March 2026 Supplement Research Papers

• March 1

  • From Fermentation to Function: Genomic Diversity and Probiotic Potential in the Reclassified Lactobacillus Lineage.

    • 2026-03-01
    • Observational
    • Computational and structural biotechnology journal 35(1)
    • • Nattarika Chaichana
      • Kamonnut Singkhamanan
      • Monwadee Wonglapsuwan
      • Sarunyou Chusri
      • Rattanaruji Pomwised
      • Komwit Surachat

    • PubMed: 41971946
    • DOI: 10.34133/csbj.0004

    2 Insights on

    • Improved Probiotic Safety
    • No Human Health Outcome Reported

    • Low evidence
• March 2

  • Probiotic cell-free supernatants as a strategy against antimicrobial resistance: a systematic review.

    • 2026-03-02
    • Systematic Review
    • Frontiers in cellular and infection microbiology 16
    • • Maisah Meyhr D'Carmo Sodré
      • Ian David Araújo Cruz
      • Uener Ribeiro Santos
      • Sheila Cristina Potente Dutra Luquetti
      • Vânia Lúcia Silva
      • Alessandra Barbosa Ferreira Machado
      • Cláudio Galuppo Diniz
      • Cláudio Teodoro de Souza
      • Carla Cristina Romano
      • Lauro Juliano Marin
      • Luciana Debortoli de Carvalho

    • PubMed: 41847440
    • DOI: 10.3389/fcimb.2026.1731341

    1 Insight on

    • Reduced Pathogenic Bacterial Activity

    • High evidence

  • Effects and mechanisms of probiotics supplement on hypertension.

    • 2026-03-02
    • Review
    • Journal of hypertension 44(5)
    • • Zhe Jiang
      • Changlin Zhai
      • Chaojie He
      • Liang Shen
      • Guanmin Tang
      • Lijia Xu
      • Haojie Yang
      • Huilin Hu
      • Jungang Han

    • PubMed: 41766653
    • DOI: 10.1097/hjh.0000000000004258

    1 Insight on

    • Reduced Blood Pressure

    • Low evidence

  • Regulatory Effects of Lactobacillus crispatus and Lactobacillus rhamnosus on the Formation and Composition of Gardnerella Biofilms.

    • 2026-03-02
    • Microorganisms 14(3)
    • • Hanyu Qin
      • Yun Liu
      • Sheng Yin
      • Zhengyuan Zhai
      • Bingbing Xiao

    • PubMed: 41900329
    • DOI: 10.3390/microorganisms14030569

    1 Insight on

    • Reduced Recurrence of Bacterial Vaginosis

    • Low evidence

  • Global landscape analysis of clinical trials on gut microbiota modulation therapies for irritable bowel syndrome.

    • 2026-03-02
    • Review
    • Frontiers in medicine 13
    • • Yiting Luo
      • Junjie Cao
      • Bingbing Li
      • Junwen Wang
      • Tianxiang Geng
      • Zining Luo
      • Jiebin Xie

    • PubMed: 41852522
    • DOI: 10.3389/fmed.2026.1737537

    1 Insight on

    • Improved Irritable Bowel Syndrome Symptoms

    • Low evidence
• March 3

  • The Role of Saffron in the Treatment of Depression: A Literature Review.

    • 2026-03-03
    • Review
    • Cureus 18(3)
    • • Luigi Dimech

    • PubMed: 41939549
    • DOI: 10.7759/cureus.104594

    1 Insight on

    • Reduced Depression Symptoms

    • Low evidence

  • Effectiveness of Streptococcus salivarius probiotics on alleviating radiation-induced oral mucositis via inflammatory and microecological modulation: a prospective pragmatic interventional study in nasopharyngeal carcinoma.

    • 2026-03-03
    • Clinical Trial
    • Frontiers in immunology 17
    • • Xiao-Tong Huang
      • Hui Feng
      • Ye Tan
      • Quan Wang
      • Jie-Mei Wei
      • Zhao-Dong Huang
      • Xin-Tong Wang
      • Hai-Jun Lu

    • PubMed: 41853273
    • DOI: 10.3389/fimmu.2026.1745549

    3 Insights on

    • Reduced Oral Mucositis Severity
    • Delayed Oral Mucositis Onset
    • Reduced Severe Oral Mucositis Duration

    • Moderate evidence

  • Marked Improvement in Treatment-Intolerant Obsessive-Compulsive Disorder in an Adolescent Using a Glutamatergic Regimen With Dextromethorphan, Piracetam, and Goldenseal Root.

    • 2026-03-03
    • Case Report
    • Cureus 18(3)
    • • Ngo Cheung

    • PubMed: 41783550
    • DOI: 10.7759/cureus.104617

    2 Insights on

    • Reduced Depression Symptoms
    • Reduced Anxiety

    • Low evidence
• March 4

  • Precision Microbiome Modulation: Exploring Lactobacillus spp. as A Targeted Strategy for Type 2 Diabetes Management.

    • 2026-03-04
    • Review
    • Current nutrition reports 15(1)
    • • Ann Sze Cheah
      • Ji Wei Tan
      • Faizul Jaafar
      • Wendy Wai Yeng Yeo

    • PubMed: 41779301
    • DOI: 10.1007/s13668-026-00739-3

    4 Insights on

    • Improved Gut Microbiota Composition
    • Modulated Gut Microbiota
    • Improved Insulin Resistance
    • Improved Glycemia

    • Low evidence

  • The relationship between intestinal flora and androgen level, glucose and lipid metabolism, inflammatory response and reproductive hormones: a systematic review and meta-analysis.

    • 2026-03-04
    • Systematic Review · n = 1,144
    • BMC endocrine disorders 26(1)
    • • Lin Guo
      • Yangxin Sun
      • Conghui Pang
      • Gaihong Liu

    • PubMed: 41782088
    • DOI: 10.1186/s12902-025-02153-2

    5 Insights on

    • Reduced Inflammation
    • Improved Glucose Metabolism
    • Improved Glycemia
    • No Significant Change in Androgen Levels
    • Stable Androgen Levels

    • High evidence

  • Lactobacillus acidophilus combined with Pediococcus acidilactici ameliorates colitis.

    • 2026-03-04
    • Frontiers in microbiology 17
    • • Peilin Yu
      • Yuanming Jin
      • Da-Jeong Park
      • Mingzhu Wang
      • Chong-Su Cho
      • Chunri Yan
      • Fuliang Sun
      • Xin Jin
      • Keesun Yu
      • Young Jin Pyung
      • Cheol-Heui Yun
      • Lianhua Cui

    • PubMed: 41859447
    • DOI: 10.3389/fmicb.2026.1773197

    8 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Reduced Colitis Severity
    • Improved Colitis Symptoms
    • Increased Short-Chain Fatty Acid Production
    • Improved Antioxidant Capacity
    • Reduced Inflammation
    • Increased Antioxidant Capacity

    • Low evidence

  • Unraveling the dynamic changes in the intestinal microbiome: impacts on pre-weaning calf health and productivity.

    • 2026-03-04
    • Review
    • Journal of animal science and biotechnology 17(1)
    • • Yang Song
      • Shubo Wen
      • Le Luo Guan

    • PubMed: 41776699
    • DOI: 10.1186/s40104-026-01354-6

    6 Insights on

    • Improved Atopic Dermatitis Symptoms
    • Modulated Gut Microbiota
    • Improved Symptom Relief
    • Improved Gut Microbiome Health
    • Reduced Severity of Allergic Rhinitis Symptoms
    • Reduced Allergic Diseases

    • Low evidence
• March 5

  • Clinical Evidence on the Use of Propolis for Oral Mucositis.

    • 2026-03-05
    • Review
    • Pharmaceuticals (Basel, Switzerland) 19(3)
    • • Matheus de Morais Assis
      • Barbara Hana Silva Morales Pino
      • Larissa Kaori Maquedano
      • Felipe Gustavo Carvalho
      • Fernando Augusto Lima Marson
      • Giovanna Barbarini Longato

    • PubMed: 41901272
    • DOI: 10.3390/ph19030425

    6 Insights on

    • Reduced Oral Mucositis Severity
    • Delayed Oral Mucositis Onset
    • Reduced Pain
    • Reduced Dysphagia
    • Reduced Dysgeusia
    • Delayed Progression of Oral Mucositis

    • Low evidence

  • INFLUENCE OF BIFIDOBACTERIUM ANIMALIS SUBSP. LACTIS BB-12 AND LACTOBACILLUS RHAMNOSUS GG ON POLARIZATION OF TUMOR-ASSOCIATED MACROPHAGES.

    • 2026-03-05
    • Experimental oncology 47(4)
    • • N Fedosova
      • T Symchych
      • S Gogol
      • N Cheremshenko
      • P Virych
      • I Voyeykova
      • V Chekhun

    • PubMed: 41788069
    • DOI: 10.15407/exp-oncology.2025.04.451

    1 Insight on

    • Shifted Tumor-Associated Macrophages Toward Pro-Inflammatory M1 Polarization

    • Low evidence
    • Animal Study

  • The Therapeutic Administration of Lactobacillus brevis ZG2488 Suppresses Influenza A Virus Replication Through a Viability-Dependent Host Transcriptional Modulation Mechanism.

    • 2026-03-05
    • Microorganisms 14(3)
    • • Mengshan Chen
      • Yulu Chen
      • Zhijie Cao
      • Zhihong Ren
      • Kun Yue
      • Jing Yang
      • Ji Pu
      • Wenbo Luo
      • Jianguo Xu

    • PubMed: 41900346
    • DOI: 10.3390/microorganisms14030586

    1 Insight on

    • Reduced Influenza Virus Titer

    • Low evidence

  • The effects of dairy products containing Lactobacillus bulgaricus and Streptococcus thermophilus on bone turnover biomarkers and bone mineral density: a pilot trial study.

    • 2026-03-05
    • Clinical Trial · n = 40
    • Frontiers in nutrition 13
    • • Narisa Rueangsri
      • Uraiporn Booranasuksakul
      • Natthapaninee Thanomsridetchai
      • Palatip Chutoam
      • Lukkamol Prapkree
      • Alongkote Singhato

    • PubMed: 41867674
    • DOI: 10.3389/fnut.2026.1785177

    5 Insights on

    • Increased Serum Calcium Levels
    • Reduced Parathyroid Hormone Levels
    • Increased Bone Mineral Density
    • Reduced Bone Turnover
    • Reduced Alkaline Phosphatase

    • High evidence
• March 6

  • Role of Gut Microbiota in Psychiatric Disorders: From Mechanistic Insights to Therapeutic Strategies.

    • 2026-03-06
    • Systematic Review
    • Journal of Korean medical science 41(8)
    • • Ye Sol Kim
      • So-Youn Woo
      • Eunhee Ha
      • So Hyun Ahn
      • Eunsol Kim
      • Soo In Kim
      • Weon-Jeong Lim
      • Sun-Young Kim

    • PubMed: 41775278
    • DOI: 10.3346/jkms.2026.41.e78

    2 Insights on

    • Reduced Anxiety
    • Unknown

    • High evidence

  • Impact of High Doses of Vitamin D on Specific Metabolic Parameters in Type 2 Diabetes Patients: A Prospective Biomedical Study.

