November 2025 Supplement Research Papers

• November 1

  • Emerging prospects of Bacillus species in attaining the sustainable development goals.

    • 2025-11-01
    • Review
    • Applied microbiology and biotechnology 109(1)
    • • Harsh Kumar
      • Shivani Guleria
      • Kamil Kuča
      • Lukas Peter
      • Arifullah Mohammed
      • Tabarak Malik
      • Nidhi Sethi
      • Daljeet Singh Dhanjal
      • Dinesh Kumar
      • Hasnita Binti Che Harun

    • PubMed: 41175226
    • DOI: 10.1007/s00253-025-13634-8

    2 Insights on

    • Improved Gastrointestinal Health
    • Improved General Well-Being

    • Low evidence
• November 2

  • Probiotic Potential of Traditional and Emerging Microbial Strains in Functional Foods: From Characterization to Applications and Health Benefits.

    • 2025-11-02
    • Review
    • Microorganisms 13(11)
    • • Chijioke Christopher Uhegwu
      • Christian Kosisochukwu Anumudu

    • PubMed: 41304207
    • DOI: 10.3390/microorganisms13112521

    1 Insight on

    • Improved Gastrointestinal Symptoms

    • Low evidence
• November 3

  • Interim Effects of Zoledronate, Denosumab, or Teriparatide on Bone Microarchitecture in Type 2 Diabetes: A Pilot Trial.

    • 2025-11-03
    • RCT
    • The Journal of clinical endocrinology and metabolism 111(5)
    • • Trupti N Prasad
      • Rimesh Pal
      • Sanjay K Bhadada
      • Sant Ram
      • Veenu Singla
      • Seema Pulami

    • PubMed: 41183496
    • DOI: 10.1210/clinem/dgaf589

    3 Insights on

    • Improved Bone Mineral Density
    • Improved Total Volumetric Bone Mineral Density
    • Improved Trabecular Number

    • High evidence

  • Probiotics in Periodontal Diseases: Mechanisms, Evidence Mapping, Limitations, and Future Directions.

    • 2025-11-03
    • Review
    • Cureus 17(11)
    • • Hamza Alasbily
      • Huda H Mohamed
      • Adnan Asheibi
      • Manal S Bazina
      • Ali Alkaseh
      • Hana M Ghaith
      • Fardous Ali Fahmi

    • PubMed: 41356942
    • DOI: 10.7759/cureus.96042

    1 Insight on

    • Improved Periodontal Health

    • Low evidence

  • Comparative efficacy and safety of anti-osteoporotic therapies for kidney transplant recipients: a systematic review and network meta-analysis.

    • 2025-11-03
    • Systematic Review · n = 66
    • Frontiers in endocrinology 16
    • • Xiaopei Liu
      • Xingyao Li
      • Yanhong Zhao
      • Qi Gao
      • Yuan Xue
      • Zhongheng Wu
      • Xingmin Shi
      • Xili Wu

    • PubMed: 41255525
    • DOI: 10.3389/fendo.2025.1689233

    1 Insight on

    • Improved Bone Mineral Density

    • High evidence
• November 4

  • Levodopa Added to Stroke Rehabilitation: The ESTREL Randomized Clinical Trial.

    • 2025-11-04
    • RCT · n = 610
    • JAMA 334(17)
    • • Stefan T Engelter
      • Josefin E Kaufmann
      • Annaelle Zietz
      • Andreas R Luft
      • Alexandros Polymeris
      • Valerian L Altersberger
      • Karin Wiesner
      • Martina Wiegert
      • Jeremia P O Held
      • Yannik Rottenberger
      • Anne Schwarz
      • Friedrich Medlin
      • Ettore A Accolla
      • Sandrine Foucras
      • Georg Kägi
      • Gian Marco De Marchis
      • Svetlana Politz
      • Matthias Greulich
      • Alexander A Tarnutzer
      • Rolf Sturzenegger
      • Mira Katan
      • Urs Fischer
      • Krassen Nedeltchev
      • Janine Schär
      • Katrien Van Den Keybus Deglon
      • Pierre-André Rapin
      • Alexander Salerno
      • David J Seiffge
      • Elias Auer
      • Julian Lippert
      • Leo H Bonati
      • Corina Schuster-Amft
      • Szabina Gäumann
      • Joelle N Chabwine
      • Andrea Humm
      • J Carsten Möller
      • Raoul Schweinfurther
      • Bartosz Bujan
      • Piotr Jedrysiak
      • Peter S Sandor
      • Roman Gonzenbach
      • Veit Mylius
      • Dietmar Lutz
      • Carmen Lienert
      • Nils Peters
      • Patrik Michel
      • René M Müri
      • Sabine Schädelin
      • Lars G Hemkens
      • Gary A Ford
      • Philippe A Lyrer
      • Henrik Gensicke
      • Christopher Traenka

    • PubMed: 40982270
    • DOI: 10.1001/jama.2025.15185

    1 Insight on

    • Improved Motor Function

    • High evidence
    • Large Human Trial
    • Rigorous Journal

  • Comparative efficacy of different dietary interventions for cardiopulmonary fitness at high altitude: a systematic review and network meta-analysis.

    • 2025-11-04
    • Systematic Review · n = 329
    • Frontiers in nutrition 12
    • • Bin Wang
      • Yanle Xiong
      • Ning Lin
      • Jiaojiao Shi
      • Bo Zou
      • Xin Ma
      • Kaihong Zeng
      • Chao Kang

    • PubMed: 41262729
    • DOI: 10.3389/fnut.2025.1658950

    2 Insights on

    • Reduced Heart Rate
    • Reduced Hematocrit

    • High evidence

  • Survival and safety evaluation of Bifidobacterium longum subsp. longum ZS-8 in healthy adults, determined using PMAxx-qPCR and amplicon sequencing.

    • 2025-11-04
    • Clinical Trial
    • Microbiology spectrum 13(11)
    • • Feng Liu
      • Biao Dong
      • Zhongsun Wang
      • Dan Lin
      • Huan Xu
      • Baisheng Ke
      • Wanying Kang
      • Yang Jin
      • Xiuting Huang
      • Hui Lu
      • Liqing Zhao
      • Yun Qian
      • Liangling Cai
      • Long Xu
      • Zhenjiang Zech Xu

    • PubMed: 40981476
    • DOI: 10.1128/spectrum.02861-24

    3 Insights on

    • Maintained Gut Microbiota Diversity
    • Increased Abundance of Gut Bacteria
    • Confirmed Safety of Oral Probiotic Administration

    • Moderate evidence

  • Efficacy of N-Acetylcysteine in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and meta-analysis.

    • 2025-11-04
    • Meta-Analysis · n = 773
    • BMC gastroenterology 25(1)
    • • Ahmad Hormati
      • Asma Mousavi
      • Shayan Shojaei
      • Atie Moghtadaei
      • Sanaz Bordbar
      • Hediyeh Alemi
      • Amir Kasaeian
      • Sadaf Sepanlou

    • PubMed: 41188701
    • DOI: 10.1186/s12876-025-04382-0

    2 Insights on

    • Reduced Incidence of Post-ERCP Pancreatitis
    • Reduced Post-ERCP Pancreatitis Severity

    • High evidence
• November 5

  • Effects of a Scutellaria baicalensis/Crataegus laevigata, magnesium and chromium supplement on stressed individuals: A randomised, double-blind, placebo-controlled, crossover trial.

    • 2025-11-05
    • RCT
    • Journal of psychopharmacology (Oxford, England) 39(12)
    • • Fiona Dodd
      • Ramon Weishaupt
      • Philipp K M Katumba
      • Rian Elcoate
      • Emma Wightman

    • PubMed: 41194549
    • DOI: 10.1177/02698811251381261

    6 Insights on

    • Reduced Trait Anxiety
    • Reduced Subtraction Error
    • Increased Correct Serial 7s Subtraction
    • Reduced Mood Disturbance
    • Reduced Anger and Hostility
    • Improved Social Satisfaction

    • High evidence

  • Effects of Whey Protein Supplementation on Body Composition, Muscular Strength, and Cardiometabolic Health in Older Adults: A Systematic Review with Pairwise Meta-Analysis.

    • 2025-11-05
    • Review · n = 1,454
    • Healthcare (Basel, Switzerland) 13(21)
    • • Mousa Khalafi
      • Saeid Fatolahi
      • Reihaneh Jafari
      • Sara K Rosenkranz
      • Michael E Symonds
      • Zeinab Abbaszadeh Bidgoli
      • Maria Luz Fernandez
      • Farnaz Dinizadeh
      • Alexios Batrakoulis

    • PubMed: 41228181
    • DOI: 10.3390/healthcare13212814

    3 Insights on

    • Improved Lower-Body Muscular Strength
    • Increased Fasting Insulin Level
    • Increased Insulin Resistance Level

    • High evidence

  • Probiotic-enhanced chemotherapy: Lactobacillus fermentum synergizes with vincristine to induce apoptosis via dual pathway activation in human cancer cells.

