Review
    • Cancer reports (Hoboken, N.J.) 8(5)
    • • Carmen Wheatley

    • PubMed: 40347057
    • DOI: 10.1002/cnr2.70106

    1 Insight on

    • Improved Lymphocyte Count

    • Low evidence

  • Effects of Daily Kombu (Laminaria japonica) Intake on Body Composition, Blood Pressure, and Fecal Microbiota in Healthy Adult Japanese: A Randomized, Double-Blind Study.

    • 2025-05
    • RCT
    • Food science & nutrition 13(5)
    • • Seiichiro Aoe
      • Hirofumi Ohtoshi
      • Fumiko Nakamura

    • PubMed: 40390848
    • DOI: 10.1002/fsn3.70298

    1 Insight on

    • Reduced Body Fat

    • High evidence

  • Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.

    • 2025-05
    • RCT
    • Clinical physiology and functional imaging 45(3)
    • • Albert Lira
      • William Boyer
      • Trevor Gillum
      • Sean Sullivan
      • Jong-Kyung Kim

    • PubMed: 40341867
    • DOI: 10.1111/cpf.70010

    8 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Reduced Mean Arterial Pressure
    • Reduced Heart Rate
    • Reduced Mean Arterial Pressure Response to Cold Pressor Test
    • Reduced Stroke Volume
    • Reduced Cardiac Output
    • Reduced Heart Rate Variability

    • High evidence