August 2025 Supplement Research Papers

• August 1

  • An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Controlled Trials Investigating the Effect of Curcumin Supplementation on Lipid Profiles.

    • 2025-08-01
    • Meta-Analysis
    • Nutrition reviews 83(8)
    • • Chanita Unhapipatpong
      • Narachai Julanon
      • Prapimporn Chattranukulchai Shantavasinkul
      • Nint Polruang
      • Pawin Numthavaj
      • Ammarin Thakkinstian

    • PubMed: 40044446
    • DOI: 10.1093/nutrit/nuaf012

    4 Insights on

    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol
    • Reduced Blood Cholesterol
    • Increased High-Density Lipoprotein Cholesterol

    • High evidence

  • Dose-related Effects of Calcium to Enhance the Effects of L-tryptophan on Gut Hormones and Energy Intake in Obesity.

    • 2025-08-01
    • RCT
    • The Journal of clinical endocrinology and metabolism 110(9)
    • • Javad Anjom-Shoae
      • Penelope C E Fitzgerald
      • Michael Horowitz
      • Jens J Holst
      • Jens F Rehfeld
      • Simon Veedfald
      • Christine Feinle-Bisset

    • PubMed: 39785828
    • DOI: 10.1210/clinem/dgaf008

    1 Insight on

    • Reduced Energy Intake

    • High evidence

  • The Effects of Prebiotic Dietary Fibers, Probiotics, and Synbiotics on Gut Permeability and Immunity: A Systematic Review.

    • 2025-08-01
    • Systematic Review · n = 1,502
    • Iranian journal of medical sciences 50(8)
    • • Leila Maghsoumi-Norouzabad
      • Alireza Bagherzadeh-Karimi
      • Shabnam Aliakbari Majd
      • Leila Hosseini
      • Fatemeh Shahi

    • PubMed: 40861839
    • DOI: 10.30476/ijms.2024.102363.3525

    10 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Intestinal Permeability
    • Improved Immune Function
    • Reduced Gut Inflammation
    • No Change in Inflammation Markers
    • Improved Intestinal Epithelial Permeability
    • Altered Microbial Composition
    • Unchanged Inflammatory Marker Levels
    • Reduced Inflammation Markers
    • Improved Gut Barrier Function

    • High evidence

  • Nephroprotective Effects of Silymarin: A Systematic Review and Meta-Analysis.

    • 2025-08-01
    • Meta-Analysis
    • Biochemistry. Biokhimiia 90(8)
    • • Negin Frounchi
      • Fariba Mahmoodpoor
      • Seyed Sina Zakavi
      • Kamala Eyvazova
      • Samira Yagubova
      • Mohammadreza Ardalan
      • Elham Ahmadian
      • Ilgiz Gareev
      • Ozal Beylerli
      • Sergey Roumiantsev

    • PubMed: 40886393
    • DOI: 10.1134/s0006297925600565

    1 Insight on

    • Reduced Serum Creatinine Levels

    • High evidence
• August 2

  • Effect of Multi-Species Probiotic Supplementation on Fecal Microbiota in Pre-Weaned Holstein Dairy Calves in California.

    • 2025-08-02
    • RCT · n = 30
    • Microorganisms 13(8)
    • • Yoonsuk Lee
      • Heidi A Rossow
      • Deniece R Williams
      • Sejin Cheong
      • Hedmon Okella
      • Logan Widmer
      • Emmanuel Okello

    • PubMed: 40871314
    • DOI: 10.3390/microorganisms13081810

    2 Insights on

    • Reduced Pathogen Association
    • Reduced Fecal Excretion of Pathogenic Bacteria

    • High evidence

  • Effectiveness of Pyridoxal-5'-Phosphate in PNPO Deficiency: A Systematic Review.

    • 2025-08-02
    • Systematic Review · n = 49
    • Journal of inherited metabolic disease 48(5)
    • • Nina N Stolwijk
      • Laura van Dussen
      • Niels D Reijnhout
      • Marion M M G Brands
      • Bregje Jaeger
      • Peter T Clayton
      • Carla E M Hollak
      • Annet M Bosch

    • PubMed: 40751583
    • DOI: 10.1002/jimd.70074

    1 Insight on

    • Improved Seizure Control

    • High evidence

  • Pomelo by-products: A bibliometric review on enhancing gut health and digestive function for metabolic regulation through advanced processing techniques.

    • 2025-08-02
    • Review
    • Current research in food science 11
    • • Thavaree Thilavech
      • Tanyawan Suantawee
      • Charoonsri Chusak
      • Sirichai Adisakwattana

    • PubMed: 40740478
    • DOI: 10.1016/j.crfs.2025.101150

    1 Insight on

    • Improved Gut Health

    • Low evidence
• August 5

  • Nature Nano-Barrier: HPMC/MD-Based Lactobacillus plantarum Pickering Emulsion to Extend Cherry Tomato Shelf Life.

    • 2025-08-05
    • Foods (Basel, Switzerland) 14(15)
    • • Youwei Yu
      • Tian Li
      • Shengwang Li
      • Silong Jia
      • Xinyu Yang
      • Yaxuan Cui
      • Hui Ma
      • Shuaishuai Yan
      • Shaoying Zhang

    • PubMed: 40807666
    • DOI: 10.3390/foods14152729

    1 Insight on

    • Reduced Microbial Contamination

    • Low evidence

  • Activity in an air-liquid interface lung infection model, feasibility of inhaled delivery, and stability of cell-free supernatants from Lacticaseibacillus rhamnosus against Pseudomonas aeruginosa pulmonary infections.

    • 2025-08-05
    • Frontiers in microbiology 16
    • • Anna Maria Piras
      • Marta Bianchi
      • Nicolò Della Bona
      • Brunella Grassiri
      • Esingül Kaya
      • Andrea Bertacca
      • Chiara Migone
      • Giuseppantonio Maisetta
      • Semih Esin
      • Giovanna Batoni

    • PubMed: 40838010
    • DOI: 10.3389/fmicb.2025.1630017

    5 Insights on

    • Reduced Pseudomonas aeruginosa-Induced Damage
    • Reduced Pseudomonas aeruginosa Lung Infection Burden
    • Maintained Antimicrobial Stability During Storage
    • Improved Deep Lung Delivery Feasibility
    • Preserved Anti-pseudomonal Activity

    • Low evidence

  • Effects of Vitamin C and/or E Supplementation on Glycemic Control and Cardiovascular Risk Factors in Type 2 Diabetes: A Systematic Review and Subgroup Meta-analysis.

    • 2025-08-05
    • Meta-Analysis · n = 1,425
    • Nutrition reviews 84(2)
    • • Jerónimo Aragón-Vela
      • Jesús R Huertas
      • Rafael A Casuso

    • PubMed: 41521729
    • DOI: 10.1093/nutrit/nuaf133

    2 Insights on

    • Reduced Systolic Blood Pressure
    • Increased HDL Cholesterol Levels

    • High evidence
• August 7

  • Effect of Plant-Based Proteins on Recovery from Resistance Exercise-Induced Muscle Damage in Healthy Young Adults-A Systematic Review.

    • 2025-08-07
    • Systematic Review
    • Nutrients 17(15)
    • • Karuppasamy Govindasamy
      • Koulla Parpa
      • Borko Katanic
      • Cain C T Clark
      • Masilamani Elayaraja
      • Ibnu Noufal Kambitta Valappil
      • Corina Dulceanu
      • Vlad Adrian Geantă
      • Gloria Alexandra Tolan
      • Hassane Zouhal

    • PubMed: 40806155
    • DOI: 10.3390/nu17152571

    2 Insights on

    • Reduced Muscle Damage Biomarker Level
    • Improved Subjective Recovery

    • High evidence
    • Rigorous Journal

  • Effects of protein supplementation on body composition, physiological adaptations, and performance during endurance training: a systematic review and meta-analysis.