    • 2026-03-06
    • Observational
    • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 96(1)
    • • Filip Max
      • Tomáš Tesař
      • Andrea Gažová
      • Juraj Smaha
      • Martin Jankovský
      • Dana Dudová
      • Peter Jackuliak
      • Martin Kužma
      • Juraj Payer
      • Ján Kyselovič

    • PubMed: 41873102
    • DOI: 10.31083/ijvnr46454

    5 Insights on

    • Reduced Hemoglobin A1c
    • Reduced Fasting Blood Glucose Levels
    • Reduced Parathyroid Hormone Levels
    • Reduced Calcium Level
    • Reduced Phosphorus Level

    • Low evidence

  • Clinical efficacy of Lactobacillus plantarum and Lactobacillus brevis as adjuncts to professional mechanical plaque removal in periodontitis: a systematic review.

    • 2026-03-06
    • Systematic Review
    • BMC oral health 26(1)
    • • R R Gheta Anggun Putri
      • Benso Sulijaya
      • Yuniarti Soeroso
      • Chia Wei Cheah
      • Dimas Ilham Hutomo

    • PubMed: 41792699
    • DOI: 10.1186/s12903-026-08032-z

    4 Insights on

    • Increased Interleukin-10 Levels
    • Reduced Probing Pocket Depth
    • Improved Clinical Attachment
    • Improved Periodontal Clinical Parameters

    • High evidence

  • Probiotic Lactobacillus rhamnosus GKLC1 enhances endurance and metabolism in mice with low exercise capacity.

    • 2026-03-06
    • BMC research notes 19(1)
    • • You-Shan Tsai
      • Yi-Ju Hsu
      • Chi-Chang Huang
      • Shih-Wei Lin
      • Yen-Lien Chen
      • Chin-Chu Chen

    • PubMed: 41792776
    • DOI: 10.1186/s13104-026-07757-y

    3 Insights on

    • Improved Endurance
    • Reduced Fatigue
    • Improved Metabolism

    • Low evidence

  • ENA1 deficiency attenuates Saccharomyces 'boulardii' probiotic yeast virulence in immunosuppressed mouse fungaemia model.

    • 2026-03-06
    • Communications biology 9(1)
    • • Alexandra Imre
      • Renátó Kovács
      • Ágnes Jakab
      • Andrea Harmath
      • Bálint Németh
      • Fruzsina Nagy
      • Lajos Forgács
      • Dávid Balázsi
      • László Majoros
      • Zsigmond Benkő
      • Nathan Crook
      • István Pócsi
      • Walter P Pfliegler

    • PubMed: 41792460
    • DOI: 10.1038/s42003-026-09763-z

    1 Insight on

    • Reduced Virulence / Lower Risk of Fungemia

    • Low evidence
• March 7

  • Bioengineering Interventions to Enhance the Capacity of the Gut Microbiota in Controlling Food Allergies.

    • 2026-03-07
    • Review
    • Life (Basel, Switzerland) 16(3)
    • • Manish Kumar
      • Shivani Nalla
      • Jatindra N Tripathy
      • Akhilesh Kumar Shakya

    • PubMed: 41900952
    • DOI: 10.3390/life16030433

    6 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Reduced Allergic Symptoms
    • Improved Tolerance
    • Improved Gut Barrier Function
    • Reduced Food Allergy Symptoms

    • Low evidence
• March 8

  • Combinatorial supplementation of fish feeds enhanced growth performance and disease resilience in aquaculture.

    • 2026-03-08
    • Journal of animal science and biotechnology 17(1)
    • • The-Thien Tran
      • Manish Mahotra
      • Kaarunya Sampathkumar
      • Wenrui Li
      • Hong Yu
      • Ling Xin Yong
      • Li Ling Tan
      • Mingyue Sun
      • Patricia Lynne Conway
      • Say Chye Joachim Loo

    • PubMed: 41794794
    • DOI: 10.1186/s40104-026-01357-3

    2 Insights on

    • Improved Growth Performance
    • Enhanced Disease Resistance

    • Low evidence
• March 9

  • Limosilactobacillus reuteri 3613-1 Delays Onset of Unconfirmed Urinary Tract Infections in Otherwise Healthy Women.

    • 2026-03-09
    • RCT · n = 130
    • Microorganisms 14(3)
    • • Valentine Turpin
      • Charles Kakilla
      • Jessica Foote
      • Oliver Chen
      • William Hooper
      • Wafaa Ayad
      • Annahita Ghassemi
      • Noah Zimmermann
      • Kieran Rea
      • Amy Wescott

    • PubMed: 41900374
    • DOI: 10.3390/microorganisms14030615

    1 Insight on

    • Delayed Onset of Urinary Tract Infections

    • High evidence

  • Probiotic improves respiratory and gastrointestinal health, immune homeostasis, and gut microbiota composition in infants: a randomized controlled trial.

    • 2026-03-09
    • Clinical Trial
    • Frontiers in nutrition 13
    • • Mageswaran Uma Mageswary
      • Lan Hanglian
      • Pin Li
      • Rocky Vester Richmond
      • Yusof Azianey
      • Joo Shun Tan
      • Min-Tze Liong
      • Adli Ali
      • Mishaleni Vejayantheran
      • Jiang Hua
      • He Jian
      • Intan Juliana Abd Hamid
      • Fahisham Taib
      • Yumei Zhang

    • PubMed: 41878569
    • DOI: 10.3389/fnut.2026.1746679

    4 Insights on

    • Improved Gut Microbiota Composition
    • Improved Gastrointestinal Health
    • Improved Immune Homeostasis
    • Improved Respiratory Immune Function

    • Moderate evidence
• March 10

  • Lactic acid bacteria isolated from mammalian feces exhibit distinct diversity and probiotic traits.

    • 2026-03-10
    • World journal of microbiology & biotechnology 42(3)
    • • Maria Isabela da Silva Figueiredo
      • Ivani Souza Mello
      • Luana de Guimarães Bueno
      • Risya Regina Westphal Mendes
      • Jonathan Mádson Dos Santos Almeida
      • Alan Eriksson
      • Gilvan Ferreira da Silva
      • Marcos Antônio Soares

    • PubMed: 41803472
    • DOI: 10.1007/s11274-026-04801-8

    6 Insights on

    • Improved Growth
    • Improved Oxidative Stress Resistance
    • Increased Longevity
    • Increased Body Length
    • Improved Longevity
    • Activation of Stress Response Pathways

    • Low evidence

  • Culture-based studies of intestinal lactobacilli in young people and centenarians.

    • 2026-03-10
    • Observational
    • Frontiers in microbiology 17
    • • Imbi Smidt
      • Tiiu Roop
      • Reet Mandar
      • Jelena Stsepetova
      • Siiri Koljalg
      • Kalle Kilk
      • Indrek Soidla
      • Mare Ainsaar
      • Helgi Kolk
      • Epp Sepp

    • PubMed: 41883793
    • DOI: 10.3389/fmicb.2026.1746411

    3 Insights on

    • Increased Lactobacillus Species Count
    • Altered Lactobacilli Composition
    • Distinct Metabolic Profile

    • Low evidence

  • Engineered bacteria: a novel era for metabolic, cardiovascular and cerebrovascular diseases therapy.

    • 2026-03-10
    • Review
    • Frontiers in cardiovascular medicine 13
    • • Yuzhe Wu
      • Ruiqi Sang
      • Xiangnan Chen
      • Songyun Wang

    • PubMed: 41884636
    • DOI: 10.3389/fcvm.2026.1757348

    1 Insight on

    • Improved Gut Microbiota Composition

    • Low evidence

  • Effects and Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics for the Prevention and Management of Alzheimer's Disease: A Narrative Review.

    • 2026-03-10
    • Review
    • Antioxidants (Basel, Switzerland) 15(3)
    • • Ting Chen
      • Haoqi Chen
      • Yingzhen Qiu
      • Yixiao Liu
      • Mengxing Xie
      • Siyu Huang
      • Kaiying Feng
      • Jie Zhuang
      • Lu Chen
      • Yanming Chen
      • Huabin Li
      • Mengtao Yang
      • Zhijun Yang
      • Huilian Zhu

    • PubMed: 41897493
    • DOI: 10.3390/antiox15030347

    2 Insights on

    • Improved Cognitive Function
    • Reduced Alzheimer’s Disease Pathology

    • Low evidence

  • Clinical Guidance and Practical Recommendations for Probiotic Use in Patients With Irritable Bowel Syndrome, Functional Constipation, and Clostridioides difficile Infection Considering Sex-based Differences.

    • 2026-03-10
    • Review
    • Journal of neurogastroenterology and motility 32(2)
    • • Yong Sung Kim
      • Seon-Young Park
      • Seung Joo Kang
      • Min Woo Lee
      • Yonghoon Choi
      • Byung Yong Kim
      • Miyoung Choi
      • Cheol Min Shin
      • Young Sun Kim
      • Nayoung Kim
      • Moo In Park

    • PubMed: 41807013
    • DOI: 10.5056/jnm25221

    5 Insights on

    • Improved Irritable Bowel Syndrome Symptoms
    • Reduced Clostridium difficile Infection
    • Improved Constipation
    • Improved Functional Constipation
    • No Reduction in Clostridioides difficile Infection

    • Low evidence

  • Probiotic and Postbiotic Interactions of Lactobacillus Strains with Candida albicans: Antifungal Effects Through Microbial Competition.

    • 2026-03-10
    • Antibiotics (Basel, Switzerland) 15(3)
    • • Andrea Vega-Vásconez
      • Diana Lucinda Castillo-Patiño
      • Javier Alberto Garza-Cervantes
      • Arlette Santacruz
      • José Rubén Morones-Ramírez

    • PubMed: 41892441
    • DOI: 10.3390/antibiotics15030279

    1 Insight on

    • Reduced Candida albicans Growth

    • Low evidence

  • Probiotic Interventions and Cognitive Performance: Insights from Recent Clinical Trials.

    • 2026-03-10
    • Review
    • Current pharmaceutical design 32
    • • Bhagavathi Sundaram Sivamaruthi
      • Periyanaina Kesika
      • Chaiyavat Chaiyasut
      • Tess Maria Mathew
      • Karthikeyan Alagarsamy

    • PubMed: 41837594
    • DOI: 10.2174/0113816128436386251216114724

    1 Insight on

    • Improved Cognitive Function

    • Low evidence

  • Postbiotic approach to antibiotic resistance: antibacterial and antibiofilm potential of Lactobacillus salivarius supernatant.