    • 2025-11-05
    • Cancer cell international 25(1)
    • • Abbas Asoudeh-Fard
      • Mohadeseh Asoudeh-Fard
      • Asghar Parsaei

    • PubMed: 41194119
    • DOI: 10.1186/s12935-025-04032-1

    1 Insight on

    • Reduced Vincristine Dose Requirement

    • Low evidence

  • Comparative Evaluation of Functional Properties of Cow, Goat, and Donkey Milks Fermented with Lactic Acid Bacteria.

    • 2025-11-05
    • Antioxidants (Basel, Switzerland) 14(11)
    • • Giusy Rita Caponio
      • Alessandro Annunziato
      • Mirco Vacca
      • Mariasimona Cavaliere
      • Ilenia Ceglie
      • Marianna Ranieri
      • Alessio Di Luca
      • Angela Gabriella D'Alessandro
      • Grazia Tamma
      • Maria De Angelis

    • PubMed: 41300487
    • DOI: 10.3390/antiox14111331

    2 Insights on

    • Reduced Oxidative Stress
    • Improved Antioxidant Activity

    • Low evidence
• November 6

  • Bifidobacterium animalis subsp. lactis BB-12 attenuates diabetic retinopathy through gut microbiota modulation: evidence for the gut-retinal axis.

    • 2025-11-06
    • Frontiers in cellular and infection microbiology 15
    • • Jiayi Lin
      • Yaqi Cheng
      • Yumin Ling
      • Simin Gu
      • Haocheng Zhu
      • Meng Li
      • Huan Yu
      • Jianbing Li
      • Qian Luo
      • Weihua Li
      • Shiqi Ling

    • PubMed: 41278472
    • DOI: 10.3389/fcimb.2025.1681943

    9 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Body Weight
    • Improved Gut Microbiota Balance
    • Reduced Hepatic Steatosis
    • Improved Treg/Th-17 Balance
    • Improved Retinal Function
    • Improved Retinal Vascular Health
    • Improved Immune Balance
    • Improved Diabetic Retinopathy

    • Low evidence
    • Animal Study

  • Whole-Genome Sequence Analysis and Subtractive Screening of Lactobacilli in the Searching for New Probiotics to Protect the Mammary Glands.

    • 2025-11-06
    • International journal of molecular sciences 26(21)
    • • Dobroslava Bujňáková
      • Tímea Galambošiová
      • Lívia Karahutová

    • PubMed: 41226844
    • DOI: 10.3390/ijms262110809

    1 Insight on

    • Reduced Mastitis Risk

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Certain fermented dairy foods as a source of multibiotics and multimetabolites: a comprehensive review.

    • 2025-11-06
    • Review
    • Frontiers in nutrition 12
    • • Duygu Ağagündüz
      • Yasemin Ertaş Öztürk
      • Büşra Ayhan
      • Tuğçe Bulmuş-Tüccar
      • Çiler Özenir
      • Nazlıcan Erdoğan Gövez
      • Yesim Ozogul
      • Tuba Esatbeyoglu
      • Fatih Ozogul

    • PubMed: 41280398
    • DOI: 10.3389/fnut.2025.1678150

    5 Insights on

    • Improved Immune Function
    • Reduced Atopic Dermatitis Severity
    • Reduced Severity of Allergic Rhinitis Symptoms
    • No Improvement in Allergy Symptoms
    • Improved Allergic Symptoms

    • Low evidence

  • Proteomic study of Akkermansia muciniphila and Bifidobacterium species co-culture under different carbon sources.

    • 2025-11-06
    • Frontiers in microbiology 16
    • • Jordy Evan Sulaiman
      • Yuewei Zhan
      • Shuchen Wang
      • Ka Lun Lai
      • James Ho Wa Li
      • Daniel Ye Yutong
      • Karl Wah Keung Tsim
      • Kenneth King Yip Cheng
      • Yong Lai
      • Henry Lam

    • PubMed: 41277960
    • DOI: 10.3389/fmicb.2025.1666747

    2 Insights on

    • Improved Intestinal Barrier Function
    • Increased Bifidobacterium Levels

    • Low evidence
• November 7

  • Effects of Moringa oleifera Lam. Supplementation on Cardiometabolic Outcomes: A Meta-Analysis of Randomized Controlled Trials with GRADE Assessment.

    • 2025-11-07
    • Meta-Analysis · n = 341
    • Nutrients 17(22)
    • • Diana Crișan
      • Laura Gavrilaș
      • Ramona Păltinean
      • Oleg Frumuzachi
      • Andrei Mocan
      • Gianina Crișan

    • PubMed: 41305552
    • DOI: 10.3390/nu17223501

    1 Insight on

    • Reduced Diastolic Blood Pressure

    • High evidence
    • Rigorous Journal
• November 8

  • Bioinformatic Analysis of Oxalate-Degrading Enzymes in Probiotics: A Systematic Genome-Scale and Structural Survey.

    • 2025-11-08
    • Review
    • Microorganisms 13(11)
    • • Shengda Du
      • Ke Sun
      • Bo Xiao
      • Zhihua Liu

    • PubMed: 41304238
    • DOI: 10.3390/microorganisms13112553

    2 Insights on

    • Reduced Kidney Stone Formation
    • Increased Oxalate-Degrading Activity

    • Low evidence
• November 10

  • Evaluation of the Impact of Probiotic Supplementation on Gingival Inflammation in Subjects Undergoing Orthodontic Treatment with Fixed Appliances or Clear Aligners: A Randomized, Single-Blind Pilot Study.

    • 2025-11-10
    • RCT
    • Dentistry journal 13(11)
    • • Jacopo Lanzetti
      • Serena Queirolo
      • Giulia Furini Evans
      • Umberto Gibello
      • Andrea Deregibus
      • Francesco Pera

    • PubMed: 41294507
    • DOI: 10.3390/dj13110526

    2 Insights on

    • Reduced Gingival Bleeding
    • Reduced Plaque Accumulation

    • High evidence

  • Progress and prospects of gut microbiota-targeted therapy for primary biliary cholangitis.

    • 2025-11-10
    • Review
    • Gut pathogens 17(1)
    • • Xuan Tang
      • Xin You

    • PubMed: 41214728
    • DOI: 10.1186/s13099-025-00753-w

    4 Insights on

    • Improved Liver Function
    • Remodeled Intestinal Microbiota
    • Reduced Symptoms
    • Symptom Alleviation

    • Low evidence

  • A phase II clinical trial of Bifidobacterium longum subsp. longum BL21 for preventing acute radiation enteritis among pelvic radiotherapy patients.

    • 2025-11-10
    • Clinical Trial · n = 52
    • Frontiers in nutrition 12
    • • Yinyin Yang
      • Xuhao Gu
      • Chang Liu
      • Li Zou
      • Liwei Xie
      • Yulong Liu
      • Peifeng Zhao
      • Ye Tian
      • Shang Cai

    • PubMed: 41293184
    • DOI: 10.3389/fnut.2025.1626169

    3 Insights on

    • Improved Gut Microbiota Diversity
    • Improved Treatment Safety
    • Reduced Acute Radiation Enteritis Severity

    • High evidence

  • The anti-allergic effect of Lactobacillus plantarum GUANKE on allergic rhinitis induced by either ragweed pollen or house dust mites in mice.

    • 2025-11-10
    • Frontiers in nutrition 12
    • • Pei Zhao
      • Bin Zhang
      • Lian S Zhao
      • Zhongli Yang
      • Ming D Li

    • PubMed: 41293187
    • DOI: 10.3389/fnut.2025.1678249

    3 Insights on

    • Reduced Severity of Allergic Rhinitis Symptoms
    • Improved Nasal Histopathology
    • Improved Nasal Mucosa Histology

    • Low evidence
• November 11

  • Dietary Glycerol Monolaurate Effect on Growth Performance, Intestinal Barrier Function, and Gut Microbiota in Weaned Piglets Challenged by Lipopolysaccharide.

    • 2025-11-11
    • RCT
    • Animals : an open access journal from MDPI 15(22)
    • • Huakai Wang
      • Ruiyu Ma
      • Renrong Qi
      • Zhen Liu
      • Yinghao Li
      • Xudong Wu
      • Chunfang Zhao
      • Qiugang Ma
      • Kai Zhan

    • PubMed: 41301971
    • DOI: 10.3390/ani15223263

    1 Insight on

    • Improved Gut Microbiota Composition

    • High evidence

  • Correlation of probiotic consumption with plaque index, salivary pH, and streptococcus mutans: A clinical experimental study.

