December 2022 Supplement Research Papers

• December 1

  • Epidemiologic Evidence on the Role of Lactobacillus iners in Sexually Transmitted Infections and Bacterial Vaginosis: A Series of Systematic Reviews and Meta-Analyses

    • 2022-12-01
    • Meta-Analysis
    • Sexually Transmitted Diseases 50(4)
    • • Kayla A. Carter
      • Molly D. Fischer
      • M. Petrova
      • J. Balkus

    • PubMed: 36729966
    • DOI: 10.1097/OLQ.0000000000001744

    2 Insights on

    • Increased Protection Against Chlamydia trachomatis
    • Protection Against Bacterial Vaginosis

    • High evidence
    • Rigorous Journal
• December 2

  • 6-Week Supplementation with Tribulus terrestris L. to Trained Male CrossFit® Athletes on Muscle, Inflammation, and Antioxidant Biomarkers: A Randomized, Single-Blind, Placebo-Controlled Trial.

    • 2022-12-02
    • RCT
    • International journal of environmental research and public health 19(23)
    • • Diego Fernández-Lázaro
      • Jesús Seco-Calvo
      • Jorge Pascual-Fernández
      • Carlos Domínguez-Ortega
      • Miguel Del Valle Soto
      • Juan Mielgo-Ayuso

    • PubMed: 36498228
    • DOI: 10.3390/ijerph192316158

    6 Insights on

    • Increased Antioxidant Enzyme Levels
    • Reduced C-Reactive Protein Levels
    • Reduced Muscle Damage
    • Reduced Inflammation Markers
    • Reduced Lactate Dehydrogenase Level
    • Reduced Muscle Damage Biomarker Level

    • High evidence

  • Gastrodia elata Blume extract improves high-fat diet-induced type 2 diabetes by regulating gut microbiota and bile acid profile.

    • 2022-12-02
    • Frontiers in microbiology 13
    • • Danqi Wang
      • Jun-Xia Wang
      • Chunri Yan
      • Yize Liu
      • Hongye Liu
      • Dongxu Li
      • Jun Zhu
      • Zhao-Bo Luo
      • Sheng-Zhong Han
      • Zheng-Yun Jin
      • Shuang-Yan Chang
      • Liu-Hui Yang
      • Jin-Dan Kang
      • Lin-Hu Quan

    • PubMed: 36532435
    • DOI: 10.3389/fmicb.2022.1091712

    3 Insights on

    • Improved Insulin Sensitivity
    • Reduced Inflammation
    • Improved Glycemia

    • Low evidence
• December 5

  • Bacillus subtilis Effects on Growth Performance and Health Status of Totoaba macdonaldi Fed with High Levels of Soy Protein Concentrate

    • 2022-12-05
    • Clinical Trial
    • Animals 12(23)
    • • J. Olmos
      • L. López
      • Antonio Gorriño
      • M. Galaviz
      • V. Mercado

    • PubMed: 36496943
    • DOI: 10.3390/ani12233422

    4 Insights on

    • Enhanced Resistance to Infections
    • Improved Growth Performance
    • Modulated Gut Microbiota
    • Improved Health Status

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • From fecal microbiota transplantation toward next-generation beneficial microbes: The case of Anaerobutyricum soehngenii

    • 2022-12-05
    • Frontiers in Medicine 9
    • • Koen Wortelboer
      • Annefleur M. Koopen
      • H. Herrema
      • W. D. de Vos
      • M. Nieuwdorp
      • E. Kemper

    • PubMed: 36544495
    • DOI: 10.3389/fmed.2022.1077275

    1 Insight on

    • Improved Insulin Sensitivity

    • Low evidence
• December 7

  • Effect of prebiotics, probiotics, and synbiotics on gastrointestinal outcomes in healthy adults and active adults at rest and in response to exercise-A systematic literature review.

    • 2022-12-07
    • Systematic Review · n = 204
    • Frontiers in nutrition 9
    • • Christopher E Rauch
      • Alice S Mika
      • Alan J McCubbin
      • Zoya Huschtscha
      • Ricardo J S Costa

    • PubMed: 36570133
    • DOI: 10.3389/fnut.2022.1003620

    13 Insights on

    • Reduced Intestinal Permeability
    • Reduced Gastrointestinal Symptoms
    • Improved Gut Microbiome Composition
    • Reduced Metabolic Endotoxemia
    • Increased Fecal Probiotic Strains
    • Altered Pro-Inflammatory Cytokine Levels
    • Increased Abundance of Specific Bacterial Species
    • Unchanged Gastrointestinal Symptoms
    • Increased Gut Microbial Supplementation
    • No Improvement in Gastrointestinal Permeability
    • No Substantial Reduction in Exercise-Induced Gastrointestinal Injury, Permeability, Endotoxin Response, or Gastrointestinal Symptoms
    • Reduced Systemic Endotoxemia at Rest
    • Exercise-Induced Gastrointestinal Symptoms

    • High evidence

  • A 60-Day Green Tea Extract Supplementation Counteracts the Dysfunction of Adipose Tissue in Overweight Post-Menopausal and Class I Obese Women.

