January 2026 Supplement Research Papers

• January 1

  • Vitamin D and Brain Health.

    • 2026-01-01
    • Review
    • Advances in experimental medicine and biology 1493
    • • Rahnuma Ahmad
      • Kona Chowdhury
      • Susmita Sinha
      • Mainul Haque

    • PubMed: 41219598
    • DOI: 10.1007/978-3-032-04357-3_5

    4 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Reduced Oxidative Stress
    • Improved Mitochondrial Respiratory Health
    • Slowed Neuronal Damage Progression

    • Low evidence

  • The Combined Effects of an Anti-Inflammatory Diet and Curcumin Supplementation on Thyroid Function and Lipid Profile in Patients With Hashimoto's Thyroiditis: A Double Blind Randomised Clinical Trial.

    • 2026-01-01
    • RCT · n = 57
    • Endocrinology, diabetes & metabolism 9(1)
    • • Fatemeh Bourbour
      • Behnam Mahdavi
      • Niayesh Naghshi
      • Zahra Yari
      • Seyedsina Moghimnejad Hosseini
      • Saeid Kalbasi
      • Golbon Sohrab

    • PubMed: 41329567
    • DOI: 10.1002/edm2.70138

    3 Insights on

    • Increased HDL Cholesterol Levels
    • Increased Serum Free Thyroxine Levels
    • Reduced Triiodothyronine Level

    • High evidence

  • Effect of Arginine Supplementation on Vasodilation and Muscular Performance in Young Men: A Randomized, Double-Blind, Crossover Study.

    • 2026-01-01
    • RCT
    • International journal of sport nutrition and exercise metabolism 36(1)
    • • Cezimar Correia Borges
      • Weder Alves da Silva
      • Alberto Souza de Sá Filho
      • Vicente Aprigliano
      • Pedro Augusto Inacio
      • Marina Silveira
      • Gerson Ferrari

    • PubMed: 41248623
    • DOI: 10.1123/ijsnem.2025-0125

    10 Insights on

    • Reduced Blood Pressure
    • Improved Muscular Endurance
    • Reduced Blood Lactate
    • Increased Nitric Oxide Level
    • Improved Fatigue Ratio
    • Improved Volume Load
    • Increased Brachial Artery Diameter
    • Increased Peak Systolic Velocity
    • Increased Velocity-Time Integral
    • Reduced Vascular Resistance Index

    • High evidence

  • School-Age Neurodevelopmental and Atopy Outcomes in Extremely Preterm Infants: Follow-Up from the Single Versus Triple-Strain Bifidobacterium Randomized Controlled Trial.

    • 2026-01-01
    • RCT
    • Nutrients 18(1)
    • • Gayatri Athalye-Jape
      • Chandra Rath
      • Meera Esvaran
      • Angela Jacques
      • Sanjay Patole

    • PubMed: 41515257
    • DOI: 10.3390/nu18010141

    10 Insights on

    • Reduced Body Mass Index
    • Improved Cognitive Function
    • Reduced Blood Pressure
    • Improved Growth
    • Improved Cognition
    • Improved Full Scale Intelligence Quotient
    • Reduced Total Difficulty Score
    • Reduced Behavioral Difficulty
    • Reduced Disability Rate
    • Reduced Atopy

    • High evidence
    • Rigorous Journal

  • Effect of iron therapy on fatigue symptoms in non-anaemic iron deficient women of reproductive age- A Randomized Controlled Trial.

    • 2026-01-01
    • RCT · n = 164
    • JPMA. The Journal of the Pakistan Medical Association 76(1)
    • • Nayyer Sultana
      • Fariha Aslam Bajwa
      • Mirza Zeeshan Sikandar
      • Muhammad Mahtab Haider
      • Tayyaba Majeed

    • PubMed: 41736325
    • DOI: 10.47391/jpma.22068

    3 Insights on

    • Increased Hemoglobin Levels
    • Increased Ferritin Level
    • Reduced Fatigue Score

    • High evidence
    • Large Human Trial

  • Transcriptome and microbiota analysis reveal differences in the cecum of weaning pigs in response to different dietary crude protein levels.

    • 2026-01-01
    • RCT
    • Animal bioscience 39(1)
    • • Yu-Hsiang Yu
      • Sheng-Bing Chen
      • Han-Tsung Wang
      • Chuan-Shun Lin
      • Andrzej Dybus
      • Beata Hukowska-Szematowicz
      • Yi-Hung Li

    • PubMed: 40808558
    • DOI: 10.5713/ab.25.0135

    2 Insights on

    • Improved Growth Performance
    • Improved Gut Health

    • High evidence

  • Prognostic value of T-lymphocyte subsets, lymphocyte-to-high-density lipoprotein ratio, interleukin 6, C-reactive protein and procalcitonin in patients with septic shock and effects of vitamin C on patients with septic shock.

    • 2026-01-01
    • RCT · n = 110
    • Pakistan journal of pharmaceutical sciences 39(1)
    • • Yuyu Lu
      • Ling Wu
      • Lingling Nie

    • PubMed: 41482786
    • DOI: 10.36721/pjps.2026.39.1.reg.14162.1

    7 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Reduced Heart Rate
    • Improved Mean Arterial Pressure
    • Reduced Central Venous Pressure
    • Reduced Procalcitonin Level
    • Reduced Sequential Organ Failure Assessment Score

    • High evidence
    • Large Human Trial

  • The Effect of Vitex Agnus - Castus Plant on Some Markers of Oxidative Stress, Lipid Profile and Insulin Resistance in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind Controlled Clinical Trial Study.

    • 2026-01-01
    • RCT
    • JBRA assisted reproduction 30(1)
    • • Aniseh Hatami
      • Fateme Seidi
      • Ali Khosrowbeygi
      • Azam Moslemi
      • Farideh Jalali-Mashayekhi

    • PubMed: 41428718
    • DOI: 10.5935/1518-0557.20250165

    2 Insights on

    • Reduced LDL Cholesterol
    • Increased HDL Cholesterol

    • High evidence

  • Genetic Engineering and Encapsulation Strategies for Lacticaseibacillus rhamnosus Enhanced Functionalities and Delivery: Recent Advances and Future Approaches.

    • 2026-01-01
    • Review
    • Foods (Basel, Switzerland) 15(1)
    • • Leontina Grigore-Gurgu
      • Florentina Ionela Leuștean-Bucur
      • Gabriela-Elena Bahrim

    • PubMed: 41517189
    • DOI: 10.3390/foods15010123

    3 Insights on

    • Improved Immune Function
    • Reduced Metabolic Disorders Incidence
    • Improved Gut Microbiome Function

    • Low evidence

  • The effects of whey protein supplementation on athletic performance and body composition in adolescent soccer players: a randomized controlled trial.

    • 2026-01-01
    • RCT
    • Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 51
    • • Grace A Zimmerman
      • Naomi Mmp de Hart
      • Isaac Z Ou
      • Victoria R Miranda
      • Eric D Bastian
      • Micah J Drummond
      • Christopher M Depner
      • Tanya M Halliday

    • PubMed: 41713391
    • DOI: 10.1139/apnm-2025-0325

    5 Insights on

    • Improved Estimated VO2max
    • Reduced Muscular Endurance
    • Unchanged Sprint Time
    • Unchanged Muscle Strength
    • Unchanged Fat Mass

    • High evidence

  • The Role of Vitamin C Supplementation in Total Knee Arthroplasty Outcomes: A Systematic Review of Randomized Controlled Trials.

    • 2026-01-01
    • Review · n = 364
    • The archives of bone and joint surgery 14(3)
    • • Fardis Vosoughi
      • Golnaz Nikeghbalii
      • Mohammadhasan Sharafi
      • Ehsan Najafi
      • Iman Menbari Oskouie

    • PubMed: 42137519
    • DOI: 10.22038/abjs.2025.92058.4177

    5 Insights on

    • Reduced Inflammation
    • Reduced Postoperative Pain
    • Reduced Complex Regional Pain Syndrome
    • Improved Functional Recovery
    • Reduced Blood Loss

    • High evidence
• January 2

  • A meta-analysis of the effects of vitamin D supplementation on endocrine metabolic and inflammatory markers in patients with polycystic ovarian syndrome.

    • 2026-01-02
    • Meta-Analysis
    • Medicine 105(1)
    • • Baohua Wu
      • Jun Yao

    • PubMed: 41496027
    • DOI: 10.1097/md.0000000000046892

    12 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Reduced Blood Cholesterol
    • Reduced Fasting Blood Glucose Levels
    • Reduced Free Androgen Index
    • Reduced High-Density Lipoprotein Cholesterol Level
    • Reduced Total Testosterone Level
    • Reduced Dehydroepiandrosterone Sulfate Level
    • Reduced Sex Hormone-Binding Globulin Level
    • Reduced Homeostatic Model Assessment-Insulin Resistance Index
    • Reduced Insulin Level
    • Reduced Hypersensitive C-Reactive Protein Level

    • High evidence

  • Microbiological Analyses of Subgingival Flora in Response to Probiotic Adjuncts to Non-surgical Periodontal Therapy: A Scoping Review.

    • 2026-01-02
    • Review
    • Cureus 18(1)
    • • Bernis Aydin
      • Seray Z Ozturk
      • Emine Cifcibasi

    • PubMed: 41635337
    • DOI: 10.7759/cureus.100604

    4 Insights on

    • Reduced Inflammatory Markers
    • Reduced Periodontal Pathogens
    • Reduced Periodontal Pathogen Burden
    • No Conclusive Long-Term Clinical Benefit

    • Low evidence

  • Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD: A Randomized Clinical Trial.

    • 2026-01-02
    • RCT
    • JAMA network open 9(1)
    • • Lubi Lei
      • Bin Wang
      • Lingshan Zhao
      • Jingkuo Li
      • Xiaofang Yan
      • Jiandong Jiang
      • Lulu Wang
      • Gang Ren
      • Yinchu Li
      • Xiaoguang Cheng
      • Xiaoyan Yan
      • Yidan Zhu
      • Yuanlin Guo
      • Hui Zhong
      • Haibo Zhang
      • Jing Li

    • PubMed: 41543854
    • DOI: 10.1001/jamanetworkopen.2025.54152

    5 Insights on

    • Reduced Visceral Fat
    • Reduced Low-Density Lipoprotein Level
    • Reduced Liver Fat Content
    • Reduced Apolipoprotein B Levels
    • Reduced High-Sensitivity C-Reactive Protein Level

    • High evidence
    • Rigorous Journal
• January 3

  • Sublingual Immunotherapy for Food Allergy: Updates in Safety, Efficacy, and Future Considerations.

    • 2026-01-03
    • Review
    • Current allergy and asthma reports 26(1)
    • • Anna A Ilyasova
      • Edwin H Kim

    • PubMed: 41484661
    • DOI: 10.1007/s11882-025-01244-3

    2 Insights on

    • Reduced Food Allergy Symptom Severity
    • Achieved Remission

    • Low evidence
• January 4

  • Exploring the Gut Microbiome in Combat Sports: A Systematic Scoping Review.

    • 2026-01-04
    • Review
    • Sports (Basel, Switzerland) 14(1)
    • • Junior Carlone
      • Carlo Rossi
      • Antonino Bianco
      • Patrik Drid
      • Attilio Parisi
      • Alessio Fasano

    • PubMed: 41590961
    • DOI: 10.3390/sports14010019

    5 Insights on

    • Reduced Gastrointestinal Symptoms
    • Improved Gastrointestinal Symptoms
    • Reduced Physical Fatigue
    • Improved Athletic Performance
    • Reduced Psychological Fatigue

    • Low evidence

  • Systematic review: Limosilactobacillus reuteri DSM 17938 for preventing antibiotic-associated diarrhoea in children.

    • 2026-01-04
    • Systematic Review · n = 998
    • Journal of pediatric gastroenterology and nutrition 82(3)
    • • Hania Szajewska
      • Maciej Kołodziej
      • Bartłomiej M Zalewski
      • Ener Cagri Dinleyici
      • Jan Łukasik

    • PubMed: 41486369
    • DOI: 10.1002/jpn3.70320

    1 Insight on

    • Reduced Antibiotic-Associated Diarrhea

    • High evidence
• January 5

  • Protective effect of Lactococcus lactis NZ9000 secreting Bcl2 against Trichinella spiralis infection in mice.

    • 2026-01-05
    • BMC veterinary research 22(1)
    • • Ruibiao Wang
      • Suxian Liu
      • Hongyan Zhang
      • Doudou Feng
      • Yukai Lin
      • Siyang Li
      • Jiyuan Shen
      • Bo Wen
      • Huarun Sun
      • Minghui Li
      • Qiangqiang Wang
      • Lan Wei
      • Yuanfang Ma
      • Yixin Lu
      • Lei Wang

    • PubMed: 41491176
    • DOI: 10.1186/s12917-025-05238-1

    3 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Intestinal Inflammation
    • Reduced Trichinella Spiralis Infection Burden

    • Low evidence
    • Animal Study

  • Optimizing phenytoin therapy: a systematic review of clinically relevant food and herb interactions.

    • 2026-01-05
    • Systematic Review
    • Frontiers in pharmacology 16
    • • Adriana Monserrath Orellana-Paucar
      • Erick Thomas Mosquera-Lopez
      • Nancy Michelle Bustamante-Alvarez
      • María Gabriela Machado-Orellana
      • Daniela Alejandra Vintimilla-Rojas
      • John Diego Atiencia-Palacios
      • Ana Cristina Espinoza-Fajardo

    • PubMed: 41560756
    • DOI: 10.3389/fphar.2025.1676685

    3 Insights on

    • Prevented Deficiency
    • Increased Plasma Level
    • Reduced Drug Concentration

    • High evidence

  • Isolation and identification of lactic acid bacteria from ginseng sprouts and research on their probiotic, anti-inflammatory, and anti-cancer activity.

    • 2026-01-05
    • n = 17
    • Frontiers in nutrition 12
    • • JeongOk Lee
      • Selin Jung
      • Ji-Eun Lee
      • Muhammad Hamayun
      • Su Hwan Park
      • Young-Jin Choi
      • Eun-Kyung Kim
      • Jong-Ho Lee
      • Ho-Youn Kim
      • Bokyung Lee

    • PubMed: 41561173
    • DOI: 10.3389/fnut.2025.1718524

    1 Insight on

    • Reduced Inflammation

    • Low evidence

  • Effects of High-Dose Vitamin D Supplementation and Physical Exercise on Vitamin D Metabolites in Professional Football Players: A Pilot Study.