    • 2025-11-11
    • Clinical Trial · n = 40
    • The Saudi dental journal 37(10-12)
    • • Rista Lewiyonah
      • Heriandi Sutadi
      • Eva Fauziah

    • PubMed: 41214230
    • DOI: 10.1007/s44445-025-00010-5

    3 Insights on

    • Reduced Plaque Index
    • Increased Salivary pH
    • No Significant Change in Streptococcus Mutans Quantification

    • High evidence

  • Nutritional and Supplemental Interventions for Prevention and Treatment of Oral Mucositis in Pediatric Oncology.

    • 2025-11-11
    • Systematic Review
    • Nutrients 17(22)
    • • Razvan Mihai Horhat
      • Alexandru Alexandru
      • Cristiana-Smaranda Ivan
      • Norberth-Istvan Varga
      • Madalina-Ianca Suba
      • Elena Ciurariu
      • Monica Susan
      • Razvan Susan
      • Adrian Cote

    • PubMed: 41305573
    • DOI: 10.3390/nu17223521

    4 Insights on

    • Reduced Abdominal Pain
    • Reduced Oral Mucositis Severity
    • Reduced Oral Mucositis Incidence
    • Reduced Oral Mucositis Duration

    • High evidence
    • Rigorous Journal
• November 12

  • Probiotics and Phytoantioxidants Target Coronary Endothelial Dysfunction in Irregular Sleep- and Obesity-Associated Cardiometabolic Syndrome.

    • 2025-11-12
    • Review
    • Life (Basel, Switzerland) 15(11)
    • • Chi-Nan Tseng
      • Yen Chu

    • PubMed: 41302164
    • DOI: 10.3390/life15111740

    3 Insights on

    • Improved Gut Microbiota Balance
    • Improved Vascular Endothelial Function
    • Reduced Vascular Damage

    • Low evidence

  • Cardioprotective Effect of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Is Mediated by Sarcolemmal but Not Mitochondrial ATP-Sensitive Potassium Channels in Rats with Systemic Inflammation.

    • 2025-11-12
    • International journal of molecular sciences 26(22)
    • • Yury Yu Borshchev
      • Inessa Yu Burovenko
      • Alena B Karaseva
      • Sarkis M Minasian
      • Alexey D Gordeev
      • Victor Yu Borshchev
      • Dmitry Yu Butko
      • Olga V Borshcheva
      • Alexander N Suvorov
      • Michael M Galagudza

    • PubMed: 41303419
    • DOI: 10.3390/ijms262210935

    3 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Restored Short-Chain Fatty Acid Levels
    • Reduced Myocardial Infarct Size

    • Low evidence
    • Rigorous Journal
    • Animal Study
• November 13

  • Lactic acid bacteria in the meat industry: flavor, function, and food safety.

    • 2025-11-13
    • Review
    • Frontiers in microbiology 16
    • • Bhagavathi Sundaram Sivamaruthi
      • Periyanaina Kesika
      • Safreena Barwin Syed Rafeek
      • Kasthuri Sivakumar
      • Shanmuga Priya Ramasamy
      • Chaiyavat Chaiaysut
      • Pranom Fukngoen
      • Karthikeyan Alagarsamy

    • PubMed: 41321821
    • DOI: 10.3389/fmicb.2025.1703213

    1 Insight on

    • Improved Lactose Digestion

    • Low evidence

  • The effect of postbiotics supplementation on obesity and metabolic health: a systematic review and meta-analysis of randomized control trials.

    • 2025-11-13
    • Meta-Analysis
    • Nutrition & metabolism 22(1)
    • • Shuwen Li
      • Mohammad Hassan Sohouli
      • Zeli Li

    • PubMed: 41233893
    • DOI: 10.1186/s12986-025-01037-5

    4 Insights on

    • Reduced Waist Circumference
    • Reduced Triglyceride Levels
    • Reduced Insulin Levels
    • Reduced Inflammation

    • High evidence
• November 14

  • Essential amino acid supplementation for pressure ulcers: pathophysiological rationale and results from a pilot study.

    • 2025-11-14
    • Clinical Trial
    • Amino acids 57(1)
    • • Maciej Świątkiewicz
      • Andrzej Lejczak
      • Piotr Foltyński
      • Paweł Grieb

    • PubMed: 41236568
    • DOI: 10.1007/s00726-025-03489-8

    1 Insight on

    • Reduced Pressure Ulcer Area

    • Moderate evidence
• November 15

  • Harnessing CRISPR-Cas9 for Lactobacillus improvement in silage production: current knowledge and future perspectives.

    • 2025-11-15
    • Review
    • Journal of animal science and biotechnology 16(1)
    • • Jing Ma
      • Jiao Zhang
      • Xusheng Guo

    • PubMed: 41239469
    • DOI: 10.1186/s40104-025-01282-x

    1 Insight on

    • No Improvement in Allergy Symptoms

    • Low evidence

  • Correction to "Lactobacillus rhamnosus LRa05 on glycemic control and gut microbiota in patients with type 2 diabetes".

    • 2025-11-15
    • World journal of diabetes 16(11)
    • • Lin Geng
      • Ting-Ting Sun
      • Wen-Bo Xia
      • Ying Qin
      • Di Huo
      • Guang-Jin Qu

    • PubMed: 41278440
    • DOI: 10.4239/wjd.v16.i11.114013

    1 Insight on

    • Improved Glycemia

    • Low evidence
• November 17

  • An Integrated Engineering Approach to Creating Health-Modulating Postbiotics.

    • 2025-11-17
    • Review
    • Molecular nutrition & food research 70(1)
    • • Michael Leonidas Chikindas
      • Diana E Roopchand
      • Santosh Kumar Tiwari
      • Liubov S Sichel
      • Mukund V Karwe
      • Nitin Nitin
      • Vitor Luis Fagundes
      • Igor V Popov
      • John R Tagg
      • Xuanxuan Lu
      • Svetoslav Dimitrov Todorov

    • PubMed: 41251175
    • DOI: 10.1002/mnfr.70326

    6 Insights on

    • Improved Skin Hydration
    • Improved Skin Barrier Function
    • Improved Skin Health
    • Improved Skin Elasticity
    • Improved Epidermal Moisturization
    • Reduced Wrinkle Severity

    • Moderate evidence
    • Rigorous Journal

  • Strain-specific qPCR assay to track the vaginal colonization of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain orally administered.

    • 2025-11-17
    • Clinical Trial
    • BMC microbiology 25(1)
    • • Amanda Vaccalluzzo
      • Alessandra Pino
      • Georgiana Bosco
      • Cinzia Caggia
      • Cinzia Lucia Randazzo

    • PubMed: 41249926
    • DOI: 10.1186/s12866-025-04470-x

    2 Insights on

    • Increased Vaginal Colonization
    • Detected Vaginal Colonization by Probiotic Strain

    • Moderate evidence

  • Lactobacilli-Derived Microbe-Associated Molecular Patterns (MAMPs) in Host Immune Modulation.

    • 2025-11-17
    • Review
    • Biomolecules 15(11)
    • • Salvatore Furnari
      • Ruben Ciantia
      • Adriana Garozzo
      • Pio Maria Furneri
      • Virginia Fuochi

    • PubMed: 41301527
    • DOI: 10.3390/biom15111609

    4 Insights on

    • Improved Immune Function
    • Modulated Immune Response
    • Reduced Inflammation
    • Improved Immune Modulation

    • Low evidence
• November 18

  • Probiotics Attenuate Food Allergy via Short-Chain Fatty Acids-Mediated Immune Modulation and Gut Barrier Restoration.

    • 2025-11-18
    • Foods (Basel, Switzerland) 14(22)
    • • Xue Feng
      • Liuying Li
      • Li Yan
      • Zhencong Yan
      • Zhoujin Xu
      • Yuting Fan
      • Philippe Madjirebaye
      • Xuli Wu

    • PubMed: 41300111
    • DOI: 10.3390/foods14223953

    5 Insights on

    • Improved Intestinal Barrier Function
    • Increased Short-Chain Fatty Acid Production
    • Increased Activation of Regulatory T Cells
    • Improved Gut Barrier Function
    • Reduced Food Allergy Symptoms

    • Low evidence

  • Koumiss (Fermented Mare's Milk) as a Functional Food: Bioactive Proteins, Peptides, and Future Perspectives.

