December 2025 Supplement Research Papers

• December 1

  • The Impact of Antioxidant Adjuncts on Periodontal Health in Type 2 Diabetes Patients: A Meta-Analysis.

    • 2025-12-01
    • Meta-Analysis · n = 315
    • Clinical and experimental dental research 11(6)
    • • Sara A Abdulla
      • Bushra A Abdalla
      • Aisha Ali Muhammed
      • Hayam A Elawamy
      • Salima M Hawda
      • Najah Mohamed
      • Enass H Abduallah
      • Mustafa Y G Younis
      • Hajir Omar Alsanfaz
      • Hiba Abdelmunim Suliman

    • PubMed: 41158097
    • DOI: 10.1002/cre2.70215

    4 Insights on

    • Reduced Hemoglobin A1c
    • Reduced Gingival Index
    • Reduced Probing Depth
    • Improved Clinical Attachment

    • High evidence

  • Efficacy of Probiotic Supplementation in the Management of Psoriasis: A Systematic Review.

    • 2025-12-01
    • Review
    • Cureus 17(12)
    • • Muhammad Waqas
      • Inzamam Sarwar

    • PubMed: 41487796
    • DOI: 10.7759/cureus.98265

    4 Insights on

    • Improved Quality of Life
    • Reduced Inflammation
    • Improved Inflammatory Biomarkers
    • Improved Psoriasis Severity

    • Low evidence

  • Probiotics and the intestinal tight junction barrier function.

    • 2025-12-01
    • Review
    • Frontiers in cell and developmental biology 13
    • • Megan M Ferris
      • Ligia Subitoni Antonio
      • Rana Al-Sadi

    • PubMed: 41403703
    • DOI: 10.3389/fcell.2025.1671152

    1 Insight on

    • Improved Intestinal Barrier Function

    • Low evidence

  • Effects of chamomile and -theanine beverage on menstrual pain, menstrual symptoms, mood, and sleep quality in young women experiencing primary dysmenorrhea: A randomized, double-blind, placebo-controlled study.

    • 2025-12-01
    • RCT · n = 15
    • Journal of food and drug analysis 33(4)
    • • Ziqing Soh
      • Soo Cing Tan
      • Tak Hiong Wong
      • Seok Tyug Tan
      • Seok Shin Tan
      • Chin Xuan Tan

    • PubMed: 41525193
    • DOI: 10.38212/2224-6614.3565

    3 Insights on

    • Reduced Severity of Complexation
    • Reduced Neuroticism
    • Reduced Confusion

    • High evidence

  • Development of a low-cost culture medium from industrial and environmental by-products for sustainable cultivation of Lactic Acid Bacteria.

    • 2025-12-01
    • PloS one 20(12)
    • • Michele Letitia Tchabou Tientcheu
      • Pierre Marie Kaktcham
      • Edith Marius Foko Kouam
      • Laverdure Tchamani Piame
      • Lysette Chabrone Djodjeu Kamega
      • Agnihotri Shekhar
      • Singh Bhim Pratap
      • François Zambou Ngoufack

    • PubMed: 41325427
    • DOI: 10.1371/journal.pone.0337684

    1 Insight on

    • Improved Viability of Lactic Acid Bacteria

    • Low evidence
    • Animal Study

  • A plasmid-borne gadRCB operon contributes to acid tolerance in Lactiplantibacillus plantarum ZR79.

    • 2025-12-01
    • Applied microbiology and biotechnology 109(1)
    • • Chengfei Fan
      • Zeyu Cao
      • Xinfeng Liu
      • Yan Hao
      • Zhengyuan Zhai
      • Yanling Hao

    • PubMed: 41326679
    • DOI: 10.1007/s00253-025-13614-y

    1 Insight on

    • Improved Tolerance

    • Low evidence

  • Network meta-analysis of the efficacy of pharmacological treatments for post-stroke cognitive impairment and vascular cognitive impairment.

    • 2025-12-01
    • Systematic Review · n = 599
    • Frontiers in neurology 16
    • • Wenting Li
      • Xinyu Liu
      • Cong Gao
      • Wenbo Li
      • Xiaoling Liao

    • PubMed: 41404461
    • DOI: 10.3389/fneur.2025.1683496

    1 Insight on

    • Improved Cognitive Function

    • High evidence

  • The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.

    • 2025-12-01
    • Systematic Review
    • Journal of preventive medicine and hygiene 66(4)
    • • Andrea Vecchietti
      • Paolo Strano
      • Giuseppa Minutolo
      • Vittorio Grieco
      • Giorgia Cappuccio
      • Giuseppa Granvillano
      • Laura Confalonieri
      • Giovanni Leonardo Briganti
      • Eleonora Raso
      • Martina Chimienti
      • Marzia Pellegrini
      • Michelangelo Mercogliano
      • Gloria Spatari
      • Camilla Lugli
      • Teresa Urbano
      • Antonio Lorenzon

    • PubMed: 42256481
    • DOI: 10.15167/2421-4248/jpmh2025.66.4.3636

    1 Insight on

    • Reduced Infection Rate

    • High evidence

  • Calcium-Sensing Receptor Regulation of Gastrointestinal Hormone Secretion.

    • 2025-12-01
    • Review
    • Endocrine reviews 47(2)
    • • Javad Anjom-Shoae
      • Simon Veedfald
      • Arthur D Conigrave
      • Michael Horowitz
      • Christine Feinle-Bisset

    • PubMed: 41321115
    • DOI: 10.1210/endrev/bnaf040

    3 Insights on

    • Reduced Energy Intake
    • Increased Gut Hormone Level
    • Reduced Postprandial Glycemia

    • Low evidence
• December 2

  • From periodontal infection to oral-systemic dysbiosis: re-framing the oral microbiome's role in systemic health and the prophylactic potential of Streptococcus salivarius probiotics.

    • 2025-12-02
    • Review
    • Frontiers in microbiology 16
    • • Francesco Di Pierro
      • Carlo Fornaini
      • Chiara Maria Palazzi
      • Alexander Bertuccioli
      • John Tagg
      • Nicola Zerbinati

    • PubMed: 41409978
    • DOI: 10.3389/fmicb.2025.1685071

    3 Insights on

    • Reduced Dental Caries
    • Improved Oral Health
    • Reduced Periodontal Pathogen Burden

    • Low evidence

  • The effect of probiotic supplementation on sexual function in premenopausal and menopausal women: a randomized controlled clinical trial.

    • 2025-12-02
    • RCT
    • Scientific reports 16(1)
    • • Roghayyeh Valizadeh
      • Fatemeh Borhani
      • Fatemeh Shabani
      • Mojgan Mirghafourvand

    • PubMed: 41326645
    • DOI: 10.1038/s41598-025-30879-5

    2 Insights on

    • Improved Sexual Function
    • Improved Menopause Quality of Life

    • High evidence
    • Rigorous Journal

  • The Effect of Fermented Lingonberry Spray on Oral Health-A Pilot Study.

    • 2025-12-02
    • Clinical Trial
    • Dentistry journal 13(12)
    • • Hanna Lähteenmäki
      • Leo Pärnänen
      • Ismo T Räisänen
      • Marjut Sakko
      • Pirjo Pärnänen
      • Timo Sorsa

    • PubMed: 41440328
    • DOI: 10.3390/dj13120568

    2 Insights on

    • Reduced Bleeding on Probing (BOP)
    • Reduced Plaque Index

    • Moderate evidence

  • The role of probiotics in preventing dental caries: a systematic review of clinical evidence.