    • 2026-01-05
    • RCT
    • Nutrients 18(1)
    • • Anna Książek
      • Aleksandra Zagrodna
      • Konrad Kowalski

    • PubMed: 41515291
    • DOI: 10.3390/nu18010175

    3 Insights on

    • Increased 25(OH)D3 Level
    • Increased 24,25-dihydroxyvitamin D Level
    • Increased 3-epi-25-(OH)D3 Level

    • High evidence
    • Rigorous Journal

  • Clinical benefits of Bifidobacterium infantis YLGB-1496 in modulating gut microbiota and immunity in young children.

    • 2026-01-05
    • Clinical Trial
    • Frontiers in nutrition 12
    • • Mageswaran Uma Mageswary
      • Pin Li
      • Rocky Vester Richmond
      • Yusof Azianey
      • Intan Juliana Abd Hamid
      • Fahisham Taib
      • Min-Tze Liong
      • Adli Ali
      • Joo Shun Tan
      • Yumei Zhang

    • PubMed: 41561177
    • DOI: 10.3389/fnut.2025.1713135

    5 Insights on

    • Reduced Gastrointestinal Inflammation
    • Reduced Diarrhea Incidence
    • Improved Stability of Gut Microbiota
    • Reduced Respiratory Infections
    • Reduced Healthcare Costs

    • Moderate evidence

  • Probiotics in the ICU: a scoping review of evidence for infection prevention.

    • 2026-01-05
    • Review · n = 500
    • Journal of translational medicine 24(1)
    • • Lulu Lou
      • Tianyu Liang
      • Maomao Lv

    • PubMed: 41491715
    • DOI: 10.1186/s12967-025-07637-2

    1 Insight on

    • Reduced Hospital-acquired Infections

    • High evidence

  • The influence of immune regulation mediated by intestinal microbiota on postmenopausal osteoporosis and intervention strategies.

    • 2026-01-05
    • Review
    • Frontiers in endocrinology 16
    • • Lili Wang
      • Shiqing Chen
      • Xiaoyu Cai
      • Yongquan Zheng
      • Caihong Zheng
      • Yao Yao

    • PubMed: 41561048
    • DOI: 10.3389/fendo.2025.1720484

    1 Insight on

    • Improved Bone Health

    • Low evidence

  • Intravenous Vitamin C in Severe Sepsis: A Systematic Review of Evidence From 2020 to 2025.

    • 2026-01-05
    • Review
    • Cureus 18(1)
    • • Rana Ahmed
      • Shashwat Shetty
      • Muhammad Qaiser Aziz Khan
      • Iqra Kalsoom
      • Shazia Qasim
      • Shair Bahadar Khan
      • Saad Abdullah

    • PubMed: 41658835
    • DOI: 10.7759/cureus.100867

    3 Insights on

    • Reduced SOFA Score
    • Reduced Vasopressor Duration
    • Reduced Oxalate Nephropathy

    • Low evidence
• January 6

  • Latilactobacillus curvatus DCF0620 and postbiotics derived from soybean germ reduce colitis severity by modulating fibrosis and gut dysbiosis.

    • 2026-01-06
    • Frontiers in immunology 16
    • • Jin-Sil Park
      • Hye Yeon Kang
      • JeongWon Choi
      • Wonjong Lee
      • Hyunbin Seong
      • Sang Hee Cho
      • Su Beom Lee
      • Nam Soo Han
      • Jaekwon Choi
      • Bo-In Lee
      • Mi-La Cho

    • PubMed: 41567191
    • DOI: 10.3389/fimmu.2025.1726298

    4 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Colitis Severity
    • Reduced Intestinal Inflammation
    • Reduced Intestinal Fibrosis

    • Low evidence
    • Animal Study

  • Bacteria-powered LA@CaDGP biomotor: a multi-modal weapon integrating calcium overload, chemotherapy, and starvation for breast cancer therapy.

    • 2026-01-06
    • Journal of nanobiotechnology 24(1)
    • • Jingrong Huang
      • Yongcheng Tang
      • Kewei Xiang
      • Biqiong Wang
      • Jia Wang
      • Yun Lu
      • Yue Li
      • Hongjun Deng
      • Tao Li
      • Kang Xiong
      • Qinglian Wen
      • Shaozhi Fu

    • PubMed: 41495746
    • DOI: 10.1186/s12951-025-03968-w

    1 Insight on

    • Enhanced Tumor-Targeted Drug Delivery

    • Low evidence

  • Lactobacillus paracasei fermentation enhances the aroma profile and antidiabetic efficacy of goji berry juice.

    • 2026-01-06
    • NPJ science of food 10(1)
    • • Junnan Xu
      • Ying Qi
      • Xiaobo Wei
      • Wei Ding
      • Hongjun Wu
      • Huiyan Liu
      • Haitian Fang

    • PubMed: 41491689
    • DOI: 10.1038/s41538-025-00683-6

    4 Insights on

    • Reduced Oxidative Stress Markers
    • Improved Blood Lipid Profile
    • Improved Glycemia
    • Improved Organ Histology

    • Low evidence

  • Effect of probiotic Limosilactobacillus reuteri on a serum sex-hormone- and metabolic-syndrome-related health evaluation: a single-arm open-label pilot study.

    • 2026-01-06
    • Clinical Trial · n = 10
    • Bioscience of microbiota, food and health 45(1)
    • • Masafumi Noda
      • Narandalai Danshiitsoodol
      • Keishi Kanno
      • Sayaka Yonezawa
      • Ryoko Ishida
      • Masanori Sugiyama

    • PubMed: 41492377
    • DOI: 10.12938/bmfh.2025-020

    4 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Blood Pressure
    • Reduced Inflammatory Markers
    • Reduced Body Fat Percentage

    • Moderate evidence

  • The food grade bacterium Lactobacillus helveticus VEL12193 promotes autophagy by releasing membrane vesicles.

    • 2026-01-06
    • Cell communication and signaling : CCS 24(1)
    • • Marie-Agnès Bringer
      • Simon Manceau
      • Jana Al Azzaz
      • Bénédicte Buteau
      • Lil Proukhnitzky
      • Amaury Aumeunier
      • Luis G Bermúdez-Humarán
      • Florian Chain
      • Catherine Daniel
      • Elise Jacquin
      • Zandile Mlamla
      • Jean-Paul Pais de Barros
      • Julia Novion Ducassou
      • Yohann Couté
      • Guilhem Faure
      • Niyazi Acar
      • Aurélie Rieu
      • Pierre Lapaquette

    • PubMed: 41495832
    • DOI: 10.1186/s12964-025-02616-y

    1 Insight on

    • Increased Autophagy

    • Low evidence

  • Enhancing essential amino acid bioavailability of soy protein through Streptococcus thermophilus ST4 supplementation.

    • 2026-01-06
    • Frontiers in microbiology 16
    • • David Agus Setiawan Wibisono
      • Chiou-Yeong Saw
      • Bo-Long Jian
      • Der-Kai Lau
      • Wei-Jen Chen
      • Hui-Fang Chu
      • Cheng-Yen Liu
      • Chi-Fai Chau

    • PubMed: 41568047
    • DOI: 10.3389/fmicb.2025.1740277

    1 Insight on

    • Improved Amino Acid Bioavailability

    • Low evidence

  • Superiority of propolis and honey over topical acyclovir for herpes simplex: A meta-analysis.

    • 2026-01-06
    • Meta-Analysis
    • International journal of STD & AIDS 37(5)
    • • Nurdjannah Jane Niode
      • Paulus Mario Christopher
      • Trina Ekawati Tallei

    • PubMed: 41496519
    • DOI: 10.1177/09564624251413431

    6 Insights on

    • Reduced Pain Intensity
    • Reduced Pain Duration
    • Reduced Lesion Healing Time
    • Increased Healing Rate
    • Reduced Attack Abortion Rate
    • Improved Symptom-Free Status

    • High evidence

  • Peptidoglycan from Bifidobacterium bifidum G9-1 induces IgA secretion in Peyer's patch-derived cells.

    • 2026-01-06
    • Bioscience of microbiota, food and health 45(1)
    • • Hiroaki Konishi
      • Koji Yamamoto
      • Aki Sakatani
      • Tatsuya Dokoshi
      • Yutaka Makizaki
      • Yoshiki Tanaka
      • Hiroshi Ohno
      • Kentaro Moriichi
      • Mikihiro Fujiya

    • PubMed: 41492380
    • DOI: 10.12938/bmfh.2025-040

    1 Insight on

    • Increased Intestinal IgA Secretion

    • Low evidence

  • The effect of probiotic supplementation on perceived stress and bowel function in healthy young adults: evidence from a randomized controlled trial in Makkah.

    • 2026-01-06
    • Clinical Trial
    • Frontiers in nutrition 12
    • • Essra A Noorwali
      • Abeer M Aljaadi
      • Wafaa F Abusudah
      • Fatmah A Bakhdar
      • Dania H Bin-Ali
      • Amani Alshinawi
      • Asma Bawazir
      • Raghad A Mutlaq
      • Heba A Maimany
      • Layan A Barnawi
      • Bshayer Murshed
      • Bayan Aljared
      • Firas S Azzeh

    • PubMed: 41567324
    • DOI: 10.3389/fnut.2025.1717047

    4 Insights on

    • Improved Bowel Movement Frequency
    • Improved Stool Consistency
    • Reduced Perceived Stress
    • Improved Gastrointestinal Symptoms

    • Moderate evidence
• January 7

  • Microbial modulators of the epigenome: probiotic regulation of MiRNAs and LncRNAs in health and disease and preventive medicine.

    • 2026-01-07
    • Review
    • Gut pathogens 18(1)
    • • Shanshan Xie
      • Yong Zhi
      • Bita Badehnoosh

    • PubMed: 41495822
    • DOI: 10.1186/s13099-025-00789-y

    3 Insights on

    • Improved Gut Health
    • Reduced Inflammation
    • Improved Effectiveness in Inflammatory Bowel Disease

    • Low evidence

  • The effects of oral probiotic intervention on brain structure and function in human adults: a systematic review.

    • 2026-01-07
    • Systematic Review
    • NPJ biofilms and microbiomes 12(1)
    • • Ashley N Hutchinson
      • Amanda E Antonsson
      • Richard A Forsgård
      • Julia König
      • John-Peter Ganda Mall
      • Julia Rode

    • PubMed: 41501074
    • DOI: 10.1038/s41522-025-00872-x

    5 Insights on

    • Improved Cognitive Function
    • Improved Sleep Quality
    • Reduced Negative Emotional Responses
    • Altered Brain Activity to Negative Emotional Stimuli
    • Modified Resting-State Brain Connectivity

    • High evidence

  • Lactobacillus gasseri CBT LGA2 alleviates muscle protein degradation and inflammation in immobilization-induced mouse.

    • 2026-01-07
    • Frontiers in microbiology 16
    • • Ji Hun Jang
      • So Jeong Lim
      • Hyo Su Choi
      • Sanghyun Lim
      • Nam Su Oh

    • PubMed: 41574345
    • DOI: 10.3389/fmicb.2025.1728172

    1 Insight on

    • Reduced Inflammation

    • Low evidence

  • Effect of probiotic supplementation on the gut microbiota diversity in healthy populations: a systematic review and meta-analysis of randomised controlled trials.

    • 2026-01-07
    • Meta-Analysis
    • BMC medicine 24(1)
    • • Anna Júlia Éliás
      • Kincső Csepke Földvári-Nagy
      • Yasmin Zubeida Al-Gharati
      • Dániel Sándor Veres
      • Tamás Schnabel
      • Brigitta Teutsch
      • Bálint Erőss
      • Péter Hegyi
      • Katalin Lenti
      • László Földvári-Nagy

    • PubMed: 41495831
    • DOI: 10.1186/s12916-025-04602-0

    3 Insights on

    • Improved Gut Microbiota Diversity
    • Maintained Gut Microbiota Diversity
    • Unchanged Gut Microbiota Diversity

    • High evidence

  • The therapeutic effects of Lacticaseibacillus rhamnosus on stress-induced anxiety: a systematic review of evidence from animal studies.

    • 2026-01-07
    • Review · n = 8
    • Gut microbiome (Cambridge, England) 6
    • • Iman Imtiyaz Ahmed Juvale
      • Alina Arulsamy

    • PubMed: 41497537
    • DOI: 10.1017/gmb.2025.10015

    6 Insights on

    • Reduced Anxiety
    • Reduced Inflammation
    • Improved Gut Barrier Function
    • Increased GABAergic Signaling
    • Modulated HPA Axis
    • Altered Monoamine Signaling

    • Low evidence

  • Complementary therapies for management of menopausal symptoms: a systematic review to inform the update of the International Menopause Society recommendations on women's midlife health.

    • 2026-01-07
    • Systematic Review
    • Climacteric : the journal of the International Menopause Society 29(2)
    • • Alison Maunder
      • Amelia K Mardon
      • Vibhuti Rao
      • Sophia Torkel
      • Najwa-Joelle Metri
      • Jing Liu
      • Guoyan Yang
      • Nora Giese
      • Evangeline Mantzioris
      • Nur K Abdul Jafar
      • Geovanna E Rodrigues de Souza
      • Ieman Al-Kanini
      • Lorena Romero
      • Nick Panay
      • Hugo Pedder
      • Carolyn Ee

    • PubMed: 41498229
    • DOI: 10.1080/13697137.2025.2584061

    2 Insights on

    • Reduced Fracture Risk
    • Reduced Vasomotor Symptom

    • High evidence
• January 8

  • Impact of selenium and selenoproteins on idiopathic male infertility: a comprehensive review.

    • 2026-01-08
    • Review
    • Frontiers in nutrition 12
    • • Nebojša Zečević
      • Ivana Šarac
      • Milan Perović
      • Milica Zeković
      • Aleksandar Stojsavljević

    • PubMed: 41586246
    • DOI: 10.3389/fnut.2025.1702028

    1 Insight on

    • Improved Sperm Motility

    • Low evidence

  • Efficacy of probiotics (Bifidobacterium bifidum G9-1) in patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation: An exploratory, multicenter, open-label, single-arm study (BIRDIE study).