    • 2025-08-07
    • Systematic Review · n = 146
    • Frontiers in nutrition 12
    • • Yang Xiao
      • ZhengWu Deng
      • Wei Sun
      • JiaYi Li
      • WeiFeng Gao

    • PubMed: 40851900
    • DOI: 10.3389/fnut.2025.1663860

    6 Insights on

    • Reduced Body Weight
    • Reduced Body Fat
    • Increased Lean Body Mass
    • Improved Anaerobic Capacity
    • Improved Time to Exhaustion
    • Improved Maximal Oxygen Uptake

    • High evidence
• August 8

  • How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study.

    • 2025-08-08
    • RCT
    • Journal of the International Society of Sports Nutrition 22(1)
    • • Joshua Dissemond
      • Tim Havers
      • Steffen Held
      • Stephan Geisler
      • Tihomir Kostov
      • Patrick Diel
      • Svea Türschmann
      • Maria K Parr
      • Eduard Isenmann

    • PubMed: 40781783
    • DOI: 10.1080/15502783.2025.2540408

    6 Insights on

    • Increased Muscle Mass
    • Reduced Body Fat Mass
    • Increased Fat-Free Mass
    • Improved Bench Press 1-RM Strength
    • Improved One Repetition Maximum Squat
    • Increased Muscle Thickness

    • High evidence
• August 9

  • Microbiome-mediated colonization resistance to carbapenem-resistant Klebsiella pneumoniae in ICU patients.

    • 2025-08-09
    • Observational
    • NPJ biofilms and microbiomes 11(1)
    • • Jing Yang
      • Yi Zhou
      • Aiping Du
      • Zhongwei Zhang
      • Bo Wang
      • Yongming Tian
      • Huan Liu
      • Lin Cai
      • Fang Pang
      • Yumei Li
      • Chunhua Du
      • Xijun Wu
      • Cong Yan
      • Wei Wu
      • Min Jiang
      • Ke Shen
      • Chi Zhang
      • Yu Feng
      • Yan Kang
      • Bairong Shen
      • Zhiyong Zong

    • PubMed: 40783567
    • DOI: 10.1038/s41522-025-00791-x

    2 Insights on

    • Improved Gut Microbial Persistence
    • Reduced CRKP Colonization

    • Low evidence
• August 11

  • Impact of probiotic supplementation on serum levels of brain-derived neurotrophic factor: GRADE-based dose-response meta-analysis.

    • 2025-08-11
    • Systematic Review · n = 2,372
    • BMC nutrition 11(1)
    • • Reza Hashemi
      • Mohammad M Hussein M Raouf
      • Tanya S Salih
      • Marzieh Feyzpour
      • Maryam Eskandarioun
      • Najmeh Nezamabadipour
      • Hossein Gandomkar

    • PubMed: 40790243
    • DOI: 10.1186/s40795-025-01152-9

    1 Insight on

    • Increased Serum BDNF Levels

    • High evidence
• August 13

  • Alternatives to antibiotics for sustainable livestock production in the context of the One Health approach: tackling a common foe.

    • 2025-08-13
    • Review
    • Frontiers in veterinary science 12
    • • Eveline M Ibeagha-Awemu
      • Faith A Omonijo
      • Laurie C Piché
      • Antony T Vincent

    • PubMed: 40881639
    • DOI: 10.3389/fvets.2025.1605215

    1 Insight on

    • Improved Growth Performance

    • Low evidence

  • Differential modulation of post-antibiotic colonization resistance to Clostridioides difficile by two probiotic Lactobacillus strains.

    • 2025-08-13
    • mBio 16(8)
    • • Matthew H Foley
      • Arthur S McMillan
      • Sarah O'Flaherty
      • Rajani Thanissery
      • Molly E Vanhoy
      • Mary Gracen Fuller
      • Rodolphe Barrangou
      • Casey M Theriot

    • PubMed: 40689613
    • DOI: 10.1128/mbio.01468-25

    2 Insights on

    • No Effect on Clostridioides difficile Colonization
    • Improved Colonization Resistance

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Bacteriophages, Antibiotics and Probiotics: Exploring the Microbial Battlefield of Colorectal Cancer.

    • 2025-08-13
    • Review
    • International journal of molecular sciences 26(16)
    • • Cristian Constantin Volovat
      • Mihai Andrei Cosovanu
      • Madalina-Raluca Ostafe
      • Iolanda Georgiana Augustin
      • Constantin Volovat
      • Bogdan Georgescu
      • Simona Ruxandra Volovat

    • PubMed: 40869155
    • DOI: 10.3390/ijms26167837

    1 Insight on

    • Reduced Severity of Allergic Rhinitis Symptoms

    • Moderate evidence
    • Rigorous Journal
• August 14

  • Molecular Mechanisms of Probiotic Action Against Gastrointestinal Cancers.

    • 2025-08-14
    • Review
    • International journal of molecular sciences 26(16)
    • • Christina Thoda
      • Maria Touraki

    • PubMed: 40869174
    • DOI: 10.3390/ijms26167857

    7 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Reduced Toxicity
    • Reduced Inflammation
    • Reduced Cancer Incidence
    • Reduced Cancer Progression
    • Reduced Gastrointestinal Cancer Risk

    • Moderate evidence
    • Rigorous Journal

  • Effects of Carnitine and Coenzyme Q10 on Sperm Quality and Pregnancy Rates in Men with Unexplained Infertility: A Systematic Review and Network Meta-Analysis.

    • 2025-08-14
    • Systematic Review
    • Reproductive sciences (Thousand Oaks, Calif.) 32(9)
    • • Changmin Niu
      • Xueyu Lu
      • Yue Xie
      • Yawen Yu
      • Yuxin Gao
      • Nuo Shen
      • Ying Zheng

    • PubMed: 40813743
    • DOI: 10.1007/s43032-025-01958-9

    2 Insights on

    • Improved Progressive Sperm Motility
    • Improved Sperm Quality

    • High evidence

  • Juice-Based Supplementation Strategies for Athletic Performance and Recovery: A Systematic Review.

    • 2025-08-14
    • Review
    • Sports (Basel, Switzerland) 13(8)
    • • Biljana Vitošević
      • Milica Filipović
      • Ljiljana Popović
      • Katarzyna Sterkowicz-Przybycień
      • Tijana Purenović-Ivanović

    • PubMed: 40863778
    • DOI: 10.3390/sports13080269

    2 Insights on

    • Reduced Inflammation
    • Reduced Muscle Soreness

    • Low evidence

  • A Single Key for Many Doors? Unlocking the Bio-chemical Potential of Lactobacillus bulgaricus Metabolic Postbiotic.

    • 2025-08-14
    • Probiotics and antimicrobial proteins 18(2)
    • • Seyed Sadeq Mousavi Ghahfarrokhi
      • Ehsan Khafipour
      • Shahram Mahmoudi
      • Angila Ataei-Pirkooh
      • Atefeh Kachooei
      • Arsalan Bateni Shalmani
      • Nasrin Samadi
      • Mohammad Reza Fazeli

    • PubMed: 40804510
    • DOI: 10.1007/s12602-025-10700-5

    2 Insights on

    • Increased Antioxidant Activity
    • No Antiviral Effect

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Amino Acid Metabolite Profiling for Predicting and Understanding the Metabolic Effects of Metabolic and Bariatric Surgery.

    • 2025-08-14
    • Review
    • Journal of metabolic and bariatric surgery 14(2)
    • • Hyeon-Seong Lee
      • Jaeyoung Kwon
      • Yeongkeun Kwon

    • PubMed: 40917202
    • DOI: 10.17476/jmbs.2025.14.2.124

    2 Insights on

    • Improved Glycemia
    • Induced Type 2 Diabetes Remission

    • Low evidence
• August 15

  • Strain specific effects of probiotic supplementation on serum amino acid profiles in Alzheimer's disease: a randomized, double blind, placebo controlled trial.