    • 2025-12-02
    • Systematic Review
    • Frontiers in oral health 6
    • • Alessio Danilo Inchingolo
      • Angelo Michele Inchingolo
      • Irene Palumbo
      • Mariafrancesca Guglielmo
      • Lilla Riccaldo
      • Roberta Morolla
      • Francesco Inchingolo
      • Andrea Palermo
      • Gianna Dipalma

    • PubMed: 41409473
    • DOI: 10.3389/froh.2025.1720036

    5 Insights on

    • Reduced Caries Lesions
    • Increased Immune Marker Levels
    • Reduced Streptococcus Mutans Levels
    • Reduced Cariogenic Bacteria
    • Reduced Caries Incidence

    • High evidence

  • Biosynthesized TiO₂ Nanoparticles to Enhance the Mechanical and Antibacterial Properties of Type-II Glass Ionomer Cement for Dental Restorative Applications.

    • 2025-12-02
    • Cureus 17(12)
    • • Shubha P
      • Harini Ks
      • Ganesh S
      • Anubhav Jannu
      • Preethi Kusugal
      • Zarir Ruttonji

    • PubMed: 41487806
    • DOI: 10.7759/cureus.98281

    1 Insight on

    • Reduced Bacterial Viability in Dental Plaque

    • Low evidence
• December 3

  • Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.

    • 2025-12-03
    • Meta-Analysis · n = 9,430
    • The Cochrane database of systematic reviews 2026(1)
    • • Catherine A Cluver
      • Christa Rohwer
      • Anke C Rohwer

    • PubMed: 41330480
    • DOI: 10.1002/14651858.cd001059.pub6

    8 Insights on

    • Increased Adverse Effects
    • Reduced Stillbirth
    • Reduced Pre-eclampsia
    • Reduced Maternal Mortality
    • Reduced Maternal Death or Severe Morbidity
    • Reduced Perinatal Loss
    • Reduced Preterm Delivery
    • Increased Neonatal Death

    • High evidence

  • Bioconversion of Geniposide from Gardenia jasminoides via Levilactobacillus Enhancing Anti-Inflammatory Activity.

    • 2025-12-03
    • n = 191
    • Foods (Basel, Switzerland) 14(23)
    • • Chun-Zhi Jin
      • Long Jin
      • Ye Zhuo
      • Ting Li
      • Huimin Liu
      • Kee-Sun Shin
      • Le Kang

    • PubMed: 41376093
    • DOI: 10.3390/foods14234156

    1 Insight on

    • Reduced Inflammation

    • Moderate evidence

  • Gut microbiota-driven dysbiosis of the SCFA-immune axis in pediatric allergic rhinitis-constipation comorbidity: mechanisms and synbiotic remodeling.

    • 2025-12-03
    • Observational
    • Frontiers in immunology 16
    • • WeiKeng Yang
      • Xiaojiao Zhang
      • Bin Wu
      • Binyu Ni
      • Hongbin Lin
      • Congfu Huang

    • PubMed: 41415290
    • DOI: 10.3389/fimmu.2025.1639359

    2 Insights on

    • Improved Constipation
    • Increased Abundance of Bifidobacterium

    • Low evidence

  • An update on probiotics in paediatrics.

    • 2025-12-03
    • Review
    • Current opinion in clinical nutrition and metabolic care 29(3)
    • • Maria Zemła
      • Maja Kotowska-Bąbol
      • Hania Szajewska

    • PubMed: 41334956
    • DOI: 10.1097/mco.0000000000001192

    1 Insight on

    • Reduced Risk of Necrotizing Enterocolitis

    • Low evidence
• December 5

  • Compiling an early life human gut microbiome atlas and identification of key microbial drivers.

    • 2025-12-05
    • Observational
    • NPJ biofilms and microbiomes 12(1)
    • • Chiara Tarracchini
      • Giulia Longhi
      • Emma Gennaioli
      • Aryanna Muscò
      • Sonia Mirjam Rizzo
      • Alice Viappiani
      • Salvatore Giovanni Vitale
      • Leonardo Mancabelli
      • Gabriele Andrea Lugli
      • Stefano Angioni
      • Francesca Turroni
      • Douwe van Sinderen
      • Christian Milani
      • Marco Ventura

    • PubMed: 41350579
    • DOI: 10.1038/s41522-025-00868-7

    1 Insight on

    • Improved Microbial Identification

    • Low evidence

  • Harnessing postbiotics for liver health: Emerging perspectives.

    • 2025-12-05
    • Review
    • World journal of gastrointestinal pharmacology and therapeutics 16(4)
    • • Naveen Jeyaraman
      • Madhan Jeyaraman
      • Tejaswin Mariappan
      • Arulkumar Nallakumarasamy
      • Preethi Subramanian
      • Priyadarshini T
      • Vinnisa Nithiakala Vetrivel

    • PubMed: 41378079
    • DOI: 10.4292/wjgpt.v16.i4.109177

    1 Insight on

    • Improved Liver Function

    • Low evidence
• December 6

  • Apple cider vinegar for prevention of urinary lithiasis (APUL): a randomized crossover trial.

    • 2025-12-06
    • RCT
    • International urology and nephrology 58(6)
    • • Benjamin Baker
      • Christine Herforth
      • Josiah Low
      • Ryan Craig
      • Matthew Christman

    • PubMed: 41351751
    • DOI: 10.1007/s11255-025-04944-x

    3 Insights on

    • Increased Urinary Citrate Level
    • Increased Urine pH
    • Increased Urine Volume

    • High evidence
• December 7

  • Experimental and Clinical Approaches to Preventing Aminoglycoside-Induced Ototoxicity: A Scoping Review.

    • 2025-12-07
    • Review
    • Antioxidants (Basel, Switzerland) 14(12)
    • • Marek Zadrożniak
      • Maciej Biskupski
      • Marcin Szymański
      • Jarogniew J Łuszczki

    • PubMed: 41462666
    • DOI: 10.3390/antiox14121467

    1 Insight on

    • Reduced Hearing Loss

    • Low evidence
• December 9

  • Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes.

    • 2025-12-09
    • Systematic Review · n = 590
    • Annals of agricultural and environmental medicine : AAEM 33(1)
    • • Joanna Łuszczak
      • Janusz Kocki

    • PubMed: 41906501
    • DOI: 10.26444/aaem/213417

    8 Insights on

    • Improved Cognitive Function
    • Reduced Anxiety
    • Improved Sleep Quality
    • Reduced Stress
    • Reduced Depressive Symptom
    • Increased Muscle Strength
    • Improved Muscle Recovery
    • Improved Hormonal Profile

    • High evidence

  • Clinical Effectiveness of Ocimum basilicum Mouthwash as an Adjunct to Toothbrushing in Managing Patients With Plaque-Induced Gingivitis: A Randomised Controlled Trial.

    • 2025-12-09
    • RCT · n = 35
    • International journal of dental hygiene 24(2)
    • • Atrey J Pai Khot
      • Anu Sara Varghese
      • Anil V Ankola
      • Roopali M Sankeshwari
      • Vinuta Hampiholi
      • Kishori P Sutar
      • Prajakta J Chavan
      • Ram Surath Kumar

    • PubMed: 41366506
    • DOI: 10.1111/idh.70017

    2 Insights on

    • Reduced Gingival Index
    • Reduced Plaque Index

    • High evidence

  • In Vitro and In Vivo Safety Evaluation of Streptococcus salivarius eK12, a Genetically Modified Dietary Probiotic Derived from the Oral Probiotic S. salivarius K12.