    • 2025-11-18
    • Review
    • Foods (Basel, Switzerland) 14(22)
    • • Borhan Shokrollahi
      • Jae-Young Choi
      • Miyoung Won
      • Eun-Tae Kim
      • Seung-Eun Lee
      • Jun-Sang Ham

    • PubMed: 41300112
    • DOI: 10.3390/foods14223954

    3 Insights on

    • Improved Lipid Metabolism
    • Improved Gut Health
    • Improved Cardiac Function

    • Low evidence

  • Effects of supplementation with two probiotic strains (Lactobacillus helveticus and Bifidobacterium longum) on hormonal status, oxidative stress, and clinical symptoms in women with polycystic ovary syndrome: a randomized clinical trial.

    • 2025-11-18
    • RCT · n = 90
    • Nutrition journal 24(1)
    • • Mahsa Shirani
      • Mohammad Bagherniya
      • Omid Sadeghi
      • Hatav Ghasemi Tehrani
      • Mohammad Hadi Eskandari
      • Manoj Sharma
      • Gholamreza Askari

    • PubMed: 41254712
    • DOI: 10.1186/s12937-025-01240-3

    6 Insights on

    • Increased Antioxidant Enzyme Levels
    • Reduced C-Reactive Protein Levels
    • Increased Total Serum Antioxidant Capacity
    • Increased Sex Hormone-Binding Globulin Level
    • Reduced Free Androgen Index
    • Reduced Malondialdehyde Level

    • High evidence

  • Role of microbiota in the outcome of immune checkpoint inhibition therapy of cancer.

    • 2025-11-18
    • Review
    • Exploration of targeted anti-tumor therapy 6
    • • Ger T Rijkers
      • Yonah Langcauon
      • Pippe van Leersum
      • Lara Popović
      • Frans J van Overveld

    • PubMed: 41281468
    • DOI: 10.37349/etat.2025.1002348

    1 Insight on

    • Improved Response to Immune Checkpoint Inhibitor Therapy

    • Low evidence

  • Effects of olive leaf extract supplementation on systemic markers of tissue aging and remodeling in postmenopausal women: a randomized controlled trial with exploratory skin outcomes.

    • 2025-11-18
    • Clinical Trial
    • Frontiers in nutrition 12
    • • Anissa Lasfar
      • Sanne L M van Stratum
      • Maria Imperatrice
      • Colin A J van Kalkeren
      • Jean L J M Scheijen
      • Casper G Schalkwijk
      • Danique La Torre
      • Freddy J Troost

    • PubMed: 41340653
    • DOI: 10.3389/fnut.2025.1670194

    2 Insights on

    • Reduced Pore Number
    • Reduced Surface Skewness

    • High evidence

  • Effects of sour soup on silage fermentation performance and bacterial community of Broussonetia papyrifera.

    • 2025-11-18
    • BMC microbiology 25(1)
    • • Qiming Cheng
      • Meiling Hou
      • Maoya Li
      • Yao Lei
      • Jiachuhan Wang
      • Yulian Chen
      • Yinghao Liu
      • Dianpeng Liu
      • Xiaoqing Zhang
      • Haoran Yu

    • PubMed: 41254562
    • DOI: 10.1186/s12866-025-04410-9

    1 Insight on

    • Increased Betaine Content

    • Low evidence

  • Bifidobacterium infantis modulates intestinal microecology to inhibit the spread of antimicrobial resistance.

    • 2025-11-18
    • mSystems 10(11)
    • • Ziyun Li
      • Jiamin Hu
      • Yingmiao Pan
      • Yaxuan Xi
      • Lei Zhang

    • PubMed: 41171056
    • DOI: 10.1128/msystems.00728-25

    2 Insights on

    • No Reduction in Antibiotic-Resistant Organism Colonization
    • Improved Gut Microbiota Balance

    • Low evidence
    • Rigorous Journal

  • Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irritable Bowel Syndrome: A Double-Blind Randomized Placebo-Controlled Trial.

    • 2025-11-18
    • RCT
    • Journal of gastroenterology and hepatology 41(1)
    • • Uday C Ghoshal
      • B S Ramakrishna
      • Pravin M Rathi
      • Akash Shukla
      • Manas Kumar Panigrahi
      • Shubham Jain
      • Indraneel Saha
      • Karmabir Chakravartty
      • Madhuri Singh
      • Uzma Mustafa
      • Shikha Sahu
      • Ujjala Ghoshal
      • Sanjay Chandnani
      • Mahesh K Goenka
      • Monjori Mitra

    • PubMed: 41255078
    • DOI: 10.1111/jgh.70137

    6 Insights on

    • Reduced Incidence of Adverse Events
    • Improved Quality of Life
    • Improved Irritable Bowel Syndrome Symptoms
    • Reduced Symptom Severity
    • No Increase in Adverse Effects
    • No Change in Fecal Microbiota Overall

    • High evidence
• November 19

  • Dosage exploration of the effects of honey and its derivatives on cardiometabolic outcomes: an overview of systematic reviews and GRADE-assessed updated meta-analysis.

    • 2025-11-19
    • Meta-Analysis · n = 3,544
    • Nutrition & diabetes 15(1)
    • • Mostafa Norouzzadeh
      • Sanaz Barazandeh
      • Minoo Hasan Rashedi
      • Sanaz Jamshidi
      • Fatemeh Hatamifar
      • Zohreh Maghsoomi
      • Farshad Teymoori
      • Mojtaba Malek

    • PubMed: 41261111
    • DOI: 10.1038/s41387-025-00403-9

    12 Insights on

    • Reduced Inflammatory Markers
    • Increased Blood Glucose Levels
    • Improved Blood Lipid Profile
    • Improved Glycemia
    • Improved Liver Enzyme Activity
    • Reduced Hemoglobin A1C Level
    • Increased Systolic Blood Pressure
    • Increased Aspartate Transferase Level
    • Reduced Triglyceride Level
    • Increased C-Reactive Protein Level
    • Reduced Anthropometric Measure
    • Reduced Oxidative Stress Marker

    • High evidence
• November 20

  • Impact of Oral Administration of Lactobacillus reuteri LMG-P 27481 on Human Gut Microbiota Diversity and Function: A Pilot Study.

    • 2025-11-20
    • Clinical Trial · n = 10
    • Biomedicines 13(11)
    • • Veronica Ojetti
      • Carmine Petruzziello
      • Alessio Migneco
      • Marcello Candelli
      • Angela Saviano

    • PubMed: 41301930
    • DOI: 10.3390/biomedicines13112840

    2 Insights on

    • Improved Gastrointestinal Symptoms
    • Improved Gut Microbiome Function

    • Moderate evidence

  • Whole Blood Thiamine Levels in Extreme Anorexia Nervosa: A Pilot Study.

    • 2025-11-20
    • Observational · n = 24
    • European eating disorders review : the journal of the Eating Disorders Association 34(3)
    • • Dennis Gibson
      • Dan Blalock
      • Marina Foster
      • Philip S Mehler

    • PubMed: 41267213
    • DOI: 10.1002/erv.70059

    1 Insight on

    • Increased Thiamine Diphosphate Level

    • Low evidence

  • Probiotic modulation of central and peripheral sensitization in a migraine model via the gut-brain-trigeminal axis.

    • 2025-11-20
    • Scientific reports 15(1)
    • • Phichaya Suthivanich
      • Sirikorn Vongseenin
      • Vichaya Auvichayapat
      • Weera Supronsinchai
      • Somying Tumwasorn
      • Maneerat Chayanupatkul
      • Saknan Bongsebandhu-Phubhakdi

    • PubMed: 41266742
    • DOI: 10.1038/s41598-025-24928-2

    6 Insights on

    • Reduced Migraine Neural Hyperexcitability
    • Reduced Trigeminal Neuron Excitability
    • Reduced Peripheral Sensitization
    • Reduced Cortical Spreading Depression
    • Increased Neuronal Firing Threshold
    • Modulated Nociceptive Signaling

    • Low evidence
    • Rigorous Journal
    • Animal Study
• November 21

  • Effect of host and gut microbiota-altering interventions on sarcopenia or its defining parameters: a systematic review and meta-analysis of nutrition-based intervention studies.

    • 2025-11-21
    • Meta-Analysis · n = 4,842
    • Aging clinical and experimental research 38(1)
    • • Laurence Lapauw
      • Nadjia Amini
      • Emiel Switsers
      • Jolan Dupont
      • Laura Vercauteren
      • Muriel Derrien
      • Jeroen Raes
      • Evelien Gielen

    • PubMed: 41269489
    • DOI: 10.1007/s40520-025-03216-z

    2 Insights on

    • Improved Muscle Strength
    • Improved Gait Speed

    • High evidence

  • The gut-brain axis in Alzheimer's disease: how gut microbiota modulate microglial function.