    • 2026-03-10
    • International microbiology : the official journal of the Spanish Society for Microbiology 29(4)
    • • E Akgol
      • Elif Aydin
      • A Temel
      • Percin Renders D

    • PubMed: 41806163
    • DOI: 10.1007/s10123-026-00791-7

    1 Insight on

    • Inhibited ESBL-Positive Escherichia Coli Growth

    • Low evidence

  • Harnessing the power of the gut microbiome: a review of supplementation diagnosis and therapy for liver cirrhosis.

    • 2026-03-10
    • Review
    • Cellular and molecular life sciences : CMLS 83(1)
    • • Yuanqing Zhu
      • Wenkang Gao
      • Mingjian Cheng
      • Xuyang Li
      • Kailin Cai
      • Liuying Chen
      • Huikuan Chu

    • PubMed: 41807803
    • DOI: 10.1007/s00018-026-06098-0

    1 Insight on

    • Reduced Liver Disease Progression

    • Low evidence

  • The Role of Quorum Sensing Mechanism in the Functional Properties of Lactic Acid Bacteria.

    • 2026-03-10
    • Review
    • Microorganisms 14(3)
    • • Annalaura Iodice
      • Giuseppina Tommonaro

    • PubMed: 41900377
    • DOI: 10.3390/microorganisms14030618

    2 Insights on

    • Improved Immune Function
    • Reduced Severity of Allergic Rhinitis Symptoms

    • Low evidence

  • Maternal probiotic and prebiotic supplementation on glucose metabolism in pregnant women and their offspring: effects and related mechanisms.

    • 2026-03-10
    • Review
    • Frontiers in microbiology 17
    • • Hanmo Lin
      • Chuhan Shao
      • Jie Yu
      • Haiyan Chen
      • Yaolin Ren
      • Jing Ren
      • Yuan Zeng
      • Yifan Wu
      • Qian Zhang
      • Xinhua Xiao

    • PubMed: 41883787
    • DOI: 10.3389/fmicb.2026.1782361

    4 Insights on

    • Improved Glycemic Control
    • Improved Insulin Resistance
    • Improved Glucose Metabolism
    • Improved Glucose Homeostasis

    • Low evidence
• March 11

  • Effects of live and heat-killed Bifidobacterium lactis in rats with induced periodontitis.

    • 2026-03-11
    • n = 32
    • Journal of applied oral science : revista FOB 34
    • • Tainá da Silva Tricoly
      • Thais Aguiar Santos
      • Camila Lopes Ferreira
      • Itza Amarilis Ribeiro Pinto
      • Victoria Clara da Silva Lima
      • Camilla Magnoni Moretto Nunes
      • Ana Lia Anbinder
      • Maria Aparecida Neves Jardini

    • PubMed: 41810630
    • DOI: 10.1590/1678-7765-2025-0634

    1 Insight on

    • Improved Periodontal Health

    • Low evidence
    • Animal Study

  • Effect of Lactoferrin in Obese Children and Adolescents with Metabolic Dysfunction-Associated Steatotic Disease: A Randomized Controlled Study.

    • 2026-03-11
    • RCT
    • Paediatric drugs 28(3)
    • • Doaa El Amrousy
      • Dalia El-Afify
      • Esraa Abd Al-Fattah Sorour
      • Shymaa Elrifaey

    • PubMed: 41811599
    • DOI: 10.1007/s40272-026-00742-9

    3 Insights on

    • Improved Insulin Sensitivity
    • Reduced Body Mass Index
    • Reduced Fasting Blood Glucose Levels

    • High evidence

  • Dietary patterns influence the in silico GABA production capacity of Bifidobacterium adolescentis HD17T2H and other human gut bacteria.

    • 2026-03-11
    • Scientific reports 16(1)
    • • Ann Homscheid
      • Karlis Arturs Moors
      • Bram Nap
      • Wolfgang Lieb
      • Andre Franke
      • Matthias Laudes
      • Ines Thiele
      • Christoph Kaleta
      • Georgios Marinos

    • PubMed: 41813835
    • DOI: 10.1038/s41598-026-43006-9

    1 Insight on

    • Improved Gut-Brain Axis Function

    • Low evidence
    • Rigorous Journal
• March 12

  • Asparagus officinalis potentially supports cancer care: a systematic review of randomized and non-randomized clinical studies.

    • 2026-03-12
    • Systematic Review · n = 898
    • Frontiers in nutrition 13
    • • Chen Shen
      • Xiao-Ti Wu
      • Xue-Feng Wang
      • Zhi-Jie Wang
      • Zi-Yu Tian
      • Nicola Robinson
      • Jian-Ping Liu

    • PubMed: 41909047
    • DOI: 10.3389/fnut.2026.1621710

    2 Insights on

    • Improved Quality of Life
    • Improved Survival

    • High evidence

  • Probiotic and Postbiotic Delivery Systems for the Management of Chronic Wounds: A Review of Emerging Strategies.

    • 2026-03-12
    • Review
    • Cureus 18(3)
    • • Maja Karmińska
      • Krystian Czernikiewicz
      • Wiktoria Głowacka-Kamińska
      • Natalia Skrzypska
      • Justyna Wróblewska
      • Olga Wojtczak
      • Jakub Tarczykowski
      • Kacper Zagaja

    • PubMed: 41994838
    • DOI: 10.7759/cureus.105081

    2 Insights on

    • Improved Wound Healing
    • Reduced Pathogenic Load

    • Low evidence

  • Probiotics as Modulators of Adult Neurogenesis and Synaptic Plasticity: New Perspectives in the Pathophysiology and Treatment of Affective Disorders.

    • 2026-03-12
    • Review
    • Biomedicines 14(3)
    • • Gilberto Uriel Rosas-Sánchez
      • León Jesús Germán-Ponciano
      • María Isabel Pérez-Vega
      • Oscar Gutiérrez-Coronado
      • José Luis Muñoz-Carrillo
      • Alejandro David Soriano-Hernández
      • Abril Alondra Barrientos-Bonilla
      • Carmen Gabriela Rosales-Muñoz
      • Cesar Soria-Fregozo

    • PubMed: 41898284
    • DOI: 10.3390/biomedicines14030637

    4 Insights on

    • Reduced Depression Symptoms
    • Reduced Anxiety
    • Improved Depressive Symptoms
    • Increased Brain-Derived Neurotrophic Factor Levels

    • Low evidence

  • Bifidobacterium animalis subsp. lactis Ca360 Promotes Oral Iron Repletion, Alters the Gut Microbiota, and Regulates Host Metabolism and Inflammatory Status in a Murine Model of Iron Deficiency Anemia Caused by a Low-Iron Diet.

    • 2026-03-12
    • Nutrients 18(6)
    • • Peiqing Jiang
      • Jing Yang
      • Yuejian Mao
      • Linjun Wu
      • Xiaoqiong Li
      • Xiangyu Bian
      • Jian Kuang
      • Jianqiang Li
      • Fangshu Shi
      • Xiaoqiang Han
      • Jinjun Li
      • Haibiao Sun

    • PubMed: 41901074
    • DOI: 10.3390/nu18060900

    5 Insights on

    • Improved Gut Microbiota Composition
    • Increased Short-Chain Fatty Acid Production
    • Reduced Inflammation
    • Modulated Gut Microbiota
    • Improved Iron Status

    • Low evidence
    • Rigorous Journal
    • Animal Study
• March 13

  • p53 mediated cell cytotoxicity and DNA damage in lung cancer cell line A549 triggered by a small peptide extracted from a probiotic strain Lacticaseibacillus casei.

    • 2026-03-13
    • BMC biotechnology 26(1)
    • • Jannatul Firdous Siddique
      • G R Shree Kumari
      • Sudarshana Deepa Vijay Kumar
      • C Subathra Devi
      • Mohanasrinivasan Vaithilingam

    • PubMed: 41826945
    • DOI: 10.1186/s12896-026-01119-z

    1 Insight on

    • Activated p53/BAX-Mediated DNA Damage Response

    • Low evidence

  • Comparative Effects of Dietary Protein, Creatine, and Omega-3 Supplementation on Muscle Strength, Endurance, and Recovery in Trained Athletes: A Systematic Review and Network Meta-Analysis.

    • 2026-03-13
    • Meta-Analysis · n = 1,211
    • Nutrients 18(6)
    • • Ziyu Wang
      • Gang Qin
      • Byung-Min Kim

    • PubMed: 41901084
    • DOI: 10.3390/nu18060909

    1 Insight on

    • Improved Endurance

    • High evidence
    • Rigorous Journal

  • Ginkgo biloba extract EGb 761 in patients with dementia and a history of cerebral infarction-meta-analysis of pooled data from randomised clinical trials.

    • 2026-03-13
    • Systematic Review · n = 488
    • Frontiers in neurology 16
    • • Jing-Xuan Feng
      • Man-Qi Zheng
      • Xue Tian
      • Andrea Zimmermann
      • An-Xin Wang
      • Xia Meng

    • PubMed: 41908799
    • DOI: 10.3389/fneur.2025.1658064

    3 Insights on

    • Improved Cognitive Function
    • Improved Activities of Daily Living
    • Improved Global Clinical Impression

    • High evidence

  • Attenuated efficacy of Streptococcus salivarius K12 against Mycoplasma pneumoniae infection in mice.

    • 2026-03-13
    • RCT
    • BMC microbiology 26(1)
    • • Xiaoling Su
      • Yuan Li
      • Ying Huang
      • Haodang Luo
      • Chao Li
      • Xinchao Yi
      • Ning Wu
      • Jun He

    • PubMed: 41820920
    • DOI: 10.1186/s12866-026-04926-8

    1 Insight on

    • Reduced Pulmonary Inflammation

    • High evidence

  • Additional treatment strategies for hypothyroidism: a network meta-analysis.

    • 2026-03-13
    • Systematic Review · n = 508
    • Endocrine connections 15(4)
    • • Xingang Lv
      • Wentao Qin
      • Jiarui Li
      • Likun Du

    • PubMed: 41838451
    • DOI: 10.1530/ec-26-0011

    2 Insights on

    • Increased Serum Free Thyroxine Levels
    • Increased Free Triiodothyronine Level

    • High evidence

  • Acetyl-L-Carnitine in the Treatment of Peripheral Neuropathies: A Narrative Review.

    • 2026-03-13
    • Review
    • Pain and therapy 15(3)
    • • Diego Maria Michele Fornasari

    • PubMed: 41824218
    • DOI: 10.1007/s40122-026-00826-x

    1 Insight on

    • Reduced Neuropathic Pain

    • Low evidence
• March 14

  • Valorization of stale bread into protein-rich biomass: an optimized Rhizopus oryzae fermentation strategy and characterization study.