    • 2025-08-15
    • RCT · n = 60
    • Scientific reports 15(1)
    • • Nagham Jouni
      • Camellia Akhgarjand
      • Zahra Vahabi
      • Sakineh Shab-Bidar
      • Hala Khalifeh
      • Kurosh Djafarian

    • PubMed: 40817120
    • DOI: 10.1038/s41598-025-15355-4

    2 Insights on

    • Improved Amino Acid Profile
    • Increased Branched Chain Amino Acid Levels

    • High evidence
    • Rigorous Journal

  • Unraveling cassia oil's efficacy in alleviating winter-triggered mood disorders in Parkinson's disease patients via aromatherapy-mediated pathways.

    • 2025-08-15
    • RCT · n = 40
    • Explore (New York, N.Y.) 21(6)
    • • Qiang Zhang
      • Peilu Zhang
      • Dongwei Yan

    • PubMed: 40840152
    • DOI: 10.1016/j.explore.2025.103240

    4 Insights on

    • Reduced Depression Symptoms
    • Reduced Anxiety
    • Improved Sleep Quality
    • Reduced Fatigue

    • High evidence
• August 16

  • Structure-dependent degradation of milk oligosaccharides by newly isolated intestinal commensal bacterial strains from suckling piglets and rabbits.

    • 2025-08-16
    • n = 240
    • BMC microbiology 25(1)
    • • Mathilde Rumeau
      • Sead Chadi
      • Frederic Pepke
      • Martin Beaumont
      • Cláudia M Vicente
      • Agathe Juppeau
      • Céline Vandecasteele
      • Laurent Cauquil
      • Géraldine Pascal
      • Philippe Langella
      • Christelle Knudsen
      • Sylvie Combes
      • Rebeca Martín

    • PubMed: 40819039
    • DOI: 10.1186/s12866-025-04205-y

    2 Insights on

    • Enhanced Beneficial Metabolite Production
    • Improved Gut Microbiota Fermentation

    • Low evidence
    • Animal Study

  • High- vs. routine-dose vitamin D3 in severe lupus on pulse methylprednisolone: a randomized, double-blind, placebo-controlled clinical trial.

    • 2025-08-16
    • RCT · n = 20
    • Clinical rheumatology 44(10)
    • • Lisbeth A Aguila
      • Rosa M R Pereira
      • Luciana P Seguro
      • Michelle R Ugolini-Lopes
      • Lissiane K N Guedes
      • Lucas P Sales
      • Alan L Fernandes
      • Felipe M de Santana
      • Valéria F Caparbo
      • Liliam Takayama
      • Eduardo F Borba
      • Diogo S Domiciano

    • PubMed: 40818016
    • DOI: 10.1007/s10067-025-07633-3

    8 Insights on

    • Improved Disease Activity Index Score
    • Increased 25-hydroxyvitamin D Level
    • Reduced Systemic Lupus Erythematosus Disease Activity Index Score
    • Increased Complement C4 Level
    • Increased Complement C3 Level
    • Normalized Complement C3 Level
    • Normalized Complement C4 Level
    • Reduced Disease Activity Marker Level

    • High evidence
• August 18

  • Ketamine and other NMDA receptor antagonists for chronic pain.

    • 2025-08-18
    • Meta-Analysis · n = 2,309
    • The Cochrane database of systematic reviews 2025(8)
    • • Michael C Ferraro
      • Aidan G Cashin
      • Eric J Visser
      • Christina Abdel Shaheed
      • Michael A Wewege
      • Benedict M Wand
      • Sylvia M Gustin
      • Neil E O'Connell
      • James H McAuley

    • PubMed: 40819842
    • DOI: 10.1002/14651858.cd015373.pub2

    1 Insight on

    • Reduced Pain Intensity

    • High evidence

  • Mucuna pruriens Treatment for Parkinson Disease: A Systematic Review of Clinical Trials.

    • 2025-08-18
    • Review · n = 108
    • Parkinson's disease 2025
    • • Fatima Hammoud
      • Ali Ismail
      • Reem Zaher
      • Rania El Majzoub
      • Linda Abou-Abbas

    • PubMed: 40860042
    • DOI: 10.1155/padi/1319419

    3 Insights on

    • Improved Parkinson's Disease Motor Symptoms
    • Reduced Time to On Stage
    • Prolonged On Stage Duration

    • High evidence

  • The potential adding therapeutic effect of pentoxifylline and/or folic acid for chronic kidney disease patients: randomized controlled trial.

    • 2025-08-18
    • RCT · n = 80
    • BMC nephrology 26(1)
    • • Amira Reda Muhammad Galal
      • Nahla Mohamed Teama
      • Karema Abu-Elfotuha
      • Ahmed D Alatawi
      • Hanan Alshareef
      • Ahmed M E Hamdan
      • Ahmed Aljabri
      • Mohannad Alshibani
      • Zeinab AlKasaby Mahmoud Zalat

    • PubMed: 40826392
    • DOI: 10.1186/s12882-025-04399-3

    2 Insights on

    • Reduced Fatigue
    • Improved Renal Function

    • High evidence

  • Synbiotic yogurt with nanoparticle entrapped rice straw hemicellulose for immediate probiotic support and prebiotic delivery.

    • 2025-08-18
    • NPJ science of food 9(1)
    • • Shaymaa A Ismail
      • Bahgat Fayed
      • Hoda S El-Sayed
      • Hanan A A Taie
      • Amira A Hassan

    • PubMed: 40825779
    • DOI: 10.1038/s41538-025-00539-z

    2 Insights on

    • Enhanced Probiotic Growth
    • Improved Blood Lipid Profile

    • Low evidence

  • Preclinical and Limited Clinical Evidence for Spirulina in Ulcerative Colitis: A Systematic Review and Meta-analysis.

    • 2025-08-18
    • Review
    • Advanced pharmaceutical bulletin 15(4)
    • • Khadije Gorgi
      • Zahra Ghanbarzadegan
      • Amir Darkhosh
      • Sara Shojaei-Zarghani
      • Seyed Vahid Hosseini

    • PubMed: 41835058
    • DOI: 10.34172/apb.025.46031

    6 Insights on

    • Improved Quality of Life
    • Reduced Disease Activity
    • Reduced Oxidative Stress
    • Improved Sleep Disturbance
    • Reduced Stress Scores
    • Reduced Anemia

    • Low evidence
• August 19

  • Goat-derived Lactobacillus amylovorus improved floppy kid syndrome via regulating gut microflora.

    • 2025-08-19
    • Clinical Trial
    • BMC veterinary research 21(1)
    • • Cheng Cheng
      • Yan Zheng
      • Xin Wang
      • Jianping Tao
      • Darong Cheng

    • PubMed: 40830792
    • DOI: 10.1186/s12917-025-04967-7

    5 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Pathogen Growth
    • Improved Gut Microbiota Balance
    • Increased Microbial Diversity
    • Reduced Pathogenic Bacterial Abundance

    • Low evidence
    • Animal Study
• August 20

  • A systematic review of health promoting effects of consumption of whey-based fermented products on adults.

    • 2025-08-20
    • Systematic Review · n = 12
    • Frontiers in nutrition 12
    • • Taner Sar
      • Bojana Bogovic Matijasic
      • Bojana Danilovic
      • Amparo Gamero
      • Mónica Gandía
      • Gabriela Krausova
      • Cristina Martínez-Villaluenga
      • Elena Peñas
      • Erfan Bagherzadehsurbagh
      • Özge Cemali
      • Dushica Santa
      • Ibrahim Ender Künili
      • Harun Kesenkas
      • Christophe Chassard
      • Smilja Pracer
      • Guy Vergères
      • Burcu Gündüz Ergün

    • PubMed: 40909889
    • DOI: 10.3389/fnut.2025.1651365

    2 Insights on

    • Improved Gastrointestinal Health
    • Improved Immune Function

    • High evidence

  • Adding L-Carnitine and Selenium to Methimazole in Graves' Disease: A Prospective Randomized Trial on Thyroid Markers and Quality of Life.