    • 2025-11-21
    • Review
    • Frontiers in aging 6
    • • Huan Wang
      • Feifan Yang
      • Zhejianyi Gao
      • Zedong Cheng
      • Xicai Liang

    • PubMed: 41356558
    • DOI: 10.3389/fragi.2025.1704047

    1 Insight on

    • Improved Cognitive Function

    • Low evidence

  • Efficacy of fermented foods for the prevention and treatment of bacterial vaginosis and vulvovaginal candidiasis.

    • 2025-11-21
    • Systematic Review
    • Frontiers in nutrition 12
    • • Aslı Akpınar
      • Lidia Hanna Markiewicz
      • Hayriye Şebnem Harsa
      • Diana Paveljšek
      • Julieta Domínguez-Soberanes
      • Zeynep Agirbasli
      • Eleni Naziri
      • Mounaim Halim El Jalil
      • Gregory Bouchaud
      • Seppo Salminen
      • Isabelle Savary-Auzeloux
      • Christèle Humblot
      • Christophe Chassard
      • Smilja Pracer
      • Guy Vergères
      • Barçın Karakaş-Budak

    • PubMed: 41356810
    • DOI: 10.3389/fnut.2025.1658988

    1 Insight on

    • Improved Vaginal Health

    • High evidence
• November 22

  • Comparison of Impacts of Essential Oils, Green Tea Powder, Betaine, Probiotics, and Other Dietary Supplements on Growth and Well-Being of Heat-Stressed White Pekin Ducks.

    • 2025-11-22
    • Clinical Trial
    • Animals : an open access journal from MDPI 15(23)
    • • Jill R Domel
      • Eric B Sobotik
      • Gabrielle M House
      • Gregory S Archer

    • PubMed: 41375441
    • DOI: 10.3390/ani15233382

    2 Insights on

    • Improved Intestinal Health
    • Reduced Stress Susceptibility

    • Moderate evidence
• November 23

  • Vitamin D3 Supplementation Modulates Inflammatory Protein CHI3L1/YKL-40 and Oxidative Stress Status in Multiple Sclerosis.

    • 2025-11-23
    • Clinical Trial · n = 35
    • Neuropsychopharmacology reports 45(4)
    • • Sevda Asadpour
      • Mehrdokht Mazdeh
      • Jamshid Karimi
      • Iraj Khodadadi
      • Gholamreza Shafiee

    • PubMed: 41277171
    • DOI: 10.1002/npr2.70076

    11 Insights on

    • Increased Antioxidant Enzyme Levels
    • Reduced Oxidative Stress
    • Increased Catalase Activity
    • Increased Glutathione Peroxidase Activity
    • Improved Total Antioxidant Capacity
    • Increased Total Serum Antioxidant Capacity
    • Reduced Malondialdehyde
    • Reduced Malondialdehyde Level
    • Increased 25-hydroxyvitamin D Level
    • Reduced CHI3L1 Level
    • Reduced Total Oxidative Stress

    • High evidence
• November 24

  • Serum CA19-9 and CEA levels, serum CAT, GSH, oxidised glutathione levels, 8-dihidro-2'-deoksiguanosina and F2-isoprostanes levels in colorectal cancer patients and Lactobacillus: A randomised double-blind controlled trial.

    • 2025-11-24
    • RCT · n = 76
    • Journal of medical biochemistry 44(7)
    • • Shiru Chen
      • Weili Ning
      • Jiye Zhang
      • Zhenting Wu
      • Hang Zhou
      • Ying Liu

    • PubMed: 41281285
    • DOI: 10.5937/jomb0-56528

    2 Insights on

    • Reduced Oxidative Stress
    • Reduced CEA Levels

    • High evidence

  • Thiamin supplementation on mitigating kidney injury and mortality in patients with septic shock: A systematic review and meta-analysis of randomized controlled trials.

    • 2025-11-24
    • Meta-Analysis · n = 438
    • Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 41(2)
    • • Guizuo Wang
      • Xu Liao
      • Yixing Liao
      • Dong Han

    • PubMed: 41277404
    • DOI: 10.1002/ncp.70073

    2 Insights on

    • Reduced In-hospital Mortality
    • Reduced Renal Replacement Therapy

    • High evidence

  • Impact of Probiotics on Atopic Dermatitis in Pediatric Patients: A Systematic Review and Meta-Analysis.

    • 2025-11-24
    • Meta-Analysis
    • Medicina (Kaunas, Lithuania) 61(12)
    • • Ritu Gaikwad
      • Soham Kondle
      • Sean Chang
      • Chris Barnes
      • Rohan Kubba
      • Christopher Lane
      • Snigdha Uppu
      • Eldo Frezza

    • PubMed: 41470092
    • DOI: 10.3390/medicina61122090

    5 Insights on

    • Improved Atopic Dermatitis Symptoms
    • Improved Atopic Dermatitis Severity
    • Reduced SCORAD Index
    • Reduced Atopic Dermatitis Severity
    • No Significant Change in IgE Levels

    • High evidence

  • Global transcriptional regulation by the CodY gene: identification of critical compounds that enhance oxidative stress resistance in Lactobacillus delbrueckii subsp. Bulgaricus.

    • 2025-11-24
    • BMC microbiology 25(1)
    • • Ting Wang
      • Jiaxin Dou
      • Xin Lin
      • Yankai Hu
      • Shuaiyan Lu
      • Lan Qin
      • Mei Wang
      • Zhenshang Xu
      • Zhaohui Liu

    • PubMed: 41286623
    • DOI: 10.1186/s12866-025-04478-3

    1 Insight on

    • Improved Oxidative Stress Resistance

    • Low evidence
• November 25

  • Comparative genomic and phenotypic analysis of potential beneficial properties of Bifidobacterium adolescentis.

    • 2025-11-25
    • mSphere 10(11)
    • • Mallory J Van Haute
      • Katherine Chacón-Vargas
      • Chloe M Christensen
      • Shara R P Yumul
      • Fatimah F Abdulaali
      • Andrew K Benson
      • Robert Hutkins
      • Thomas A Auchtung

    • PubMed: 41186414
    • DOI: 10.1128/msphere.00673-25

    4 Insights on

    • Improved Lactose Tolerance
    • Improved Metabolic Health
    • Improved Folate Levels
    • Improved Mood

    • Low evidence

  • Effects of Pediococcus acidilactici on growth, blood physiology, health and gene expression in red tilapia.

    • 2025-11-25
    • Clinical Trial · n = 180
    • AMB Express 15(1)
    • • Yousef Ahmed Alkhamis
      • Roshmon Thomas Mathew
      • Ahmed Saud Alsaqufi
      • Hesham Abdallah Hassanien
      • Abdallah Tageldein Mansour
      • Nagarajan Ganesan
      • Ehab El-Haroun
      • Layla A Almutairi
      • Sultan Mohammed Areshi
      • Zulhisyam Abdul Kari
      • El-Sayed Hemdan Eissa
      • Moaheda E H Eissa

    • PubMed: 41288812
    • DOI: 10.1186/s13568-025-01954-x

    5 Insights on

    • Improved Immune Function
    • Improved Growth Performance
    • Enhanced Disease Resistance
    • Improved Body Composition
    • Improved Hematological Health

    • High evidence

  • Role of Probiotics in Enhancing Immune Function and Improving the Effectiveness of Treatments for Pancreatic Cancer.

    • 2025-11-25
    • Review
    • Microorganisms 13(12)
    • • Kawaljit Kaur

    • PubMed: 41471890
    • DOI: 10.3390/microorganisms13122687

    3 Insights on

    • Improved Immune Function
    • Reduced Tumor Risk
    • Improved Antitumor Response

    • Low evidence

  • Natural strategies to optimize estrogen levels in aging women: mini review.

    • 2025-11-25
    • Review
    • Frontiers in aging 6
    • • Olena Bolgova
      • Inna Shypilova
      • Volodymyr Mavrych

    • PubMed: 41377590
    • DOI: 10.3389/fragi.2025.1706117

    4 Insights on

    • Increased Bone Mineral Density
    • Reduced Hot Flash Intensity
    • Reduced Hot Flashes
    • Increased Estrogen Level

    • Low evidence

  • Comparative effects of traditional Thai abdominal massage versus prune consumption on constipation and quality of life in elderly women: A randomized controlled trial.