    • 2025-12-09
    • Journal of microbiology and biotechnology 35
    • • Francesco Di Pierro
      • Gayathri Veeraraghavan
      • Kuppusamy Kalaiselvan
      • Bahrudeen Ashif
      • Logeshwari Jeyakumar
      • Gopikrishnan Gopalakrishnan
      • Massimiliano Cazzaniga
      • Alexander Bertuccioli
      • Maria Laura Tanda
      • Nicola Zerbinati
      • Ikram Ujjan
      • Ali Akbar Bugti
      • Aasiya Bano
      • Yasmeen Gull
      • Nasrin Mumtaz
      • Amjad Khan

    • PubMed: 41391486
    • DOI: 10.4014/jmb.2509.09016

    4 Insights on

    • No Adverse Health Effects
    • Improved Oral Tolerance
    • No Mutagenic Effects
    • Maintained Safety with Repeated Oral Exposure

    • Low evidence
    • Animal Study
• December 10

  • Comparative Genomics Analysis Combined with Homologous Overexpression Reveals the Mechanism of Species-Specific Acid Stress Resistance in Bifidobacterium animalis.

    • 2025-12-10
    • Foods (Basel, Switzerland) 14(24)
    • • Li Lin
      • Yanyu Zhang
      • Fazheng Ren
      • Shaoyang Ge
      • Yanling Hao
      • Zhengyuan Zhai
      • Ming Zhang
      • Shusen Li
      • Liang Zhao
      • Erna Sun

    • PubMed: 41464950
    • DOI: 10.3390/foods14244243

    1 Insight on

    • Improved Acid Stress Resistance

    • Low evidence

  • Elucidating the Probiotic Potential of Lactobacillus and Bifidobacterium Species in Modulating Glucose Metabolism and Inflammation in Gestational Diabetes Mellitus: A Scoping Review.

    • 2025-12-10
    • Systematic Review
    • Nutrition reviews 84(5)
    • • Sidra A Uzair
      • Angela Ajeesh
      • Salma H Ahmed
      • Shaikha Alabduljabbar
      • Fatima Ahmad
      • Arun P Lakshmanan
      • Annalisa Terranegra

    • PubMed: 41370015
    • DOI: 10.1093/nutrit/nuaf238

    3 Insights on

    • Improved Insulin Sensitivity
    • Reduced Inflammation
    • Improved Glucose Metabolism

    • High evidence

  • Clinical Assessment of the Efficacy of Natural Nutraceuticals in Gingival Massage Therapy: A Randomized Clinical Study.

    • 2025-12-10
    • RCT
    • International journal of dental hygiene 24(2)
    • • Fizza Khalid
      • Shahbaz Ahmed
      • Waqas Ahmed Farooqui
      • Haseeb Pervaiz
      • Sania Riaz
      • Sumaiya Shabbir
      • Mehwish Ghazal
      • Ziaur Rahman Khan

    • PubMed: 41373073
    • DOI: 10.1111/idh.70014

    3 Insights on

    • Reduced Gingival Index
    • Reduced Bleeding on Probing (BOP)
    • Reduced Plaque Index

    • High evidence

  • Zinc deficiency and zinc/copper ratio imbalance in autism spectrum disorder: a reanalysis of six multinational studies.

    • 2025-12-10
    • Meta-Analysis
    • Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 39(1)
    • • Geir Bjørklund

    • PubMed: 41372683
    • DOI: 10.1007/s10534-025-00761-y

    1 Insight on

    • Improved Motor Function

    • High evidence

  • From Ancient Fermentations to Modern Biotechnology: Historical Evolution, Microbial Mechanisms, and the Role of Natural and Commercial Starter Cultures in Shaping Organic and Sustainable Food Systems.

    • 2025-12-10
    • Review
    • Foods (Basel, Switzerland) 14(24)
    • • Yasmin Muhammed Refaie Muhammed
      • Fabio Minervini
      • Ivana Cavoski

    • PubMed: 41464947
    • DOI: 10.3390/foods14244240

    5 Insights on

    • Improved Gastrointestinal Health
    • Improved Immune Response
    • Improved Gut Microbiota Balance
    • Improved Digestive Health
    • Improved Metabolic Health

    • Low evidence

  • Thermal Versus Ultrasound Inactivation of Bifidobacterium animalis subsp. lactis BB-12: Functional Implications for Postbiotics.

    • 2025-12-10
    • Probiotics and antimicrobial proteins 18(1)
    • • Nimet Marsak
      • Ecem Akan
      • Adem Yavaş
      • Zafer Erbay

    • PubMed: 41369876
    • DOI: 10.1007/s12602-025-10876-w

    5 Insights on

    • Increased Short-Chain Fatty Acid Production
    • Enhanced Probiotic Growth
    • Enhanced Probiotic Activity
    • Reduced Bacterial Culturability
    • Increased Bioactive Postbiotic Production

    • Low evidence
    • Rigorous Journal
• December 11

  • Leveraging microbiome-based interventions to improve the management of neurodegenerative diseases: evidence for effects along the microbiota-gut-brain axis.

    • 2025-12-11
    • Review
    • Frontiers in nutrition 12
    • • Noémie Auclair-Ouellet
      • Ola Kassem
      • Stéphane Bronner
      • Marie-Laure Oula
      • Sylvie Binda

    • PubMed: 41459056
    • DOI: 10.3389/fnut.2025.1699884

    4 Insights on

    • Improved Gut Microbiota Balance
    • Reduced Neurodegeneration Symptoms
    • Modulated Microbiota-Gut-Brain Axis
    • Improved Gut-Brain Axis Function

    • Low evidence

  • Yacon root is a functional food beneficial for human health: a meta-analysis of clinical trials.

    • 2025-12-11
    • Systematic Review
    • Frontiers in nutrition 12
    • • Ling-Hui Pan
      • Zhong-Wei Yao
      • Wei-Feng Hu
      • Hui-Tian Jia
      • Wen-Lu Ren
      • Pan-Pan Wang
      • Su-Ping Ling
      • He Zhu

    • PubMed: 41459090
    • DOI: 10.3389/fnut.2025.1739768

    2 Insights on

    • Reduced Body Mass Index
    • Improved Bowel Movement Frequency

    • High evidence

  • Optimization of solid-state fermentation conditions for high β-galactosidase-producing lactic acid bacteria and its application in low-lactose dairy products.

    • 2025-12-11
    • Frontiers in bioengineering and biotechnology 13
    • • Zhanjia Zhang

    • PubMed: 41459252
    • DOI: 10.3389/fbioe.2025.1708601

    1 Insight on

    • Reduced Lactose Content in Milk

    • Low evidence

  • Exploring the molecular interaction of bioactive peptides with antioxidative, antidiabetic and anti-inflammatory attributes from sheep milk fermented with lactobacillus and yeast.

    • 2025-12-11
    • Scientific reports 16(1)
    • • Prashantkumar Natubhai Padhiyar
      • Pooja M Mankad
      • Amar A Sakure
      • Arka Bhattacharya
      • Kanthi Kiran Kondepudi
      • Brij Pal Singh
      • Souparno Paul
      • Preetam Sarkar
      • Ashish Patel
      • Shaikh Adil
      • Subrota Hati

    • PubMed: 41381711
    • DOI: 10.1038/s41598-025-30657-3

    6 Insights on

    • Increased Antioxidant Activity
    • Reduced α-Glucosidase Activity
    • Reduced Inflammation
    • Reduced Enzyme Activity
    • Improved Antioxidant Activity
    • Reduced Alpha-Amylase Activity

    • Low evidence
    • Rigorous Journal

  • EFFICACY OF PROBIOTICS IN PREVENTING CHEMOTHERAPY-INDUCED DIARRHEA IN GASTROINTESTINAL CANCER PATIENTS.

    • 2025-12-11
    • RCT · n = 28
    • Arquivos de gastroenterologia 62
    • • Gabriel Caio DE Souza
      • Humberto Bezerra de Araujo Filho
      • Cleyton Zanardo DE Oliveira
      • Ana Paula Ribeiro Paiotti
      • Nora Manoukian Forones

    • PubMed: 41379184
    • DOI: 10.1590/s0004-2803.24612025-020

    2 Insights on

    • Reduced Chemotherapy-Induced Diarrhea
    • Probiotic-Related Infection

    • High evidence

  • Effects of Combined Exercise and Calcium/Vitamin D Supplementation on Bone Mineral Density in Postmenopausal Women: A Systematic Review and Meta-Analysis.