    • 2026-01-08
    • Clinical Trial · n = 30
    • Journal of diabetes investigation 17(3)
    • • Fuki Ikeda
      • Junko Sato
      • Hidenori Yoshii
      • Masahiro Sugawara
      • Hiroaki Satoh
      • Yukiko Sugawara
      • Hirotsugu Uzawa
      • Daisuke Sugimoto
      • Reina Muto
      • Yuya Nishida
      • Hirotaka Watada

    • PubMed: 41504339
    • DOI: 10.1111/jdi.70236

    14 Insights on

    • Reduced Straining
    • Increased Serum Albumin Levels
    • Reduced Flatulence
    • Reduced Abdominal Pain
    • Reduced Abdominal Discomfort
    • Improved Constipation Symptoms
    • Improved Stool Formation
    • Increased Defecation Frequency
    • Reduced Sense of Incomplete Evacuation
    • Unchanged Glycemic Control
    • Stable Kidney Function
    • Reduced Urinary Albumin
    • Reduced Glycated Hemoglobin
    • Improved Estimated Glomerular Filtration Rate

    • High evidence

  • Probiotic intake and mental health in healthy working adults: a systematic review and meta-analysis of randomized controlled trials.

    • 2026-01-08
    • Meta-Analysis · n = 350
    • BMC psychology 14(1)
    • • Sihem Ben Fredj
      • Hela Kechiche
      • Asma Chouchen
      • Imen Akkari
      • Rim Ghammam
      • Nawel Zammit
      • Nour Douss
      • Afef Skhiri
      • Maher Maoua
      • Jihen Maatoug
      • Imed Harrabi
      • Olfa El Maalel

    • PubMed: 41501907
    • DOI: 10.1186/s40359-025-03885-5

    8 Insights on

    • Reduced Psychological Distress
    • Improved Mental Health
    • Reduced C-Reactive Protein Levels
    • Reduced Cortisol Levels
    • Reduced Depression and Anxiety Scores
    • No Change in C-Reactive Protein
    • No Clear Effect on Systemic Inflammation
    • No Significant Effect on C-Reactive Protein Levels

    • High evidence

  • Impact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.

    • 2026-01-08
    • Review
    • Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 37(2)
    • • Anoohya Gandham
      • Konstantinos Prokopidis
      • Costas Glavas
      • David Scott
      • Mattias Lorentzon

    • PubMed: 41507594
    • DOI: 10.1007/s00198-025-07801-w

    4 Insights on

    • Improved Insulin Sensitivity
    • Improved Gut Microbiota Composition
    • Improved Gut Microbiome Composition
    • Reduced Inflammation

    • Low evidence

  • Targeted isolation of bacteria with potential to competitively exclude Staphylococcus aureus in the upper respiratory tract of pigs.

    • 2026-01-08
    • Observational
    • BMC microbiology 26(1)
    • • Abel A Vlasblom
      • Shriram Patel
      • Peadar G Lawlor
      • Marcus J Claesson
      • Daniel Crespo-Piazuelo
      • Julia Eckenberger
      • Chloe E Huseyin
      • Christian Elend
      • Jaap A Wagenaar
      • Aldert L Zomer
      • Birgitta Duim

    • PubMed: 41507781
    • DOI: 10.1186/s12866-025-04613-0

    1 Insight on

    • Reduced Staphylococcus aureus Carriage

    • Low evidence
    • Animal Study

  • Effects of personalized vitamin D3 on inflammation in colorectal cancer patients: a randomized trial.

    • 2026-01-08
    • RCT · n = 126
    • British journal of cancer 134(6)
    • • Tafirenyika Gwenzi
      • Alexander N R Weber
      • Kira Trares
      • Tomislav Vlaski
      • Marija Slavic
      • Sha Sha
      • Edelmann Dominic
      • Reiner Caspari
      • Bettine Bilsing
      • Harald Fischer
      • Cristina-Maria Fernandes-Almeida
      • David Czock
      • Ben Schöttker
      • Hermann Brenner

    • PubMed: 41507560
    • DOI: 10.1038/s41416-025-03333-6

    3 Insights on

    • Reduced Interleukin-6 Levels
    • Reduced Interferon-gamma Level
    • Reduced Matrix Metalloproteinase-1 Level

    • High evidence
    • Large Human Trial

  • The Vaginal Microbiome and Host Health: Implications for Cervical Cancer Progression.

    • 2026-01-08
    • Review
    • International journal of molecular sciences 27(2)
    • • María Del Carmen Lagunas-Cruz
      • Arturo Valle-Mendiola
      • Isabel Soto-Cruz

    • PubMed: 41596292
    • DOI: 10.3390/ijms27020640

    1 Insight on

    • Reduced Allergic Symptoms

    • Moderate evidence
    • Rigorous Journal
• January 9

  • PHARMACOLOGICAL TREATMENTS FOR FATIGUE IN INFLAMMATORY BOWEL DISEASE PATIENTS: AN INTEGRATIVE REVIEW.

    • 2026-01-09
    • Review · n = 935
    • Arquivos de gastroenterologia 62
    • • Tayane Morais
      • Genalva Couto
      • Raquel Rocha
      • Genoile Santana

    • PubMed: 41538673
    • DOI: 10.1590/s0004-2803.24612025-081

    1 Insight on

    • Reduced Fatigue

    • High evidence

  • The Role of Astaxanthin as an Antioxidant and Anti-Inflammatory Agent in Human Health: A Systematic Review.

    • 2026-01-09
    • Systematic Review
    • International journal of molecular sciences 27(2)
    • • Giuseppina Malcangi
      • Angelo Michele Inchingolo
      • Lucia Casamassima
      • Irma Trilli
      • Laura Ferrante
      • Marialuisa Longo
      • Francesco Inchingolo
      • Grazia Marinelli
      • Andrea Palermo
      • Gianna Dipalma
      • Alessio Danilo Inchingolo

    • PubMed: 41596351
    • DOI: 10.3390/ijms27020700

    6 Insights on

    • Improved Insulin Sensitivity
    • Reduced Pro-Inflammatory Cytokines
    • Improved Body Composition
    • Increased Antioxidant Capacity
    • Improved Vascular Endothelial Function
    • Improved Blood Lipid Profile

    • High evidence
    • Rigorous Journal

  • Clinical Assessment of the Effect of Hypericum perforatum Chewing Gum on Salivary Streptococcus mutans Count, pH, Plaque Index, and Gingival Bleeding: A Randomized Clinical Trial.

    • 2026-01-09
    • RCT · n = 54
    • Clinical and experimental dental research 12(1)
    • • Aylin Jamali
      • Hamed Hamishehkar
      • Mohammad Yousef Memar
      • Seyedeh Elham Mousavi Kalajahi
      • Maryam Kouhsoltani
      • Morteza Kosari-Nasab

    • PubMed: 41510676
    • DOI: 10.1002/cre2.70285

    4 Insights on

    • Reduced Gingival Bleeding
    • Reduced Plaque Index
    • Increased Salivary pH
    • Reduced Salivary Streptococcus mutans Count

    • High evidence

  • Lactic Acid Bacteria as the Green and Safe Food Preservatives: Their Mechanisms, Applications and Prospects.

    • 2026-01-09
    • Review
    • Foods (Basel, Switzerland) 15(2)
    • • Yuwei Zhang
      • Lianrui Li
      • Xiaoyang Pang
      • Shuwen Zhang
      • Yang Liu
      • Yunna Wang
      • Ning Xie
      • Xu Li

    • PubMed: 41596840
    • DOI: 10.3390/foods15020241

    6 Insights on

    • Reduced Gastrointestinal Symptoms
    • Improved Immune Function
    • Improved Gut Health
    • Reduced Allergic Symptoms
    • Improved Gut Microbiota Balance
    • Antimicrobial Food Preservation

    • Low evidence

  • Differences in Nutrition and Sensory Quality Between Cooked Soybeans, Fermented Natto, and Post-Ripening Natto.

    • 2026-01-09
    • Foods (Basel, Switzerland) 15(2)
    • • Yuguang He
      • Yuanyuan Jiang
      • Da Li
      • Xue Ou
      • Xinyu Miao
      • Mubai Sun
      • Honghong Niu
      • Mei Hua
      • Ying Su
      • Jinghui Wang
      • Zhuo Liu

    • PubMed: 41596835
    • DOI: 10.3390/foods15020237

    3 Insights on

    • Improved Nutritional Status
    • Increased Nattokinase Activity
    • Increased Bioactive Compound Production

    • Low evidence
• January 10

  • Mechanistic insights into propolis in targeting adipokines including leptin, resistin, and adiponectin: A systematic review.

    • 2026-01-10
    • Review
    • Journal of diabetes and metabolic disorders 25(1)
    • • Aida Malek Mahdavi
      • Zeinab Javadivala
      • Hatice Ozcaliskan Ilkay
      • Atefeh Ansarin

    • PubMed: 41527546
    • DOI: 10.1007/s40200-026-01855-1

    2 Insights on

    • Reduced Uric Acid Levels
    • Increased Adiponectin Levels

    • Low evidence

  • Effects of wilting and additives on fermentation characteristics, microbial composition, metabolome, and ruminal degradation properties of mulberry silage.

    • 2026-01-10
    • Clinical Trial
    • BMC microbiology 26(1)
    • • Fangshu Di
      • Jian Gao
      • Jing Ma
      • Xi Wang
      • Yufei Jiang
      • Shixiu Qiu
      • Haitao Shi

    • PubMed: 41519713
    • DOI: 10.1186/s12866-025-04669-y

    3 Insights on

    • Improved Nutritional Quality
    • Improved Fermentation Quality
    • Reduced Rumen Ammonia Nitrogen

    • Low evidence
    • Animal Study
• January 11

  • Effects of Different Types of Lactobacillus helveticus Exopolysaccharides on Immune Function in Immunodeficient Mice.

    • 2026-01-11
    • Observational
    • Foods (Basel, Switzerland) 15(2)
    • • Shunyu Wang
      • Hongchao Wang
      • Fuhao Li
      • Yurong Zhao
      • Zhangming Pei
      • Wenwei Lu
      • Jianxin Zhao
      • Shourong Lu

    • PubMed: 41596860
    • DOI: 10.3390/foods15020261

    4 Insights on

    • Improved Immune Function
    • Improved Gut Microbiota Balance
    • Reduced Liver Fat
    • Improved Immune Organ Integrity

    • Low evidence
• January 12

  • Curcumin for the clinical treatment of rheumatoid arthritis: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.

    • 2026-01-12
    • Meta-Analysis · n = 244
    • Frontiers in immunology 16
    • • Yihua Fan
      • Zhiqiang Yi
      • Shijie Mao
      • Jialu Wen
      • Jiwei Zhang
      • Qiang Zhang
      • Ruihan Liu

    • PubMed: 41601662
    • DOI: 10.3389/fimmu.2025.1726157

    8 Insights on

    • Reduced C-Reactive Protein Levels
    • Reduced Disease Activity Score
    • Reduced Erythrocyte Sedimentation Rate
    • Reduced Pain
    • Improved ACR20 Response
    • Reduced Tender Joint Count
    • Reduced Swollen Joint Count
    • Reduced Rheumatoid Factor Level

    • High evidence

  • Optimizing Magnesium Uptake in Lacticaseibacillus Rhamnosus To Advance Nutribiotic Strategies.

    • 2026-01-12
    • Current microbiology 83(2)
    • • Rodica-Anita Varvara
      • Heike Budde
      • Ruth Ley
      • Dan Cristian Vodnar

    • PubMed: 41524909
    • DOI: 10.1007/s00284-026-04721-8

    2 Insights on

    • Increased Magnesium Absorption
    • Improved Magnesium Bioaccessibility

    • Low evidence

  • Jujube powder supplementation optimized high-moisture alfalfa silage through regulating microbial community.

    • 2026-01-12
    • Frontiers in microbiology 16
    • • Zhenyu Liu
      • Pengfei Liu
      • Nan Xie
      • Jianfei Zhi
      • Haoyu Wang
      • Shenglin Hou
      • Xuewei Pang
      • Entao Wang
      • Guoli Hu
      • Lige Guo
      • Zhongkuan Liu
      • Xiaoyun Liu

    • PubMed: 41602748
    • DOI: 10.3389/fmicb.2025.1740083

    2 Insights on

    • Increased Abundance of Beneficial Microbes
    • Reduced Pathogenic Contamination

    • Low evidence

  • Lacticaseibacillus rhamnosus WH.FH-19: Probiotic Traits, Fermentation Performance, and Potential for Functional Fermented Milk Production.

    • 2026-01-12
    • Foods (Basel, Switzerland) 15(2)
    • • Shiyuan Sun
      • Lu Feng
      • Liping Sun
      • Xuemei Zhu
      • Mo Zhou
      • Xinling Li
      • Guangqing Mu

    • PubMed: 41596870
    • DOI: 10.3390/foods15020271

    4 Insights on

    • Increased Antioxidant Activity
    • Improved Cholesterol Metabolism
    • Improved Cell Adhesion
    • Improved Stress Tolerance

    • Low evidence
• January 13

  • Potential benefits of Cuminum cyminum L supplementation on components of metabolic syndrome in adults with metabolic disorders: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials.

    • 2026-01-13
    • Systematic Review
    • Frontiers in nutrition 12
    • • Man Liu
      • Songze Wu
      • Maryam Falahatzadeh

    • PubMed: 41608519
    • DOI: 10.3389/fnut.2025.1618108

    4 Insights on

    • Reduced Waist Circumference
    • Reduced Triglyceride Levels
    • Reduced Fasting Blood Glucose Levels
    • Increased High-Density Lipoprotein Cholesterol

    • High evidence

  • The interplay between childhood obesity and vitamin D deficiency: mechanisms and implications.

    • 2026-01-13
    • Review
    • Frontiers in pediatrics 13
    • • Xiao Zhou
      • Yuhe Chen
      • Jianxin Xu
      • Xiaobing Li
      • Yanmei Wu
      • Lidan Xu

    • PubMed: 41608325
    • DOI: 10.3389/fped.2025.1700949

    2 Insights on

    • Improved Insulin Sensitivity
    • Reduced Systolic Blood Pressure

    • Low evidence
• January 14

  • The Differential Effects of Vitamin K Across Glycaemic Outcomes in Prediabetes and Type 2 Diabetes Mellitus.