    • 2026-03-14
    • Letters in applied microbiology 79(4)
    • • Burcu Kaya
      • Özlem Şahiner
      • Gökçe Örüntaş
      • Erol Kestek
      • Harun Efe Bozaslan
      • Seda Savranoğlu Kulabaş
      • Tugba Boyunegmez Tumer
      • Onur Güneşer
      • Yonca Karagül Yüceer

    • PubMed: 41830919
    • DOI: 10.1093/lambio/ovag034

    1 Insight on

    • Improved Cell Compatibility

    • Low evidence

  • Synergistic metabolism between Veillonella ratti and Lactobacillus acidophilus and its inhibition of enterohemorrhagic Escherichia coli infection in piglet.

    • 2026-03-14
    • Archives of microbiology 208(5)
    • • Wenhui Zheng
      • Yi Hao
      • Hejing Wang
      • Yuxin Han
      • Wenchao Song
      • Yanan Mu
      • Tianjia Feng
      • Zhaoyu Zhang
      • Bianfang Liu

    • PubMed: 41831043
    • DOI: 10.1007/s00203-026-04826-5

    1 Insight on

    • Reduced Enterohemorrhagic Escherichia coli Infection

    • Low evidence
• March 15

  • Microbial Fermentation as a Tool to Improve the Antioxidant and Functional Value of Milk Products.

    • 2026-03-15
    • Review
    • Foods (Basel, Switzerland) 15(6)
    • • Sion Seol
      • JuDong Yeo

    • PubMed: 41897746
    • DOI: 10.3390/foods15061024

    2 Insights on

    • Improved Antioxidant Activity
    • Improved Functional Properties of Food

    • Low evidence
• March 16

  • Post spike syndrome (PSS): Simple solution leading to resolving results, five cases report.

    • 2026-03-16
    • Case Report
    • IDCases 41
    • • Roberto S Zeballos
      • Mariely Fernanda da Silva Helbingen
      • Paulo Macio Porto Melo
      • Francisco Eduardo Cardoso Alves
      • Caio Roberto Salvino
      • Ewerton Paes Seródio
      • Edimilson Ramos Migowski de Carvalho

    • PubMed: 40671933
    • DOI: 10.1016/j.idcr.2025.e02278

    4 Insights on

    • Improved Gut Microbiome Composition
    • Improved Symptoms
    • Improved Symptoms in Post-Spike Syndrome
    • Improved Multisystem Symptoms

    • Low evidence

  • The effect of ginseng extract on fatigue in cancer survivors: a randomized double-blind clinical trial.

    • 2026-03-16
    • RCT
    • Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 34(4)
    • • Azad Rahmani
      • Zohreh Sanaat
      • Hosein Nazemiyeh H
      • Afzal Shamsi
      • Musab Ghaderi

    • PubMed: 41838185
    • DOI: 10.1007/s00520-026-10398-3

    5 Insights on

    • Reduced Fatigue
    • Improved Mood
    • Improved Walking Ability
    • Improved General Activity
    • Improved Enjoyment of Life

    • High evidence

  • Lactobacillus acidophilus alleviates slow transit constipation by modulating 5-HT pathway and gut microbial composition.

    • 2026-03-16
    • Frontiers in nutrition 13
    • • Yunhe Fan
      • Hao Qin
      • Jiayao Liu
      • Mureed Abbas
      • Chuanli Yang
      • Haixia Cheng
      • Xiushan Dong

    • PubMed: 41919078
    • DOI: 10.3389/fnut.2026.1775405

    4 Insights on

    • Reduced Intestinal Inflammation
    • Improved Gut Motility
    • Improved Gut Integrity
    • Improved Constipation Symptoms

    • Low evidence

  • Early modulatory effects of Porphyromonas gingivalis and Lactobacillus salivarius on oncogenic processes in dysplastic oral keratinocytes.

    • 2026-03-16
    • Molecular biology reports 53(1)
    • • Umme Samia
      • Tamara Vlajic Tovilovic
      • Ilinka Pecinar
      • Milena Radunovic
      • Sanja Petrovic
      • Milos Lazarevic
      • Dijana Mitic
      • Milica Jaksic Karisik
      • Nadja Nikolic
      • Jelena Carkic
      • Maria Cristina Curia
      • Jelena Milasin

    • PubMed: 41838299
    • DOI: 10.1007/s11033-026-11667-4

    1 Insight on

    • Modulated Oral Cancer-Related Signaling

    • Low evidence

  • Enhanced Quality and Metabolic Profile of Fermented Milk Through Fucose Supplementation with Lactobacillus helveticus.

    • 2026-03-16
    • Molecules (Basel, Switzerland) 31(6)
    • • Shunyu Wang
      • Hongchao Wang
      • Yurong Zhao
      • Zhangming Pei
      • Wenwei Lu
      • Jianxin Zhao
      • Shourong Lu

    • PubMed: 41900089
    • DOI: 10.3390/molecules31060990

    1 Insight on

    • Increased Levels of Beneficial Metabolites

    • Low evidence
    • Animal Study

  • Assessing the impact of Spirulina supplementation on the growth of children and adolescents: a systematic review and meta-analysis.

    • 2026-03-16
    • Systematic Review
    • Frontiers in nutrition 13
    • • Bijaya Kumar Mishra
      • Jaya Singh Kshatri
      • Bharati Kulkarni
      • Swagatika Pati
      • Harshita Dhusiya
      • Pritimayee Sethy
      • Tanveer Rehman
      • Aparna Mukherjee
      • Srikanta Kanungo
      • Sanghamitra Pati

    • PubMed: 41919083
    • DOI: 10.3389/fnut.2026.1779491

    2 Insights on

    • Reduced Body Weight
    • Increased Weight

    • High evidence

  • Production of Xylooligosaccharides (XOSs) with Anti-inflammatory and Prebiotic Activities Using Recombinant Endo-1,4-β-xylanases from Bacillus subtilis.

    • 2026-03-16
    • Journal of agricultural and food chemistry 74(11)
    • • Nguyen Cao Cuong
      • Dietmar Haltrich
      • Apichat Boontawan
      • Montarop Yamabhai

    • PubMed: 41838424
    • DOI: 10.1021/acs.jafc.5c13633

    2 Insights on

    • Reduced Inflammation
    • Enhanced Prebiotic Activity

    • Low evidence
    • Rigorous Journal

  • Lacticaseibacillus rhamnosus CRL1505 Ameliorates Liver Injury and Inflammation in Poly(I:C)-Induced Acute Hepatitis.

    • 2026-03-16
    • Foods (Basel, Switzerland) 15(6)
    • • María José Lorenzo Pisarello
      • Ayelen Antonella Baillo
      • Mariano Elean
      • Leonardo Albarracín
      • Luciano Arellano-Arriagada
      • Yoshihito Suda
      • Haruki Kitazawa
      • Julio Villena

    • PubMed: 41897754
    • DOI: 10.3390/foods15061034

    1 Insight on

    • Improved Antiviral Immune Response

    • Low evidence

  • Bifidobacterium breve inhibits colorectal cancer via extracellular vesicles containing formate acetyltransferase.

    • 2026-03-16
    • Journal of nanobiotechnology 24(1)
    • • Yuefeng Zhang
      • Qian Zhang
      • Yue Luo
      • Xiaohan Li
      • Ruirui Zhao
      • Yaning Xu
      • Saixuan Zhang
      • Xinyu Bai
      • Haopeng Chen
      • Hao Li
      • Yanjun Hong
      • Zhiyong Xie

    • PubMed: 41840625
    • DOI: 10.1186/s12951-026-04275-8

    3 Insights on

    • Increased Anti-Tumor Activity
    • Reduced Colon Cancer Tumor Growth
    • Improved Response to PD-1 Immunotherapy

    • Low evidence
• March 17

  • Lactose intolerance and probiotics: from pathophysiological mechanisms to clinical applications.

    • 2026-03-17
    • Review
    • Antonie van Leeuwenhoek 119(4)
    • • Tsachi Tsadok Perets
      • Rachel Gingold-Belfer
      • Ram Dickman

    • PubMed: 41843249
    • DOI: 10.1007/s10482-026-02278-x

    3 Insights on

    • Improved Lactose Digestion
    • Improved Lactose Tolerance
    • Improved Symptom Relief for Lactose Intolerance

    • Low evidence

  • Pulmonary Hypertension Associated With Vitamin C Deficiency Is Rapidly Reversible.

    • 2026-03-17
    • Case Report
    • Pediatrics 157(4)
    • • Tomás Woodgate
      • Jay Patel
      • Thomas Day
      • Brodie Knight
      • Adriani Spanaki
      • Alistair Calder
      • Shahin Moledina
      • Sadia Quyam

    • PubMed: 41839225
    • DOI: 10.1542/peds.2025-073645

    3 Insights on

    • Reduced Abdominal Pain
    • Improved Right Ventricular Function
    • Reduced N-terminal Pro-B-type Natriuretic Peptide Level

    • Low evidence

  • Coffee and Tea Intake, Dementia Risk, and Cognitive Function.

    • 2026-03-17
    • Observational · n = 821
    • JAMA 335(11)
    • • Yu Zhang
      • Yuxi Liu
      • Yanping Li
      • Yuhan Li
      • Xiao Gu
      • Jae H Kang
      • A Heather Eliassen
      • Molin Wang
      • Eric B Rimm
      • Walter C Willett
      • Frank B Hu
      • Meir J Stampfer
      • Dong D Wang

    • PubMed: 41661604
    • DOI: 10.1001/jama.2025.27259

    4 Insights on

    • Improved Global Cognition
    • Reduced Dementia Risk
    • Reduced Subjective Cognitive Decline
    • Improved Telephone Interview for Cognitive Status Score

    • High evidence
    • Rigorous Journal

  • Probiotics for ulcerative colitis: mechanisms, therapeutic advances, and emerging strategies.

    • 2026-03-17
    • Review
    • Frontiers in microbiology 17
    • • Chao Niu
      • Jing Wang
      • Xinping Lu
      • Yongduo Yu

    • PubMed: 41924481
    • DOI: 10.3389/fmicb.2026.1787284

    1 Insight on

    • Reduced Ulcerative Colitis Symptoms

    • Low evidence
• March 18

  • Radiomitigators: Breakthroughs in Post-Radiation Recovery.

    • 2026-03-18
    • Review
    • Antioxidants (Basel, Switzerland) 15(3)
    • • Elena Obrador
      • José M Estrela
      • Rafael López-Blanch
      • Paz Moreno-Murciano
      • Alegría Montoro
      • María Oriol-Caballo

    • PubMed: 41897526
    • DOI: 10.3390/antiox15030381

    1 Insight on

    • No Human Health Outcome Reported

    • Low evidence

  • A bile acid-GPBAR1 network supports anti-inflammatory and anti-fibrotic benefits of probiotics in colitis.

    • 2026-03-18
    • Gut microbes 18(1)
    • • Michele Biagioli
      • Cristina Di Giorgio
      • Silvia Marchianò
      • Benedetta Sensini
      • Ginevra Urbani
      • Eleonora Giannelli
      • Ginevra Lachi
      • Carmen Massa
      • Maria Rosaria Sette
      • Francesca Paniconi
      • Elva Morretta
      • Maria Chiara Monti
      • Angela Zampella
      • Eleonora Distrutti
      • Stefano Fiorucci

    • PubMed: 41851067
    • DOI: 10.1080/19490976.2026.2645125

    2 Insights on

    • Reduced Intestinal Inflammation
    • Reduced Intestinal Fibrosis

    • Low evidence

  • The role of vitamin K in the prognosis of patients with hepatocellular carcinoma: a systematic review and meta-analysis.