    • 2025-12-11
    • Meta-Analysis
    • Nutrients 17(24)
    • • Jie Bai
      • Wenrui Huang
      • Ruixiang Yan
      • Xuelian Du

    • PubMed: 41470812
    • DOI: 10.3390/nu17243866

    1 Insight on

    • Increased Total Hip Bone Mineral Density

    • High evidence
    • Rigorous Journal

  • Effectiveness and safety of dietary supplements in the adjunctive treatment of psoriasis: a systematic review and network meta-analysis.

    • 2025-12-11
    • Systematic Review · n = 463
    • Frontiers in nutrition 12
    • • Danping Chen
      • Jie Yang
      • Wenwen Yang
      • Xinying Liu
      • Zhihong Li

    • PubMed: 41459063
    • DOI: 10.3389/fnut.2025.1718828

    3 Insights on

    • Reduced Interleukin-6 Levels
    • Reduced Interleukin-1β Levels
    • Reduced Psoriasis Area and Severity Index

    • High evidence

  • Metabolic and Neuroenergetic Effects of Intranasal Vitamin C Application in the Human Brain.

    • 2025-12-11
    • RCT
    • Nutrients 17(24)
    • • Lena-Christin Ingwersen
      • Alina Kistenmacher
      • Uwe H Melchert
      • Kerstin M Oltmanns

    • PubMed: 41470820
    • DOI: 10.3390/nu17243875

    1 Insight on

    • Improved Insulin Sensitivity

    • High evidence
    • Rigorous Journal

  • Effect of oral silymarin in patients with acute hepatotoxic mushroom poisoning: an analysis of poison center data.

    • 2025-12-11
    • Observational · n = 255
    • Clinical toxicology (Philadelphia, Pa.) 64(2)
    • • Theerapon Tangsuwanaruk
      • Phantakan Tansuwannarat
      • Achara Tongpoo
      • Kanyapak Mirin
      • Satariya Trakulsrichai

    • PubMed: 41378447
    • DOI: 10.1080/15563650.2025.2586098

    4 Insights on

    • Reduced Mortality Risk
    • Reduced Length of Hospital Stay
    • Reduced Acute Kidney Injury
    • Reduced Acute Liver Failure

    • High evidence
• December 12

  • Gut-lung axis in allergic rhinitis: microbial dysbiosis and therapeutic strategies.

    • 2025-12-12
    • Review
    • Frontiers in microbiology 16
    • • WeiKeng Yang
      • Hui Wu
      • Xiuyun Li
      • Zhi Wan
      • Wei Kong
      • Congfu Huang

    • PubMed: 41459210
    • DOI: 10.3389/fmicb.2025.1654997

    1 Insight on

    • Reduced Immunoglobulin E Level

    • Low evidence

  • Associations of Lactoferrin-Fortified Formula with Infant Growth and Gut Microbiota: A Real-World Observational Study.

    • 2025-12-12
    • Observational
    • Nutrients 17(24)
    • • Xiaojin Shi
      • Biao Liu
      • Wenhui Ye
      • Xuanjing Qi
      • Menglu Xi
      • Shuqi Liu
      • Qihan Zhu
      • Lutong Zheng
      • Ai Zhao

    • PubMed: 41470843
    • DOI: 10.3390/nu17243896

    2 Insights on

    • Improved Height-for-Age Z-Score
    • Reduced Feeding Difficulties

    • Moderate evidence
    • Rigorous Journal

  • Probiotics and amelioration of periodontitis: significant roles of Lacticaseibacillus casei DS31.

    • 2025-12-12
    • Frontiers in microbiology 16
    • • Yang Liu
      • Peng Wu
      • Yizhen Li
      • Xiaofeng Chen
      • Ling Wang
      • Yanjun Su
      • Lianzhong Luo
      • Yihuang Cai
      • Qinmiao Huang
      • Xu Tang

    • PubMed: 41459202
    • DOI: 10.3389/fmicb.2025.1715664

    2 Insights on

    • Reduced Severity of Periodontitis
    • Reduced Gingival Inflammation

    • Low evidence

  • Antidepressant Effects of Bifidobacterium animalis CP-9 in LPS-Induced Depressive Mice.

    • 2025-12-12
    • Foods (Basel, Switzerland) 14(24)
    • • Shenglan Su
      • Ziyi Jiang
      • Fang He
      • Cailing Chen
      • Yuping Yang
      • Liang Dong
      • Youhua Ren
      • Ke Li
      • Zongjun Li
      • Yuanliang Wang

    • PubMed: 41464995
    • DOI: 10.3390/foods14244289

    5 Insights on

    • Reduced Inflammatory Response
    • Increased Short-Chain Fatty Acid Production
    • Improved Gut Microbiota Balance
    • Reduced Depression-like Behavior
    • Improved Neurotransmitter Metabolism

    • Low evidence

  • Does micronutrient supplementation improve outcomes in adult gastrointestinal surgery patients? A systematic review.

    • 2025-12-12
    • Systematic Review · n = 12
    • Frontiers in nutrition 12
    • • Daoud Salman
      • Trevor Smith
      • Philip C Calder

    • PubMed: 41459083
    • DOI: 10.3389/fnut.2025.1719617

    9 Insights on

    • Improved Quality of Life
    • Improved Immune Function
    • Reduced Inflammation
    • Reduced Postoperative Pain
    • Reduced Bone Density Loss
    • Improved Survival Time
    • Prevented Relapse
    • Reduced Surgical Site Infection
    • Reduced Hospital Stay Length

    • High evidence

  • Effects of Supplementation with Milk Proteins on Body Composition and Anthropometric Parameters: A Systematic Review and Dose-Response Meta-Analysis.

    • 2025-12-12
    • Meta-Analysis · n = 150
    • Nutrients 17(24)
    • • Shooka Mohammadi
      • Damoon Ashtary-Larky
      • Navid Alaghemand
      • Amneh F Alnsour
      • Shokoufeh Shokouhifar
      • Aida Borzabadi
      • Milad Mehrbod
      • Darren G Candow
      • Scott C Forbes
      • Jose Antonio
      • Katsuhiko Suzuki
      • Omid Asbaghi

    • PubMed: 41470822
    • DOI: 10.3390/nu17243877

    8 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Body Weight
    • Reduced Body Fat Percentage
    • Reduced Body Fat Mass
    • Improved Muscle Mass
    • Improved Lean Body Mass
    • Improved Fat-Free Mass

    • High evidence
    • Rigorous Journal

  • Postbiotics: Multifunctional Microbial Products Transforming Animal Health and Performance.

    • 2025-12-12
    • Review
    • Veterinary sciences 12(12)
    • • Sahdeo Prasad
      • Bhaumik Patel
      • Prafulla Kumar
      • Rajiv Lall

    • PubMed: 41472171
    • DOI: 10.3390/vetsci12121191

    13 Insights on

    • Improved Immune Function
    • Improved Growth Performance
    • Enhanced Disease Resistance
    • Improved Gut Health
    • Improved Total Antioxidant Status
    • Reduced Inflammation
    • Improved Intestinal Health
    • Reduced Bacterial Load
    • Reduced Oxidative Stress
    • Reduced Pathogenic Bacteria
    • Improved Oxidative Stress Resistance
    • Improved Antioxidant Defense
    • Improved Immune Modulation

    • Low evidence
• December 13

  • Effect of baby food supplement on the growth and metabolite of lactic acid bacteria.