    • 2026-01-14
    • Meta-Analysis
    • Nutrients 18(2)
    • • Syeda Ruwaida Ahmed
      • Kabelo Mokgalaboni
      • Wendy N Phoswa

    • PubMed: 41599883
    • DOI: 10.3390/nu18020269

    2 Insights on

    • Reduced Insulin Levels
    • Reduced Fasting Blood Glucose Levels

    • High evidence
    • Rigorous Journal

  • A Randomized, Placebo-Controlled Trial Evaluating Multi-Species Synbiotic Supplementation for Bloating, Gas, and Abdominal Discomfort.

    • 2026-01-14
    • RCT
    • Nutrients 18(2)
    • • Jessica R Allegretti
      • Zain Kassam
      • Colleen R Kelly
      • Ari Grinspan
      • Najwa El-Nachef
      • Courtney Van Den Elzen
      • Ralf Jäger
      • Paul Feuerstadt

    • PubMed: 41599868
    • DOI: 10.3390/nu18020255

    2 Insights on

    • Improved Quality of Life
    • Reduced Abdominal Discomfort

    • High evidence
    • Rigorous Journal

  • Utilizing an In Vitro Fermentation Model to Assess Probiotics on Eimeria-Disturbed Cecal Microbiome and Metabolome.

    • 2026-01-14
    • Animals : an open access journal from MDPI 16(2)
    • • Yani Wu
      • Xueting You
      • Shuping Huang
      • Ju Chai
      • Yongqi Zeng
      • Haitao Shi
      • Xi Wang

    • PubMed: 41594435
    • DOI: 10.3390/ani16020245

    1 Insight on

    • Improved Metabolome Profile

    • Low evidence
• January 15

  • Genome-Based Evaluation of Safety and Probiotic Traits in Infant Feces-Sourced Bifidobacterium animalis subsp. lactis BD1.

    • 2026-01-15
    • Foods (Basel, Switzerland) 15(2)
    • • Meng Tian
      • Zihao Liu
      • Jiahang Li
      • Jialin Wang
      • Dayong Ren
      • Yue Leng

    • PubMed: 41596914
    • DOI: 10.3390/foods15020316

    4 Insights on

    • Improved Gastrointestinal Tolerance
    • Increased Bile Salt Tolerance
    • Improved Probiotic Function
    • Enhanced Functional Traits

    • Low evidence

  • Preparation of Polylactic Acid/Modified Natto Composite Films and Property Evaluation.

    • 2026-01-15
    • ACS omega 11(3)
    • • Weepol Pramualkijja
      • Kawee Srikulkit

    • PubMed: 41626485
    • DOI: 10.1021/acsomega.5c06426

    1 Insight on

    • Improved Mechanical Properties

    • Low evidence

  • In Vitro Assessment of Gut Microbiota Modulation Through Functional Biscuits Enriched with Almond By-Products.

    • 2026-01-15
    • Foods (Basel, Switzerland) 15(2)
    • • Angela Racioppo
      • Maria Rosaria Corbo
      • Angela Guerrieri
      • Milena Sinigaglia
      • Antonio Bevilacqua
      • Rossella Caporizzi
      • Antonio Derossi
      • Barbara Speranza

    • PubMed: 41596911
    • DOI: 10.3390/foods15020313

    1 Insight on

    • Improved Gut Microbiota Composition

    • Low evidence

  • "Attacking" the Gut-Brain Axis with Psychobiotics: An Umbrella Review of Depressive and Anxiety Symptoms.

    • 2026-01-15
    • Review
    • Pharmaceuticals (Basel, Switzerland) 19(1)
    • • Alberto Souza Sá Filho
      • Tatiane Bastos Souza
      • José Luís Rodrigues Martins
      • Gunnar P H Dietz
      • Katia Flávia Fernandes
      • Stone de Sá
      • Pedro Augusto Inacio
      • Iransé Oliveira-Silva
      • Gustavo Pedrino
      • Vicente Aprigliano
      • Gaspar R Chiappa
      • James Oluwagbamigbe Fajemiroye

    • PubMed: 41599756
    • DOI: 10.3390/ph19010156

    2 Insights on

    • Reduced Depression Symptoms
    • Reduced Anxiety

    • Low evidence
• January 16

  • Mendelian randomization study of the role of TD CD4+ T cells in the association between Streptococcus thermophilus and esophageal cancer.

    • 2026-01-16
    • Observational
    • Medicine 105(3)
    • • Yonglun Zhang
      • Qian Li

    • PubMed: 41560008
    • DOI: 10.1097/md.0000000000047174

    1 Insight on

    • Reduced Cancer Risk

    • Low evidence

  • Vitamin D and Omega-3 Supplementation for Emotional and Behavioral Dysregulation in Autism Spectrum Disorders: A Systematic Review.

    • 2026-01-16
    • Review
    • Journal of clinical medicine 15(2)
    • • Marta Berni
      • Giulia Mutti
      • Raffaella Tancredi
      • Filippo Muratori
      • Sara Calderoni

    • PubMed: 41598699
    • DOI: 10.3390/jcm15020745

    4 Insights on

    • Reduced Hyperactivity
    • Reduced Irritability
    • Reduced Agitation
    • Reduced Self-Injurious Behavior

    • Low evidence
• January 17

  • Recent Research on the Role of Lactobacilli Probiotics in Cancer Management.

    • 2026-01-17
    • Review
    • Nutrients 18(2)
    • • See-Hyoung Park

    • PubMed: 41599910
    • DOI: 10.3390/nu18020297

    5 Insights on

    • Improved Immune Function
    • Improved Immune Response
    • Reduced Allergic Symptoms
    • Reduced Tumor Growth
    • Increased Apoptosis

    • Moderate evidence
    • Rigorous Journal

  • Bacillus amyloliquefaciens BA5 Attenuates Carbon Tetrachloride-Induced Hepatotoxicity in Mice.

    • 2026-01-17
    • Nutrients 18(2)
    • • Yuanyuan He
      • Feiran Li
      • Yangrui Li
      • Mengen Xu
      • Chuxian Quan
      • Shah Nawaz
      • Md F Kulyar
      • Mudassar Iqbal
      • Jiakui Li

    • PubMed: 41599912
    • DOI: 10.3390/nu18020298

    4 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Reduced Oxidative Stress
    • Reduced Acute Liver Injury

    • Low evidence
    • Rigorous Journal
    • Animal Study
• January 19

  • Phytotherapeutic Supplementation with Momordica charantia: Beneficial Effects in Patients with Suboptimal Glycemic Control on Double Antidiabetic Therapy-A Real-World Evidence Observational Study.

    • 2026-01-19
    • Observational · n = 85
    • Nutrients 18(2)
    • • Cosmin Mihai Vesa
      • Timea Claudia Ghitea
      • Ada Radu
      • Andrei Flavius Radu
      • Teodora Maria Bodog
      • Ruxandra Florina Bodog
      • Roxana Daniela Brata
      • Cristiana Bustea

    • PubMed: 41599921
    • DOI: 10.3390/nu18020309

    2 Insights on

    • Improved Fasting Plasma Glucose
    • Reduced HbA1c Level

    • High evidence
    • Rigorous Journal

  • The role of fermented foods in healthy longevity: A review of potential anti-aging mechanisms.

    • 2026-01-19
    • Review
    • Current research in food science 12
    • • Hongyu Mu
      • Yeyan Yao
      • Yongqiang Gong
      • Tao Yang

    • PubMed: 41551173
    • DOI: 10.1016/j.crfs.2025.101300

    5 Insights on

    • Improved Gut Microbiota
    • Improved Immune Function
    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Improved Antioxidant Defense

    • Low evidence

  • Antiviral Role of Surface Layer Protein A (SlpA) of Lactobacillus acidophilus.

    • 2026-01-19
    • Pathogens (Basel, Switzerland) 15(1)
    • • Govindaraj Anumanthan
      • Ananta Prasad Arukha
      • Ayalew Mergia
      • Bikash Sahay

    • PubMed: 41599087
    • DOI: 10.3390/pathogens15010103

    1 Insight on

    • Reduced Viral Load

    • Low evidence
• January 20

  • Whey protein intakes up to 0.4g/kg body mass are well tolerated before a 10km run at 85% of race pace: a clinical trial.

    • 2026-01-20
    • Clinical Trial
    • Journal of the International Society of Sports Nutrition 23(1)
    • • Keely Shaw
      • Brynn Lindstrom
      • Amy Moss
      • Jill A Parnell

    • PubMed: 41556283
    • DOI: 10.1080/15502783.2026.2615270

    1 Insight on

    • Increased Bloating

    • High evidence

  • Correction: Adjunctive use of Streptococcus salivarius M18 probiotic in the treatment of periodontitis: a randomized controlled trial.

    • 2026-01-20
    • 3 Biotech 16(2)
    • • Wei-Ju Chen
      • Lavanya Ajay Sharma
      • Peng Shao
      • Tia Griffith
      • Robert Love
      • Rohit Jain
      • John Hale
      • Ajay Sharma

    • PubMed: 41567852
    • DOI: 10.1007/s13205-026-04700-7

    1 Insight on

    • Improved Periodontal Health

    • Low evidence

  • Oral health benefits of Heyndrickxia coagulans: a systematic review and meta-analysis of current evidence.

    • 2026-01-20
    • Review · n = 183
    • Frontiers in oral health 6
    • • Silvia Cirio
      • Guglielmo Campus
      • Claudia Salerno
      • Aesha Allam
      • Maria Grazia Cagetti

    • PubMed: 41641154
    • DOI: 10.3389/froh.2025.1733955

    1 Insight on

    • Reduced Salivary Levels of Mutans Streptococci

    • High evidence

  • Exploring the potential for competitive exclusion of commensal probiotic candidates against the insidious swine pathogen Brachyspira hyodysenteriae.

    • 2026-01-20
    • Animal microbiome 8(1)
    • • Samuel Gómez-Martínez
      • Lucía Pérez-Pérez
      • Alejandro Ucero-Carrretón
      • Álvaro López-García
      • Cristina Galisteo
      • Ana Carvajal
      • Héctor Argüello

    • PubMed: 41559772
    • DOI: 10.1186/s42523-025-00511-y

    2 Insights on

    • Reduced Brachyspira hyodysenteriae Growth
    • Maintained Anti-Pathogen Activity

    • Low evidence

  • Evaluating the Quality of Selected Commercial Probiotic Products, Both Dietary Supplements and Foods for Special Medical Purposes.

    • 2026-01-20
    • Foods (Basel, Switzerland) 15(2)
    • • Anna Zawistowska-Rojek
      • Justyna Rybak
      • Paulina Smoleń
      • Agnieszka Kociszewska
      • Paweł Rudnicki-Velasquez
      • Karolina Węgrzyńska
      • Tomasz Zaręba
      • Stefan Tyski
      • Anna Baraniak

    • PubMed: 41596971
    • DOI: 10.3390/foods15020373

    1 Insight on

    • No Human Health Outcome Reported

    • Low evidence
• January 21

  • Effect of Vitamin B12 Supplementation on Hematological and Athropometric Parameters in Children With Severe Acute Malnutrition, Aged 1 to 60 Months in Nutritional Rehabilitation Center (RCT).

    • 2026-01-21
    • RCT
    • Clinical pediatrics 65(5)
    • • Bhartendu Krishna Pathak
      • Manisha Maurya
      • Nandita Mishra
      • Rajesh Kumar Yadav
      • Anshul Singh
      • Madhu Sonkar

    • PubMed: 41566649
    • DOI: 10.1177/00099228251415045

    2 Insights on

    • Improved Height-for-Age Z-Score
    • Improved Weight-for-Age Z Score

    • High evidence

  • Probiotic bacteria Bifidobacterium bifidum upregulation of intestinal epithelial tight junction barrier is mediated by TLR-2/TLR-6 receptor complex activation of occludin gene.

    • 2026-01-21
    • NPJ biofilms and microbiomes 12(1)
    • • Raz Abdulqadir
      • Rana Al-Sadi
      • Yash Gupta
      • Manmeet Rawat
      • Thomas Ma

    • PubMed: 41559082
    • DOI: 10.1038/s41522-025-00903-7

    1 Insight on

    • Improved Intestinal Barrier Function

    • Low evidence

  • Antioxidant and Anti-Inflammatory Activities of Probiotic Strains.

    • 2026-01-21
    • Review
    • International journal of molecular sciences 27(2)
    • • Olga Adriana Caliman-Sturdza
      • Josiana A Vaz
      • Ancuta Veronica Lupaescu
      • Andrei Lobiuc
      • Codruta Bran
      • Roxana Elena Gheorghita

    • PubMed: 41596722
    • DOI: 10.3390/ijms27021079

    8 Insights on

    • Reduced Allergic Symptoms
    • Improved Atopic Dermatitis Symptoms
    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Improved Antioxidant Defense
    • Improved Cognitive Behavior
    • Improved Gastrointestinal Inflammation
    • Improved Cedar Pollinosis Symptoms

    • Moderate evidence
    • Rigorous Journal
• January 22

  • Extremely oxygen-sensitive next-generation probiotics: can current microcomposite formulations ensure effective colonic delivery?

    • 2026-01-22
    • Review
    • Microsystems & nanoengineering 12(1)
    • • L P Ta
      • S Corrigan
      • H Abeysekera
      • R D Horniblow

    • PubMed: 41571627
    • DOI: 10.1038/s41378-025-01151-7

    4 Insights on

    • Improved Gastrointestinal Health
    • No Human Health Outcome Reported
    • Improved Colonic Delivery Feasibility of Oxygen-Sensitive Probiotics
    • Improved Colonic Delivery

    • Low evidence

  • Lactic Acid Bacteria for Fungal Control and Shelf-Life Extension in Fresh Pasta: Mechanistic Insights and Clean-Label Strategies.