    • 2025-08-20
    • RCT · n = 60
    • Nutrients 17(16)
    • • Mattia Rossi
      • Letizia Meomartino
      • Marco Zavattaro
      • Gloria Selvatico
      • Ruth Rossetto Giaccherino
      • Loredana Pagano

    • PubMed: 40871722
    • DOI: 10.3390/nu17162693

    8 Insights on

    • Reduced TRAb Level
    • Reduced Medication Requirement
    • Increased Spontaneous Remission Rate
    • Reduced Tremor
    • Reduced Irritability
    • Reduced Mood Lability
    • Reduced Heat Intolerance
    • Reduced Exertional Dyspnea

    • High evidence
    • Rigorous Journal
• August 21

  • Association of high consumption of soy products with the risk of cognitive impairment and major neurocognitive disorders: a systematic review and dose-response meta-analysis.

    • 2025-08-21
    • Systematic Review · n = 691
    • Frontiers in nutrition 12
    • • Jialin Yu
      • Hongmei Zeng

    • PubMed: 40917087
    • DOI: 10.3389/fnut.2025.1635844

    1 Insight on

    • Reduced Risk of Major Neurocognitive Disorder

    • High evidence

  • Efficacy of Lactobacillus spp. Interventions to Modulate Mood Symptoms: A Scoping Review of Clinical Trials.

    • 2025-08-21
    • Systematic Review
    • International journal of molecular sciences 26(16)
    • • Diego Fernández-Rodríguez
      • María Consuelo Bravo
      • Marcela Pizarro
      • Pablo Vergara-Barra
      • María José Hormazábal
      • Marcell Leonario-Rodriguez

    • PubMed: 40869419
    • DOI: 10.3390/ijms26168099

    6 Insights on

    • Reduced Inflammatory Markers
    • Reduced Depression Symptoms
    • Reduced Anxiety
    • Improved Sleep Quality
    • Improved Mood
    • Altered Neurobiological Markers

    • High evidence
    • Rigorous Journal

  • A Triple-blind randomized controlled trial on the effects of turmeric versus ginger on inflammatory biomarkers in patients with COVID-19.

    • 2025-08-21
    • RCT · n = 144
    • Scientific reports 15(1)
    • • Zahra Saleh
      • Mohammad Reza Asgari
      • Raheb Ghorbani
      • Hassan Babamohamadi

    • PubMed: 40841392
    • DOI: 10.1038/s41598-025-16092-4

    2 Insights on

    • Reduced C-Reactive Protein Levels
    • Reduced Erythrocyte Sedimentation Rate

    • High evidence
    • Large Human Trial
    • Rigorous Journal

  • Synergistic effects of Bifidobacterium longum subsp. infantis B8762 and milk-derived osteopontin on male reproductive health in mice.

    • 2025-08-21
    • Journal of the science of food and agriculture 105(15)
    • • Chunyan Zhao
      • Guangqi Gao
      • Tao Zhang
      • Na Li
      • Yue Zhao
      • Zerong Lu
      • Yong Zhang
      • Zhihong Sun

    • PubMed: 40841926
    • DOI: 10.1002/jsfa.70121

    1 Insight on

    • Improved Reproductive Health

    • Low evidence
• August 22

  • Effects of vitamins C and E supplementation combined with 12-week resistance training in older women with sarcopenia: A randomized, double-blind, placebo-controlled trial.

    • 2025-08-22
    • RCT
    • Medicine 104(34)
    • • Xu Liu
      • Bo Chen
      • Yutian Jin
      • Feiyan Zhong
      • Yunjuan Zhang
      • Yu Li
      • Yun Zhang
      • Runhong Cui
      • Bing Wu
      • Cui Li
      • Sheng Xu
      • Xiaohong Chen

    • PubMed: 40859523
    • DOI: 10.1097/md.0000000000043976

    15 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Increased Muscle Mass
    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Improved Physical Performance
    • Reduced Malondialdehyde
    • Increased Skeletal Muscle Mass
    • Increased Lean Mass
    • Increased Muscle Strength
    • Increased Handgrip Strength
    • Increased Knee Extension Strength
    • Increased Glutathione Level
    • Increased Glutathione Disulfide Ratio
    • Reduced Oxidized Glutathione Level

    • High evidence

  • A Review of Modulation of Gut Microbiota to Mitigate Gestational Diabetes: Implications for Maternal and Child Health.

    • 2025-08-22
    • Review
    • Medical science monitor : international medical journal of experimental and clinical research 31
    • • Olimpia Mora-Janiszewska
      • Kinga Bialic
      • Anna Faryniak
      • Dorota Darmochwał-Kolarz

    • PubMed: 40842120
    • DOI: 10.12659/msm.948897

    3 Insights on

    • Reduced Prevalence of Gestational Diabetes Mellitus
    • No Human Health Outcome Reported
    • Improved Maternal Metabolic Health

    • Low evidence

  • Unlocking Casein Bioactivity: Lactic Acid Bacteria and Molecular Strategies for Peptide Release.

    • 2025-08-22
    • Review
    • International journal of molecular sciences 26(17)
    • • Chenxi Huang
      • Lianghui Cheng

    • PubMed: 40943047
    • DOI: 10.3390/ijms26178119

    1 Insight on

    • Increased Bioactive β-Casein-Derived Peptide Release

    • Low evidence
    • Rigorous Journal
    • Animal Study
• August 23

  • Multi-Species Synbiotic Supplementation Enhances Gut Microbial Diversity, Increases Urolithin A and Butyrate Production, and Reduces Inflammation in Healthy Adults: A Randomized, Placebo-Controlled Trial.

    • 2025-08-23
    • RCT
    • Nutrients 17(17)
    • • Brooke A Napier
      • Jessica R Allegretti
      • Paul Feuerstadt
      • Colleen R Kelly
      • Nicholas W Van Hise
      • Ralf Jäger
      • Zain Kassam
      • Gregor Reid

    • PubMed: 40944126
    • DOI: 10.3390/nu17172734

    2 Insights on

    • Reduced Inflammation
    • Increased Butyrate Production

    • High evidence
    • Rigorous Journal
• August 25

  • Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review and network meta-analysis.

    • 2025-08-25
    • Systematic Review · n = 3,154
    • European journal of gastroenterology & hepatology 38(1)
    • • Theodore Rokkas
      • Konstantinos Ekmektzoglou
      • Evangelia Tsanou
      • Ludovica Bricca
      • Alexandra-Eleftheria Menni
      • Paraskevas Golfakis
      • Katerina Kotzampassi

    • PubMed: 40929652
    • DOI: 10.1097/meg.0000000000003062

    2 Insights on

    • Improved Quality of Life
    • Reduced Anxiety

    • High evidence

  • The resident gut microbiome modulates the effect of synbiotics on the immunogenicity after SARS-COV-2 vaccination in elderly and diabetes patients.

    • 2025-08-25
    • RCT · n = 369
    • NPJ biofilms and microbiomes 11(1)
    • • Lin Zhang
      • Shilan Wang
      • Martin C S Wong
      • Chris K P Mok
      • Jessica Y L Ching
      • Joyce W Y Mak
      • Chunke Chen
      • Bing Huo
      • Shuai Yan
      • Chun Pan Cheung
      • Emily O L Chiu
      • Emily Y T Fung
      • Pui Kuan Cheong
      • Francis K L Chan
      • Siew C Ng

    • PubMed: 40851072
    • DOI: 10.1038/s41522-025-00804-9

    1 Insight on

    • Improved Immune Response to Vaccination

    • High evidence
    • Large Human Trial

  • Does One Shot Work? The Acute Impact of a Single Taurine Dose on Exercise Performance: A Meta-Analytic Review.