    • 2022-12-07
    • RCT
    • Nutrients 14(24)
    • • Mariangela Rondanelli
      • Clara Gasparri
      • Simone Perna
      • Giovanna Petrangolini
      • Pietro Allegrini
      • Teresa Fazia
      • Luisa Bernardinelli
      • Alessandro Cavioni
      • Francesca Mansueto
      • Letizia Oberto
      • Zaira Patelli
      • Alice Tartara
      • Antonella Riva

    • PubMed: 36558368
    • DOI: 10.3390/nu14245209

    20 Insights on

    • Reduced Waist Circumference
    • Increased Anti-Inflammatory Cytokine Levels
    • Improved Insulin Levels
    • Improved Liver Function
    • Reduced Insulin Levels
    • Reduced Inflammation
    • Reduced C-Reactive Protein Levels
    • Improved Body Composition
    • Improved Kidney Function
    • Improved Blood Lipid Profile
    • Reduced HOMA-IR
    • Increased Fat Oxidation
    • Reduced Respiratory Quotient
    • Increased Resting Energy Expenditure
    • Improved Glucose Level
    • Improved Satiety Hormonal Status
    • Improved Catecholamine Status
    • Improved Carbohydrate Oxidation
    • Altered Hormonal Status Regarding Satiety
    • Altered Catecholamine Level

    • High evidence
    • Rigorous Journal

  • "Probiotic Lactobacillus rhamnosus EM1107 prevents hyperglycemia, alveolar bone loss and inflammation in a rat model of diabetes and periodontitis".

    • 2022-12-07
    • RCT · n = 114
    • Journal of Periodontology 94(3)
    • • D. Silva
      • Natália T S Cruz
      • A. Martins
      • Régia C M Silva
      • Hursula C Almeida
      • Heloísa E S Costa
      • Karina M O Santos
      • B. Vieira
      • F. B. Sousa
      • Francisco S Junior
      • R. F. A. Júnior
      • G. C. B. Guerra
      • F. Pirih
      • A. Araújo
      • A. R. L. Martins

    • PubMed: 36322996
    • DOI: 10.1002/JPER.22-0262

    4 Insights on

    • Reduced Inflammation Levels
    • Reduced Blood Glucose Levels
    • Reduced Bone Loss
    • Reduced Inflammatory Infiltrate

    • Low evidence
    • Animal Study

  • Impact of Bifidobacterium animalis subsp. lactis HN019 probiotic in the prevention of periodontitis associated with immunosuppression.

    • 2022-12-07
    • Journal of periodontology 94(3)
    • • Luciana Prado Maia
      • Yara Loyanne de Almeida Silva Levi
      • Pedro Henrique Félix Silva
      • Luana Carla Wons
      • Livia Pizzo Pitelli
      • Jéssica Goulart de Castro
      • Eder da Silva Dólens
      • Danielle Gregorio
      • Fabiana Gouveia Straioto
      • Carolina Dos Santos Santinoni
      • Renato Casarin
      • Edilson Ervolino
      • Flávia Aparecida Chaves Furlaneto
      • Michel Reis Messora

    • PubMed: 36245273
    • DOI: 10.1002/jper.22-0146

    3 Insights on

    • Reduced Severity of Periodontitis
    • Reduced Expression of Periodontal Pathogens
    • Improved Bone Preservation

    • Low evidence
    • Animal Study

  • The impact of Bifidobacterium animalis subsp. lactis HN019 probiotic in the prevention of periodontitis associated with immunosuppression.

    • 2022-12-07
    • RCT · n = 80
    • Journal of Periodontology 94(3)
    • • Luciana Prado Mai
      • Yara Loyanne de Almeida Silva Levi
      • Pedro Henrique Félix Silva
      • Luana Carla Wons
      • Livia Pizzo Pitelli
      • Jéssica Goulart de Castro
      • Eder da Silva Dólens
      • D. Gregório
      • Fabiana Gouveia Straioto
      • Carolina Dos Santos Santinoni
      • R. Casarin
      • E. Ervolino
      • Flávia Aparecida Chaves Furlaneto
      • Michel Reis Messora