    • 2026-01-22
    • Review
    • Molecules (Basel, Switzerland) 31(2)
    • • Noor Sehar
      • Roberta Pino
      • Michele Pellegrino
      • Monica Rosa Loizzo

    • PubMed: 41599436
    • DOI: 10.3390/molecules31020389

    3 Insights on

    • Reduced Fungal Growth
    • Reduced Microbial Spoilage
    • Reduced Microbial Growth

    • Low evidence

  • Effect of Citrus bergamia Supplementation on Body Composition in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    • 2026-01-22
    • Review
    • Obesity reviews : an official journal of the International Association for the Study of Obesity 27(7)
    • • Carmelo Pujia
      • Yvelise Ferro
      • Alberto Castagna
      • Elisa Mazza
      • Samantha Maurotti
      • Francesca Rita Noto
      • Valeria Rizzo
      • Tiziana Montalcini
      • Arturo Pujia

    • PubMed: 41572527
    • DOI: 10.1111/obr.70094

    5 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Body Weight
    • Reduced Body Fat Percentage
    • Reduced Waist-to-Hip Ratio

    • Low evidence

  • Intratumoral Lactobacillus johnsonii Enhances Sensitivity to PD-1 Blockade by Inducing CD8+ T-cell Expansion in Hepatocellular Carcinoma.

    • 2026-01-22
    • Observational
    • Cancer research 86(8)
    • • Qianshi Liu
      • Yiqiang Liu
      • Yue Zhou
      • Liang Liang
      • Yejian Wan
      • Ying Wang
      • Ting Huang
      • Ling Zhong
      • Zhaoshen Li
      • Tao Luo
      • Ming Zhao
      • Zhe-Xuan Li
      • Yu-Cong Li
      • Hai-Tao Lan
      • Hong Wu
      • Chuan Xu
      • Jie Chen

    • PubMed: 41570324
    • DOI: 10.1158/0008-5472.can-25-0346

    3 Insights on

    • Improved Response to PD-1 Immunotherapy
    • Reduced Hepatocellular Carcinoma Recurrence
    • Increased Intratumoral CD8+ T-cell Expansion

    • Low evidence

  • Current Evidence from Animal Models on Molecular Changes Underlying Antidepressant Effects of Psychobiotics.

    • 2026-01-22
    • Review
    • Pharmaceutics 18(1)
    • • Nevena Todorović Vukotić
      • Neda Đorđević
      • Andrijana Stanisavljević Ilić
      • Svetlana Soković Bajić
      • Ivana Perić

    • PubMed: 41599247
    • DOI: 10.3390/pharmaceutics18010140

    8 Insights on

    • Regulated Tryptophan Metabolism
    • Reduced Inflammation
    • Reduced Inflammatory Immune Mediators
    • Normalized Neurotransmitter Levels
    • Reduced Hyperactivity of the Hypothalamic-Pituitary-Adrenal Axis
    • Reduced Anxiety-like Behavior
    • Reduced Depression-like Behavior
    • Normalized HPA Axis Activity

    • Low evidence
• January 23

  • Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.

    • 2026-01-23
    • Meta-Analysis · n = 441
    • International journal of medical sciences 23(3)
    • • Wu-Hsien Kuo
      • Ko-Shih Chang
      • Fu-Hsuan Kuo
      • Kuan-Po Cheng
      • Ru-Yin Tsai

    • PubMed: 41799776
    • DOI: 10.7150/ijms.123717

    1 Insight on

    • Reduced Fasting Blood Glucose Levels

    • High evidence

  • Lactiplantibacillus plantarum Q180 supplementation restores high-fat diet-induced gut dysbiosis and intestinal barrier dysfunction in mice.

    • 2026-01-23
    • Journal of applied microbiology 137(2)
    • • Minseo Cho
      • Jaeryang Chu
      • Chae-Won No
      • Yeon-Woo Kim
      • Jiwoo Lee
      • Hyunchae Joung
      • Yoo Jin Kwon
      • Chang Hun Shin
      • Jisu Lee
      • Jung-Heun Ha

    • PubMed: 41574946
    • DOI: 10.1093/jambio/lxag021

    4 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Improved Gut Microbiota Balance
    • Reduced Metabolic Endotoxemia

    • Low evidence
    • Animal Study

  • Bifidobacterium Infantis Promotes FOSL1-Mediated Transcriptional Repression of VDR to Accelerate Autoimmune Pancreatitis Progression Through Activation of Oxidative Stress.

    • 2026-01-23
    • Inflammation 49(1)
    • • Jie Tang
      • Qin Li
      • Kai Li
      • Dongyun Hang
      • Danyin Gu
      • Lingmei Feng
      • Guoyu Chen
      • Ming Xu

    • PubMed: 41572095
    • DOI: 10.1007/s10753-025-02368-4

    2 Insights on

    • Increased Oxidative Stress
    • Accelerated Autoimmune Pancreatitis Progression

    • Low evidence

  • Autoinducer 2 as a universal language in microbial consortia: decoding molecular mechanisms, ecological impacts, and application.

    • 2026-01-23
    • Review
    • Gut microbes 18(1)
    • • Shuyu Guo
      • Bingyong Mao
      • Xin Tang
      • Qiuxiang Zhang
      • Jianxin Zhao
      • Wei Chen
      • Shumao Cui

    • PubMed: 41574816
    • DOI: 10.1080/19490976.2026.2615494

    3 Insights on

    • Improved Immune Function
    • Reduced Allergic Symptoms
    • No Improvement in Allergy Symptoms

    • Low evidence

  • Metabolic modulation of yogurt fermentation kinetics and acidification by Bifidobacterium-starter culture interactions.

    • 2026-01-23
    • Frontiers in microbiology 17
    • • Zhi Zhao
      • Shaoqi Shi
      • Lele Zhang
      • Meilun An
      • Pengcheng Wen
      • Yue Sang
      • Haihong Feng
      • Baochao Hou
      • Jian He
      • Wei-Lian Hung
      • Baolei Li
      • Liang Zhao
      • Xiaoxia Li
      • Ran Wang

    • PubMed: 41657908
    • DOI: 10.3389/fmicb.2026.1724590

    1 Insight on

    • Reduced Postprandial Acidification

    • Low evidence

  • Multi-Strain Probiotic and Common Infections in Early Childhood Education Settings: A Randomised Controlled Trial.

    • 2026-01-23
    • RCT · n = 118
    • Journal of paediatrics and child health 62(3)
    • • Hafiz Haris Ahmad
      • Blake Peck
      • Daniel Terry

    • PubMed: 41574644
    • DOI: 10.1111/jpc.70295

    3 Insights on

    • Reduced Upper Respiratory Infections
    • Reduced Gastrointestinal Infections
    • No Significant Reduction in Lower Respiratory Tract Infections

    • High evidence
    • Large Human Trial

  • Long-term safety and efficacy of a highly purified plant-based nutraceutical for improving clinical parameters of liver function in healthy participants: a randomized, double-blind, placebo-controlled clinical trial.

    • 2026-01-23
    • Clinical Trial · n = 130
    • Frontiers in nutrition 12
    • • Ghanashyam Patel
      • Saumin Shah
      • Christopher R D'Adamo

    • PubMed: 41659807
    • DOI: 10.3389/fnut.2025.1721748

    4 Insights on

    • Reduced Gamma-Glutamyl Transferase Levels
    • Reduced Alanine Aminotransferase Level
    • Reduced Alkaline Phosphatase Level
    • Reduced Aspartate Aminotransferase Level

    • High evidence
• January 24

  • Efficacy of L-methylfolate and methylcobalamin in treating resistant hypertension associated with elevated serum homocysteine in hemodialysis patients.

    • 2026-01-24
    • RCT
    • BMC nephrology 27(1)
    • • Mohamed Sherif Salem
      • Noha Alaa Hamdy
      • Hesham Abdallah Elghoneimy
      • Hanan Ms El Gowelli

    • PubMed: 41580678
    • DOI: 10.1186/s12882-025-04726-8

    1 Insight on

    • Reduced Blood Pressure

    • High evidence

  • Oxygen-driven nebulization of Clostridium butyricum prevents drug-resistant bacterial pneumonia.

    • 2026-01-24
    • RCT · n = 310
    • Applied microbiology and biotechnology 110(1)
    • • Mei-Hua Zhan
      • Shuai-Hua Zhan
      • Hui-Qiang Han
      • Li-Na Kang
      • Xin-Gang Yang
      • A-Xia Chai

    • PubMed: 41580563
    • DOI: 10.1007/s00253-026-13716-1

    8 Insights on

    • Reduced Body Temperature
    • Reduced White Blood Cell Count
    • Reduced Incidence of Bacterial Pneumonia
    • Reduced Pathogenic Bacterial Colonization
    • Reduced High-Sensitivity C-Reactive Protein Level
    • Reduced Pneumonia Incidence
    • Improved Chest X-Ray Finding
    • Improved Airway Secretion Clearance

    • High evidence
    • Large Human Trial

  • The Intervention Effect of Externally Applying or Orally Administering Bifidobacterium animalis Subsp. lactis J12 on Atopic Dermatitis Induced by 2,4-Dinitrofluorobenzene.

    • 2026-01-24
    • Microorganisms 14(2)
    • • Yan Zhang
      • Yixuan Jiang
      • Weilian Hong
      • Shaoyang Ge
      • Nanqing Jing
      • Jianjun Yang
      • Yuanhong Xie
      • Hongxing Zhang
      • Junhua Jin

    • PubMed: 41753561
    • DOI: 10.3390/microorganisms14020274

    5 Insights on

    • Improved Gut Microbiota Diversity
    • Improved Immune Function
    • Improved Atopic Dermatitis Symptoms
    • Modulated Immune Response
    • Reduced Skin Inflammation

    • Low evidence

  • Efficacy of Ayurveda interventions (Pushkar Guggulu and Haritaki) as an adjunct to standard care in stable coronary artery disease: study protocol for a double-blind, randomized controlled study.

    • 2026-01-24
    • RCT · n = 100
    • BMC complementary medicine and therapies 26(1)
    • • Sakshi Sharma
      • Anunay Gupta
      • Amit K Rai
      • Puneet Gupta
      • Bharti Gupta
      • Bhagwan S Sharma
      • Rakesh K Rana
      • Bhogavalli Chandrasekhararao
      • Narayanam Srikanth
      • Rabinarayan Acharya

    • PubMed: 41580651
    • DOI: 10.1186/s12906-025-05204-2

    8 Insights on

    • Reduced Interleukin-6 Levels
    • Improved Quality of Life
    • Reduced Lipid Levels
    • Improved Angina Symptom
    • Improved Canadian Cardiovascular Society Angina Grade
    • Improved Exercise Stress Test Grade
    • Reduced Pro-brain Natriuretic Peptide Level
    • Reduced Standard Care Medication Need

    • High evidence
    • Large Human Trial

  • Probiotics Lactobacillus acidophilus LA4 and Lacticaseibacillus paracasei F5 Alleviate Cognitive Dysfunction in Alzheimer's Disease Models: A Dual-Screening Study in Drosophila and Mice.

    • 2026-01-24
    • Foods (Basel, Switzerland) 15(3)
    • • Jia Liu
      • Guoqing Ren
      • Siyi Niu
      • Yongshuai Liu
      • Yuqing Zhao
      • Zhenou Sun
      • Qiaomei Zhu
      • Jixiang Zhang
      • Yufeng Mao
      • Zhengqi Liu
      • Qingbin Guo
      • Huanhuan Liu

    • PubMed: 41683016
    • DOI: 10.3390/foods15030429

    1 Insight on

    • Improved Cognitive Function

    • Low evidence
• January 26

  • The role of probiotics in modulation of the gut-brain axis: a prospective therapy for depression and mood disorders.

    • 2026-01-26
    • Review
    • Frontiers in pharmacology 16
    • • Hui Wang
      • Yining Chen
      • Allen Zhao
      • Zhongxia Shen
      • Yu Zhang

    • PubMed: 41668811
    • DOI: 10.3389/fphar.2025.1709060

    1 Insight on

    • Improved Depressive Symptoms

    • Low evidence

  • Using in vitro gastrointestinal (GI) tract digestive products to investigate fermentation dynamics of Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. lactis BB-12, and Escherichia coli.

    • 2026-01-26
    • Gut microbes reports 3(1)
    • • He Lyu
      • Saartje Hernalsteens
      • Qijun Zheng
      • Aibing Yu
      • Xiao Dong Chen

    • PubMed: 41907520
    • DOI: 10.1080/29933935.2026.2620183

    3 Insights on

    • Reduced Escherichia coli Growth
    • Increased Probiotic Activity
    • Improved Survival

    • Low evidence

  • Qing-Chang-Hua-Shi granule ameliorates experimental colitis by modulating Lactobacillus gasseri-mediated ferroptosis metabolic pathway.

    • 2026-01-26
    • Chinese medicine 21(1)
    • • Cheng Cheng
      • Lei Zhu
      • Jingyi Hu
      • Wan Feng
      • Weiyang Li
      • Ryan Au
      • Yanan Li
      • Feng Xu
      • Yuguang Wu
      • Yuan Cui
      • Zhe Di
      • Bin Li
      • Yongchang Miao
      • Yao Lin
      • Lilin Ge
      • Hong Shen

    • PubMed: 41582187
    • DOI: 10.1186/s13020-025-01317-5

    2 Insights on

    • Reduced Colitis Severity
    • Reduced Ferroptosis

    • Low evidence

  • Efficacy of Phytotherapy for Cancer-Related Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    • 2026-01-26
    • Review
    • Diseases (Basel, Switzerland) 14(2)
    • • Silvio Matsas
      • Ursula Medeiros Araujo de Matos
      • Carolina Molina Llata
      • Auro Del Giglio

    • PubMed: 41745077
    • DOI: 10.3390/diseases14020039

    1 Insight on

    • Reduced Cancer-Related Fatigue

    • Low evidence

  • Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.

    • 2026-01-26
    • Systematic Review
    • BMC women's health 26(1)
    • • Hossein Bahari
      • Elmira Ramezani
      • Mahsa Malekahmadi

    • PubMed: 41588439
    • DOI: 10.1186/s12905-026-04277-6

    9 Insights on

    • Reduced Systolic Blood Pressure
    • Reduced Body Weight
    • Improved Insulin Levels
    • Improved Muscle Strength
    • Reduced Arterial Stiffness
    • Improved Blood Lipid Profile
    • Improved Flow-Mediated Dilation
    • Reduced Mean Arterial Pressure
    • Reduced Fasting Glucose

    • High evidence
• January 27

  • Adaptive metabolic rewiring and ion homeostasis enhance oxidative stress resistance in Lacticaseibacillus casei.