    • 2025-08-25
    • Meta-Analysis · n = 308
    • Scandinavian journal of medicine & science in sports 35(9)
    • • Hengzhi Deng
      • Tianyu Song
      • Mingyue Yin
      • Kai Xu
      • Yuming Zhong
      • Ping Liu
      • Shengze Sun
      • Mohamed Nashrudin Bin Naharudin
      • Ashril Yusof
      • Xiaohan Fan

    • PubMed: 40852891
    • DOI: 10.1111/sms.70123

    6 Insights on

    • Improved Exercise Performance
    • Improved Anaerobic Capacity
    • Improved Aerobic Endurance Performance
    • Improved Strength and Power Performance
    • Improved Agility and Coordination Performance
    • Improved Muscular Endurance

    • High evidence

  • Diet-Controlled Whey Protein Supplementation: Mitigating Serum Creatine Kinase Levels After Continuous Resistance Exercise.

    • 2025-08-25
    • RCT
    • Journal of the American Nutrition Association 45(2)
    • • Chae-Been Kim
      • Dohyun Ahn
      • Ji-Been Kim
      • Hyoung-Su Park
      • Hye-Jin Kim
      • Jung-Jun Park

    • PubMed: 40854076
    • DOI: 10.1080/27697061.2025.2548514

    1 Insight on

    • Reduced Creatine Kinase Activity

    • High evidence

  • Effects of Lactic Acid Bacteria Inoculants on Fermentation Quality, Bacteria Communities and Antibiotic Resistance Genes in Whole-Crop Corn Silage.

    • 2025-08-25
    • Microorganisms 13(9)
    • • Dandan Chen
      • Dan Yang
      • Tianxin Guo
      • Qing Zhang

    • PubMed: 41011310
    • DOI: 10.3390/microorganisms13091977

    1 Insight on

    • Increased Abundance of Antibiotic Resistance Genes

    • Low evidence
• August 26

  • The Role of Gut Microbiota in the Modulation of Pulmonary Immune Response to Viral Infection Through the Gut-Lung Axis.

    • 2025-08-26
    • Review · n = 19
    • Journal of inflammation research 18
    • • Na Chen
      • Lianke Li
      • Yanhua Han
      • Zhu Chen

    • PubMed: 40901024
    • DOI: 10.2147/jir.s525880

    2 Insights on

    • Improved Respiratory Infection Resistance
    • Reduced Infection Severity

    • Low evidence

  • The mechanism of probiotics in pregnancy outcomes in overweight or obese pregnant women based on meta-analysis, network pharmacology and molecular docking.

    • 2025-08-26
    • Meta-Analysis · n = 1,563
    • BMC pregnancy and childbirth 25(1)
    • • Ting Zhong
      • Jihan Sun
      • Miao Miao
      • Guiju Sun

    • PubMed: 40859213
    • DOI: 10.1186/s12884-025-07999-x

    2 Insights on

    • Reduced Risk of Small-for-Gestational-Age Birth
    • No Improvement in Adverse Pregnancy Outcomes

    • High evidence

  • Modulators of urinary pH in the context of urinary stone disease: a literature review.

    • 2025-08-26
    • Review · n = 86
    • Translational andrology and urology 14(8)
    • • Carter Chan
      • Wilson Sui
      • Matthew C Breeggemann
      • Marshall Stoller

    • PubMed: 40949433
    • DOI: 10.21037/tau-2025-275

    1 Insight on

    • Decreased Urinary pH

    • Moderate evidence

  • Probiotics: a supplement to the gluten-free diet in celiac disease.

    • 2025-08-26
    • Review
    • Gastroenterology and hepatology from bed to bench 18(3)
    • • Hasna Ait Said
      • Lahcen Elmoumou
      • Bouchra Rherissi
      • Nadia El Kadmiri

    • PubMed: 41116854
    • DOI: 10.22037/ghfbb.v18i3.3145

    1 Insight on

    • Improved Gastrointestinal Symptom Management

    • Low evidence

  • The Effect of Curcumin on Postmenopausal Symptoms: A Systematic Review Based on Randomized Controlled Trials.

    • 2025-08-26
    • Systematic Review
    • International journal of molecular sciences 26(17)
    • • Buket Akyakar
      • İrem Nur Şahin
      • Duygu Ağagündüz
      • Dávid Szép
      • Ferenc Budán

    • PubMed: 40943181
    • DOI: 10.3390/ijms26178260

    10 Insights on

    • Reduced Fasting Blood Glucose Levels
    • Increased Estradiol Level
    • Reduced Fasting Insulin Level
    • Reduced HOMA-IR
    • Improved Sexual Function
    • Improved Physical Function
    • Reduced Vasomotor Symptom
    • Improved Bone Density Marker
    • Improved Psychological Function
    • Improved Lipid Parameter

    • High evidence
    • Rigorous Journal

  • Sennosides vs magnesium hydroxide vs polyethylene glycol as a treatment for constipation in anorectal malformation: a randomized crossover trial.

    • 2025-08-26
    • RCT
    • Pediatric surgery international 41(1)
    • • Butsarin Nate-Anong
      • Jiraporn Khorana
      • Sireekarn Chantakhow
      • Jesda Singhavejsakul
      • Kanokkan Tepmalai

    • PubMed: 40856829
    • DOI: 10.1007/s00383-025-06174-9

    3 Insights on

    • Reduced Fecal Loading
    • Achieved Clean Fecal Loading
    • Improved User Preference

    • High evidence

  • Clinical and microbiological effectiveness of limosilactobacillus reuteri in supportive periodontal therapy: randomized clinical trial.

    • 2025-08-26
    • RCT
    • Clinical oral investigations 29(9)
    • • Magda Mensi
      • Eleonora Scotti
      • Silvia Marchetti
      • Annamaria Sordillo
      • Gianluca Garzetti
      • Stefano Calza
      • Mark J Buijs
      • Egija Zaura
      • Bernd W Brandt

    • PubMed: 40856866
    • DOI: 10.1007/s00784-025-06508-w

    6 Insights on

    • Reduced Probing Pocket Depth
    • Reduced Bleeding on Probing (BOP)
    • Reduced Periodontal Pocket Depth ≥6 mm
    • Reduced Clinical Attachment Loss
    • Reduced Red Complex Bacteria Count
    • Reduced Subgingival Microbial Dysbiosis Index

    • High evidence
• August 27

  • Changes in Quality of Life Among Glaucoma Patients Following Six Months of Niacinamide Supplementation.

    • 2025-08-27
    • Clinical Trial
    • Nutrients 17(17)
    • • Constantin Alin Nicola
      • Maria Cristina Marinescu
      • Anne Marie Firan
      • Georgica Tartea
      • Mihaela Simona Naidin
      • Radu Constantin Ciuluvica
      • Marina Daniela Dimulescu
      • Nicoleta Mirela Voicu
      • Carmen Marinela Mihailescu
      • Andreea-Daniela Meca
      • Maria Bogdan
      • Adina Turcu-Stiolica

    • PubMed: 40944166
    • DOI: 10.3390/nu17172775

    5 Insights on

    • Improved Quality of Life
    • Improved Vision
    • Improved Peripheral Vision
    • Improved Dark Adaptation
    • Reduced Intraocular Pressure

    • High evidence
    • Rigorous Journal

  • Can Rhodiola rosea supplementation mitigate digital eye strain? A triple-blinded placebo-controlled study.