    • PubMed: 36245273
    • DOI: 10.1002/JPER.22-0146

    12 Insights on

    • Reduced Inflammatory Response
    • Reduced Pathogenic Load
    • Reduced Severity of Periodontitis
    • Increased Bone Volume
    • Increased Osteoprotegerin Immunostaining
    • Reduced Interleukin-1β Levels
    • Increased Fecal Bifidobacterium lactis Levels
    • Modulated Inflammatory Response
    • Modulated Immunoinflammatory Parameters
    • Reduced Expression of Periodontal Pathogens
    • Reduced Immunoinflammatory Markers
    • Improved Bone Volume

    • Low evidence
    • Animal Study

  • Impact of oral administration of single strain Lactococcus lactis spp. cremoris on immune responses to keyhole limpet hemocyanin immunization and gut microbiota: A randomized placebo-controlled trial in healthy volunteers

    • 2022-12-07
    • RCT · n = 81
    • Frontiers in Immunology 13
    • • Mahdi Saghari
      • P. Gal
      • H. Grievink
      • E. Klaassen
      • A. Itano
      • D. Mchale
      • M. Moerland

    • PubMed: 36582231
    • DOI: 10.3389/fimmu.2022.1009304

    6 Insights on

    • Enhanced Immune Response
    • Improved Gut Microbial Alpha Diversity
    • Presence of Lactococcus Lactis in Gut Microbiota
    • No Significant Impact on Immune Response to KLH Immunization
    • Reduced Cytokine Response
    • Unchanged Microbiome Alpha-Diversity

    • High evidence
• December 8

  • Heat-Killed Bifidobacterium bifidum B1628 May Alleviate Dextran Sulfate Sodium-Induced Colitis in Mice, and the Anti-Inflammatory Effect Is Associated with Gut Microbiota Modulation.

    • 2022-12-08
    • Nutrients 14(24)
    • • Cuijiao Feng
      • Weiqin Zhang
      • Tao Zhang
      • Qiuwen He
      • Lai-Yu Kwok
      • Yan Tan
      • Heping Zhang

    • PubMed: 36558391
    • DOI: 10.3390/nu14245233

    4 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Colitis Severity
    • Improved Colitis Symptoms
    • Reduced Inflammation

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Breast Milk-Derived Limosilactobacillus reuteri Prevents Atopic Dermatitis in Mice via Activating Retinol Absorption and Metabolism in Peyer's Patches.

    • 2022-12-08
    • Clinical Trial
    • Molecular Nutrition & Food Research 67(2)
    • • Ce Qi
      • Huayu Tu
      • Yuning Zhao
      • Jingbo Zhou
      • Jie Chen
      • Haiting Hu
      • R. Yu
      • Jin Sun

    • PubMed: 36480309
    • DOI: 10.1002/mnfr.202200444

    4 Insights on

    • Relapse Prevention in Atopic Dermatitis
    • Reduced Ear Inflammation
    • Improved Mucosal Barrier Function
    • Increased Abundance of Specific Anti-Alzheimer's Disease Bacteria

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Potential Probiotic Properties of Exopolysaccharide-Producing Lacticaseibacillus paracasei EPS DA-BACS and Prebiotic Activity of Its Exopolysaccharide

    • 2022-12-08
    • Microorganisms 10(12)
    • • M. Lee
      • H. Joeng
      • Jaein Shin
      • Suin Kim
      • Chaeeun Lee
      • Youngbo Song
      • Byung-Hoo Lee
      • Hyoung-Geun Park
      • Tae-Ho Lee
      • H. Jiang
      • Young-Sun Han
      • B. Lee
      • Ho-Jin Lee
      • Min‐Ju Park
      • Yun-Ju Jun
      • Young-Seo Park

    • PubMed: 36557684
    • DOI: 10.3390/microorganisms10122431

    3 Insights on

    • Reduced Inflammation Levels
    • Inhibition of Harmful Bacterial Growth
    • Enhanced Prebiotic Activity

    • Low evidence
    • Rigorous Journal

  • Interferon Gamma Response in Human Saliva Following Exposure to the Oral Probiotic Streptococcus salivarius BLIS K12.

    • 2022-12-08
    • Probiotics and antimicrobial proteins 16(1)
    • • Gemma A Laws
      • Liam K Harold
      • John R Tagg
      • John D F Hale

    • PubMed: 36477439
    • DOI: 10.1007/s12602-022-10010-0

    2 Insights on

    • Increased Interferon-Gamma Levels
    • Reduced Salivary Gamma-Interferon Levels

    • Low evidence
    • Rigorous Journal

  • Intake of Lactobacillus paragasseri SBT2055 improves subjective symptoms of common cold during winter season in healthy adults: A randomized, double-blind, placebo-controlled parallel-group comparative study

    • 2022-12-08
    • RCT · n = 200
    • Frontiers in Nutrition 9
    • • Eiji Kobatake
      • Y. Iwama
      • Toshinobu Arai
      • Nobuhiko Shioya
      • Mai Kise
      • T. Kabuki

    • PubMed: 36570128
    • DOI: 10.3389/fnut.2022.1063584

    5 Insights on

    • Improved Immune Function
    • Reduced Hepatic Oxidative Stress
    • Reduced Oxidative Stress
    • Reduced Cold Symptoms
    • Improved Salivary IgA Levels

    • High evidence
• December 9

  • The Inhibition of SARS-CoV-2 and the Modulation of Inflammatory Responses by the Extract of Lactobacillus sakei Probio65.