    • 2026-03-18
    • Systematic Review · n = 688
    • Frontiers in oncology 16
    • • Lang Guo
      • Yaqiong Wang
      • Zhenkun Tan
      • Tingli Lu
      • Zha Peng
      • Hai Huang

    • PubMed: 41930200
    • DOI: 10.3389/fonc.2026.1765445

    3 Insights on

    • Improved Progression-free Survival
    • Reduced Recurrence Risk
    • Improved Overall Survival

    • High evidence

  • Membrane Vesicles from Lactobacillus acidophilus Promote Superior Cytokine Modulation and Antimicrobial Signaling Compared with Their Whole Cells in RAW 264.7 Macrophages.

    • 2026-03-18
    • International journal of molecular sciences 27(6)
    • • Cristal Dafne Lonngi Sosa
      • Francisco Rodolfo González Díaz
      • Hugo Ramírez Álvarez
      • Alejandro Vargas Ruiz
      • Rosa Isabel Higuera Piedrahita
      • Héctor Alejandro de la Cruz Cruz
      • Jorge Alfredo Cuéllar Ordaz
      • Gerardo Ramírez-Rico
      • Erasmo Negrete Abascal
      • Magda Reyes López
      • Cynthia González Ruíz

    • PubMed: 41898624
    • DOI: 10.3390/ijms27062764

    2 Insights on

    • Enhanced Innate Immune Function
    • Balanced Cytokine Response

    • Low evidence
    • Rigorous Journal
    • Animal Study
• March 19

  • The Association Between Vitamin D and Polycystic Ovary Syndrome (PCOS) in Women: A Systematic Review.

    • 2026-03-19
    • Systematic Review · n = 1,063
    • Nutrients 18(6)
    • • Batoul Jaafar
      • Nour Chami
      • Mohamad Tlais
      • Maria Matar
      • Nazih Obeid
      • Nadia Taha
      • Karim El Haddad
      • Jessica Abou Chaaya
      • Sami Azar

    • PubMed: 41901143
    • DOI: 10.3390/nu18060968

    7 Insights on

    • Improved Insulin Sensitivity
    • Reduced Body Mass Index
    • Reduced Uric Acid Levels
    • Improved Insulin Resistance
    • Improved Cycle Regularity
    • Improved Ovulation
    • Reduced Total Testosterone Level

    • High evidence
    • Rigorous Journal
• March 20

  • Anti-Inflammatory Effects of Lactiplantibacillus plantarum Strain FS4722 Through MAPK and NF-κB Signaling Pathways and Its Lyophilization Optimization.

    • 2026-03-20
    • Foods (Basel, Switzerland) 15(6)
    • • Bista Sunita
      • Yuxing Liu
      • Hanwei Zheng
      • Yue Su
      • Mingyue Liu
      • Linfeng Xu
      • Ikram Alouk
      • Zhiqing Liu
      • Wenyong Lou

    • PubMed: 41897819
    • DOI: 10.3390/foods15061096

    1 Insight on

    • Reduced Inflammation

    • Low evidence

  • Gut Microbiota Profile and the Impact of Probiotic Supplementation in Competitive Cyclists: A Scoping Review.

    • 2026-03-20
    • Review
    • Nutrients 18(6)
    • • Giacomo Belmonte
      • Marco Gervasi
      • Deborah Agostini
      • Sabrina Donati Zeppa
      • Eugenio Formiglio
      • Irene Rosa Di Mitri
      • Eneko Fernández-Peña
      • Alessia Bartolacci
      • Vilberto Stocchi
      • Antonio Paoli
      • Antonino Bianco
      • Antonino Patti

    • PubMed: 41901166
    • DOI: 10.3390/nu18060991

    2 Insights on

    • Reduced Exhaustion
    • Improved Athletic Performance

    • Moderate evidence
    • Rigorous Journal

  • Efficacy of probiotic supplementation for body weight management in overweight and obese adults: a meta-analysis of randomized controlled trials predominantly from East Asia.

    • 2026-03-20
    • Meta-Analysis
    • Frontiers in public health 14
    • • Shuying Liu
      • Kani Ouyang
      • Xuelian Fang
      • Huijuan He
      • Mengying Li

    • PubMed: 41938967
    • DOI: 10.3389/fpubh.2026.1767108

    6 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Body Weight
    • Reduced Body Fat Percentage
    • No Significant Change in Triglyceride Levels
    • No Significant Change in Total Cholesterol

    • High evidence

  • Genomic and Metabolic Features of the Lactobacillus sakei HRB10 Isolated from Traditional Dry Sausage in Northeast China Based on Whole Genome Sequencing Technology.

    • 2026-03-20
    • Foods (Basel, Switzerland) 15(6)
    • • Qian Chen
      • Yunlong Bai
      • Yingying Fan
      • Jiasheng Lu
      • Yumeng Sui
      • Baohua Kong
      • Yingying Hu

    • PubMed: 41897811
    • DOI: 10.3390/foods15061089

    1 Insight on

    • Identified Candidate Strains for Meat Fermentation Applications

    • Low evidence

  • GABA-Producing Capabilities of Lactococcus lactis PL186 in Murine and Human.

    • 2026-03-20
    • Journal of microbiology and biotechnology 36
    • • Jennifer Jaemin Paek
      • Hyungwon Yang
      • Kyung Soo Paek
      • Yeonhee Lee

    • PubMed: 41866909
    • DOI: 10.4014/jmb.2512.12040

    2 Insights on

    • Increased Systemic GABA Levels
    • Increased Brain GABA Levels

    • Low evidence

  • N-acetylcysteine nano-spray versus conventional treatment in the management of radiotherapy-induced oral mucositis in oral cancer patients: a randomized clinical trial.

    • 2026-03-20
    • RCT · n = 20
    • BMC oral health 26(1)
    • • Alaa Essam
      • Shahira El Domiaty
      • Nahed Attia
      • Hala Helal
      • Mohamed Meheissen

    • PubMed: 41862922
    • DOI: 10.1186/s12903-026-07959-7

    3 Insights on

    • Improved Quality of Life
    • Reduced Mucositis Severity
    • Increased Serum Gastrin-17 Level

    • High evidence
• March 22

  • Efficacy of Vitamin E Supplementation During Pregnancy on the Vitamin E Nutritional Status of the Mother-Child Dyad: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.

    • 2026-03-22
    • Review
    • Food science & nutrition 14(3)
    • • Byanca Rodrigues Carneiro
      • Anny Cristine de Araújo
      • Yvi Melo Sisinano
      • Amanda Freitas de Oliveira
      • Adriana Augusto de Rezende
      • Karla Danielly da Silva Ribeiro

    • PubMed: 42016265
    • DOI: 10.1002/fsn3.71677

    1 Insight on

    • Increased Alpha-Tocopherol Level

    • Low evidence
• March 23

  • Engineered Lactobacillus casei targets the IgT-pIgR axis to confer mucosal protection against Aeromonas veronii in snakehead (Channa argus).

    • 2026-03-23
    • Frontiers in immunology 17
    • • Kui-Peng Gao
      • Jian-Ran Dou
      • Bing-Bing Ma
      • Tian-Bao Ma
      • Na Li
      • Ai-Dong Qian
      • Xiao-Feng Shan
      • Wu-Wen Sun
      • Lei Zhang
      • Di Zhang
      • Chun-Feng Wang
      • Dong-Xing Zhang

    • PubMed: 41948342
    • DOI: 10.3389/fimmu.2026.1759765

    3 Insights on

    • Enhanced Mucosal Immune Response
    • Improved Mucosal Immunity
    • Improved Survival

    • Low evidence
    • Animal Study
• March 24

  • Assessment of genome evolution in Bifidobacterium adolescentis indicates genetic adaptation to the human gut.

    • 2026-03-24
    • Observational
    • mSystems 11(3)
    • • Emanuele Selleri
      • Chiara Tarracchini
      • Silvia Petraro
      • Leonardo Mancabelli
      • Christian Milani
      • Francesca Turroni
      • Yan Shao
      • Hilary P Browne
      • Trevor D Lawley
      • Douwe van Sinderen
      • Marco Ventura
      • Gabriele Andrea Lugli

    • PubMed: 41649278
    • DOI: 10.1128/msystems.01173-25

    1 Insight on

    • Genetic Adaptation to the Human Gut

    • Moderate evidence
    • Rigorous Journal

  • Probiotics and human health: biological activities, nutritional aspects, immunomodulatory properties, applications, and future perspectives - a comprehensive review.

    • 2026-03-24
    • Review
    • Frontiers in immunology 16
    • • Mohamed T El-Saadony
      • Ahmed M Saad
      • Mahmoud Sitohy
      • Samar Sami Alkafaas
      • Mthokozisi Dladla
      • Soumya Ghosh
      • Dina Mostafa Mohammed
      • Essam H Ibrahim
      • Mohamed A Fahmy
      • Amr Elkelish
      • Synan F AbuQamar
      • Khaled A El-Tarabily

    • PubMed: 41953220
    • DOI: 10.3389/fimmu.2025.1713426

    10 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Gastrointestinal Symptoms
    • Improved Atopic Dermatitis Symptoms
    • Improved Gut Microbiota Balance
    • Reduced Duration of Infectious Diseases
    • Modulated Gut Microbiota
    • Improved Immune Modulation
    • Reduced Severity of Allergic Rhinitis Symptoms
    • Reduced Gastrointestinal Disorders
    • Reduced Risk of Infection

    • Low evidence

  • The role of N-acetylcysteine and glutathione in the management of Parkinson's disease: a systematic review of oxidative biomarkers and clinical outcomes.

    • 2026-03-24
    • Systematic Review · n = 196
    • Amino acids 58(1)
    • • Imran Mohammed
      • Yasimin Nankya
      • U Teng Hong
      • Amy Kan
      • Alya Masoud Abdelhafid
      • Gladys O Latunde-Dada

    • PubMed: 41874704
    • DOI: 10.1007/s00726-026-03513-5

    1 Insight on

    • Improved Non-Motor Symptoms

    • High evidence

  • Correction: Protective effects of engineered Lactobacillus crispatus on intrauterine adhesions in mice via delivering CXCL12.

    • 2026-03-24
    • Frontiers in immunology 17
    • • Yao Kong
      • Zhaoxia Liu
      • Qin Xiao
      • Fei Wu
      • Lijuan Hu
      • Xiaorong Deng
      • Tingtao Chen

    • PubMed: 41953017
    • DOI: 10.3389/fimmu.2026.1794467

    1 Insight on

    • Reduced Intrauterine Adhesions

    • Low evidence

  • Time-dependent efficacy of zinc supplements in preventing oral mucositis after chemoradiotherapy: a meta-analysis.