    • 2026-01-27
    • Applied and environmental microbiology 92(1)
    • • Lei Su
      • Ruisi Yang
      • Shan Li
      • Qilin Zhang
      • Feng Wang
      • Lianbing Lin
      • Yicen Lin

    • PubMed: 41400365
    • DOI: 10.1128/aem.01854-25

    1 Insight on

    • Improved Oxidative Stress Resistance

    • Low evidence
    • Rigorous Journal

  • The enteric DNA virome differs in infants at risk for atopic disease.

    • 2026-01-27
    • Observational · n = 131
    • Gut microbes 18(1)
    • • Tyrus J Perdue
      • Cassandra E Newkirk
      • Robert Beblavy
      • Antti E Seppo
      • Erin C Davis
      • Michael B Sohn
      • Kirsi M Järvinen
      • Cynthia L Monaco

    • PubMed: 41593042
    • DOI: 10.1080/19490976.2026.2616066

    2 Insights on

    • Reduced Atopic Diseases
    • Altered Infant Enteric Virome

    • High evidence

  • Occurrence and applications of CRISPR-Cas systems in bifidobacteria.

    • 2026-01-27
    • Review
    • Applied and environmental microbiology 92(1)
    • • Jiyong Shin
      • Rodolphe Barrangou

    • PubMed: 41489362
    • DOI: 10.1128/aem.01703-25

    2 Insights on

    • Reduced Gastrointestinal Symptoms
    • Improved Gut Health

    • Moderate evidence
    • Rigorous Journal

  • Dynamics of fermentation, bacterial community, and nutritional value in alfalfa-sunflower mixed silage with different additives.

    • 2026-01-27
    • BMC microbiology 26(1)
    • • Yuting Yan
      • La Zhu
      • Jian Bao
      • Muqier Zhao
      • Pengbo Sun
      • Xingquan Yan
      • Wei Wang
      • Zhijun Wang
      • Yushan Jia
      • Gentu Ge

    • PubMed: 41593473
    • DOI: 10.1186/s12866-025-04702-0

    3 Insights on

    • Reduced Harmful Gut Microbiota
    • Increased Beneficial Gut Lactic Acid Bacteria
    • Improved Fermentation Quality

    • Low evidence
• January 28

  • Multispecies Probiotic Supplementation in Chronic Kidney Disease (CKD): Insights From Indian Nephrology Experts.

    • 2026-01-28
    • Review
    • Cureus 18(1)
    • • Pankaj Beniwal
      • Manish Singla
      • Deba Prasad Kar
      • Vinant Bhargava
      • Naman Chandra
      • D K Sinha
      • Vivek Ruhela
      • Rathan Jha
      • Rajesh Joseph
      • Vishnu Rs
      • Nitin Bhosle
      • Kapil Mehta
      • Sarita Bajpai

    • PubMed: 41769608
    • DOI: 10.7759/cureus.102520

    6 Insights on

    • Improved Gut Integrity
    • Improved Gut Microbiota Balance
    • Reduced Inflammation
    • Reduced Uremic Toxins Levels
    • Improved Kidney Function
    • Slower CKD Progression

    • Low evidence

  • Dietary intake of individual and total carotenoids in relation to overweight and obesity: findings from the PERSIAN cohort study.

    • 2026-01-28
    • Review · n = 4,202
    • Nutrition & metabolism 23(1)
    • • Majid Kamali
      • Golsa Khalatbari Mohseni
      • Mahsa Shapouri
      • Masoomeh Alsadat Mirshafaei
      • Yeganeh Shekari
      • Malikeh Mohajerani
      • Torsten Bohn
      • Ali Nouri
      • Faezeh Tejareh
      • Barbod Alhouei
      • Maryam Gholamalizadeh
      • Farhad Vahid
      • Akram Kooshki
      • Saeid Doaei

    • PubMed: 41606677
    • DOI: 10.1186/s12986-025-01059-z

    1 Insight on

    • Reduced Obesity

    • High evidence

  • Therapeutic effects of Lactobacillus rhamnosus, thymol and their combination against neurotoxicity in propionic acid (PA)-induced autistic rats: insights into the role of the Nrf2/HO-1, Wnt3/β-catenin/GSK3β BDNF/p-TrkB/CREB, pI3K/Akt/mTOR, AMPK/SIRT-1, and PERK/CHOP/Bcl-2 pathways.

    • 2026-01-28
    • RCT
    • Frontiers in pharmacology 16
    • • Hoda A Salem
      • Nermin I Rizk
      • Moustafa H AbdelSalam
      • Rehab Ahmed
      • Hebatallah Husseini Atteia
      • Ahmed M E Hamdan
      • Areej A Alghamdi
      • Manar A Alghusn
      • Renad A Alatawi
      • Rawan A Atallah
      • Maryam M Alfuhaymani
      • Hatun A Alqahtani
      • Karema Abu-Elfotuh

    • PubMed: 41684518
    • DOI: 10.3389/fphar.2025.1728908

    2 Insights on

    • Improved Neurobehavioral Function
    • Improved Neurotrophic Signaling

    • High evidence

  • Self-aggregating Lactiplantibacillus plantarum enhances type-I interferon responses via the cytosolic sensors NOD2 and cGAS.

    • 2026-01-28
    • Gut microbes 18(1)
    • • Selvin Solis
      • Elaina M Maldonado
      • Subhankar Mukhopadhyay
      • Gwénaël Jan
      • José María Landete
      • Carlos Maluquer de Motes
      • Jorge Gutierrez-Merino

    • PubMed: 41605865
    • DOI: 10.1080/19490976.2026.2615490

    3 Insights on

    • Increased Type I Interferon Production
    • Increased Immune Marker Activation
    • Improved Immune Activation

    • Low evidence

  • The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial.

    • 2026-01-28
    • RCT
    • Nutrients 18(3)
    • • Mehran Alipour
      • Ayoub Saeidi
      • Keyvan Hejazi
      • Rashmi Supriya
      • Hassane Zouhal

    • PubMed: 41683255
    • DOI: 10.3390/nu18030433

    1 Insight on

    • Reduced Body Weight

    • High evidence
    • Rigorous Journal
• January 29

  • Improving Lipid Profiles Through Lactobacillus rhamnosus Supplementation in Dyslipidemic Animal Models: A Systematic Review and Meta-Analysis.

    • 2026-01-29
    • Review
    • Foods (Basel, Switzerland) 15(3)
    • • Sungmin Chung
      • Jiill Jeong
      • Yeonwoo Park
      • Bogyeong Lee
      • Sumin Kang
      • Gwang-Woong Go

    • PubMed: 41683053
    • DOI: 10.3390/foods15030465

    1 Insight on

    • Improved Blood Lipid Profile

    • Low evidence

  • Efficacy of selected dietary supplements and pharmacological agents on metabolic and oxidative stress outcomes in metabolic dysfunction-associated fatty liver disease (MAFLD): a Bayesian network meta-analysis.

    • 2026-01-29
    • Systematic Review · n = 273
    • Frontiers in pharmacology 16
    • • Yunyi Yang
      • Xiaoli He
      • Jiayuan Cai
      • Xiaoxiao Qu
      • Shufa Tan
      • Jiawen You
      • Yanming He
      • Zheng Yao
      • Hongjie Yang

    • PubMed: 41695987
    • DOI: 10.3389/fphar.2025.1682688

    2 Insights on

    • Improved Antioxidant Capacity
    • Reduced Malondialdehyde Level

    • High evidence

  • Encapsulated probiotics as antimicrobial agents: mechanisms and delivery strategies against multidrug-resistant pathogens.

    • 2026-01-29
    • Review
    • Frontiers in cellular and infection microbiology 16
    • • Ulpan Kart
      • Dinara Smagulova
      • Dana Khairetdinova
      • Aigul Raimbekova
      • Gonzalo Hap Hortelano

    • PubMed: 41696359
    • DOI: 10.3389/fcimb.2026.1738291

    2 Insights on

    • Reduced Pathogen Growth
    • Improved Therapeutic Consistency

    • Low evidence

  • Lactobacillus paracasei WIS43 alleviates DSS-induced colitis by modulating gut microbiota and suppressing inflammation.

    • 2026-01-29
    • Meta-Analysis
    • Frontiers in microbiology 16
    • • Yu Fu
      • Shuxia Chen
      • Lei Cui
      • Ying Cao
      • Yanan Dong
      • Yunfeng Duan
      • Chongming Wu

    • PubMed: 41695140
    • DOI: 10.3389/fmicb.2025.1721585

    5 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Colitis Severity
    • Reduced Ulcerative Colitis Symptoms
    • Reduced Inflammation
    • Modulated Gut Microbiota

    • High evidence
• January 30

  • Rhodotorula mucilaginosa ZTHY2 as a promising antibiotic alternative in Leizhou black ducks: impact on growth, meat quality, intestinal health, and microbiota composition.

    • 2026-01-30
    • RCT · n = 150
    • BMC veterinary research 22(1)
    • • Jiang Wu
      • Namula Zhao
      • Wei Yang
      • Yingxin Hu
      • Zhibao Chen

    • PubMed: 41612385
    • DOI: 10.1186/s12917-026-05292-3

    1 Insight on

    • Improved Growth Performance

    • High evidence

  • Role and Mechanisms of Gut Microbiota in Infectious Diseases: Recent Evidence from Animal Models.

    • 2026-01-30
    • Review
    • Biology 15(3)
    • • Tao Zeng
      • Linxue Zuo
      • Qiaorui Yu
      • Qiurui Wu
      • Zhiru Bao
      • Hairong Xiong
      • Mei Luo
      • Bei Li

    • PubMed: 41677726
    • DOI: 10.3390/biology15030256

    4 Insights on

    • Improved Gut Integrity
    • Enhanced Immune Function
    • Reduced Susceptibility to Infection
    • Reduced Risk of Infection

    • Low evidence

  • The Effect of Oral Supplementation with a Multi-Strain Probiotic Preparation on Group B Streptococcus (GBS) Carriage in Pregnant Women-A Pilot Study.

    • 2026-01-30
    • Clinical Trial · n = 46
    • Journal of clinical medicine 15(3)
    • • Katarzyna Zych-Krekora
      • Oskar Sylwestrzak
      • Michał Krekora

    • PubMed: 41682795
    • DOI: 10.3390/jcm15031113

    2 Insights on

    • Reduced Group B Streptococcus Colonization
    • Well Tolerated

    • High evidence

  • A randomized controlled trial in healthy participants to compare the insulinogenic effects of whey protein and pea protein co-ingested with glucose.

    • 2026-01-30
    • RCT
    • PloS one 21(1)
    • • Pariyarath Sangeetha Thondre
      • Elysia Young
      • Sam Pledger
      • Sarah Kefyalew
      • Isabel Hatami
      • Caroline Perreau
      • Laetitia Guérin Deremaux
      • Catherine Lefranc-Millot
      • Jonathan Tammam

    • PubMed: 41615946
    • DOI: 10.1371/journal.pone.0340386

    3 Insights on

    • Reduced Glycemic Response
    • Reduced Insulin Response
    • Increased Insulin Response

    • High evidence

  • Combined B-vitamin supplementation on homocysteine and vascular outcomes in coronary heart disease: a meta-analysis.

    • 2026-01-30
    • Meta-Analysis · n = 539
    • Annals of medicine 58(1)
    • • Liping Guo
      • Xiangfen Shi
      • Gaobiao Wang
      • Wenchao Han
      • Rui Ding
      • Shihao Wang
      • Dongdong Yuan

    • PubMed: 41615824
    • DOI: 10.1080/07853890.2026.2622208

    4 Insights on

    • Reduced Homocysteine Level
    • Reduced Vascular Restenosis
    • No Change in Major Cardiovascular Event
    • No Change in Cardiovascular Mortality

    • High evidence

  • Folate and global health umbrella review series, part 1: methodological framework and syntheses on anaemia and neural tube defects.

    • 2026-01-30
    • Systematic Review
    • Journal of global health 16
    • • Samantha Yoo
      • Azita Montazeri
      • Derrick Bennett
      • Yacong Bo
      • Peizhan Chen
      • Susan Duthie
      • Natalie Jensen
      • Atipatsa Kaminga
      • Jun-Shi Lai
      • Xue Li
      • Amanda J MacFarlane
      • Homero Martinez
      • Helene McNulty
      • Franco Momoli
      • Peter Mossey
      • Patrick Mullie
      • Ron Munger
      • Rajendra Prasad Parajuli
      • Monique Potvin Kent
      • Michele Rubini
      • Marjanne Senekal
      • Lindsey Sikora
      • Alain Stintzi
      • Evropi Theodoratou
      • Hui Wang
      • Chittaranjan Yajnik
      • Ann Yaktine
      • Julian Little

    • PubMed: 41612855
    • DOI: 10.7189/jogh.16.04014

    2 Insights on

    • Reduced Obesity
    • Reduced Risk of Megaloblastic Anemia

    • High evidence

  • Process Analysis of Millet Bran Fermentation by Bacillus natto: Dynamic Changes in Enzyme Activities and Bioactive Components.

    • 2026-01-30
    • Foods (Basel, Switzerland) 15(3)
    • • Shimei Zhang
      • Fanqiang Meng
      • Xia Fan
      • Fengxia Lv
      • Xiaomei Bie
      • Haizhen Zhao

    • PubMed: 41683071
    • DOI: 10.3390/foods15030483

    1 Insight on

    • Increased Bioactive Compound Production

    • Low evidence

  • Antimicrobial Activity of Cell-Free Supernatants Produced by Strains of Lactic Acid Bacteria Against Staphylococcus aureus.

    • 2026-01-30
    • Veterinary sciences 13(2)
    • • Xinru Li
      • Yuejie Yang
      • Zijian Geng
      • Rui Wu
      • Shuai Lian
      • Jianfa Wang

    • PubMed: 41745933
    • DOI: 10.3390/vetsci13020139

    1 Insight on

    • Reduced Staphylococcus aureus Growth

    • Low evidence

  • Bacterial cell envelope components of gut commensals: effects in host-microbe interaction.

    • 2026-01-30
    • Review
    • Annals of medicine 58(1)
    • • Thaís Vilela Rodrigues
      • Luís Lima de Jesus
      • Philippe Langella
      • Siomar de Castro Soares
      • Gwénaël Jan
      • Vasco Ariston de Carvalho Azevedo
      • Jean-Marc Chatel

    • PubMed: 41614625
    • DOI: 10.1080/07853890.2026.2618429

    4 Insights on

    • Improved Gut Health
    • Improved Atopic Dermatitis Symptoms
    • Reduced Severity of Allergic Rhinitis Symptoms
    • Improved Gut Barrier Function

    • Low evidence
• January 31

  • Efficacy of a Naturally Calcium and Magnesium-Rich Mineral Water on Musculoskeletal Fragility: A Randomized, Double-Blind Controlled Trial.