    • 2025-08-27
    • RCT
    • Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) 45(7)
    • • Paula M Lara
      • Jesús Vera
      • Daniel Marcos-Frutos
      • Carlos Alix-Fages
      • Pablo Jiménez-Martínez
      • Amador García-Ramos
      • Beatriz Redondo

    • PubMed: 40873122
    • DOI: 10.1111/opo.70005

    4 Insights on

    • Reduced Blurred Vision
    • Reduced Accommodation Variability
    • Reduced Lag of Accommodation
    • Reduced Digital Eye Strain Symptoms

    • High evidence

  • The efficacy of oral L-arginine therapy for the treatment of vaso-occlusive pain episodes in children with sickle cell disease.

    • 2025-08-27
    • RCT · n = 20
    • Pediatric hematology and oncology 42(6-7)
    • • Aya Mohamed Abd Elglil
      • Mohamed Ramadan El-Shanshory
      • Hamed Mohamed Elsharkawy
      • Walaa Arafa Keshk
      • Nahed M Hablas
      • Lamia M Morad

    • PubMed: 40862485
    • DOI: 10.1080/08880018.2025.2549365

    6 Insights on

    • Reduced Length of Hospital Stay
    • Reduced Pain
    • Reduced Analgesic Use
    • Reduced Time to Crisis Resolution
    • Reduced Tricuspid Regurgitation
    • Increased Arginine/ADMA Ratio

    • High evidence

  • The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.

    • 2025-08-27
    • RCT · n = 30
    • Nutrients 17(17)
    • • Shuqi Li
      • Clarinda Nataria Sutanto
      • Xuejuan Xia
      • Jung Eun Kim

    • PubMed: 40944161
    • DOI: 10.3390/nu17172773

    2 Insights on

    • Improved Cognitive Function
    • Reduced Depression Symptoms

    • High evidence
    • Rigorous Journal

  • The effects of L-carnitine in children with kidney failure undergoing dialysis: a systematic review.

    • 2025-08-27
    • Review · n = 194
    • Pediatric nephrology (Berlin, Germany) 41(3)
    • • Jingjing Chen
      • Yannan Guo
      • Liang Huang
      • Linan Zeng
      • Guo Cheng
      • Limei Zhao
      • Lingli Zhang

    • PubMed: 40864195
    • DOI: 10.1007/s00467-025-06929-5

    2 Insights on

    • Reduced Apolipoprotein B Levels
    • Improved Cardiac Function

    • High evidence

  • Dietary factors and colorectal cancer risk in Asian populations: a systematic review and meta-analysis of cohort studies.

    • 2025-08-27
    • Meta-Analysis
    • Cancer causes & control : CCC 36(12)
    • • Hyobin Lee
      • Linda Ngoun
      • Sukhong Min
      • Jialei Fu
      • Woo-Kyoung Shin
      • Daehee Kang
      • Sangah Shin

    • PubMed: 40866745
    • DOI: 10.1007/s10552-025-02053-9

    1 Insight on

    • Reduced Risk of Colorectal Cancer

    • High evidence
• August 28

  • Effects of spirulina (Arthrospira) platensis supplementation on inflammation, physical and mental quality of life, and anthropometric measures in patients with relapsing-remitting multiple sclerosis (RRMS): a triple-blinded, randomized, placebo-controlled trial.

    • 2025-08-28
    • RCT · n = 80
    • Nutrition journal 24(1)
    • • Sheno Karimi
      • Vahid Shaygannejad
      • Adel Mohammadalipour
      • Awat Feizi
      • Sahar Hooshmand
      • Marzieh Kafeshani

    • PubMed: 40877830
    • DOI: 10.1186/s12937-025-01200-x

    19 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Interleukin-6 Levels
    • Improved Quality of Life
    • Reduced Body Weight
    • Improved Cognitive Function
    • Reduced Waist-to-Hip Ratio
    • Improved Social Functioning
    • Improved Mental Health
    • Increased Energy Levels
    • Reduced Energy Intake
    • Improved Emotional Well-being
    • Increased Physical Activity
    • Improved Sexual Function
    • Improved Health Perception
    • Improved Physical Function
    • Improved Physical Role Limitation
    • Reduced Health Distress
    • Improved Sexual Satisfaction

    • High evidence

  • Medicinal Plants for Child Mental Health: Clinical Insights, Active Compounds, and Perspectives for Rational Use.

    • 2025-08-28
    • Review
    • Children (Basel, Switzerland) 12(9)
    • • Giovanna Rigillo
      • Joan M C Blom
      • Arianna Cocchi
      • Valentina Martinucci
      • Francesca Favaro
      • Giulia Baini
      • Giorgio Cappellucci
      • Fabio Tascedda
      • Marco Biagi

    • PubMed: 41007011
    • DOI: 10.3390/children12091142

    6 Insights on

    • Improved Cognitive Function
    • Reduced Depression Symptoms
    • Reduced Anxiety
    • Improved Sleep
    • Reduced ADHD Symptoms
    • Reduced Agitation

    • Low evidence

  • Beneficial Role of Resveratrol on Oxidative Stress in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial.

    • 2025-08-28
    • RCT
    • Reproductive sciences (Thousand Oaks, Calif.) 32(10)
    • • Negar Ajabi Ardehjani
      • Marzieh Agha-Hosseini
      • Maryam Shabani Nashtaei
      • Mahshad Khodarahmian
      • Shadi Sadat Seyyed Ebrahimi
      • Mohammad Hossein Bagheri
      • Farzane Fereidouni
      • Tayebeh Rastegar
      • Fardin Amidi

    • PubMed: 40877487
    • DOI: 10.1007/s43032-025-01967-8

    9 Insights on

    • Increased Antioxidant Enzyme Levels
    • Increased Total Serum Antioxidant Capacity
    • Reduced Malondialdehyde Level
    • Increased Total Thiol Level
    • Reduced Total Oxidant Status
    • Reduced Oxidative Stress Index
    • Increased Catalase Expression
    • Increased Uncoupling Protein 2 Expression
    • Increased Uncoupling Protein 2 Level

    • High evidence

  • Integrative Evidence on Mulberry Extract for Modulating Metabolic Risk Factors Associated with Vascular Dementia.

    • 2025-08-28
    • Meta-Analysis · n = 1,202
    • International journal of molecular sciences 26(17)
    • • Jui-Ting Yu
      • Chen-Pi Li
      • Yao Hsiao
      • Kuan-Po Cheng
      • Ru-Yin Tsai

    • PubMed: 40943306
    • DOI: 10.3390/ijms26178380

    11 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Reduced Triglyceride Levels
    • Improved Insulin Levels
    • Reduced Hemoglobin A1c
    • Reduced Blood Cholesterol
    • Reduced Fasting Blood Glucose Levels
    • Reduced Alanine Aminotransferase Level
    • Reduced High-Sensitivity C-Reactive Protein Level
    • Reduced Aspartate Aminotransferase Level

    • High evidence
    • Rigorous Journal

  • [Study on the efficacy of combination therapy with rifaximin and Saccharomyces boulardii CNCM I-745 in patients with small intestinal bacterial overgrowth associated with long-term use of proton pump inhibitors].

    • 2025-08-28
    • RCT · n = 108
    • Terapevticheskii arkhiv 97(8)
    • • I V Maev
      • D N Andreev
      • R I Shaburov
      • A V Zaborovsky
      • A K Fomenko
      • P S Sokolov
      • S V Tsaregorodtsev
      • M K Devkota
      • D T Dicheva
      • S V Cheremushkin
      • N V Cheremushkinа
      • A V Vychkin

    • PubMed: 40884341
    • DOI: 10.26442/00403660.2025.08.203301

    7 Insights on

    • Improved Quality of Life
    • Reduced Diarrhea Rate
    • Reduced Symptom Severity
    • Reduced Diarrhea
    • Reduced Symptom Severity Scale Score
    • Increased SIBO Eradication
    • Reduced Small Intestinal Bacterial Overgrowth Persistence

    • High evidence
    • Large Human Trial
• August 29

  • Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.