    • 2022-12-09
    • Vaccines 10(12)
    • • Irfan A Rather
      • Lee-Ching Lew
      • Majid Rasool Kamli
      • Khalid Rehman Hakeem
      • Jamal S M Sabir
      • Yong-Ha Park
      • Yan-Yan Hor

    • PubMed: 36560517
    • DOI: 10.3390/vaccines10122106

    3 Insights on

    • Reduced Proinflammatory Signaling
    • Reduced Oxidative Stress
    • Reduced SARS-CoV-2 Replication

    • Low evidence
• December 11

  • The Bioavailability of Glycyrrhizinic Acid Was Enhanced by Probiotic Lactobacillus rhamnosus R0011 Supplementation in Liver Fibrosis Rats.

    • 2022-12-11
    • Nutrients 14(24)
    • • Huifang Li
      • Jing Wang
      • Yifan Fu
      • Ke Zhu
      • Zhiling Dong
      • Jinjun Shan
      • Liuqing Di
      • Shu Jiang
      • Tianjie Yuan

    • PubMed: 36558437
    • DOI: 10.3390/nu14245278

    2 Insights on

    • Improved Gut Microbiome Function
    • Increased Glycyrrhetinic Acid Bioavailability

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Microbiome-Targeted Therapies as an Adjunct to Traditional Weight Loss Interventions: A Systematic Review and Meta-Analysis.

    • 2022-12-11
    • Meta-Analysis · n = 11
    • Diabetes, metabolic syndrome and obesity : targets and therapy 15
    • • Tina Peckmezian
      • Vanessa Garcia-Larsen
      • Kayla Wilkins
      • Rana H Mosli
      • Nasser F BinDhim
      • George Kunnackal John
      • Muhammad Yasir
      • Esam Ibraheem Azhar
      • Gerard E Mullin
      • Saleh A Alqahtani

    • PubMed: 36530587
    • DOI: 10.2147/dmso.s378396

    3 Insights on

    • Reduced Waist Circumference
    • Reduced Body Weight
    • Reduced Body Fat Mass

    • High evidence
• December 14

  • Chili pepper preference development and its impact on dietary intake: A narrative review.

    • 2022-12-14
    • Review
    • Frontiers in nutrition 9
    • • Emily Siebert
      • Soo-Yeun Lee
      • Melissa Pflugh Prescott

    • PubMed: 36590220
    • DOI: 10.3389/fnut.2022.1039207

    5 Insights on

    • Reduced Sensory Desire for Sweet Foods
    • Reduced Sensory Desire for Fatty Foods
    • Reduced Hunger
    • Increased Satiety
    • Reduced Calorie Intake

    • Low evidence

  • Lyophilized cell-free supernatants of the oral probiotics Streptococcus salivarius M18 and Streptococcus salivarius K12 show promises for milk safety.

    • 2022-12-14
    • Letters in applied microbiology 76(1)
    • • Sevinç Karaçam
      • Sinem Tunçer

    • PubMed: 36688767
    • DOI: 10.1093/lambio/ovac034

    1 Insight on

    • Reduced Pathogen Growth

    • Low evidence
• December 15

  • Dietary Lactobacillus fermentum and Lactobacillus paracasei improve the intestinal health of broilers challenged with coccidia and Clostridium perfringens

    • 2022-12-15
    • RCT · n = 3
    • Frontiers in Veterinary Science 9
    • • Peng Li
      • Liyun Zheng
      • Y.Y. Qi
      • Zhipeng Liu
      • E. Du
      • Jintao Wei
      • Z. Zhang
      • Shuangshuang Guo
      • B. Ding

    • PubMed: 36590818
    • DOI: 10.3389/fvets.2022.1025677

    2 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Liver Lesion Severity

    • Low evidence
    • Animal Study

  • Levilactobacillus brevis MG5311 Alleviates Ethanol-Induced Liver Injury by Suppressing Hepatic Oxidative Stress in C57BL/6 Mice.

    • 2022-12-15
    • Microorganisms 10(12)
    • • Hyunna Jung
      • Sohyeon You
      • Soo-Im Choi
      • Chang-Ho Kang
      • Gun-Hee Kim

    • PubMed: 36557739
    • DOI: 10.3390/microorganisms10122488

    5 Insights on

    • Reduced Hepatic Oxidative Stress
    • Improved Lipid Metabolism
    • Reduced Liver Injury
    • Reduced Oxidative Stress
    • Increased Hepatic Lipid Metabolism Markers

    • Low evidence

  • Lactobacillus fermentum 1.2133 display probiotic potential in vitro and protect against Salmonella pullorum in chicken of infection.