    • 2025-12-13
    • BMC microbiology 26(1)
    • • Daniel Imanuel Yaurentus
      • Yogiara
      • Diana Elizabeth Waturangi
      • Adi Yulandi
      • Raymond Rubianto Tjandrawinata

    • PubMed: 41390363
    • DOI: 10.1186/s12866-025-04407-4

    2 Insights on

    • Improved Cell Adhesion
    • Increased Bioactive Compound Production

    • Low evidence

  • Effect of coffee and coffee extract on liver function test in non-alcoholic fatty liver disease ‎patients, a systematic review and meta-analysis.

    • 2025-12-13
    • Review
    • Gastroenterology and hepatology from bed to bench 18(4)
    • • Mobina Sayedi
      • Zahra Chaghazardi
      • Amin Sharifi

    • PubMed: 41777919
    • DOI: 10.22037/ghfbb.v18i4.3123

    2 Insights on

    • Reduced Alanine Aminotransferase Level
    • Reduced Aspartate Aminotransferase Level

    • Low evidence

  • Habitual Coffee Consumption and Systemic Health Outcomes: A Comprehensive Review.

    • 2025-12-13
    • Review
    • Cureus 17(12)
    • • Eliza Kwapien
      • Mateusz Piszka
      • Filip Czarnecki
      • Marceli Mesyasz
      • Aleksandra Owczarska
      • Hubert Dacyl
      • Jan Banach
      • Wiktoria Z Kasprzyk
      • Jan K Luczak
      • Jakub Bartkowski

    • PubMed: 41531586
    • DOI: 10.7759/cureus.99094

    10 Insights on

    • Reduced All-Cause Mortality
    • Reduced Liver Fibrosis
    • Reduced Prostate Cancer Risk
    • Reduced Cardiovascular Mortality
    • Reduced Heart Failure Risk
    • Reduced Liver Cancer Risk
    • Reduced Type 2 Diabetes Mellitus Incidence
    • Reduced Alzheimer Disease Risk
    • Reduced Parkinson Disease Risk
    • Increased Hemodynamic Disturbance

    • Low evidence
• December 15

  • Effects of Turmeric and Turmeric Plus Piperine Supplementation on Lipid Profiles in Adults with Cardiometabolic Risk Conditions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Following PRISMA Guidelines.

    • 2025-12-15
    • Review
    • Pharmaceutics 17(12)
    • • Francisco Epelde

    • PubMed: 41471123
    • DOI: 10.3390/pharmaceutics17121609

    4 Insights on

    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol
    • Reduced Blood Cholesterol
    • Increased High-Density Lipoprotein Cholesterol

    • Low evidence

  • Dietary interventions and nutritional strategies for menopausal health: a mini review.

    • 2025-12-15
    • Review
    • Frontiers in nutrition 12
    • • Yi-Chen Liu
      • Zhi-Qing Guo

    • PubMed: 41473185
    • DOI: 10.3389/fnut.2025.1702105

    2 Insights on

    • Reduced Fracture Risk
    • Preserved Bone Mineral Density

    • Low evidence
• December 16

  • Gut microbiome-derived indole-3-carboxaldehyde promotes intestinal development via AHR-NRF2 signaling in the early-life of chicks.

    • 2025-12-16
    • Clinical Trial
    • Microbiome 14(1)
    • • Yu-Xuan Huang
      • Zhang-Chao Deng
      • Ke-Xin Cao
      • Jia-Cheng Yang
      • Meng Liu
      • Ling Zhao
      • Jin-Shui Zheng
      • Lv-Hui Sun

    • PubMed: 41402846
    • DOI: 10.1186/s40168-025-02289-2

    2 Insights on

    • Improved Intestinal Barrier Function
    • Increased Antioxidant Capacity

    • Low evidence
    • Rigorous Journal
    • Animal Study
• December 17

  • Postbiotics in pediatric clinical practice: position paper from Special Group of Latin American Society of Pediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN).

    • 2025-12-17
    • Review
    • Frontiers in nutrition 12
    • • Rodrigo Vázquez-Frias
      • Gabriel Vinderola
      • Ana Teresa Abreu Y Abreu
      • Diana Angulo
      • Natasha Giler-Párraga
      • Liliana Ladino
      • Carolina Ortiz
      • Sebastián Pereira
      • Juan Pablo Bustamante

    • PubMed: 41479668
    • DOI: 10.3389/fnut.2025.1716791

    1 Insight on

    • Improved Body Composition

    • Low evidence

  • Casein Supplementation Timing and Exercise Performance in Soccer Players: Pre-Sleep vs. Post-Exercise Intake-A Randomized Controlled Trial.

    • 2025-12-17
    • RCT
    • Nutrients 17(24)
    • • Serdar Bayrakdaroğlu
      • Zeynep Hazal Ateş
      • Halil İbrahim Ceylan
      • Murat Kul
      • Raul Ioan Muntean
      • Wissem Dhahbi

    • PubMed: 41470882
    • DOI: 10.3390/nu17243938

    4 Insights on

    • Improved Anaerobic Power
    • Improved Jump Height
    • Reduced Fatigue Index
    • Improved Agility Performance

    • High evidence
    • Rigorous Journal

  • Bifidobacterium adolescentis Strengthens Gut Barrier in Post-Voyage Functional Constipation.

    • 2025-12-17
    • International journal of molecular sciences 26(24)
    • • Huidie Zhao
      • Hongli Wang
      • Xinyuan Zhao
      • Yishan Song
      • Dong Liang
      • Yuhao Ma
      • Zheng Xu

    • PubMed: 41465567
    • DOI: 10.3390/ijms262412142

    3 Insights on

    • Improved Gut Microbiota Balance
    • Improved Constipation
    • Improved Gut Barrier Function

    • Low evidence
    • Rigorous Journal
• December 18

  • The applicability of the Migratest® kit for evaluating the chemotactic activity of peripheral blood granulocytes in lambs supplemented with a multi-strain probiotic formulation (Lactobacillus, Bifidobacterium).

    • 2025-12-18
    • BMC veterinary research 22(1)
    • • Roman Wójcik
      • Dawid Tobolski
      • Grzegorz Zwierzchowski

    • PubMed: 41413579
    • DOI: 10.1186/s12917-025-05202-z

    1 Insight on

    • Improved Immune Cell Chemotactic Activity

    • Low evidence
    • Animal Study

  • Effectiveness of 0.1% triamcinolone acetonide compared with those of other therapies for minor recurrent aphthous stomatitis: a systematic review and meta-analysis of randomized controlled trials.

    • 2025-12-18
    • Meta-Analysis · n = 1,474
    • BMC oral health 26(1)
    • • Anas Saeed Al-Zaghruri
      • Mohammed M Al Moaleem
      • Ahmed Yaseen Alqutaibi
      • Abbas Ahmed Abdulqader
      • Baleegh Abdulraoof Al-Kadasi
      • Nashwan Abduljabbar Noman
      • Ayman Ali Saad
      • Ammar Ahmed Al-Hiagem
      • Magdi Abdullah Abdulsalam

    • PubMed: 41408255
    • DOI: 10.1186/s12903-025-07358-4

    2 Insights on

    • Reduced Ulcer Size
    • Reduced Pain

    • High evidence

  • Glucose-Lowering Effects and Safety of Bifidobacterium longum CKD1 in Diabetic Dogs and Cats.

    • 2025-12-18
    • Clinical Trial
    • Microorganisms 13(12)
    • • Yukyung Choi
      • Ji-Eun Kim
      • Kyung Hwan Kim
      • Sunghee Lee
      • Chang Hun Shin

    • PubMed: 41472082
    • DOI: 10.3390/microorganisms13122881

    4 Insights on

    • Improved Gut Microbiota Composition
    • No Adverse Effects
    • Improved Glycemia
    • Reduced Insulin Requirement

    • Moderate evidence

  • Oyster Peptides Prepared by Lactobacillus casei Fermentation Enhance Immune Activity in RAW264.7 Cells via Activation of the MAPK Pathway.