    • 2025-08-29
    • Meta-Analysis · n = 1,610
    • Medicine 104(35)
    • • Heng Zhang
      • Yunkai Yang
      • Shaohua Liu
      • Yang Yang
      • Zhelong Liu

    • PubMed: 40898469
    • DOI: 10.1097/md.0000000000044043

    3 Insights on

    • Increased Serum Free Thyroxine Levels
    • Reduced Thyroid Peroxidase Antibody Level
    • Reduced Thyroglobulin Antibody Level

    • High evidence

  • Biochemical changes associated with non-alcoholic fatty liver disease in response to berberine treatment: a systematic review and meta-analysis of clinical and preclinical research.

    • 2025-08-29
    • Systematic Review
    • Frontiers in pharmacology 16
    • • Wenyu Zhu
      • Lele Yang
      • Yufan Dai
      • Hanyang Wang
      • Jiaxuan Zhou
      • Lina Xia
      • Tao Shen

    • PubMed: 40949129
    • DOI: 10.3389/fphar.2025.1460643

    1 Insight on

    • Reduced Fasting Blood Glucose Levels

    • High evidence

  • Optimizing the Routine Use of Clinical Guidelines by Addition of Supplements (Probiotics and/or Bismuth) to Helicobacter pylori Eradication Protocols in a Clarithromycin Resistant and Tetracycline/Bismuth Naive Area: A Real-World Data Retrospective Analysis of 402 Cases (2016-24) in a Single Gastroenterology Unit.

    • 2025-08-29
    • Observational
    • Antibiotics (Basel, Switzerland) 14(9)
    • • András Gelley
      • Noémi Kéri
      • Péter Birinyi
      • Kinga Komka
      • Vajk Hardy
      • László Döngölő
      • Dóra Szeli
      • Ibolya Czegle

    • PubMed: 41009849
    • DOI: 10.3390/antibiotics14090870

    1 Insight on

    • Increased Helicobacter pylori Eradication Rate

    • Low evidence
• August 30

  • Comparing the Effects of Dairy and Soybean on Bone Health in Women: A Food- and Component-Level Network Meta-Analysis.

    • 2025-08-30
    • Systematic Review · n = 6,284
    • Nutrients 17(17)
    • • Li You
      • Langrun Wang
      • Shiwen Zhou
      • Yiran Guan
      • Yan Liu
      • Ruixin Zhu
      • Huiyu Chen
      • Jie Guo
      • Keji Li
      • Xingyu Bao
      • Haotian Feng
      • Ignatius M Y Szeto
      • Jian He
      • Ran Wang
      • Jingjing He

    • PubMed: 40944221
    • DOI: 10.3390/nu17172833

    1 Insight on

    • Improved Bone Mineral Density

    • High evidence
    • Rigorous Journal

  • Probiotics: A Little Help for Enteral Nutritional Therapy in Critically Ill Adults.

    • 2025-08-30
    • Review
    • International journal of molecular sciences 26(17)
    • • Graciele Magda de Almeida
      • Mariana Buranelo Egea

    • PubMed: 40943377
    • DOI: 10.3390/ijms26178458

    2 Insights on

    • Reduced Antibiotic-Associated Diarrhea
    • Improved Gastrointestinal Function

    • Moderate evidence
    • Rigorous Journal

  • The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.

    • 2025-08-30
    • Meta-Analysis · n = 718
    • Journal of health, population, and nutrition 44(1)
    • • Xiu Zhang
      • Qion Lou
      • Sho Liou
      • Xiaoshan Wang

    • PubMed: 40886028
    • DOI: 10.1186/s41043-025-01067-y

    14 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Body Mass Index
    • Reduced Low-Density Lipoprotein Level
    • Reduced Systolic Blood Pressure
    • Reduced Body Weight
    • Reduced Triglyceride Levels
    • Improved Insulin Levels
    • Increased HDL Cholesterol Levels
    • Reduced LDL Cholesterol
    • Reduced Blood Cholesterol
    • Reduced Fasting Blood Glucose Levels
    • Increased High-Density Lipoprotein Cholesterol
    • Reduced HOMA-IR
    • Reduced Glycated Hemoglobin

    • High evidence
• August 31

  • Bifidobacteria and Celiac Disease: Mechanisms of Probiotic Action in Reducing Gluten-Induced Cytotoxicity and Inflammation.

    • 2025-08-31
    • Review
    • Molecular nutrition & food research 69(22)
    • • Taynara Cipriano Scherer
      • Ivan De Marco
      • Natália Regina Coldebella Ferreira
      • Tatiana Colombo Pimentel
      • Marciane Magnani
      • Guilherme de Souza Hassemer
      • Amanda Bagolin do Nascimento
      • Silvani Verruck

    • PubMed: 40887812
    • DOI: 10.1002/mnfr.70222

    1 Insight on

    • Reduced Inflammation

    • Moderate evidence
    • Rigorous Journal

  • A Narrative Hypothesis: The Important Role of Gut Microbiota in the Modulation of Effort Tolerance in Endurance Athletes.

    • 2025-08-31
    • Review
    • Nutrients 17(17)
    • • Jesus Álvarez-Herms
      • Martin Burtscher
      • Francisco Corbi
      • Adriana González
      • Adrián Odriozola

    • PubMed: 40944224
    • DOI: 10.3390/nu17172836

    4 Insights on

    • Improved Tolerance
    • Modulated Microbiota-Gut-Brain Axis
    • Improved Fatigue Tolerance
    • Increased Fatigue Threshold During Exercise

    • Moderate evidence
    • Rigorous Journal

  • Serum lipids changes following cocoa intake in type 2 diabetes patients: a graded dose-response systematic review and meta-analysis of clinical trials.

    • 2025-08-31
    • Meta-Analysis · n = 506
    • Acta diabetologica 62(12)
    • • Razieh Anari
      • Houra Mohseni
      • Soudabe Motamed
      • Elham Anari
      • Reza Amani

    • PubMed: 40886195
    • DOI: 10.1007/s00592-025-02554-8

    4 Insights on

    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol
    • Reduced Blood Cholesterol
    • Increased High-Density Lipoprotein Cholesterol

    • High evidence
• Undated – 12 supplement studies

  • Postbiotics: an insightful review of the latest category in functional biotics.

    • 2025-08
    • Review
    • World journal of microbiology & biotechnology 41(8)
    • • Ayodeji Amobonye
      • Brynita Pillay
      • Felicity Hlope
      • Stella Tofac Asong
      • Santhosh Pillai

    • PubMed: 40751848
    • DOI: 10.1007/s11274-025-04483-8

    4 Insights on

    • Improved Gut Microbiota
    • Increased Antioxidant Activity
    • Reduced Inflammation
    • Modulated Gut Microbiota

    • Low evidence

  • Unlocking Relief: Investigating the Impact of a Fixed Combination of Acetyl-L-Carnitine and Palmitoylethanolamide on Traumatic Acute Low Back Pain.

    • 2025-08
    • Observational · n = 48
    • European journal of neurology 32(8)
    • • Mattia Cominacini
      • Maria Teresa Valenti
      • Michele Braggio
      • Alberto Caramori
      • Ermes Vedovi
      • Luca Dalle Carbonare

    • PubMed: 40853095
    • DOI: 10.1111/ene.70334

    3 Insights on

    • Reduced Neuropathic Pain
    • Improved Physical Quality of Life
    • Reduced NSAID Consumption

    • Moderate evidence

  • Combination Therapy with Pyridoxine and Arginine Supplementations along with a Lysine-Restricted Diet in Individuals with Pyridoxine-Dependent Epilepsy: A Comprehensive Systematic Review.