    • 2022-12-15
    • Letters in Applied Microbiology 76(1)
    • • Min Wang
      • Jie Hu
      • Han Yu
      • Wenhui Li
      • Guangyu He
      • Jinsheng Dong
      • Yannan Liu
      • Shuiqin Shi

    • PubMed: 36688785
    • DOI: 10.1093/lambio/ovac041

    3 Insights on

    • Improved Abundance of Beneficial Bacteria
    • Reduced Pathogenic Bacteria Load
    • Improved Intestinal Defense Mechanism

    • Low evidence
• December 16

  • The administration of Enterococcus faecium SF68 counteracts compositional shifts in the gut microbiota of diet-induced obese mice.

    • 2022-12-16
    • Frontiers in microbiology 13
    • • Adelaide Panattoni
      • Marco Calvigioni
      • Laura Benvenuti
      • Vanessa D'Antongiovanni
      • Carolina Pellegrini
      • Clelia Di Salvo
      • Diletta Mazzantini
      • Francesco Celandroni
      • Matteo Fornai
      • Luca Antonioli
      • Emilia Ghelardi

    • PubMed: 36590404
    • DOI: 10.3389/fmicb.2022.1054097

    3 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Inflammation
    • Reduced Weight Gain

    • Low evidence
• December 19

  • The Antimicrobial Effect of Various Single-Strain and Multi-Strain Probiotics, Dietary Supplements or Other Beneficial Microbes against Common Clinical Wound Pathogens.

    • 2022-12-19
    • Microorganisms 10(12)
    • • Sabina Fijan
      • Primož Kocbek
      • Andrej Steyer
      • Polona Maver Vodičar
      • Maja Strauss

    • PubMed: 36557771
    • DOI: 10.3390/microorganisms10122518

    1 Insight on

    • Reduced Clinical Wound Pathogen Growth

    • Low evidence

  • Lactobacillus salivarius SNK-6 Regulates Liver Lipid Metabolism Partly via the miR-130a-5p/MBOAT2 Pathway in a NAFLD Model of Laying Hens

    • 2022-12-19
    • Clinical Trial
    • Cells 11(24)
    • • Lihui Zhu
      • R. Liao
      • Jiwen Huang
      • Changfeng Xiao
      • Yunzhou Yang
      • Huiying Wang
      • D. He
      • Huaxiang Yan
      • Changsuo Yang

    • PubMed: 36552896
    • DOI: 10.3390/cells11244133

    11 Insights on

    • Reduced Triglyceride Levels
    • Improved Liver Function
    • Reduced Liver Fat
    • Reduced Liver Fat Deposition
    • Reduced Aspartate Transaminase Activity
    • Reduced Alanine Transaminase Activity
    • Regulated Lipid Metabolism
    • Regulated miR-130a-5p Levels
    • Reduced Liver Enzyme Activity
    • Suppressed PPAR/SREBP Pathway Gene Activity
    • Modulated PPAR/SREBP Pathway

    • Low evidence
    • Animal Study

  • Enteral supplementation with probiotics in preterm infants: A retrospective cohort study and 6-year follow-up

    • 2022-12-19
    • Observational · n = 737
    • Frontiers in Nutrition 9
    • • B. Brown
      • Esther Huisman
      • Michael R Miller
      • Cindy Ulrich
      • G. Reid
      • O. da Silva

    • PubMed: 36643974
    • DOI: 10.3389/fnut.2022.1063121

    2 Insights on

    • Reduced Occurrence of Necrotizing Enterocolitis
    • Reduced Risk of Necrotizing Enterocolitis

    • High evidence
• December 21

  • Non-Hormonal Treatment Options for Regulation of Menstrual Cycle in Adolescents with PCOS.

    • 2022-12-21
    • Review
    • Journal of clinical medicine 12(1)
    • • Elisabeth Reiser
      • Julia Lanbach
      • Bettina Böttcher
      • Bettina Toth

    • PubMed: 36614868
    • DOI: 10.3390/jcm12010067

    1 Insight on

    • Improved Menstrual Frequency

    • Low evidence

  • Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial

    • 2022-12-21
    • RCT
    • Nutrients 15(1)
    • • H. Sung
      • S. Youn
      • Yong Choi
      • S. Eun
      • S. Shin

    • PubMed: 36615686
    • DOI: 10.3390/nu15010028

    6 Insights on

    • Reduced Waist Circumference
    • Reduced Body Weight
    • Reduced Body Fat
    • Reduced Hip Circumference
    • Reduced Waist-to-Hip Ratio
    • Absence of Severe Adverse Reactions