    • 2026-01-31
    • RCT · n = 98
    • Nutrients 18(3)
    • • Antimo Moretti
      • Sara Liguori
      • Marco Paoletta
      • Francesca Gimigliano
      • Giovanni Iolascon

    • PubMed: 41683292
    • DOI: 10.3390/nu18030470

    2 Insights on

    • Reduced Fall Incidence
    • Improved Muscle Mass

    • High evidence
    • Rigorous Journal
• Undated – 41 supplement studies

  • Peanut Oral Immunotherapy Using 30 and 300 mg Maintenance Doses.

    • 2026-01
    • RCT · n = 51
    • The journal of allergy and clinical immunology. In practice 14(1)
    • • Julia E M Upton
      • Diana Toscano-Rivero
      • Danbing Ke
      • Alireza Berenjy
      • Duncan Lejtenyi
      • Liane Beaudette
      • Xiaojun Yin
      • Carmen Hong Li
      • Lucy Y Duan
      • Casey G Cohen
      • Vy Kim
      • Shireen Marzouk
      • Eyal Grunebaum
      • Christine T McCusker
      • Bruce Mazer
      • Thomas Eiwegger
      • Moshe Ben-Shoshan

    • PubMed: 41109568
    • DOI: 10.1016/j.jaip.2025.10.007

    5 Insights on

    • Increased Antigen-Specific IgG1 Levels
    • Increased Tolerance to Peanut Protein
    • Increased Peanut Protein Tolerance
    • Increased Tolerated Peanut Dose
    • Reduced Peanut-Specific IgE Level

    • High evidence

  • The Investigation of Vitamin D and Menstrual Cycles Trial (the inVitD Trial): A clinical trial of vitamin D supplementation on the hypothalamic-pituitary-ovarian axis.

    • 2026-01
    • RCT
    • Contemporary clinical trials 160
    • • Michelle R Klawans
      • Olivia Kohrman
      • W Braxton Jackson
      • Chandra L Jackson
      • Christine N Metz
      • Ganesa Wegienka
      • Alison Motsinger-Reif
      • Anne Z Steiner
      • Donna D Baird
      • Dale P Sandler
      • Anne Marie Z Jukic

    • PubMed: 41352534
    • DOI: 10.1016/j.cct.2025.108176

    3 Insights on

    • Changed Mid-luteal Progesterone Level
    • Reduced Estrogen Rise Rate
    • Changed Pre-ovulatory Luteinizing Hormone Level

    • High evidence

  • Role of 70 °C heating on immunostimulatory effects of probiotic bifidobacteria in infant formula.

    • 2026-01
    • Food research international (Ottawa, Ont.) 223
    • • Akira Sen
      • Sayaka Ishihara
      • Masahiro Ando
      • Hiroki Kaneko
      • Riko Mishima
      • Tatsuki Nishimura
      • Yukihiro Hishida
      • Miyuki Tanaka
      • Haruko Takeyama
      • Toshitaka Odamaki

    • PubMed: 41360542
    • DOI: 10.1016/j.foodres.2025.117846

    1 Insight on

    • Improved Immunostimulatory Activity

    • Low evidence

  • Programming the Infant Gut: How Maternal and Early Life Nutrition Shape the Infant Microbiome and Long-term Health-A Narrative Review.

    • 2026-01
    • Review
    • Molecular nutrition & food research 70(2)
    • • Fanette Fontaine
      • Sondra Turjeman
      • Meriam Haib
      • Maria Carmen Collado
      • Karel Callens
      • Omry Koren

    • PubMed: 41555705
    • DOI: 10.1002/mnfr.70385

    1 Insight on

    • Improved Atopic Dermatitis Symptoms

    • Moderate evidence
    • Rigorous Journal

  • Efficacy of Probiotic Lactobacillus spp. Isolated From Healthy Korean Indigenous Calves.

    • 2026-01
    • Clinical Trial
    • Veterinary medicine and science 12(1)
    • • Ji-Yeong Ku
      • Mi-Jin Lee
      • Youngwoo Jung
      • Youngjun Kim
      • Kwang-Man Park
      • Jonghun Baek
      • Byoungsoo Kim
      • Ji-Seon Yoon
      • Jinho Park

    • PubMed: 41482829
    • DOI: 10.1002/vms3.70742

    5 Insights on

    • Improved Gut Microbiota Diversity
    • Increased Beneficial Gut Bacteria
    • Reduced Abundance of Harmful Bacteria
    • Reduced Pathogen Colonization
    • Improved Serum Protein Status

    • Low evidence
    • Animal Study

  • The effect of exercise and soy protein intake on physical frailty score improvement in community-dwelling elderly: a randomized controlled trial.

    • 2026-01
    • RCT · n = 84
    • Experimental gerontology 213
    • • Masakazu Imaoka
      • Mitsumasa Hida
      • Misa Nakamura
      • Keiko Sakai
      • Emi Anzai
      • Takashi Ichise
      • Nobuhiko Tachibana
      • Ien Tei
      • Yoshinori Hasegawa

    • PubMed: 41386386
    • DOI: 10.1016/j.exger.2025.112995

    1 Insight on

    • Improved Walking Speed

    • High evidence

  • Therapeutic Mechanisms of Lactiplantibacillus plantarum NXU0014 Against Chronic Alcohol-Induced Liver Injury Mediated by Gut-Liver Axis Modulation.

    • 2026-01
    • Molecular nutrition & food research 70(1)
    • • Quan Ji
      • Yanhong Wang
      • Longxuan Huo
      • Chen Qiao
      • Fuqi Li
      • Fan Yang
      • Lin Pan

    • PubMed: 41543328
    • DOI: 10.1002/mnfr.70375

    4 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Alcohol-Induced Liver Injury
    • Improved Gut Barrier Function
    • Reduced Hepatic Inflammation and Oxidative Stress

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • The effect of propolis supplementation on blood pressure: a systematic review and meta-analysis of controlled trials.

    • 2026-01
    • Meta-Analysis · n = 30
    • Minerva cardiology and angiology 73(6)
    • • Hongyan Qu
      • Li Cao
      • Ziye Wen
      • Chao Li
      • Meihong Xiao

    • PubMed: 39846965
    • DOI: 10.23736/s2724-5683.24.06656-0

    2 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure

    • High evidence

  • Folate and vitamin B12 supplementation in patients with schizophrenia and low serum folate level: A 24-week randomized, double-blind, placebo-controlled study.

    • 2026-01
    • RCT · n = 36
    • Journal of the Formosan Medical Association = Taiwan yi zhi 125(1)
    • • Chun-Hsin Chen
      • Chih-Chiang Chiu
      • Yi-Hang Chiu
      • Chin-Hao Chang
      • Yu-Han Chang
      • Ming-Chyi Huang
      • Mong-Liang Lu
      • Po-Yu Chen

    • PubMed: 39645464
    • DOI: 10.1016/j.jfma.2024.11.019

    2 Insights on

    • Improved Cognitive Function
    • Reduced Psychotic Symptom Severity

    • High evidence

  • Structural, genomic and phenotypic analysis of exopolysaccharide produced by Streptococcus thermophilus ST65.

    • 2026-01
    • International journal of biological macromolecules 340
    • • Yanyan Zhang
      • Wenyan Liao
      • Luyao Zhang
      • Xia Gong
      • Mei Han

    • PubMed: 41539519
    • DOI: 10.1016/j.ijbiomac.2026.150200

    2 Insights on

    • Improved Immune Response
    • Improved Antioxidant Activity

    • Low evidence
    • Animal Study

  • Gut Microbiota and Dyslipidemia in Type 2 Diabetes: A Pilot Study of 16S rRNA Profiles and Predicted Functional Shifts.

    • 2026-01
    • Observational · n = 15
    • Journal of diabetes research 2026(1)
    • • Godfred Antony Menezes
      • Priyadharshini Sekar
      • Areebah Akhter
      • Ketaki Devendra Tayade
      • Sana Fathima
      • Zaina Falak Zahir Hussain
      • Abhay Nigam

    • PubMed: 41923582
    • DOI: 10.1155/jdr/9317962

    2 Insights on

    • Improved Blood Lipid Profile
    • Atherogenic Lipid Profile

    • Low evidence

  • Clinical Safety and Tolerability of Bifidobacterium bifidum BBi32: An 8-Week Randomized, Double-Blind, Placebo-Controlled Trial With Genomic and In Vitro Corroboration.

    • 2026-01
    • RCT
    • Food science & nutrition 14(1)
    • • Shuguang Fang
      • Shanni Wang
      • Yinhua Liu
      • Chengsheng Zhu
      • Sijia Wang
      • Fei Xu

    • PubMed: 41523287
    • DOI: 10.1002/fsn3.71420

    12 Insights on

    • Reduced Uric Acid Levels
    • Enhanced Antimicrobial Peptide Levels
    • Improved Gut Microbiome Composition
    • Improved Gut Microbiome Diversity
    • Improved Gastrointestinal Symptoms
    • Improved Kidney Function
    • Improved Gastrointestinal Symptom Score
    • Increased LL-37 Levels
    • Reduced Creatinine Level
    • Improved Hepatic Function
    • Reduced Urea Level
    • Improved Hematological Profile

    • High evidence

  • A randomized controlled trial of probiotics to reduce the severity of oral mucositis in patients with oropharyngeal carcinoma undergoing concurrent chemoradiotherapy.

    • 2026-01
    • RCT · n = 70
    • Journal of cancer research and therapeutics 22(1)
    • • Saloni Sojitra
      • Tej Prakash Soni
      • Nidhi Patni
      • Dinesh Kumar Singh
      • Naresh Jakhotia
      • Sheh Rawat
      • Anil Kumar Gupta
      • Tara Chand Gupta
      • Naresh Ledwani
      • Harish Singhal
      • Shantanu Sharma
      • Ravindra Singh Gothwal

    • PubMed: 41910295
    • DOI: 10.4103/jcrt.jcrt_1070_25

    4 Insights on

    • Reduced Body Weight
    • Reduced Oral Mucositis Severity
    • Reduced Dysphagia Severity
    • Improved Treatment Compliance

    • High evidence

  • Lactobacillus gasseri-derived postbiotics promote osteogenic differentiation in BMSCs via ameliorating mitochondrial oxidative stress.

    • 2026-01
    • Biochemical and biophysical research communications 795
    • • Ziwei Guo
      • Yun Yuan
      • Keyu Lu
      • Shi Yin
      • Wei Bi

    • PubMed: 41389616
    • DOI: 10.1016/j.bbrc.2025.153113

    3 Insights on

    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Improved Bone Regeneration

    • Low evidence
    • Animal Study

  • Streptococcus thermophilus alleviates fatty liver disease by regulating gut microbiota, lipid metabolism, and inflammation.

    • 2026-01
    • International immunopharmacology 168
    • • Junlin Xia
      • Yanbin Cheng
      • Lixuan Sang
      • Qingyu Wei
      • Quansheng Li
      • Bing Chang

    • PubMed: 41275833
    • DOI: 10.1016/j.intimp.2025.115905

    4 Insights on

    • Improved Gut Microbiota Composition
    • Improved Liver Function
    • Reduced Inflammation
    • Reduced Hepatic Lipid Accumulation

    • Low evidence

  • Thiamine Use in Hospitalized Patients: A Clinical Review.

    • 2026-01
    • Review
    • Journal of nutrition and metabolism 2026(1)
    • • Rowan E Rosewarne
      • Nicholas Farina

    • PubMed: 41684754
    • DOI: 10.1155/jnme/7143046

    2 Insights on

    • Reduced Wernicke Encephalopathy Symptoms
    • Prevented Exacerbation of Thiamine Deficiency

    • Low evidence

  • The Efficacy and Safety of Nutritional Supplements for Cancer Supportive Care: An Umbrella Review and Hierarchical Evidence Synthesis.

    • 2026-01
    • Systematic Review
    • Integrative cancer therapies 25
    • • Sarah Benna-Doyle
      • Suzanne Grant
      • Alison Maunder
      • Jing Liu
      • Melik Ibrahim
      • Adele Cave
      • Chhiti Pandey
      • Monica Tang
      • Eng-Siew Koh
      • Geoff Delaney
      • Deep Jyoti Bhuyan
      • Victoria Choi
      • Ki Kwon
      • Maria Gonzalez
      • Susannah Graham
      • Ashanya Malalasekera
      • Carolyn Ee

    • PubMed: 41482855
    • DOI: 10.1177/15347354251405267

    13 Insights on

    • Reduced Allergic Symptoms
    • Improved Gastrointestinal Symptoms
    • Reduced Mucositis
    • Improved Symptom Relief
    • Reduced Severity of Allergic Rhinitis Symptoms
    • Reduced Oral Mucositis Severity
    • Improved Gastrointestinal Function
    • Reduced Radiation-Induced Dermatitis Severity
    • Reduced Chemotherapy-Induced Peripheral Neuropathy
    • Improved Oral Mucositis
    • No Reported Health Outcome
    • Prevented Chemotherapy-Induced Peripheral Neuropathy
    • Reduced Oral Mucositis

    • High evidence

  • Impact of Sodium Ascorbate High Dose on Quality of Life and Pain in Patients Diagnosed With and Treated for Terminal Cancer (Real-World Data Study).

    • 2026-01
    • Observational · n = 92
    • Integrative cancer therapies 25
    • • Hugo Mario Galindo Salom
      • Carlos Alberto Carrillo Bravo
      • Helber Armando Prieto Lozano
      • Paulo Andrés López Posada

    • PubMed: 41606996
    • DOI: 10.1177/15347354251414640

    2 Insights on

    • Improved Quality of Life
    • Reduced Pain

    • Moderate evidence

  • Red cabbage anthocyanin-rich natural colorant: Optimization of ultrasound-assisted extraction, microencapsulation, bioaccessibility, and functional yogurt development.