    • 2026-03-24
    • Meta-Analysis · n = 1,076
    • Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 34(4)
    • • Jiale Wang
      • Jianyu Hu
      • Yongshi Luo
      • Jinfeng Nie
      • Mangui Deng
      • Zhihong Wang

    • PubMed: 41872524
    • DOI: 10.1007/s00520-026-10572-7

    5 Insights on

    • Reduced Oral Mucositis Severity
    • Delayed Oral Mucositis Onset
    • Reduced Pain
    • Reduced Incidence of Oral Mucositis
    • Reduced Xerostomia

    • High evidence

  • Modulation of Glucose Homeostasis, Metabolic Endotoxemia and Circulating Short-Chain Fatty Acids Following Multi-Species Probiotic Supplementation: Findings from a 12-Week Randomised Placebo-Controlled Trial.

    • 2026-03-24
    • RCT · n = 39
    • Nutrients 18(7)
    • • George Moschonis
      • Pauline Dacaya
      • Thy T Truong
      • Angela Amoruso
      • Marco Pane

    • PubMed: 41978077
    • DOI: 10.3390/nu18071025

    6 Insights on

    • Reduced Inflammatory Markers
    • Reduced Inflammation
    • Reduced Metabolic Endotoxemia
    • Improved Glucose Regulation
    • Improved Fasting Glucose Levels
    • Reduced GIP

    • High evidence
    • Rigorous Journal
• March 25

  • Crystal structure of PM1Pgh, a poly-γ-glutamate hydrolase from Bacillus phage PM1.

    • 2026-03-25
    • Acta crystallographica. Section F, Structural biology communications 82(4)
    • • Kyoko Abe
      • Kenji Fukui
      • Yasunori Ogura

    • PubMed: 41879646
    • DOI: 10.1107/s2053230x26002189

    1 Insight on

    • No Human Health Outcome Reported

    • Low evidence

  • Association between probiotic intervention and sleep quality in the general adult population: a systematic review and meta-analysis.

    • 2026-03-25
    • Systematic Review · n = 890
    • Frontiers in nutrition 13
    • • Tingjing Ren
      • Yilin Wang
      • Bingnan Zhang
      • Haiyan Du
      • Huixia Ren
      • Naijin Zhang
      • Hongwu Wang
      • Yuanyuan Guan

    • PubMed: 41958906
    • DOI: 10.3389/fnut.2026.1795450

    2 Insights on

    • Reduced Insomnia
    • Improved Sleep Quality

    • High evidence

  • Probiotics in atherosclerosis: mechanisms, efficacy and future directions - a review study.

    • 2026-03-25
    • Review
    • Frontiers in immunology 17
    • • Yue Cai

    • PubMed: 41958663
    • DOI: 10.3389/fimmu.2026.1722134

    7 Insights on

    • Improved Lipid Metabolism
    • Reduced Inflammation
    • Improved Vascular Endothelial Function
    • Improved Blood Lipid Profile
    • Reduced Cardiovascular Risk
    • Reduced Atherosclerosis Risk Factors
    • Improved Atherosclerosis-Related Cardiovascular Risk Markers

    • Low evidence
• March 26

  • The effects of probiotics intervention on oral health outcomes: a comprehensive umbrella review of meta-analyses.

    • 2026-03-26
    • Review
    • Frontiers in oral health 7
    • • Zhen Tang
      • Yunzhen Deng
      • Gang Guo
      • LiLi Zhou

    • PubMed: 41969406
    • DOI: 10.3389/froh.2026.1768508

    3 Insights on

    • Reduced Caries Risk
    • Reduced Halitosis
    • Reduced Cariogenic Bacteria

    • Low evidence

  • Maternal probiotic supplementation and offspring health: an umbrella review with re-analysis of systematic reviews and meta-analyses.

    • 2026-03-26
    • Systematic Review
    • Frontiers in nutrition 13
    • • Wenrui Sun
      • Yu Cao
      • Shumin Li
      • Liping Sun
      • Yuexia Liao

    • PubMed: 41971379
    • DOI: 10.3389/fnut.2026.1764109

    2 Insights on

    • Reduced Pathogenic Bacterial Abundance
    • Reduced Offspring Eczema Risk

    • High evidence

  • Probiotic Lactic Acid Bacteria-Fermented Beverages from Bambara Groundnut and Cowpea Sprouts Modulate Gut Microbiota and Short-Chain Fatty Acids.

    • 2026-03-26
    • Foods (Basel, Switzerland) 15(7)
    • • Nobahle Pretty Cele
      • Yusuf Olamide Kewuyemi
      • Oladipupo Adiamo
      • Eshetu Mulisa Bobasa
      • Jiale Zhang
      • Maral Seididamyeh
      • Yasmina F Sultanbawa
      • Dharini Sivakumar

    • PubMed: 41976435
    • DOI: 10.3390/foods15071141

    1 Insight on

    • Increased Short-Chain Fatty Acid Production

    • Low evidence

  • Differential and Dose-Dependent Redistribution of Vitamin D Metabolites After Acute High-Intensity Exercise in Mixed Martial Arts Athletes and Untrained Men: Pilot Study.

    • 2026-03-26
    • RCT
    • Nutrients 18(7)
    • • Katarzyna Patrycja Dzik
      • Katarzyna Jagłowska
      • Miłosz Palicki
      • Sylwester Kujach
      • Piotr Sawicki
      • Konrad Kowalski
      • Jan Jacek Kaczor

    • PubMed: 41978112
    • DOI: 10.3390/nu18071061

    4 Insights on

    • Increased Vitamin D Level
    • Improved Maximal Power
    • Improved Mean Power
    • Improved Work Capacity

    • High evidence
    • Rigorous Journal

  • Role of Bifidobacterium breve PRL2020 in reducing symptoms of antibiotic-associated diarrhea in children.

    • 2026-03-26
    • Clinical Trial
    • Frontiers in pediatrics 14
    • • Alexander Bertuccioli
      • Annalisa Belli
      • Davide Sisti
      • Marco Bruno Luigi Rocchi
      • Chiara Maria Palazzi
      • Giordano Bruno Zonzini
      • Filippo Boccellari
      • Roberto Sacchetti
      • Francesco Di Pierro
      • Giuseppe Gregori

    • PubMed: 41971733
    • DOI: 10.3389/fped.2026.1726821

    2 Insights on

    • Reduced Antibiotic-Associated Diarrhea
    • Reduced Abdominal Pain

    • Moderate evidence

  • Effects of probiotic and metformin co-administration versus metformin monotherapy on anthropometric measurements, hormones, and glucolipid profile in women with polycystic ovary syndrome: a systematic review and meta-analysis.

    • 2026-03-26
    • Meta-Analysis
    • Frontiers in endocrinology 17
    • • Mohammed Hamsho
      • Wijdan Shkorfu
      • Meriem Bensaoua
      • Carlos Eduardo Carvalho Martins
      • Hale Hacıbayram
      • Abdulmannan Fadel
      • Yazan Ranneh

    • PubMed: 41970993
    • DOI: 10.3389/fendo.2026.1802369

    4 Insights on

    • Improved Insulin Sensitivity
    • Absence of Severe Gastrointestinal Adverse Effects
    • Reduced Gastrointestinal Disorders
    • Reduced Luteinizing Hormone

    • High evidence
• March 27

  • Efficacy and potential pharmacological mechanisms of total glucosides of paeony in treating ankylosing spondylitis in Asian populations: a meta-analysis, network pharmacology, and molecular dynamics simulation.

    • 2026-03-27
    • Systematic Review · n = 130
    • Frontiers in nutrition 13
    • • Wenjun Mu
      • Jianhui Ma
      • Xudong Zhang
      • Jun Su
      • Xiang Wang
      • Cong Huang

    • PubMed: 41971360
    • DOI: 10.3389/fnut.2026.1738150

    1 Insight on

    • Reduced Inflammatory Response

    • High evidence

  • N-Acetylcysteine in Neurological Disorders: A Systematic Review of Clinical and Translational Evidence Across Seven Disorders.

    • 2026-03-27
    • Systematic Review
    • International journal of molecular sciences 27(7)
    • • Robert Mîndreanu
      • Irina Camelia Chiș
      • Alexandra Sevastre-Berghian
      • Cezar Login
      • Adina Stan
      • Teodora Stan
      • Simona Clichici
      • Șoimița Suciu

    • PubMed: 41977262
    • DOI: 10.3390/ijms27073076

    4 Insights on

    • Improved Symptom Resolution
    • Improved Dopamine Transporter Binding
    • Improved Cognitive Stabilization
    • Improved Oxidative Stress Biomarker

    • High evidence
    • Rigorous Journal

  • Psychobiotics in mental health: insights from human clinical trials via the gut-brain axis.

    • 2026-03-27
    • Review
    • Frontiers in microbiology 17
    • • Natarajan Sisubalan
      • Periyanaina Kesika
      • Bhagavathi Sundaram Sivamaruthi
      • Chaiyavat Chaiyasut

    • PubMed: 41971341
    • DOI: 10.3389/fmicb.2026.1804560

    7 Insights on

    • Improved Cognitive Function
    • Reduced Psychological Distress
    • Reduced Anxiety
    • Improved Mental Health
    • Improved Sleep Quality
    • Improved Psychological Well-being
    • Improved Mood

    • Low evidence

  • Dietary Bacillus subtilis PB6 Enhances Reproductive Performance by Modulating Gut Microbiota, Barrier Function, and Inflammation in Clostridium perfringens Type A-Infected Sows.

    • 2026-03-27
    • Animals : an open access journal from MDPI 16(7)
    • • Mengran Zhang
      • Aohang Yu
      • Chihao Wang
      • Chaojie Chen
      • Chenchen Wu

    • PubMed: 41976011
    • DOI: 10.3390/ani16071032

    3 Insights on

    • Improved Intestinal Barrier Function
    • Improved Gut Microbiota Balance
    • Reduced Inflammation

    • Low evidence
• March 29

  • Dysregulated eating behaviour and microbiota-based interventions targeting eating disorders and food addiction.

    • 2026-03-29
    • Review
    • Gut microbes 18(1)
    • • Solveiga Samulėnaitė
      • Jan Rodriguez Parkitna
      • Daiva Baltriukienė
      • Elena Martín-García
      • Rafael Maldonado
      • Aurelijus Burokas

    • PubMed: 41906418
    • DOI: 10.1080/19490976.2026.2647535

    4 Insights on

    • Improved Gastrointestinal Health
    • Reduced Binge Eating Tendencies
    • Reduced Anxiety-like Behavior
    • No Applicable Outcome Reported

    • Low evidence

  • Lactobacillus acidophilus Postbiotics Differentially Modulate Nutrient Sensing, Intestinal Barrier Integrity, and Inflammatory Signaling in Broiler.