    • High evidence
• December 22

  • Probiotic Bifidobacterium longum BB68S Improves Cognitive Functions in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

    • 2022-12-22
    • RCT · n = 60
    • Nutrients 15(1)
    • • Shaoqi Shi
      • Qi Zhang
      • Yu-Xi Sang
      • Shaoyang Ge
      • Qi Wang
      • Ran Wang
      • Jingjing He

    • PubMed: 36615708
    • DOI: 10.3390/nu15010051

    4 Insights on

    • Improved Cognitive Function
    • Reduced Harmful Gut Bacteria
    • Improved Gut Microbiome Composition
    • Increased Beneficial Gut Bacteria

    • High evidence

  • Effects of 8 Weeks of Shilajit Supplementation on Serum Pro-c1α1, a Biomarker of Type 1 Collagen Synthesis: A Randomized Control Trial.

    • 2022-12-22
    • RCT
    • Journal of dietary supplements 21(1)
    • • Tyler J Neltner
      • Prakash K Sahoo
      • Robert W Smith
      • John Paul V Anders
      • Jocelyn E Arnett
      • Richard J Schmidt
      • Glen O Johnson
      • Sathish Kumar Natarajan
      • Terry J Housh

    • PubMed: 36546868
    • DOI: 10.1080/19390211.2022.2157522

    2 Insights on

    • Increased Type 1 Collagen Synthesis
    • Increased Clinically Meaningful Collagen Synthesis

    • High evidence
• December 23

  • Bifidobacterium lactis IDCC 4301 Exerts Anti-Obesity Effects in High-Fat Diet-Fed Mice Model by Regulating Lipid Metabolism.

    • 2022-12-23
    • Molecular nutrition & food research 67(3)
    • • O-Hyun Ban
      • Minjee Lee
      • Won Yeong Bang
      • Eoun Ho Nam
      • Hyeon Ji Jeon
      • Minhye Shin
      • Jungwoo Yang
      • Young Hoon Jung

    • PubMed: 36517937
    • DOI: 10.1002/mnfr.202200385

    1 Insight on

    • Improved Serum Lipids

    • Low evidence
    • Animal Study

  • Probiotic Bifidobacterium longum subsp. longum Protects against Cigarette Smoke-Induced Inflammation in Mice

    • 2022-12-23
    • Clinical Trial
    • International Journal of Molecular Sciences 24(1)
    • • K. Budden
      • S. Gellatly
      • Annalicia Vaughan
      • N. Amorim
      • J. Horvat
      • Nicole G. Hansbro
      • David L. A. Wood
      • P. Hugenholtz
      • P. Dennis
      • P. Wark
      • P. Hansbro

    • PubMed: 36613693
    • DOI: 10.3390/ijms24010252

    2 Insights on

    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Allergic Lung Inflammation

    • Low evidence
    • Animal Study
• December 26

  • Probiotics for preventing gestational diabetes in overweight or obese pregnant women: A review.

    • 2022-12-26
    • Review
    • World journal of clinical cases 10(36)
    • • Ya-Fang Deng
      • Li-Ping Wu
      • Yan-Ping Liu

    • PubMed: 36683622
    • DOI: 10.12998/wjcc.v10.i36.13189

    2 Insights on

    • Improved Glucose Metabolism
    • Reduced Prevalence of Gestational Diabetes Mellitus

    • Low evidence
• December 27

  • Probiotic consumption can modify the resilience of periodontal tissues in rats under experimental periodontitis.

    • 2022-12-27
    • RCT · n = 32
    • Journal of Periodontology 94(2)
    • • L. F. F. de Oliveira
      • P. Silva
      • S. Salvador
      • E. Ervolino
      • R. Casarin
      • L. Figueiredo
      • Milla Tavares Ricoldi
      • S. L. D. de Souza
      • F. Furlaneto
      • M. Messora

    • PubMed: 35690993
    • DOI: 10.1002/JPER.21-0555

    5 Insights on

    • Reduced Alveolar Bone Resorption
    • Altered Oral Microbiota
    • Reduced Proinflammatory/Anti-inflammatory Cytokine Ratios
    • Increase in Bifidobacterium lactis HN019
    • Reduced TRAP-Positive Cell Count

    • Low evidence
    • Animal Study

  • The Sustainability of Sweet Potato Residues from Starch Processing By-Products: Preparation with Lacticaseibacillus rhamnosus and Pediococcus pentosaceus, Characterization, and Application

    • 2022-12-27
    • Foods 12(1)
    • • Lili Zhu
      • Hongnan Sun
      • Mengmei Ma
      • Taihua Mu
      • Guohua Zhao
      • M. Lwin

    • PubMed: 36613345
    • DOI: 10.3390/foods12010128

    1 Insight on

    • Increased Short-Chain Fatty Acid Production

    • Low evidence
    • Rigorous Journal
• December 28

  • Bile acids and microbes in metabolic disease.