    • 2025-11-25
    • RCT · n = 35
    • Aging clinical and experimental research 37(1)
    • • Adeleh Assadollahzadeh
      • Ali Ravari
      • Zahra Assadollahi
      • Tayebeh Mirzaei

    • PubMed: 41288808
    • DOI: 10.1007/s40520-025-03227-w

    1 Insight on

    • Improved Quality of Life

    • High evidence

  • Temporal dynamics of the resistome in gilts raised in an organic operation in which semen used for artificial insemination is the primary source of antimicrobial exposure.

    • 2025-11-25
    • Observational
    • Scientific reports 15(1)
    • • Leonardo F C Brito
      • Gary C Althouse
      • Dipti W Pitta
      • Nagaraju Indugu
      • Marisol Parada Sarmiento
      • Nithiya Sri Balamurugan

    • PubMed: 41290836
    • DOI: 10.1038/s41598-025-25776-w

    1 Insight on

    • Unchanged Fecal Antibiotic Resistance

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • The Effect of Short-Term Rhodiola rosea Supplementation on Simulated Game Time, Perceived Fatigue, and Performance in Basketball Players.

    • 2025-11-25
    • RCT · n = 48
    • Nutrients 17(23)
    • • Jing Wang
      • Haotian Zhao
      • Longqi Yu
      • Kai Zhao
      • Wei Jiang
      • Shuning Liu
      • Jin Dai
      • Lina Xu
      • Peng Sun
      • Hezhang Yun
      • Chang Liu

    • PubMed: 41373984
    • DOI: 10.3390/nu17233694

    9 Insights on

    • Improved Total Antioxidant Capacity
    • Reduced Fatigue
    • Improved Superoxide Dismutase Level
    • Reduced Heart Rate
    • Improved Yo-Yo Test Performance
    • Improved VO2max
    • Improved Countermovement Jump
    • Improved Simulated Game Total Completion Time
    • Improved Run Time

    • High evidence
    • Rigorous Journal

  • Can vitamin D supplementation affect cardiometabolic factors in children and adolescence with overweight and obesity? A grade-assessed systematic review and meta-analysis of randomized controlled trials.

    • 2025-11-25
    • Meta-Analysis · n = 440
    • BMC pediatrics 25(1)
    • • Amir Hossein Faghfouri
      • Mahsa Mahmoudinezhad
      • Pedram Pam
      • Sanaz Barazandeh
      • Fatemeh Faramarzi
      • Yousef Mohammadpour
      • Vali Musazadeh
      • Shahsanam Gheibi

    • PubMed: 41291584
    • DOI: 10.1186/s12887-025-05795-2

    9 Insights on

    • Improved Insulin Sensitivity
    • Reduced Body Mass Index
    • Reduced Triglyceride Levels
    • Increased HDL Cholesterol Levels
    • Reduced LDL Cholesterol
    • Reduced Insulin Levels
    • Reduced Total Cholesterol
    • Reduced Fasting Blood Glucose
    • Reduced HOMA-IR

    • High evidence

  • Efficacy and safety of probiotic supplements on cognitive function: a systematic review and meta-analysis of randomized clinical trials.

    • 2025-11-25
    • Meta-Analysis · n = 390
    • BMC complementary medicine and therapies 25(1)
    • • Nancy Calzada-Gonzales
      • Ismael Moreno-Colina
      • Linn Chu-Fuentes
      • Daniel Andrade-Girón
      • Hugo E Tito-Chura
      • Carlos Quispe-Vicuña
      • Pedro I Torres-Balarezo
      • Anthony Bautista-Pariona
      • Joshuan J Barboza

    • PubMed: 41291638
    • DOI: 10.1186/s12906-025-05149-6

    3 Insights on

    • Improved Cognitive Function
    • No Change in Adverse Events
    • Adverse Events

    • High evidence
• November 26

  • Effects of Nutritional Supplements on Explosive Lower Limb Performance in Volleyball Players: A Systematic Review and Network Meta-Analysis.

    • 2025-11-26
    • Systematic Review · n = 35
    • Nutrients 17(23)
    • • Haoyu Du
      • Shuning Liu
      • Mu Li
      • Kai Zhao
      • Wei Jiang
      • Ting You
      • Zheng Wang
      • Dixin Zou
      • Jingdan Shu
      • Chang Liu

    • PubMed: 41373993
    • DOI: 10.3390/nu17233702

    2 Insights on

    • Improved Vertical Jump Height
    • Improved Lower Limb Peak Power

    • High evidence
    • Rigorous Journal

  • Effect of probiotics and synbiotics on antimicrobial resistance in frequent infections: a systematic review of clinical trials.

    • 2025-11-26
    • Systematic Review
    • Annals of medicine and surgery (2012) 88(1)
    • • Mahdi Mazandarani
      • Narges Lashkarbolouk
      • Hanieh-Sadat Ejtahed
      • Mostafa Qorbani

    • PubMed: 41497081
    • DOI: 10.1097/ms9.0000000000004383

    9 Insights on

    • Reduced Recurrence of Urinary Tract Infections
    • Reduced Risk of Antimicrobial Resistance
    • Improved Respiratory Infection Resistance
    • Improved Infection Protection
    • Modulated Gut Microbiome Composition
    • Reduced Nontransferable Antibiotic Resistance
    • Reduced Infection Recurrence
    • Improved Gastrointestinal Infection Outcomes
    • Improved Antibiotic Resistance Outcomes

    • High evidence
• November 27

  • Preparation and characterization of Lactobacillus rhamnosus, Lactobacillus casei, glycyrrhizin, vitamin-D3, and citric acid-loaded mucoadhesive pectin microparticles for the management of dental caries.

    • 2025-11-27
    • BMC pharmacology & toxicology 26(1)
    • • Sumita Mishra
      • Somnath Ghosh
      • Koushik Jana
      • Biplab Debnath
      • Sudhanshu Ranjan Rout
      • Vineet Kumar Rai
      • Rakesh Kumar Sahoo
      • Jitu Halder
      • Ritu Mahanty
      • Priyanka Dash
      • Chandan Das
      • Salim Manoharadas
      • Jameel Al-Tamimi
      • Muralidhar Tata
      • Neeta Mohanty
      • Biswakanth Kar
      • Goutam Ghosh
      • Goutam Rath

    • PubMed: 41310863
    • DOI: 10.1186/s40360-025-01010-1

    4 Insights on

    • Reduced Dental Caries
    • Increased Antioxidant Activity
    • Reduced Inflammation
    • Improved Oral Retention

    • Low evidence
• November 28

  • Gut microbial-derived indole-3-propionate improves cognitive function in Alzheimer's disease.

    • 2025-11-28
    • Science advances 11(48)
    • • Ling Li
      • Mengzhen Jia
      • Cong Yang
      • Yihang Zhao
      • Jun Hu
      • Yu Zhao
      • Xinyu Hu
      • Fangjie Ning
      • Chen Ding
      • Qingyuan Li
      • Jun Gong
      • Xiaoran Jia
      • Kun Xu
      • Yuhao Wang
      • Shuang Zhou
      • Lu Deng
      • Lin Shi
      • Xuhui Chen
      • Xuebo Liu
      • Zhigang Liu

    • PubMed: 41313780
    • DOI: 10.1126/sciadv.adw8410

    1 Insight on

    • Improved Cognitive Function

    • Low evidence

  • Habitual natto intake elevates serum MK-7 levels, enhances osteocalcin carboxylation, and supports bone density: a meta-analysis of Japanese evidence.

    • 2025-11-28
    • Systematic Review
    • Frontiers in nutrition 12
    • • Zhixiang Wen
      • Mengqi Zhen
      • Jing Wang
      • Agudamu Agudamu
      • Yang Zhang

    • PubMed: 41393956
    • DOI: 10.3389/fnut.2025.1713726

    1 Insight on

    • Increased Bone Mineral Density

    • High evidence

  • Histopathological effects of lactic acid bacteria enriched white soft cheese in testes of albino rats.

    • 2025-11-28
    • Scientific reports 15(1)
    • • Ruwaida Elhanbaly
      • Khaled H Salman
      • Fatma M Abdel-Maksoud
      • Fatma Abo Zakaib Ali

    • PubMed: 41309727
    • DOI: 10.1038/s41598-025-26073-2

    1 Insight on

    • Improved Reproductive Health

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Identification of immunomodulating properties of postbiotics from lactobacilli using the zebrafish (Danio rerio) model.

    • 2025-11-28
    • n = 330
    • BMC veterinary research 22(1)
    • • Chamilani Nikapitiya
      • Jayasinghage Nirmani Chathurangika Jayasinghe
      • Mawalle Kankanamge Hasitha Madhawa Dias
      • E H T Thulshan Jayathilaka
      • Shan Lakmal Edirisinghe
      • Cheol- Hee Kim
      • Marion Schiavone
      • Eric Leclercq
      • Emmanuelle Apper
      • Amélie Mugnier
      • Mahanama De Zoysa

    • PubMed: 41316341
    • DOI: 10.1186/s12917-025-05159-z

    2 Insights on

    • Preserved Gastrointestinal Histological Structure
    • Improved Antiviral Immune Response

    • Low evidence
    • Animal Study

  • Effects of bromelain supplementation on disease activity and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled study.