    • 2026-03-29
    • RCT · n = 400
    • Comprehensive Physiology 16(2)
    • • Meng Yu
      • Zhiyun Qin
      • Atique Ahmed Behan
      • Shabbir Ahmed
      • Muhammad Asif Arain
      • Nazrin Malikli
      • Jameel Ahmed Budar
      • Hesham Hassanien

    • PubMed: 41905960
    • DOI: 10.1002/cph4.70139

    6 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Improved Immune Function
    • Reduced Proinflammatory Signaling
    • Improved Growth Performance
    • Improved Antioxidative Response

    • Low evidence
    • Animal Study
• March 30

  • Effect of Probiotic and Synbiotic Oral Supplementation in Autoimmune Diseases: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    • 2026-03-30
    • Meta-Analysis · n = 703
    • Nutrients 18(7)
    • • Yuan-Yow Chiou
      • Tsu-Yun Chiu
      • Mei-Ju Chen

    • PubMed: 41978157
    • DOI: 10.3390/nu18071107

    3 Insights on

    • Reduced Inflammatory Markers
    • Reduced Inflammation
    • Improved Inflammatory Profile

    • High evidence
    • Rigorous Journal

  • Encapsulation of probiotics to improve their survival: A focus on Bifidobacterium animalis subsp. lactis BB-12.

    • 2026-03-30
    • Review
    • Food chemistry: X 35
    • • Defeng Shu
      • Tianning Zhang
      • Yajie Dong
      • Jinlong Xu
      • Yongkai Yuan

    • PubMed: 41994549
    • DOI: 10.1016/j.fochx.2026.103802

    2 Insights on

    • Improved Gastrointestinal Transit
    • Improved Food Matrix Resistance

    • Low evidence
• March 31

  • Magnesium supplementation as an adjunct to fluoxetine therapy for depression.

    • 2026-03-31
    • RCT · n = 32
    • East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan 36(1)
    • • A S Walyddaini
      • S T Lisal
      • Ilhamuddin
      • A A Zainuddin
      • A J Tanra
      • Y Widianingsih
      • S Syamsuddin

    • PubMed: 41916937
    • DOI: 10.12809/eaap25122

    1 Insight on

    • Improved Depressive Symptoms

    • High evidence

  • Effects of Probiotic Supplementation on Core Symptoms of Autism Spectrum Disorder in Children.

    • 2026-03-31
    • Systematic Review · n = 924
    • Nutrients 18(7)
    • • Meng Xian Chan
      • Chui Yan Hoh
      • Ying Yi Teh
      • Xin Yian Toh
      • Noor Akmal Shareela Ismail

    • PubMed: 41978177
    • DOI: 10.3390/nu18071127

    1 Insight on

    • Improved Social Behavior

    • High evidence
    • Rigorous Journal

  • Tart cherry supplementation for exercise recovery: an evidence-informed narrative review and applied monitoring framework.

    • 2026-03-31
    • Review
    • Physical activity and nutrition 30(1)
    • • Jooyoung Kim

    • PubMed: 41956499
    • DOI: 10.20463/pan.2026.0009

    6 Insights on

    • Reduced Inflammatory Markers
    • Reduced Delayed-Onset Muscle Soreness
    • Improved Perceived Recovery
    • Improved Neuromuscular Strength
    • Improved Neuromuscular Power
    • Reduced Biochemical Markers of Muscle Damage

    • Low evidence
• Undated – 25 supplement studies

  • Effects of Asparagus officinalis for burning mouth syndrome: A systematic review of randomized controlled trials.

    • 2026-03
    • Review · n = 336
    • Integrative medicine research 15(1)
    • • Chen Shen
      • Xue-Feng Wang
      • Xiao-Ti Wu
      • Xin-Xin Liu
      • Nicola Robinson
      • Jian-Ping Liu

    • PubMed: 40950801
    • DOI: 10.1016/j.imr.2025.101223

    9 Insights on

    • Reduced Depression Symptoms
    • Reduced Anxiety
    • Reduced Pain Intensity
    • Improved Sleep Duration
    • Improved Saliva Flow Rate
    • Improved Symptoms
    • Improved Pain Intensity
    • Reduced Pain Score
    • Improved Water Intake

    • High evidence

  • Effect of Flaxseed Supplementation on Headache Characteristics and Quality of Life in Patients with Migraine: A Randomized Controlled Trial.

    • 2026-03
    • RCT · n = 68
    • The Journal of nutrition 156(3)
    • • Amirhosein Jafarpour
      • Vahid Reza Ostovan
      • Masoumeh Akhlaghi

    • PubMed: 41478596
    • DOI: 10.1016/j.tjnut.2025.101312

    10 Insights on

    • Reduced Body Weight
    • Reduced Blood Pressure
    • Reduced Anxiety
    • Improved Sleep Quality
    • Reduced Stress
    • Reduced Headache Duration
    • Reduced Headache Severity
    • Improved Headache-Related Quality of Life
    • Reduced Headache Frequency
    • Reduced Depression

    • High evidence

  • Maternal supplementation of vitamin B12 in predominantly vegetarian pregnant women improves their vitamin B12 status and the neurodevelopment of their infants: the MATCOBIND multicentric double-blind randomised control trial.

    • 2026-03
    • RCT · n = 276
    • BMJ paediatrics open 10(1)
    • • Jitender Nagpal
      • Manu Mathur
      • Swapnil Rawat
      • Atul Singhal
      • Rajendra Pant
      • Anita Shah
      • Laura Nixon
      • Vijay Kumar Mishra
      • Deepti Nagrath
      • Michelle Heys
      • Mario Cortina-Borja
      • Colin Michie
      • Jageshwor Gautam
      • Shailendra Bir Karmacharya
      • Snighda Rai
      • Monica Lakhanpaul

    • PubMed: 41850742
    • DOI: 10.1136/bmjpo-2025-004112

    1 Insight on

    • Improved Mental Developmental Quotient

    • High evidence
    • Large Human Trial

  • N-acetylcysteine reduces incidence and duration of linezolid-associated thrombocytopenia in critically ill patients: A randomized controlled trial.

    • 2026-03
    • RCT
    • Environmental toxicology and pharmacology 122
    • • Mohamed Abdeltawab
      • Abdel-Hameed Ebid
      • Osama Ahmed
      • Mohamed A Mobarez
      • Mahmoud Ibrahim

    • PubMed: 41577060
    • DOI: 10.1016/j.etap.2026.104944

    4 Insights on

    • Increased Platelet Count
    • Reduced Thrombocytopenia
    • Reduced Linezolid Discontinuation
    • Delayed Onset of Thrombocytopenia

    • High evidence

  • Acute Effects of a High-Fat Meal Enriched with Pomegranate Seed Oil on Postprandial Lipemia and Endothelial Function in Postmenopausal Women: a Randomized Controlled Crossover Trial.

    • 2026-03
    • RCT
    • The Journal of nutrition 156(3)
    • • Manal M Almoraie
      • Jeremy Pe Spencer
      • Carol Wagstaff
      • Kim G Jackson

    • PubMed: 41580088
    • DOI: 10.1016/j.tjnut.2026.101374

    6 Insights on

    • Reduced Systolic Blood Pressure
    • Reduced Postprandial Triacylglycerol Response
    • Improved Endothelium-Dependent Vasodilation
    • Reduced Pulse Wave Velocity
    • Reduced Soluble Intercellular Adhesion Molecule-1 Level
    • Increased Nitrite Level

    • High evidence

  • Comparative genomics reveals population structure and ecological adaptation in Lactobacillus helveticus.

    • 2026-03
    • Observational
    • Food research international (Ottawa, Ont.) 227
    • • Haimin Hu
      • Jiao Wu
      • Jiaqi Sun
      • Simeng Wang
      • Jinhui Liu
      • Tong Dan

    • PubMed: 41652681
    • DOI: 10.1016/j.foodres.2025.118266

    1 Insight on

    • Reduced Angiotensin I-Converting Enzyme Activity

    • Low evidence

  • Niacin Modulates Immune Responses in a Phase I Dose-Escalation Clinical Trial of Newly Diagnosed Glioblastoma.

    • 2026-03
    • Clinical Trial
    • Neurology(R) neuroimmunology & neuroinflammation 13(2)
    • • Candice C Poon
      • Kathleen M Hagen
      • Susobhan Sarkar
      • Reza Mirzaei
      • Claudia Silva
      • Aito Ueno
      • Paula de Robles
      • Gloria Roldan-Urgoiti
      • V Wee Yong

    • PubMed: 41632924
    • DOI: 10.1212/nxi.0000000000200530

    6 Insights on

    • Increased Immune Factor Levels
    • Increased IL-12 Levels
    • Increased Memory T Cell Frequency
    • Increased Natural Killer Cell Frequency
    • Reduced Nonclassical Monocyte Frequency
    • Reduced Growth-Regulated Alpha Protein Level

    • Moderate evidence

  • Effect of Perioperative Glutamine-Enhanced Parenteral Nutrition on Short-Term Outcomes in Colorectal Cancer Patients Undergoing Radical Resection: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    • 2026-03
    • Meta-Analysis · n = 950
    • Technology in cancer research & treatment 25
    • • Yong Huang
      • Xiuzhi Yang
      • Songhan Qin
      • Tao Zhang
      • Ming Xie
      • Jiwei Wang

    • PubMed: 41891764
    • DOI: 10.1177/15330338261438204

    3 Insights on

    • Reduced Length of Hospital Stay
    • Reduced Infectious Complication
    • Reduced Non-Infectious Complication Morbidity

    • High evidence

  • Paecilomyces hepiali Chen (Cs-4) polysaccharides ameliorate chronic liver fibrosis via inhibiting TGF-β1/Smad and NLRP3/Caspase-1-mediated hepatic stellate cells activation in vivo and in vitro.

    • 2026-03
    • Journal of ethnopharmacology 359
    • • Lumeng Yao
      • Qiuying Xu
      • Yongbin Xu
      • Yue Chen
      • Zhun Xiao
      • Zhenjie Gao
      • Lingyan Zhu
      • Jianjun Wu
      • Luping Qin
      • Siqi Gao

    • PubMed: 41443484
    • DOI: 10.1016/j.jep.2025.121066

    3 Insights on

    • Reduced Hepatic Inflammation Markers
    • Reduced Liver Fibrosis
    • Reduced Hepatic Stellate Cell Activation

    • Low evidence

  • Alginate-Based Microencapsulation of Saccharomyces Boulardii for Enhanced In Vitro Stability in Poultry Sector: A Novel Strategy for Probiotic Delivery.

    • 2026-03
    • Veterinary medicine and science 12(2)
    • • Elahe Khademi
      • Fahimeh Nemati
      • Tohid Piri-Gharaghie

    • PubMed: 41840959
    • DOI: 10.1002/vms3.70841

    1 Insight on

    • Increased Antibacterial Activity Against Pathogens

    • Low evidence
    • Animal Study

  • Regulation effect of Lactobacillus johnsonii on chickens infected with Ascaridia galli.