    • 2022-12-28
    • Review
    • World journal of gastroenterology 28(48)
    • • Dhiraj Kumar Sah
      • Archana Arjunan
      • Sun Young Park
      • Young Do Jung

    • PubMed: 36632317
    • DOI: 10.3748/wjg.v28.i48.6846

    1 Insight on

    • Reduced Metabolic Disease Risk

    • Low evidence
• December 29

  • The effects of Gymnema Sylvestre supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults: A systematic review and meta-analysis.

    • 2022-12-29
    • Meta-Analysis
    • Phytotherapy research : PTR 37(3)
    • • Mohammad Zamani
      • Damoon Ashtary-Larky
      • Saeed Nosratabadi
      • Reza Bagheri
      • Alexei Wong
      • Mohammad Mahdi Rafiei
      • Mojtaba Mahdavi Asiabar
      • Pardis Khalili
      • Omid Asbaghi
      • Sayed Hosein Davoodi

    • PubMed: 36580574
    • DOI: 10.1002/ptr.7585

    5 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Reduced Total Cholesterol
    • Reduced Fasting Blood Glucose

    • High evidence
• December 31

  • Probiotics and Postbiotics as the Functional Food Components Affecting the Immune Response.

    • 2022-12-31
    • Review
    • Microorganisms 11(1)
    • • Aleksandra Szydłowska
      • Barbara Sionek

    • PubMed: 36677396
    • DOI: 10.3390/microorganisms11010104

    3 Insights on

    • Improved Immune Function
    • Improved Skin Health
    • Reduced Fatigue

    • Low evidence
• Undated – 11 supplement studies

  • Chronic Treatment with the Probiotics Lacticaseibacillus rhamnosus GG and Bifidobacterium lactis BB12 Attenuates Motor Impairment, Striatal Microglial Activation, and Dopaminergic Loss in Rats with 6-Hydroxydopamine-induced Hemiparkinsonism.

    • 2022-12
    • Neuroscience 507
    • • Sergio G Cuevas-Carbonell
      • Lizbeth Vásquez-Celaya
      • Daniel García-López
      • Diego Granados-Patrón
      • María Del R García-Miss
      • Fernando J Álvarez-Cervera
      • Mirza Mut-Martín
      • Irving Parra
      • Liliana Mendieta
      • Humberto Salgado
      • Javier Alamilla
      • Reyna Cruz-Bojórquez
      • María Luisa Ávila-Escalante
      • Irma I Aranda-González
      • José L Góngora-Alfaro

    • PubMed: 36370934
    • DOI: 10.1016/j.neuroscience.2022.11.004

    3 Insights on

    • Reduced Neuroinflammation
    • Improved Motor Function
    • Preserved Dopaminergic Neurons

    • Low evidence
    • Animal Study

  • Effects of tart cherry juice consumption on cardio-metabolic risk factors: A systematic review and meta-analysis of randomized-controlled trials.

    • 2022-12
    • Meta-Analysis
    • Complementary therapies in medicine 71
    • • Seyedeh Parisa Moosavian
      • Maryam Maharat
      • Mahla Chambari
      • Fateme Moradi
      • Mehran Rahimlou

    • PubMed: 36038032
    • DOI: 10.1016/j.ctim.2022.102883

    10 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Body Mass Index
    • Reduced Systolic Blood Pressure
    • Reduced Triglyceride Levels
    • Improved Insulin Levels
    • Reduced LDL Cholesterol
    • Reduced Body Fat Mass
    • Reduced Fasting Blood Glucose Levels
    • Reduced Total Cholesterol
    • Increased High-Density Lipoprotein Cholesterol

    • High evidence

  • Effectiveness of herbal medicines to prevent and control symptoms of urinary tract infections and to reduce antibiotic use: A literature review.

    • 2022-12
    • Review
    • Integrative medicine research 11(4)
    • • Herman van Wietmarschen
      • Noortje van Steenbergen
      • Esther van der Werf
      • Erik Baars

    • PubMed: 36345487
    • DOI: 10.1016/j.imr.2022.100892

    1 Insight on

    • Reduced Risk of Urinary Tract Infection

    • Low evidence

  • The use of probiotics and prebiotics can enable the ingestion of dairy products by lactose intolerant individuals.