    • 2025-12-18
    • Marine drugs 23(12)
    • • Lingyue Zhong
      • Yirui Wu
      • Xuefang Guan
      • Mei Xu
      • Juqing Huang
      • Yafeng Zheng
      • Qi Wang

    • PubMed: 41440918
    • DOI: 10.3390/md23120484

    1 Insight on

    • Improved Immune Function

    • Low evidence
    • Animal Study

  • The Role of Swine Gut Microbiota and Its Metabolites in Maintaining Intestinal Barrier Integrity and Mitigating Stress via the Gut-Brain Axis.

    • 2025-12-18
    • Review
    • Animals : an open access journal from MDPI 15(24)
    • • Katarzyna Woś
      • Karol Pachciński
      • Marianna Wacko
      • Oliwia Koszła
      • Przemysław Sołek
      • Anna Czech

    • PubMed: 41463937
    • DOI: 10.3390/ani15243653

    3 Insights on

    • Improved Intestinal Barrier Integrity
    • Improved Gut Microbiota Balance
    • Reduced Stress Response

    • Low evidence
• December 19

  • Effects of probiotics on liver function, inflammation, and gut microbiota in alcoholic liver injury: a systematic review and meta-analysis.

    • 2025-12-19
    • Systematic Review · n = 12
    • Frontiers in nutrition 12
    • • Mohamed J Saadh
      • Zahraa Sabah Ghnim
      • Morug Salih Mahdi
      • Vimal Arora
      • M M Rekha
      • Ashish Sharma
      • Bhanu Juneja
      • Zafar Aminov
      • Waam Mohammed Taher
      • Mariem Alwan
      • Mahmood Jasem Jawad
      • Atheer Khdyair Hamad

    • PubMed: 41487669
    • DOI: 10.3389/fnut.2025.1717393

    7 Insights on

    • Improved Gut Microbiota
    • Improved Gut Microbiota Composition
    • Reduced Inflammatory Markers
    • Reduced Inflammation
    • Modulated Gut Microbiota
    • Improved Alcohol Metabolism
    • Improved Liver Enzyme Function

    • High evidence

  • Comparative Evaluation of Postbiotic Preparation Methods for Antibacterial Activity in Fresh Cheese Applications.

    • 2025-12-19
    • Foods (Basel, Switzerland) 15(1)
    • • Joanna Gajewska
      • Arkadiusz Zakrzewski
      • Zuzanna Byczkowska-Rostkowska
      • Sylwester Czaplicki

    • PubMed: 41517071
    • DOI: 10.3390/foods15010006

    2 Insights on

    • Reduced Pathogen Growth
    • Improved Safety Profile

    • Low evidence

  • Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.

    • 2025-12-19
    • Clinical Trial · n = 134
    • Frontiers in aging 6
    • • Amanda Rao
      • David Briskey
      • Georgia Roche
      • Annie Tremblay
      • Marcia Da Silva Pinto
      • Thomas A Tompkins

    • PubMed: 41488277
    • DOI: 10.3389/fragi.2025.1727244

    13 Insights on

    • Reduced Flatulence
    • Improved Skin Hydration
    • Improved Skin Elasticity
    • Reduced Pore Size
    • Reduced Wrinkle Score
    • Increased Sebum Level
    • Reduced Skin Age
    • Reduced Skin Age Score
    • Reduced Forehead Lines
    • Reduced Glabellar Lines
    • Reduced Crow's Feet
    • Reduced Nasolabial Folds
    • Reduced Pigmentation

    • High evidence
• December 20

  • The association of serum vitamin D3 and vitamin D binding protein levels before and after treatment with the response to neoadjuvant chemotherapy in Egyptian breast cancer patients: a prospective observational study.

    • 2025-12-20
    • Observational · n = 71
    • Naunyn-Schmiedeberg's archives of pharmacology 399(6)
    • • Dina Y El-Shabrawy
      • Ahmed Hassan
      • Amal Halim
      • Laila A Eissa

    • PubMed: 41420735
    • DOI: 10.1007/s00210-025-04644-4

    3 Insights on

    • Improved Pathological Response
    • Reduced Tumor Grade
    • Reduced Tumor Stage

    • Moderate evidence
• December 21

  • Streptococcus dentisani as an oral probiotic: a systematic review of clinical evidence on the pH modulation and microbiota shifts.

    • 2025-12-21
    • Review
    • Journal of oral microbiology 18(1)
    • • Martín Pérez-Leal
      • Matteo Nakhle
      • Cristina Estornut
      • Germán Sánchez-Herrera
      • Pilar Ribera
      • Inés Roger
      • Nicla Flacco

    • PubMed: 41477312
    • DOI: 10.1080/20002297.2025.2605796

    5 Insights on

    • Reduced Caries Incidence
    • Increased Salivary pH
    • Improved Oral pH
    • Reduced Cariogenic Oral Microbiota
    • Reduced Cariogenic Markers

    • Low evidence

  • High-dose vitamin D supplementation and prostate cancer progression: a phase II randomised trial in localised prostate cancer cases with intermediate risk of progression (ProsD).

    • 2025-12-21
    • RCT
    • British journal of cancer 134(5)
    • • Visalini Nair-Shalliker
      • David P Smith
      • Val Gebski
      • Manish I Patel
      • Mark Frydenberg
      • John Yaxley
      • Robert 'Frank' Gardiner
      • David Espinoza
      • Michael G Kimlin
      • Varinderpal Dhillon
      • Wayne Leifert
      • David Gillatt
      • Henry Woo
      • Krishan Rasiah
      • Nader Awad
      • James Symons
      • Jadon K Wells
      • Hilda A Pickett
      • Michael Fenech
      • Paul H Anderson
      • Bruce K Armstrong
      • Howard Gurney

    • PubMed: 41423505
    • DOI: 10.1038/s41416-025-03278-w

    4 Insights on

    • Improved Progression-free Survival
    • Reduced Adverse Event
    • Improved Active Therapy-Free Survival
    • Reduced Lymphocytic Genome Damage

    • High evidence
• December 22

  • The Efficacy and Safety of Traditional Chinese Medicine Qufenghuoxue Formula on Treating Peripheral Neuropathy Induced by Paclitaxel in Advanced Lung Cancer: A Randomized Clinical Trial.

    • 2025-12-22
    • RCT
    • Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 34(1)
    • • Yijun Song
      • Zhidan Hua
      • Mengting Sun
      • Nuo Xu
      • Xinyuan Lu
      • Dawei Yang
      • Xixi Gu
      • Yuanlin Song
      • Jun She

    • PubMed: 41428261
    • DOI: 10.1007/s00520-025-10273-7

    6 Insights on

    • Improved Quality of Life
    • Reduced Neuropathic Pain
    • Reduced Chemotherapy-Induced Peripheral Neuropathy Severity
    • Improved Neuropathy-Specific Quality of Life
    • Increased Paclitaxel Dose Completion
    • Reduced Paclitaxel Dose Reduction or Cessation Due to CIPN

    • High evidence

  • Eastern European Fermented Foods: Nutritional Value, Functional Potential, and Cultural Heritage.

    • 2025-12-22
    • Review
    • Foods (Basel, Switzerland) 15(1)
    • • Corina-Aurelia Zugravu
      • Ciprian Constantin

    • PubMed: 41517094
    • DOI: 10.3390/foods15010028

    2 Insights on

    • Improved Gastrointestinal Health
    • Improved Metabolic Health

    • Low evidence
• December 23

  • Probiotics at the Frontline: Redefining Therapeutic Possibilities.