    • 2026-03
    • RCT
    • Poultry science 105(3)
    • • Zhi-Hui Xu
      • Kai-Zhi Mo
      • Peng-Xi Cai
      • Jing-Yun Xu
      • Qian Han

    • PubMed: 41539233
    • DOI: 10.1016/j.psj.2026.106399

    8 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Intestinal Inflammation
    • Improved Growth Performance
    • Enhanced Digestive Enzyme Activity
    • Improved Total Antioxidant Status
    • Reduced Apoptosis
    • Reduced Parasite Larval Burden
    • No Sustained Protective Effect

    • Low evidence
    • Animal Study

  • Decreased risk of cardiovascular disease in dermatology patients taking niacinamide: A TriNetX cohort study.

    • 2026-03
    • Observational · n = 3,231
    • Journal of the American Academy of Dermatology 94(3)
    • • Yousef Salem
      • Mahnoor Liaqat
      • Nadeen Gonna
      • Dina Zamil
      • Ferris Abu-Ghosh
      • Anwar Merie
      • Dimitri Cassimatis
      • Ida Orengo

    • PubMed: 41177359
    • DOI: 10.1016/j.jaad.2025.10.115

    3 Insights on

    • Reduced Risk of ST Elevation Myocardial Infarction
    • Reduced Risk of Peripheral Vascular Disease
    • Reduced Cardiac Arrest Risk

    • High evidence

  • Genomic atlas of Bifidobacterium infantis and B. longum informs infant probiotic design.

    • 2026-03
    • Cell 189(6)
    • • Yan Shao
      • Shuyi Wang
      • Bonface M Gichuki
      • Mark D Stares
      • Timothy J Rozday
      • Nitin Kumar
      • Hilary P Browne
      • Nicholas J R Dawson
      • James M Njunge
      • Caroline Tigoi
      • Narshion Ngao
      • Mohammod Jobayer Chisti
      • Benson O Singa
      • Samuel Kariuki
      • Abdoulaye Hama Diallo
      • Ali Faisal Saleem
      • Syed Asad Ali
      • Ezekiel Mupere
      • Emmie Mbale
      • Kirkby D Tickell
      • Wieger P Voskuijl
      • Christina L Lancioni
      • Robert H J Bandsma
      • Tahmeed Ahmed
      • Judd L Walson
      • James A Berkley
      • Trevor D Lawley

    • PubMed: 41713418
    • DOI: 10.1016/j.cell.2026.01.007

    1 Insight on

    • Enhanced Disease Resistance

    • Moderate evidence
    • Rigorous Journal

  • Probiotic-derived extracellular vesicles attenuate cholestatic liver damage via gut-liver axis.

    • 2026-03
    • Pharmacological research 225
    • • Xianjiao Liu
      • Yanyan Wang
      • Andrea Abreo Medina
      • Dandan Liu
      • Jinyan Liu
      • Wenxuan Tang
      • Mengmeng Wang
      • Xingxiang Chen
      • Kehe Huang
      • Min Liu
      • Chunfeng Wang
      • Yunhuan Liu

    • PubMed: 41747917
    • DOI: 10.1016/j.phrs.2026.108152

    3 Insights on

    • Reduced Oxidative Stress
    • Improved Bile Acid Metabolism
    • Improved Gut Barrier Function

    • Low evidence
    • Animal Study

  • The impact of vitamin D supplementation on sudden sensorineural hearing loss in vitamin D deficient patients: A double-blind, placebo-controlled trial: A pilot study.

    • 2026-03
    • RCT
    • American journal of otolaryngology 47(2)
    • • Bahareh Tavakoli
      • Sohrab Rabiei

    • PubMed: 41570758
    • DOI: 10.1016/j.amjoto.2026.104793

    6 Insights on

    • Improved Pure-Tone Average
    • Improved Hearing
    • Improved Hearing Level
    • Improved Hearing at 6000 Hz
    • Improved Speech Reception Threshold
    • Improved Speech Discrimination Score

    • High evidence

  • Red panda intestinal organoids for the functional analysis of Lactobacillus salivarius.

    • 2026-03
    • iScience 29(3)
    • • Qiang Guo
      • Junjin Xie
      • Qian Zhou
      • Rong Hou
      • Xia Yan
      • Xu Li
      • Lin Li
      • Shuran Yu
      • Yubao Duan
      • Jielong Zhou
      • Wenping Zhang
      • Xiaoyan Su

    • PubMed: 41852748
    • DOI: 10.1016/j.isci.2026.114844

    3 Insights on

    • Reduced Intestinal Inflammation
    • Increased Mucin Secretion
    • Reduced Susceptibility to Bacterial Infection

    • Low evidence

  • Vaginal-Derived Potential Probiotics and Their Postbiotics Alleviate Aerobic Vaginitis via Suppressing TLR4/MyD88/NF-κB Signalling Pathway and Potentially Enhancing Vaginal Barrier.

    • 2026-03
    • Microbial biotechnology 19(3)
    • • Meiyun Tian
      • Xinyi Zhang
      • Xuan Xu
      • Xia He
      • Xiaoyun Wu
      • Jing Wei
      • Buzhen Tan
      • Tingtao Chen

    • PubMed: 41807990
    • DOI: 10.1111/1751-7915.70327

    4 Insights on

    • Reduced Proinflammatory Signaling
    • Improved Immune Balance
    • Reduced Vaginal Inflammation
    • Improved Vaginal Barrier Integrity

    • Low evidence
    • Animal Study

  • The Effect of Nigella sativa Supplementation on Cardiometabolic Health in Patients With Metabolic Diseases: A GRADE-Assessed Systematic Review and Meta-Analysis.

    • 2026-03
    • Meta-Analysis · n = 2,145
    • Endocrinology, diabetes & metabolism 9(2)
    • • Vali Musazadeh
      • Melika Jahangir
      • Mahsa Mahmoudinezhad
      • Amir Hossein Faghfouri
      • Farshad Teymoori
      • Ali Arash Anoushirvani
      • Mohsen Khaleghian

    • PubMed: 41858302
    • DOI: 10.1002/edm2.70207

    7 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Body Mass Index
    • Reduced Systolic Blood Pressure
    • Reduced Body Weight
    • Reduced Fasting Blood Glucose Levels
    • Reduced Fasting Blood Glucose
    • Reduced HbA1c Level

    • High evidence

  • Screening for Biotinidase deficiency in children with spinal cord demyelination.

    • 2026-03
    • Observational
    • Multiple sclerosis and related disorders 107
    • • Maha Mohammed
      • Iman El Agouza
      • Raghda Zaitoun
      • Khaled Ahmad
      • Shaimaa Mohammad
      • Ola Sallam
      • Hoda Tomoum

    • PubMed: 41483680
    • DOI: 10.1016/j.msard.2025.106946

    1 Insight on

    • Improved Neurobehavioral Function

    • Low evidence

  • N-Acetylcysteine is associated with changes in functional connectivity in patients with Parkinson's disease.

    • 2026-03
    • RCT
    • Parkinsonism & related disorders 144
    • • Daniel A Monti
      • George Zabrecky
      • Daniel Kremens
      • Tsao-Wei Liang
      • Nancy A Wintering
      • Faezeh Vedaei
      • Emily Navarreto
      • Monisha Gupta
      • Alicia Steinmetz
      • Anthony J Bazzan
      • Feroze Mohammed
      • Andrew B Newberg

    • PubMed: 41619526
    • DOI: 10.1016/j.parkreldis.2026.108216

    2 Insights on

    • Improved Parkinson's Disease Symptoms
    • Changed Functional Connectivity

    • High evidence

  • Neuroprotective effects of Bifidobacterium animalis HN019 and Lactobacillus acidophilus NCFM in MPTP-induced Parkinson's disease mice.

    • 2026-03
    • Brain, behavior, and immunity 133
    • • Chengjun Mo
      • Yiwei Qian
      • Yi Zhang
      • Xiaoqin He
      • Yiqiu Lai
      • Shaoqing Xu
      • Penghui Ai
      • Xiaodong Yang
      • Qin Xiao

    • PubMed: 41513011
    • DOI: 10.1016/j.bbi.2026.106257

    6 Insights on

    • Reduced Neuroinflammation
    • Reduced Alpha-Synuclein Accumulation
    • Increased Short-Chain Fatty Acid Production
    • Reduced Inflammation
    • Improved Motor Function
    • Improved Non-Motor Symptoms

    • Low evidence
    • Animal Study

  • Safety and Tolerability of Xanthohumol in Adults With Crohn's Disease: Results of a Triple-Masked, Randomized, Placebo-Controlled Phase 2 Trial.

    • 2026-03
    • RCT · n = 20
    • Molecular nutrition & food research 70(6)
    • • Ryan Bradley
      • Carina A Staab
      • Paige E Jamieson
      • Blake O Langley
      • Thomas O Metz
      • Jan F Stevens

    • PubMed: 41834265
    • DOI: 10.1002/mnfr.70438

    2 Insights on

    • Reduced Body Mass Index
    • Reduced Gamma-Glutamyl Transferase Levels

    • High evidence
    • Rigorous Journal

  • The unsaturated fatty acid of the cell membrane and the accumulation of intracellular glutamic acid as key determinants of freeze-drying tolerance in Bifidobacterium bifidum.

    • 2026-03
    • Food research international (Ottawa, Ont.) 228
    • • Shuyu Guo
      • Wenrui Zhou
      • Bingyong Mao
      • Xin Tang
      • Qiuxiang Zhang
      • Jianxin Zhao
      • Wei Chen
      • Shumao Cui

    • PubMed: 41703885
    • DOI: 10.1016/j.foodres.2026.118444

    1 Insight on

    • Improved Survival

    • Low evidence

  • Bifidobacterium animalis RH exopolysaccharide bidirectionally modulates inflammatory bone metabolism disorders.

    • 2026-03
    • International journal of biological macromolecules 349
    • • Shuyuan Shi
      • Zeqian Yang
      • Zixin Han
      • Boqing Yao
      • Pinglan Li
      • Nan Shang

    • PubMed: 41672177
    • DOI: 10.1016/j.ijbiomac.2026.150784

    3 Insights on

    • Reduced Proinflammatory Signaling
    • Reduced Osteoclast Activity
    • Improved Bone Metabolism

    • Low evidence
    • Animal Study

  • Whole genome sequence analysis of Bifidobacterium animalis subsp. lactis KL101 and comparative genomics with BB12.

    • 2026-03
    • Journal of animal science and technology 68(2)
    • • Kiyeop Kim
      • Junghee Lee
      • Seung-Ji Kang
      • Sejong Oh

    • PubMed: 41983001
    • DOI: 10.5187/jast.2024.e76

    3 Insights on

    • Improved Carbohydrate Metabolism
    • Improved Gut Health
    • Improved Gut Stress Resistance

    • Low evidence