    • 2022-12
    • Systematic Review · n = 830
    • Clinical nutrition (Edinburgh, Scotland) 41(12)
    • • Luiza Scalcon de Oliveira
      • Guilherme Welter Wendt
      • Ana Paula Jaqueline Crestani
      • Kérley Braga Pereira Bento Casaril

    • PubMed: 36308983
    • DOI: 10.1016/j.clnu.2022.10.003

    1 Insight on

    • Improved Symptom Relief for Lactose Intolerance

    • High evidence

  • Effects of galactosyltransferase on EPS biosynthesis and freeze-drying resistance of Lactobacillus acidophilus NCFM.

    • 2022-12
    • Food chemistry. Molecular sciences 5
    • • Lingyu Kong
      • Yuze Huang
      • Xiaoqun Zeng
      • Congyan Ye
      • Zhen Wu
      • Yuxing Guo
      • Daodong Pan

    • PubMed: 36573108
    • DOI: 10.1016/j.fochms.2022.100145

    3 Insights on

    • Improved Survival of Probiotic Bacteria
    • Increased Exopolysaccharide Production
    • Improved Gut Stress Resistance

    • Low evidence

  • Bifidobacterium animalis subsp. lactis Bi-07 supports lactose digestion in vitro and in randomized, placebo- and lactase-controlled clinical trials

    • 2022-12
    • RCT
    • The American Journal of Clinical Nutrition 116(6)
    • • Pia Rasinkangas
      • S. Forssten
      • M. Marttinen
      • A. Ibarra
      • G. Bothe
      • J. Junnila
      • R. Uebelhack
      • Y. Donazzolo
      • A. Ouwehand

    • PubMed: 36149331
    • DOI: 10.1093/ajcn/nqac264

    5 Insights on

    • Reduced Abdominal Pain
    • Improved Lactose Digestion
    • Reduced Breath Hydrogen Production
    • Increased Nausea
    • Reduced Breath Hydrogen Level

    • High evidence

  • Effects of L-carnitine supplementation on glucolipid metabolism: a systematic review and meta-analysis.

    • 2023
    • Meta-Analysis
    • Food & function 14(5)
    • • Yanfei Li
      • Yuchen Xie
      • Chensheng Qiu
      • Bowen Yu
      • Fangzheng Yang
      • Yuanchao Cheng
      • Weizhen Zhong
      • Junhua Yuan

    • PubMed: 36815696
    • DOI: 10.1039/d2fo02930h

    9 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Improved Insulin Levels
    • Reduced Fasting Blood Glucose Levels
    • Reduced Aspartate Aminotransferase Levels
    • Reduced Alanine Aminotransferase Level
    • Reduced HOMA-IR
    • Reduced HDL Cholesterol Level

    • High evidence
    • Rigorous Journal

  • Effect of Tart Cherry Juice Consumption on Body Composition and Anthropometric Measures: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    • 2023
    • Review · n = 126
    • Clinical nutrition research 12(1)
    • • Mohammad Reza Amini
      • Nastaran Payandeh
      • Fatemeh Sheikhhossein
      • Hossein Shahinfar
      • Sanaz Pourreza
      • Azita Hekmatdoost

    • PubMed: 36793776
    • DOI: 10.7762/cnr.2023.12.1.65

    6 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Body Weight
    • Reduced Body Fat Percentage
    • Reduced Body Fat Mass
    • Reduced Fat-Free Mass

    • High evidence

  • Association between Dietary Consumption of Vitamin B1 and Advanced Age-Related Macular Degeneration: A Cross-Sectional Observational Study in NHANES 2005-2008.

    • 2023
    • Observational
    • Ophthalmic research 66(1)
    • • Qingqing Zheng
      • Ting Shen
      • Mengyue Xu
      • Lingtong Tan
      • Zeqi Shen
      • Chaoyang Hong

    • PubMed: 37926095
    • DOI: 10.1159/000534819

    1 Insight on

    • Reduced Prevalence of Late Age-Related Macular Degeneration

    • Low evidence

  • Plum supplementation and lipid profile: a systematic review and meta-analysis of randomised controlled trials.

    • 2023
    • Meta-Analysis
    • Journal of nutritional science 12
    • • Moein Askarpour
      • Hamid Ghalandari
      • Leila Setayesh
      • Ehsan Ghaedi

    • PubMed: 36721717
    • DOI: 10.1017/jns.2022.101

    2 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Low-Density Lipoprotein Level

    • High evidence

  • Effectiveness of natural-based products for radiation-induced oral mucositis therapy: A systematic review.

    • 2023
    • Systematic Review
    • Cancer treatment and research communications 36
    • • Zulfa Fidi Pranadwista
      • Nanan Nur'aeny

    • PubMed: 37209466
    • DOI: 10.1016/j.ctarc.2023.100720

    5 Insights on

    • Reduced Oral Mucositis Severity
    • Reduced Pain
    • Reduced Oral Lesion Size
    • Reduced Dysphagia
    • Reduced Burning Mouth Syndrome

    • High evidence