    • 2025-12-23
    • Review
    • Nutrients 18(1)
    • • George Stavrou
      • Alexandra-Eleftheria Menni
      • Katerina Kotzampassi

    • PubMed: 41515166
    • DOI: 10.3390/nu18010048

    2 Insights on

    • Improved Gut Microbiota Composition
    • Improved Gastrointestinal Health

    • Moderate evidence
    • Rigorous Journal

  • Soy isoflavones for the treatment of cocaine use disorder: an open-label pilot study.

    • 2025-12-23
    • Clinical Trial
    • Adicciones 37(4)
    • • Roser Martínez-Riera
      • Francina Fonseca
      • Rafael De La Torre
      • Nieves Pizarro
      • Liliana Galindo
      • Joan Ignasi Mestre-Pinto
      • Magí Farré
      • Marta Torrens

    • PubMed: 41557447
    • DOI: 10.20882/adicciones.2428

    13 Insights on

    • Reduced Bodily Pain
    • Improved Social Functioning
    • Improved Mental Health
    • Improved General Health
    • Reduced Craving
    • Improved Physical Function
    • Reduced Cocaine Consumption Days
    • Reduced Urine Cocaine Metabolite Level
    • Reduced Dependence Severity
    • Reduced Cocaine Withdrawal Severity
    • Improved Role Physical
    • Improved Vitality
    • Improved Role Emotional

    • Moderate evidence

  • Insights into toxin-antitoxin systems in the genus Bifidobacterium.

    • 2025-12-23
    • Review
    • Applied and environmental microbiology 91(12)
    • • Claudia Lefimil
      • Paula Bustamante

    • PubMed: 41190831
    • DOI: 10.1128/aem.01934-25

    1 Insight on

    • Improved Infant Gut Health

    • Moderate evidence
    • Rigorous Journal
• December 24

  • Clinical Potential of Curcuma longa Linn. as Nutraceutical/Dietary Supplement for Metabolic Syndrome: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    • 2025-12-24
    • Review
    • Foods (Basel, Switzerland) 15(1)
    • • Samuel Abiodun Kehinde
      • Zahid Naeem Qaisrani
      • Rinrada Pattanayaiying
      • Bo Bo Lay
      • Khin Yadanar Phyo
      • Wai Phyo Lin
      • Myat Mon San
      • Nurulhusna Awaeloh
      • Sasithon Aunsorn
      • Ran Kitkangplu
      • Sasitorn Chusri

    • PubMed: 41517125
    • DOI: 10.3390/foods15010060

    9 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Interleukin-6 Levels
    • Reduced Triglyceride Levels
    • Increased HDL Cholesterol Levels
    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Hemoglobin A1c
    • Reduced C-Reactive Protein Levels
    • Reduced Fasting Blood Glucose Levels
    • Increased Total Serum Antioxidant Capacity

    • Low evidence

  • "Bifidobacterium longum-reactive T helper cells as marker for intestinal barrier impairment in ICU patients with sepsis".

    • 2025-12-24
    • Observational · n = 19
    • Gut pathogens 18(1)
    • • Lea-Maxie Haag
      • Markus Müller
      • Jörn Ziegler
      • Malte Lehmann
      • Julia Hecker
      • Rainer Glauben
      • Markus M Heimesaat
      • Friederike Compton
      • Britta Siegmund

    • PubMed: 41444646
    • DOI: 10.1186/s13099-025-00770-9

    1 Insight on

    • Impaired Intestinal Barrier Function

    • Low evidence

  • Effect of Heat-Killed Lactiplantibacillus plantarum SNK12 on Sleep Quality and Stress-Related Neuroendocrine and Inflammatory Biomarkers in Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial.

    • 2025-12-24
    • RCT
    • Life (Basel, Switzerland) 16(1)
    • • Takumi Watanabe
      • Shiho Kurosaka
      • Yuriko Namatame
      • Toshio Kawahara

    • PubMed: 41598182
    • DOI: 10.3390/life16010026

    4 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced TNF-α Levels
    • Improved Sleep Quality
    • Reduced Cortisol Levels

    • High evidence

  • Probiotic fermentation of soybeans and use of fermented soy in cookies.

    • 2025-12-24
    • Journal of the science of food and agriculture 106(5)
    • • Xin Chen
      • Zhenjia Chen
      • Perry K W Ng
      • Yan Liu

    • PubMed: 41443672
    • DOI: 10.1002/jsfa.70409

    2 Insights on

    • Increased GABA Production
    • Increased GABA Content

    • Low evidence
• December 25

  • Probiotics for Anxiety and Depressive Symptoms in Cancer: A Systematic Review of Animal and Human Studies with Mechanistic Insights.

    • 2025-12-25
    • Review
    • Microorganisms 14(1)
    • • Zahra Amirkhanzadeh Barandouzi
      • Deborah Watkins Bruner
      • Yufen Lin
      • Hannah Choi
      • Layla R Zeki
      • Tobi Akangbe
      • Amruta Epari
      • Hongjin Li

    • PubMed: 41597571
    • DOI: 10.3390/microorganisms14010051

    6 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Depression Symptoms
    • Reduced Anxiety
    • Reduced Inflammation
    • Reduced Neuroinflammatory Markers
    • Improved Neuroendocrine Stress Markers

    • Low evidence

  • Combined Inhibition of Thrombosis by Lactobacillus paracasei and Clopidogrel.

    • 2025-12-25
    • n = 6
    • International journal of general medicine 18
    • • Xiaona Ren
      • Caicai Liu

    • PubMed: 41473340
    • DOI: 10.2147/ijgm.s548609

    3 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Inflammation
    • Reduced Thrombosis

    • Low evidence

  • Effects of Dichrostachys glomerata and Cissus quadrangularis Extracts on GLP-1 Secretion and DPP-4 Activity in Overweight and Obese Individuals: A Randomized Controlled Trial.

    • 2025-12-25
    • RCT · n = 248
    • Medicina (Kaunas, Lithuania) 62(1)
    • • Janvier Youovop
      • Guy Takuissu
      • Régine Minoue
      • Felix Nwang
      • Maryam Adegboyega
      • Crista Arrey
      • Inelle Makamwe
      • Julius Oben

    • PubMed: 41597327
    • DOI: 10.3390/medicina62010041

    8 Insights on

    • Reduced Body Weight
    • Reduced Body Fat Percentage
    • Increased Intestinal GLP-1 Levels
    • Reduced Fasting Blood Glucose Levels
    • Reduced Energy Intake
    • Improved Satiety Response
    • Improved Blood Lipid Profile
    • Reduced Dipeptidyl Peptidase-4 Activity

    • High evidence
    • Large Human Trial
• December 26

  • Microbiome and Skin Health: A Systematic Review of Nutraceutical Interventions, Disease Severity, Inflammation, and Gut Microbiota.

    • 2025-12-26
    • Review
    • Microorganisms 14(1)
    • • Alia Ashkanani
      • Ghalya Ashkanani
      • Mahmoud Yousef
      • Mlaak Rob
      • Maha Al-Marri
      • Nesha Naseem
      • Sa'ad Laws
      • Ali Chaari

    • PubMed: 41597583
    • DOI: 10.3390/microorganisms14010063

    6 Insights on

    • Improved Quality of Life
    • Reduced Inflammatory Markers
    • Improved Atopic Dermatitis Severity
    • Reduced Atopic Dermatitis Severity
    • Improved Psoriasis Severity
    • Improved Skin Disease Severity

    • Low evidence

  • SIRT1 mediated autophagy enhancement by Lactobacillus fermentum derived oligosaccharides accelerates wound healing in biofilm associated infection.