    • 2025-11-28
    • RCT
    • Scientific reports 15(1)
    • • Pedram Delgarm
      • Marjan Mokhtare
      • Nasser Ebrahimi Daryani
      • Jamile Abolghasemi
      • Seyedeh Tayebeh Rahideh

    • PubMed: 41315628
    • DOI: 10.1038/s41598-025-26975-1

    1 Insight on

    • Improved Quality of Life

    • High evidence
    • Rigorous Journal

  • Meta-analysis on the safety and efficacy of long-term garlic consumption as an adjunctive treatment for hypertension.

    • 2025-11-28
    • Systematic Review
    • Frontiers in nutrition 12
    • • Yiyue Tang
      • Yunzhen Lei
      • Ming Xu
      • Qingxian Tu
      • Xiaochun Mao
      • Nanqu Huang
      • Qianfeng Jiang

    • PubMed: 41393949
    • DOI: 10.3389/fnut.2025.1656809

    4 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Low-Density Lipoprotein Level
    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Systolic Blood Pressure

    • High evidence

  • Psychobiotics at the Frontiers of Neurodegenerative and Neuropsychiatric Research.

    • 2025-11-28
    • Review
    • Microorganisms 13(12)
    • • Guillermo Roberto Jiménez-Pareyón
      • José Melesio Cristóbal-Luna
      • Yuliana García-Martínez
      • Cynthia Garfias-Noguez
      • Morayma Ramírez-Damián
      • Edgar Torres-Maravilla
      • María Elena Sánchez-Pardo

    • PubMed: 41471921
    • DOI: 10.3390/microorganisms13122718

    6 Insights on

    • Reduced Neuroinflammation
    • Improved Mental Health
    • No Human Health Outcome Reported
    • Improved Gut-Brain Axis Homeostasis
    • Improved Neuropsychiatric Outcomes
    • Improved Gut-Brain Axis-Related Neuropsychiatric Health

    • Low evidence
• November 29

  • Role of Probiotics in Management of Depressive Symptoms and Cognitive Impairment in Patients With Depression: An Updated Analysis of Trials.

    • 2025-11-29
    • Meta-Analysis
    • Brain and behavior 15(12)
    • • Syed Ali Arsal
      • Aashish Kumar
      • Umer Iqbal
      • Shafin Bin Amin
      • Muhammad Aniq Amir
      • Muhammad Abrar Amir
      • Muhammad Ashir Shafique
      • Suhaib Ahmed
      • Laksh Kumar
      • Oluwatobiloba Israel Popoola
      • Inibehe Ime Okon

    • PubMed: 41319022
    • DOI: 10.1002/brb3.71108

    2 Insights on

    • Improved Cognitive Function
    • Reduced Depression Symptoms

    • High evidence

  • Role of vitamin C infusion in postoperative mechanically ventilated neonates with sepsis: a randomized controlled trial.

    • 2025-11-29
    • RCT
    • European journal of pediatrics 184(12)
    • • Asmaa Mahmoud Elmesiry
      • Mai Rabie Elsheikh
      • Khalid Mohamed Elshimy
      • Amany Mohamed Abotaleb

    • PubMed: 41315087
    • DOI: 10.1007/s00431-025-06625-4

    6 Insights on

    • Reduced Duration of Mechanical Ventilation
    • Reduced Respiratory Rate
    • Reduced Peak Inspiratory Pressure
    • Reduced Oxygen Requirement
    • Improved Oxygenation Index
    • Reduced Inotropic Support Requirement

    • High evidence

  • The Effect of Aronia melanocarpa (Chokeberry) on Body Weight and Fasting Blood Sugar: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

    • 2025-11-29
    • Meta-Analysis
    • Endocrinology, diabetes & metabolism 9(1)
    • • Negin Lohrasbi
      • Mahsa Elahikhah
      • Masoomeh Gholizadeh
      • Farhang Djafari
      • Nazgol Bahreini
      • Fatemeh Sheikhhossein
      • Gholamreza Askari
      • Mohammad Reza Amini

    • PubMed: 41317342
    • DOI: 10.1002/edm2.70139

    3 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Body Weight

    • High evidence

  • Dietary Supplement Strategies During Conditioning Training in Athletes: A Network Meta-Analysis of Peak and Mean Anaerobic Power, VO2max, and Endurance Performance.

    • 2025-11-29
    • Review
    • Food science & nutrition 13(12)
    • • Beiwang Deng
      • Haoran Li
      • Cheng Chen
      • Jiaxin He
      • Wenfeng Zhang
      • Hong Lin

    • PubMed: 41323837
    • DOI: 10.1002/fsn3.71243

    4 Insights on

    • Improved Endurance
    • Improved Anaerobic Power
    • Improved VO2max
    • Improved Peak Anaerobic Power

    • Low evidence

  • Effects of supplementation with Bifidobacterium animalis subsp. lactis CECT 8145-in live probiotic and heat-treated postbiotic form-on fecal metabolites, fecal microbiota, blood metabolites and systemic biomarkers of oxidative stress and inflammation, and white blood cell gene expression of adult cats.

    • 2025-11-29
    • RCT · n = 90
    • Journal of animal science 103
    • • Sergio Miranda de Souza Junior
      • Empar Chenoll
      • Adrian Howard-Varona
      • Araceli Lamelas
      • Juan F Martinez-Blanch
      • Gary M Davenport
      • Sophie Nixon
      • Fei He
      • Maria R C de Godoy

    • PubMed: 41117771
    • DOI: 10.1093/jas/skaf355

    5 Insights on

    • Change in Body Weight
    • Increased Abundance of Bifidobacterium animalis
    • No Change in Inflammation Markers
    • No Significant Change in Body Weight or Systemic Inflammation
    • No Change in Metabolic Health

    • Low evidence
    • Animal Study

  • The effect of Lactobacillus casei on postpartum depression: a randomized controlled trial.

    • 2025-11-29
    • RCT
    • BMC psychiatry 26(1)
    • • Derakhshan Abdollahpour
      • Aziz Homayouni-Rad
      • Roghaiyeh Nourizadeh
      • Sevil Hakimi
      • Esmat Mehrabi

    • PubMed: 41318456
    • DOI: 10.1186/s12888-025-07658-7

    1 Insight on

    • Reduced Depressive Symptoms Postpartum

    • High evidence
• November 30

  • Marine-Algal-Derived Postbiotics Modulating the Gut Microbiota-Adipose Tissue Axis in Obesity: A New Frontier.

    • 2025-11-30
    • Review
    • Nutrients 17(23)
    • • Edward Kurnia Setiawan Limijadi
      • Kevin Christian Tjandra
      • Happy Kurnia Permatasari
      • Piko Satria Augusta
      • Reggie Surya
      • Dante Saksono Harbuwono
      • Fahrul Nurkolis

    • PubMed: 41374064
    • DOI: 10.3390/nu17233774

    2 Insights on

    • Reduced Body Weight
    • Reduced Adverse Event

    • Moderate evidence
    • Rigorous Journal
• Undated – 16 supplement studies

  • Dual-functional probiotic hydrogel with puerarin integration for microbiota-neuroimmune regulation in antibiotic-free periodontitis therapy.

    • 2025-11
    • Bioactive materials 53
    • • Yi Wang
      • Yansheng Qu
      • Xiangmei Liu
      • Jin Huang
      • Congyang Mao
      • Chaofeng Wang
      • Shengli Zhu
      • Yufeng Zheng
      • Zhaoyang Li
      • Zhenduo Cui
      • Hui Jiang
      • Yang Lv
      • Jie Shen
      • Shuilin Wu

    • PubMed: 40688024
    • DOI: 10.1016/j.bioactmat.2025.07.004

    2 Insights on

    • Reduced Periodontal Inflammation
    • Improved Oral Microbial Balance

    • Low evidence

  • Emerging Nonthermal Technologies for the Production of Postbiotics.

    • 2025-11
    • Review
    • Comprehensive reviews in food science and food safety 24(6)
    • • Rohit Thirumdas
      • Priti Mudgil

    • PubMed: 41273201
    • DOI: 10.1111/1541-4337.70335

    3 Insights on

    • Improved Gastrointestinal Health
    • Improved Gut Health
    • Improved Metabolic Health

    • Low evidence

  • Psychiatric and cognitive outcomes of iron supplementation in non-anemic children, adolescents, and menstruating adults: A meta-analysis and systematic review.