    • 2026-01
    • Ultrasonics sonochemistry 124
    • • Sumandeep Kaur
      • Amisha Rani
      • Reshma Thakur
      • Abhilasha Sharma
      • Kritika Kuksal
      • Aman Sharma
      • Arti Shivraj Nile
      • Shivraj Hariram Nile

    • PubMed: 41351955
    • DOI: 10.1016/j.ultsonch.2025.107702

    2 Insights on

    • Improved Antioxidant Activity
    • Improved Cell Viability

    • Low evidence

  • Vitamin E and cognitive function: A systematic review of clinical evidence.

    • 2026-01
    • Systematic Review · n = 488
    • Nutrition research (New York, N.Y.) 145
    • • Arwa M Amin
      • Hamza Mostafa

    • PubMed: 41418497
    • DOI: 10.1016/j.nutres.2025.11.009

    1 Insight on

    • Reduced Cognitive Impairment

    • High evidence

  • Vitis vinifera seed extract reduces venous reflux time in patients with varicose veins: VICTORY randomized controlled trial.

    • 2026-01
    • RCT · n = 176
    • Journal of vascular surgery. Venous and lymphatic disorders 14(1)
    • • SungA Bae
      • Hakju Kim
      • Nak-Hoon Son
      • Minkwan Kim
      • Sungjoon Park
      • In Hyun Jung

    • PubMed: 41242464
    • DOI: 10.1016/j.jvsv.2025.102355

    4 Insights on

    • Improved Quality of Life
    • Reduced Venous Reflux Time
    • Improved Reflux
    • Improved Venous Clinical Severity Score

    • High evidence
    • Large Human Trial

  • Successful Treatment of Lactobacillus rhamnosus Endocarditis With Intravenous Daptomycin: A Case Report and Literature Review.

    • 2026-01
    • Case Report
    • Case reports in infectious diseases 2026(1)
    • • Mehboob A Rehan
      • J Todd Bagwell
      • S Blake Wachter
      • Sandeep Singh Jubbal

    • PubMed: 41607419
    • DOI: 10.1155/crdi/9295802

    1 Insight on

    • Resolved Endocarditis

    • Low evidence

  • Ginsenosides for Multi-target Intervention in Alzheimer's Disease: Current Evidence, Challenges, and Future Directions.

    • 2026-01
    • Review
    • Molecular neurobiology 63(1)
    • • Ghaleb Oriquat
      • Afaq Mahdi Ali
      • Malathi H
      • Israa Abdulhameed Ahmad
      • Laxmidhar Maharana
      • Laxmidhar Maharana
      • Ashish Singh Chauhan
      • Vimal Arora
      • Bilakshan Purohit
      • Manoj Kumar-Mishra

    • PubMed: 42141250
    • DOI: 10.1007/s12035-026-05910-z

    3 Insights on

    • Improved Cognitive Function
    • Improved Mini-Mental State Examination Score
    • Improved Alzheimer Disease Assessment Scale-Cognitive Subscale Score

    • Low evidence

  • Artichoke leaf extract reduces steatosis and decreases liver size in prebariatric patients: A randomized placebo-controlled pilot trial-The "SteatoChoke-Study".

    • 2026-01
    • RCT
    • Journal of clinical lipidology 20(1)
    • • Sebastian Holländer
      • Evelyn Marth
      • Philipp Robert Scherber
      • Antonios Spiliotis
      • Ammar Al-Ali
      • Gereon Gäbelein
      • Matthias Glanemann

    • PubMed: 41274796
    • DOI: 10.1016/j.jacl.2025.10.063

    6 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Improved Liver Steatosis
    • Reduced Body Fat Percentage
    • Reduced Blood Cholesterol
    • Increased Aspartate Transferase Level
    • Reduced Liver Size

    • High evidence

  • Optimizing Aeromonas hydrophila vaccine efficacy in common carp: The role of free vs. microencapsulated Lactiplantibacillus plantarum and Lactobacillus delbrueckii bulgaricus.

    • 2026-01
    • n = 540
    • Fish & shellfish immunology 168
    • • M Alishahi
      • M A K Aakool
      • R Peyghan
      • M Khosravi
      • D Gharibi

    • PubMed: 41238066
    • DOI: 10.1016/j.fsi.2025.110996

    5 Insights on

    • Improved Immune Function
    • Improved Growth Performance
    • Reduced Mortality Risk
    • Improved Digestive Enzyme Activity
    • Improved Vaccine Efficacy

    • Low evidence
    • Animal Study

  • Comparison of oral ketorolac and oral magnesium for postoperative pain management in anorectal surgery: A randomized double-blind clinical trial.

    • 2026-01
    • RCT · n = 104
    • The Journal of international medical research 54(1)
    • • Seyed Jalal Eshagh Hoseini
      • Farzaneh Sadat Ghazi
      • Mohsen Eshraghi
      • Mostafa Vahedian
      • Mohammad Reza Pashaei
      • Mojdeh Bahadorzadeh
      • Sajjad Ahmadpour

    • PubMed: 41529918
    • DOI: 10.1177/03000605251409937

    2 Insights on

    • Reduced Pain
    • Increased Narcotic Consumption

    • High evidence
    • Large Human Trial

  • From Supplements to Sight: Quantifying the Impact of Lutein and Carotenoid on Age-Related Macular Degeneration-A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    • 2026-01
    • Review · n = 860
    • Journal of ophthalmology 2026(1)
    • • Wei-Xiang Wang
      • Chen-Chi Wang
      • Wei-Cherng Hsu
      • Yi-Jie Peng

    • PubMed: 42028334
    • DOI: 10.1155/joph/2155378

    4 Insights on

    • Improved Macular Pigment Optical Density
    • Improved Best-Corrected Visual Acuity
    • Improved Contrast Sensitivity
    • Increased Lutein Level

    • High evidence

  • Efficacy of Topical Betamethasone Valerate and Olive Oil in Preventing Acute Radiation Dermatitis in Breast Cancer: A Randomized Double-Blind Placebo-Controlled Study.

    • 2026-01
    • RCT · n = 132
    • Clinical breast cancer 26(1)
    • • Israa K Mohamed
      • Maggie M Abbassi
      • Mohamed R Kelany
      • Samar F Farid

    • PubMed: 40973558
    • DOI: 10.1016/j.clbc.2025.08.008

    4 Insights on

    • Reduced Incidence of Dermatitis
    • Reduced Radiation-Induced Dermatitis Severity
    • Delayed Onset of Grade 2 Dermatitis
    • Delayed Onset of Grade 3 Dermatitis

    • High evidence
    • Large Human Trial

  • Efficacy of the herbal product of Cuscuta campestris Yunck. and Polypodium vulgare L. in patients with obsessive-compulsive disorder: A triple-blind clinical trial.

    • 2026-01
    • RCT · n = 84
    • Journal of ethnopharmacology 354
    • • Behnaz Bakhshinejad
      • Abdolreza Sabahi
      • Tania Dehesh
      • Zarrin Sarhadynejad
      • Mehrnaz Mehrabani
      • Mahdiyeh Khazaneha
      • Mehrzad Mehrbani
      • Mitra Mehrabani

    • PubMed: 40848906
    • DOI: 10.1016/j.jep.2025.120452

    1 Insight on

    • Improved Quality of Life

    • High evidence

  • Update on novel acne treatments: a narrative review focused on microbiome modulation and non-pharmacological approaches.

    • 2026-01
    • Review
    • Anais brasileiros de dermatologia 101(1)
    • • Valentina Burckhardt-Bravo
      • Rodrigo Funes-Ferrada
      • Fernando Valenzuela

    • PubMed: 41544313
    • DOI: 10.1016/j.abd.2025.501249

    1 Insight on

    • Reduced Acne Severity

    • Low evidence

  • Fat Amount Rather Than Fatty Acid Composition Influences Postprandial Hunger, Satiety and Attention in Men and Women with a Risk Phenotype for Cardiometabolic Diseases: A Randomized Crossover Trial.

    • 2026-01
    • RCT
    • The Journal of nutrition 156(1)
    • • Christina Diekmann
      • Tim B Schiemann
      • Hannah F Kienēs
      • Carolin Wiechmann
      • Christina Kopp
      • Birgit Stoffel-Wagner
      • Martin Coenen
      • Robert Németh
      • Michael Wagner
      • Sarah Egert

    • PubMed: 41232773
    • DOI: 10.1016/j.tjnut.2025.11.003

    1 Insight on

    • Reduced Hunger Ratings

    • High evidence

  • Probiotic strain identification and safety assessment of unlabeled bacteria in infant products.

    • 2026-01
    • International journal of food microbiology 445
    • • Nanlan Wang
      • Yarong Wu
      • Yang Liu
      • Qian Wen
      • Fan Bai
      • Yafang Tan
      • Yujun Cui
      • Xingyin Liu
      • Yujing Bi
      • Ruifu Yang
      • Peng Luo

    • PubMed: 41175552
    • DOI: 10.1016/j.ijfoodmicro.2025.111500

    1 Insight on

    • Reduced Toxicity

    • Low evidence

  • Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.

    • 2026-01
    • RCT
    • The journal of prevention of Alzheimer's disease 13(1)
    • • Yinyue Liu
      • Zili Yu
      • Zhengjun Cai
      • Li Zhao
      • Yu Wang
      • Yajie Guo
      • Xiaonan Su
      • Yuli Miao
      • Bin Yi
      • Yanhong Wang
      • Xumei Zhang

    • PubMed: 40945966
    • DOI: 10.1016/j.tjpad.2025.100369

    1 Insight on

    • Improved Cognitive Function

    • High evidence

  • Probiotic Supplementation With Bifidobacterium longum Subsp. Longum BL21 Improves Glycemic Control and Modulates Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial.

    • 2026-01
    • RCT
    • Food science & nutrition 14(1)
    • • Chengsheng Zhu
      • Yinhua Liu
      • Yanyan Chen
      • Zhiying Wang
      • Ya Gao
      • Fei Xu
      • Junyi Huang

    • PubMed: 41523285
    • DOI: 10.1002/fsn3.71437

    3 Insights on

    • Modulated Gut Microbiota
    • Improved Glycemia
    • Well Tolerated

    • High evidence

  • Which Protein-Based Dietary Supplements Most Effectively Enhance Fat-Free Mass and Strength Gains in Healthy Adults Undergoing Resistance Training? A Network Meta-Analysis.

    • 2026-01
    • Review · n = 4,755
    • Translational sports medicine 2026(1)
    • • Marcos D M Drummond
      • Ronaldo A D Silva
      • Nelson Carvas Junior
      • Miércio S Melo
      • Matheus H L Ferreira

    • PubMed: 41635649
    • DOI: 10.1155/tsm2/5557511

    2 Insights on

    • Increased Muscle Strength
    • Increased Fat-Free Mass

    • High evidence

  • Comparative effectiveness of Panax notoginseng saponins-related agents and antiplatelet agents in ischemic stroke: A systematic review and network meta-analysis.

    • 2026-01
    • Systematic Review · n = 424
    • Journal of ethnopharmacology 355
    • • Hongrui Zhang
      • Luda Feng
      • Xinxing Lai
      • Yonghong Gao
      • Ning Liang
      • Cuilin Que
      • Zixin Cheng
      • Na Li
      • Jiawang Li
      • Ziteng Hu
      • Yannan He
      • Zhenhong Liu
      • Ying Gao

    • PubMed: 40769440
    • DOI: 10.1016/j.jep.2025.120364

    3 Insights on

    • Improved Functional Outcome
    • Reduced Neurological Deficit
    • Improved Barthel Index

    • High evidence

  • Interaction of Lactic Acid Bacteria and Bifidobacterium with starch-lipid complex and effects on structure and digestibility of starch-lipid complex.

    • 2026-01
    • International journal of biological macromolecules 335
    • • Shujun Feng
      • Yifan Wang
      • Xiaojiao Cheng
      • Yu Bai
      • Shujun Wang

    • PubMed: 41317777
    • DOI: 10.1016/j.ijbiomac.2025.149302

    5 Insights on

    • Increased Short-Chain Fatty Acid Production
    • Enhanced Beneficial Metabolite Production
    • Increased Bifidobacteria Growth
    • Improved Digestibility
    • Increased Gut Microbial Growth

    • Low evidence

  • Comparing the Direct Oral Anticoagulants versus Vitamin K Antagonists in Bioprosthetic Valves: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    • 2026-01
    • Meta-Analysis · n = 3,863
    • Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 32
    • • Muhammad Hassan Waseem
      • Zain Ul Abideen
      • Ameer Haider Cheema
      • Kanza Farhan
      • Hafsa Arshad Azam Raja
      • Muhammad Zubair Tahir
      • Fahad Saleem
      • Amna Nadeem
      • Pawan Kumar Thada

    • PubMed: 41589822
    • DOI: 10.1177/10760296251415375

    1 Insight on

    • Reduced All-Cause Mortality

    • High evidence

  • The effect of riboflavin on the mean attack frequency, severity, and duration of migraine headaches: A systematic review and dose-response meta-analysis of clinical trials.

    • 2026-01
    • Review
    • Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 31(1)
    • • Sepide Amini
      • Zahra Heidari
      • Cain C T Clark
      • Mohammad Bagherniya

    • PubMed: 41769676
    • DOI: 10.4103/jrms.jrms_547_24

    2 Insights on

    • Reduced Migraine Frequency
    • Reduced Migraine Duration

    • Low evidence

  • Engineered bacteria and bacteria-derived nanomaterials for cancer therapy: Mechanisms, designs and advances.

    • 2026-01
    • Review
    • Bioactive materials 55
    • • Qinzhen Cheng
      • Yalan Zhu
      • Shiwen Lv
      • Jiacheng Shi
      • Mingjie Kuang
      • Li Wang
      • Xiaoyuan Ji

    • PubMed: 41368325
    • DOI: 10.1016/j.bioactmat.2025.09.012

    1 Insight on

    • Cancer Treatment Support

    • Low evidence

  • Gut microbiota and immune regulation by Lactobacillus delbrueckii subsp. bulgaricus LB42: From preclinical safety assessment to clinical evidence.

    • 2026-01
    • RCT
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 207
    • • Jingyan Wang
      • Yinhua Liu
      • Chengsheng Zhu
      • Zhiying Wang
      • Sijia Wang
      • Shuguang Fang
      • Fei Xu

    • PubMed: 41241129
    • DOI: 10.1016/j.fct.2025.115851

    5 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Intestinal Inflammation
    • Enhanced Immune Response
    • Improved Sleep Quality
    • Improved Gastrointestinal Symptoms

    • High evidence