    • 2025-08
    • Review
    • Current developments in nutrition 9(8)
    • • Ali Jafari
      • Mohammad Mehdi Abbasi
      • Hamid Abbasi
      • Sama Rahnemayan
      • Farnush Bakhshimoghaddam
      • Saeid Doaei

    • PubMed: 40800672
    • DOI: 10.1016/j.cdnut.2025.107504

    3 Insights on

    • Improved Cognitive Function
    • Improved Motor Function
    • Improved Seizure Control

    • Low evidence

  • The impact of Bifidobacterium breve BBr60 (BBr60) on metabolic and gastrointestinal health in healthy adults: A combined in vitro metabolomic and randomized, double-blind, placebo-controlled study.

    • 2025-08
    • RCT
    • Clinical nutrition (Edinburgh, Scotland) 51
    • • Yao Dong
      • Yihui Cai
      • Hairui Tian
      • Jian Wen
      • Mei Han
      • Yan Tan
      • Kang Zou

    • PubMed: 40652782
    • DOI: 10.1016/j.clnu.2025.07.004

    4 Insights on

    • Improved Gastrointestinal Symptoms
    • Improved Blood Lipid Profile
    • Improved Alcohol-Related Neuropsychiatric Symptoms
    • Improved Emotional State

    • High evidence

  • Microbial fermentation of soybeans: synergistic enhancement of bioactivity and sensory properties.

    • 2025-08
    • Review
    • Food chemistry: X 30
    • • Ruizhen Gong
      • Zsolt Zalán
      • Jiajia Song
      • Huayi Suo

    • PubMed: 41049771
    • DOI: 10.1016/j.fochx.2025.102924

    2 Insights on

    • Improved Antioxidant Activity
    • Improved Functional Properties of Food

    • Low evidence

  • Mechanism and application of phenyllactic acid on the control of yogurt post-acidification caused by Lactobacillus bulgaricus.

    • 2025-08
    • Food research international (Ottawa, Ont.) 214
    • • Hongxin Zhou
      • Xuanxuan Pang
      • Panpan Han
      • Zhixin Wang
      • Shijie Wang
      • Yingmin Jia
      • Yawei Ning

    • PubMed: 40467252
    • DOI: 10.1016/j.foodres.2025.116688

    1 Insight on

    • Reduced Postprandial Acidification

    • Low evidence

  • Acute effects of l-arginine intake on heart rate variability after a submaximal exercise test in healthy men: randomized clinical trial.

    • 2025-08
    • RCT
    • Nitric oxide : biology and chemistry 157
    • • Andrey Alves Porto
      • Luana Almeida Gonzaga
      • Rayana Loch Gomes
      • Bruno M Candeloro
      • Rodrigo Daminello Raimundo
      • Luiz Carlos Marques Vanderlei
      • Vitor Engrácia Valenti

    • PubMed: 40389021
    • DOI: 10.1016/j.niox.2025.05.003

    5 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Increased Heart Rate Variability
    • Reduced Heart Rate
    • Improved Vagal Reactivation

    • High evidence

  • Effects of maternal allergy and supplementation with ω-3 fatty acid and probiotic on human milk oligosaccharides.

    • 2025-08
    • RCT · n = 136
    • Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 36(8)
    • • Ahmed Al-Kaabawi
      • Eva Landberg
      • Magalí Martí
      • Elisabet Severin
      • Lina Tingö
      • Karel Duchén
      • Maria C Jenmalm

    • PubMed: 40747696
    • DOI: 10.1111/pai.70162

    1 Insight on

    • Increased Human Milk Oligosaccharide Level

    • High evidence
    • Large Human Trial

  • Effectiveness of Lactobacillus therapy in women with cervical human papillomavirus infection: A systematic review and meta-analysis.

    • 2025-08
    • Meta-Analysis · n = 326
    • The Journal of international medical research 53(8)
    • • Devi Artami Susetiati
      • Satiti Retno Pudjiati
      • Yohanes Widodo Wirohadidjojo
      • Lukman Ade Chandra

    • PubMed: 40762255
    • DOI: 10.1177/03000605251363006

    4 Insights on

    • Improved Cervical HPV Clearance
    • Improved Cervical Lesion Resolution
    • Resolved Cervical Lesion
    • Cleared Human Papillomavirus Infection

    • High evidence

  • New Approach Combination-Dosed Therapy for Nonalcoholic Steatohepatitis Versus Vitamin E: A Randomized Controlled Trial.

    • 2025-08
    • RCT · n = 45
    • Clinical therapeutics 47(8)
    • • Amr Y Zakaria
      • Rehab Badawi
      • Hasnaa Osama
      • Mona A Abdelrahman
      • Asmaa M El-Kalaawy

    • PubMed: 40480879
    • DOI: 10.1016/j.clinthera.2025.05.006

    13 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Improved Liver Steatosis
    • Improved Metabolic Parameters
    • Improved Health-related Quality of Life
    • Reduced Liver Fibrosis
    • Reduced Malondialdehyde
    • Reduced Fibrosis-4 Index
    • Reduced MACK-3 Score
    • Reduced NOD-like Receptor-associated Protein 3 Inflammasome Level
    • Reduced Tissue Inhibitor of Metalloproteinase 1 Level
    • Reduced N-terminal Propeptide of Procollagen Type III Level
    • Reduced Cytokeratin-18 Level
    • Reduced Fibroblast Growth Factor-21 Level

    • High evidence

  • Effects of combined gamma aminobutyric acid supplementation and exercise training on the body composition of women: A randomized double-blind trial.

    • 2025-08
    • RCT
    • Clinical nutrition ESPEN 68
    • • Larissa Vitalina de Medeiros Pires
      • Adilson de Barros Martins
      • Cristina Maria de Oliveira Trindade
      • Raianne Dos Santos Baleeiro
      • Thainá Gomes Peixoto
      • Vitória Louise Teixeira E Silva
      • Kelerson Mauro de Castro Pinto
      • Fernanda Guimarães Drummond E Silva
      • Daniel Barbosa Coelho
      • Emerson Cruz de Oliveira
      • Lenice Kappes Becker

    • PubMed: 40345658
    • DOI: 10.1016/j.clnesp.2025.04.028

    16 Insights on

    • Reduced Waist-to-Height Ratio
    • Reduced Blood Pressure
    • Reduced Uric Acid Levels
    • Reduced Triglyceride Levels
    • Reduced Body Fat
    • Reduced Hip Circumference
    • Reduced Body Fat Mass
    • Reduced Blood Glucose Levels
    • Reduced Heart Rate
    • Reduced Body Mass
    • Reduced Resistin Level
    • Reduced Basal Metabolic Rate
    • Reduced Fat-Free Mass
    • Reduced Chemokine C-C Motif Ligand 2 Level
    • Reduced Chemokine Ligand 16 Level
    • Reduced Growth Hormone Level

    • High evidence

  • Effects of probiotic supplementation on infectious and gastrointestinal complications of critically ill patients: Randomized, blinded, placebo-controlled clinical trial.

    • 2025-08
    • RCT · n = 70
    • Clinical nutrition ESPEN 68
    • • Janaina Bach Naslowski
      • Maria Eliana Madalozzo Schieferdecker
      • Antonio Carlos Ligocki Campos

    • PubMed: 40345657
    • DOI: 10.1016/j.clnesp.2025.05.006

    8 Insights on

    • Reduced Gastrointestinal Symptoms
    • Reduced Mortality Risk
    • Reduced Infection Rate
    • Reduced Antibiotic Use
    • Reduced Duration of Mechanical Ventilation
    • Reduced Length of Intensive Care Unit Stay
    • Reduced Laxative Use
    • Reduced Prokinetic Use Duration

    • High evidence