    • 2025-11
    • Meta-Analysis · n = 1,408
    • Neuroscience and biobehavioral reviews 178
    • • Dimitri Fiani
      • Sana Chahine
      • Mira Zaboube
      • Marco Solmi
      • Jacquelyn M Powers
      • Chadi Calarge

    • PubMed: 40945632
    • DOI: 10.1016/j.neubiorev.2025.106372

    7 Insights on

    • Improved Cognitive Function
    • Improved Attention Span
    • Reduced Depression Symptoms
    • Reduced Anxiety
    • Reduced Fatigue
    • Improved Physical Well-being
    • Improved Short-term Memory

    • High evidence

  • The effects of whole foods and dietary patterns on flow-mediated dilation: a systematic review and meta-analysis of randomized controlled trials.

    • 2025-11
    • Meta-Analysis
    • The American journal of clinical nutrition 122(5)
    • • Nina M Trinquet
      • Nicole J Kellow
      • Rafika Eviana
      • Gary Williamson
      • Aimee L Dordevic

    • PubMed: 40972869
    • DOI: 10.1016/j.ajcnut.2025.09.020

    1 Insight on

    • Improved Flow-Mediated Dilation

    • High evidence

  • Herbal Medicine for Treating Herpes Labialis: A Systematic Review.

    • 2025-11
    • Systematic Review · n = 250
    • Journal of integrative and complementary medicine 31(11)
    • • Melanie Anheyer
      • Holger Cramer
      • Thomas Ostermann
      • Alfred Längler
      • Dennis Anheyer

    • PubMed: 40526027
    • DOI: 10.1089/jicm.2025.0131

    2 Insights on

    • Reduced Time to Lesion Encrustation
    • Reduced Healing Time

    • High evidence

  • Impact of ginger supplementation on obesity indices and Adipokine profiles in adults: A GRADE-based systematic review and dose-response meta-analysis of randomized controlled trials.

    • 2025-11
    • Meta-Analysis
    • Complementary therapies in medicine 94
    • • Shrin Rjabi
      • Seyed Sina Seyedhatami
      • Maede Makhtoomi
      • Mohammad Reza Ahmadi
      • Saeede Alimohamadi
      • Ehsan Aliabadi
      • Soroush Talakesh
      • Mehran Nouri
      • Behzad Zamani
      • Moein Askarpour

    • PubMed: 41101746
    • DOI: 10.1016/j.ctim.2025.103260

    6 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Body Weight
    • Reduced Uric Acid Levels
    • Reduced Body Fat Percentage
    • Increased Adiponectin Levels

    • High evidence

  • Acute effects of cocoa flavanols on cognitive control and response inhibition.

    • 2025-11
    • RCT
    • Nutrition (Burbank, Los Angeles County, Calif.) 139
    • • Ahmet Altinok
      • Monica Moruzzi
      • Elkan G Akyürek

    • PubMed: 40614481
    • DOI: 10.1016/j.nut.2025.112860

    8 Insights on

    • Improved Flanker Task Accuracy
    • Reduced Interference Score
    • Reduced Response Time on Flanker Task
    • Improved Simon Task Accuracy
    • Reduced Interference Score on Simon Task
    • Reduced Response Time
    • Reduced Commission Error
    • Reduced Omission Errors

    • High evidence

  • Gut Virome: What's the Role in Irritable Bowel Syndrome?

    • 2025-11
    • Review
    • Reviews in medical virology 35(6)
    • • Francesco Rettura
      • Christian Lambiase
      • Andrea Bottari
      • Fabio Filippini
      • Luca Giacomelli
      • Mauro Pistello
      • Massimo Bellini

    • PubMed: 41296916
    • DOI: 10.1002/rmv.70080

    1 Insight on

    • Improved Irritable Bowel Syndrome Symptoms

    • Low evidence

  • The Effects of Peppermint on Menstrual Disorders: A Systematic Review of Randomized Controlled Trials.

    • 2025-11
    • Review · n = 499
    • Iranian journal of nursing and midwifery research 30(6)
    • • Yegane Lagzian
      • Fariba Askari
      • Rahele Mehrabi

    • PubMed: 41311590
    • DOI: 10.4103/ijnmr.ijnmr_283_23

    3 Insights on

    • Improved Cognitive Function
    • Improved Gastrointestinal Symptoms
    • Reduced Pain Severity

    • High evidence

  • Probiotic secretomes attenuate inflammation and disrupted antioxidant status induced by polychlorinated biphenyls in human intestinal T84 epithelial cells.

    • 2025-11
    • Free radical biology & medicine 239
    • • Fang Lu
      • Chad W MacPherson
      • Michèle M Iskandar
      • Stan Kubow

    • PubMed: 40659225
    • DOI: 10.1016/j.freeradbiomed.2025.07.008

    2 Insights on

    • Reduced Intestinal Inflammation
    • Improved Total Antioxidant Status

    • Low evidence

  • Lactobacillus helveticus R0052 attenuates DSS-induced colitis via modulation of gut microbiota, intestinal metabolites and immunological profiles in a mouse model.

    • 2025-11
    • Microbial pathogenesis 208
    • • Xiangmin Dong
      • Shengyi Han
      • Hua Zha
      • Lanjuan Li

    • PubMed: 40849096
    • DOI: 10.1016/j.micpath.2025.108002

    3 Insights on

    • Reduced Colitis Symptoms
    • Reduced Intestinal Inflammation
    • Improved Gut Integrity

    • Low evidence
    • Animal Study

  • Probiotic supplementation attenuates dental pain and inhibits pain-induced cognitive impairment in male rats.

    • 2025-11
    • RCT · n = 8
    • Archives of oral biology 179
    • • Pegah Abazari-Bozhgani
      • Saeed Esmaeili-Mahani
      • Mehdi Abbasnejad
      • Maryam Raoof
      • Frank Lobbezoo

    • PubMed: 40902425
    • DOI: 10.1016/j.archoralbio.2025.106382

    2 Insights on

    • Improved Cognitive Function
    • Reduced Oral Pain

    • Low evidence
    • Animal Study

  • Examining the effect of L-theanine on sleep: a systematic review of dietary supplementation trials.

    • 2025-11
    • Systematic Review
    • Nutritional neuroscience 29(2)
    • • Jack Cotter
      • Charlotte E Caddick
      • Jessica L Harper
      • James K Ebajemito

    • PubMed: 41176609
    • DOI: 10.1080/1028415x.2025.2556925

    6 Insights on

    • Reduced Sleep Latency
    • Improved Sleep Satisfaction
    • Improved Sleep Efficiency
    • Improved Sleep Maintenance
    • Improved Refreshment on Waking
    • Improved Recovery on Waking

    • High evidence

  • Spirulina's impacts on cardiovascular health: Insights from a systematic meta-analysis of RCT.

    • 2025-11
    • Meta-Analysis
    • Complementary therapies in medicine 94
    • • Hamidreza Shiri
      • Ali Akbar Soleimani
      • Behnam Omidi Sarajar
      • Abdolkarim Talebi Taheri
      • Fataneh Esmaeili
      • Mohammad Hadi Nematollahi
      • Mahmood Alizadeh Sani

    • PubMed: 40953712
    • DOI: 10.1016/j.ctim.2025.103242

    8 Insights on

    • Improved Insulin Sensitivity
    • Reduced Body Mass Index
    • Reduced Body Weight
    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol
    • Reduced Fasting Blood Glucose Levels
    • Reduced Total Cholesterol
    • Increased High-Density Lipoprotein Cholesterol

    • High evidence

  • Pharmacological interventions in primary or secondary male anorgasmia: A systematic review.

    • 2025-11
    • Systematic Review · n = 234
    • Actas urologicas espanolas 49(9)
    • • M P Gómez-Bueno
      • A M Diaz-Hung
      • H A García-Perdomo

    • PubMed: 40939836
    • DOI: 10.1016/j.acuroe.2025.501835

    1 Insight on

    • Improved Sexual Function

    • High evidence

  • Genomic mechanisms underlying the adaptation of Anaerobutyricum species to the human host.

    • 2025-11
    • Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 135
    • • Chaoyang Gu
      • Dezhong Wang
      • Kai Han
      • Jiarui Li
      • Liang Chen
      • Qinghui Zhuang
      • Tingzhu Yao
      • HengKun Wei
      • Jinglin Yue
      • Mingxi Hua
      • Chen Chen

    • PubMed: 41109491
    • DOI: 10.1016/j.meegid.2025.105844

    1 Insight on

    • Not Reported

    • Low evidence