    • 2025-12-26
    • Scientific reports 15(1)
    • • Amany E Ragab
      • Lamiaa A Al-Madboly
      • Ghada M Al-Ashmawy
      • Mariam A Abo-Saif

    • PubMed: 41453907
    • DOI: 10.1038/s41598-025-30280-2

    3 Insights on

    • Improved Wound Healing
    • Reduced Bacterial Load
    • Reduced Biofilm Mass

    • Low evidence
    • Rigorous Journal

  • Systematic Review and Meta-Analysis on Heavy Metals and Trace Elements in Mild Cognitive Impairment.

    • 2025-12-26
    • Meta-Analysis · n = 16
    • Biological trace element research 204(6)
    • • Yaxin Dong
      • Lu Ren
      • TianRan Tang
      • Xinyi Zhang
      • Dan Han
      • Yingyi Luo
      • Liqiang Wang
      • Zonghui Cui
      • Sheng Ji
      • Jianheng Zheng
      • Ying Qing

    • PubMed: 41454207
    • DOI: 10.1007/s12011-025-04941-2

    2 Insights on

    • Reduced Selenium Level
    • Reduced Zinc Level

    • High evidence
• December 27

  • The effect of resveratrol supplementation on anthropometric indices, adiponectin and leptin levels in individuals with overweight and obesity: a graded, systematic review and meta-analysis of randomized controlled trials.

    • 2025-12-27
    • Meta-Analysis · n = 1,005
    • International journal of obesity (2005) 50(3)
    • • Azin Setayesh
      • Pishva Arzhang
      • Mohammadreza Moradi Baniasadi
      • Maryam Lahouti
      • Leila Azadbakht

    • PubMed: 41455817
    • DOI: 10.1038/s41366-025-01994-0

    9 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Waist-to-Height Ratio
    • Reduced Body Weight
    • Reduced Body Fat Percentage
    • Increased Adiponectin Levels
    • Reduced Body Fat Mass
    • Increased Fat-Free Mass
    • Increased Leptin Level

    • High evidence
• December 29

  • The Therapeutic Effect and Mechanism of Lactobacillus gardneri on Nonalcoholic Fatty Liver Disease.

    • 2025-12-29
    • Journal of microbiology and biotechnology 35
    • • Keyan Zhu
      • Jie Xiang
      • Fengqin Lu
      • Jiabo Wang
      • Yu Zhang
      • Haibo Feng
      • Xiaoxing Xiang

    • PubMed: 41466504
    • DOI: 10.4014/jmb.2501.01051

    3 Insights on

    • Reduced Intestinal Inflammation
    • Reduced Liver Injury
    • Modulated Gut Microbiome Composition

    • Low evidence
    • Animal Study

  • Aronia melanocarpa extract supplementation affects brain vascular function and cognitive performance: A randomized, double-blind, placebo-controlled, cross-over study in older adults with overweight or obesity.

    • 2025-12-29
    • RCT
    • Clinical nutrition (Edinburgh, Scotland) 57
    • • Sanne Ahles
      • Jogchum Plat
      • Kevin Mr Nijssen
      • Peter J Joris

    • PubMed: 41499921
    • DOI: 10.1016/j.clnu.2025.106561

    7 Insights on

    • Improved Memory Function
    • Improved Spatial Working Memory
    • Reduced Cerebral Blood Flow
    • Improved Cerebral Blood Flow
    • Improved Psychomotor Speed
    • Improved Cerebral Perfusion
    • Improved Peripheral Vascular Function

    • High evidence

  • Current Therapeutic Approaches in Infantile Colic: A Comprehensive Review.

    • 2025-12-29
    • Review
    • Turkish archives of pediatrics 61(6)
    • • Vefik Arica
      • Emine Gözde Özdrama Yildiz
      • Sevilay Kök
      • Belen Ateş
      • Taner Adigüzel
      • Eren Güzeloğlu
      • Hüseyin Dağ

    • PubMed: 42228814
    • DOI: 10.5152/turkarchpediatr.2025.25388

    2 Insights on

    • Reduced Crying Duration
    • Reduced Colic Symptoms

    • Low evidence
• December 30

  • Effect of Oral Colostrum Administration Duration on Clinical Outcomes in Preterm Infants: A Randomized Controlled Trial.

    • 2025-12-30
    • RCT · n = 138
    • Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine 21(3)
    • • Elif Ceren Oruc
      • Kiymet Celık
      • Sema Arayici
      • Hakan Ongun

    • PubMed: 41467993
    • DOI: 10.1177/15568253251407971

    5 Insights on

    • Reduced Necrotising Enterocolitis
    • Reduced Incidence of Late-Onset Sepsis
    • Reduced Time to Full Enteral Feeding
    • Reduced Antibiotic Duration
    • Improved Exclusive Breastfeeding Rate

    • High evidence
    • Large Human Trial
• December 31

  • Advancement on the Association between Gut Microbiota and Autism Spectrum Disorder in Children.

    • 2025-12-31
    • Review
    • Annals of nutrition & metabolism 82(2)
    • • Adila Abulaiti
      • Huanhuan Yu
      • Junmei Ma
      • Anikezi Wuji
      • Honggang Chi

    • PubMed: 41474687
    • DOI: 10.1159/000549716

    4 Insights on

    • Reduced Gastrointestinal Symptoms
    • Improved Gastrointestinal Symptoms
    • Modulated Gut Microbiota
    • Improved Autism Spectrum Disorder Symptoms

    • Low evidence

  • An overview of types of antibacterial coatings and methods for creating them on orthodontic wires.

    • 2025-12-31
    • Review
    • Journal of materials science. Materials in medicine 37(1)
    • • Mona Mohajeri Tehrani
      • Pardis Chaboki
      • Reza Mohammadi
      • Shamim Chinian
      • Saman Motallebzadeh
      • Munthar Kadhim Abosaoda
      • Mayank Kundlas
      • Sudhakar Theerthagiri
      • Ali Ebrahimi
      • Sina Hamzehzadeh

    • PubMed: 41474460
    • DOI: 10.1007/s10856-025-06992-2

    1 Insight on

    • Reduced Plaque Accumulation

    • Low evidence

  • Efficacy of Specific Probiotic Strains in Subtypes of Irritable Bowel Syndrome: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    • 2025-12-31
    • Meta-Analysis
    • Medicina (Kaunas, Lithuania) 62(1)
    • • Abdulrahman Saud Almalki
      • Norah Yhya Jaafari
      • Norah Ghalib Aldossari
      • Anwar Ayed Alharbi
      • Abdulrahman Abdullah Alrdeeni
      • Alanoud Abdullah Alshareef
      • Abdulrahman Abed Al-Subhi
      • Ammar Faisal Alsubhi
      • Muath Salem Alsubhi
      • Abdullah Almaqhawi

    • PubMed: 41597375
    • DOI: 10.3390/medicina62010089

    4 Insights on

    • Reduced Incidence of Adverse Events
    • Improved Quality of Life
    • Improved Irritable Bowel Syndrome Symptoms
    • Reduced Irritable Bowel Syndrome Symptoms

    • High evidence

  • Hypoglycemic and Antioxidant Activities of Exopolysaccharides Produced by Lactic Acid Bacteria: A Systematic Review.

    • 2025-12-31
    • Review
    • Preventive nutrition and food science 30(6)
    • • Neny Mariyani
      • Lilis Nuraida
      • Hanifah Nuryani Lioe
      • Ratih Dewanti-Hariyadi

    • PubMed: 41492432
    • DOI: 10.3746/pnf.2025.30.6.509

    2 Insights on

    • Improved Glycemic Control
    • Improved Antioxidant Activity

    • Low evidence

  • Synergistic anti-obesity effects of Bifidobacterium breve BR3 and Lactiplantibacillus plantarum LP3 via coordinated regulation of lipid metabolism and gut microbiota.

    • 2025-12-31
    • Journal of microbiology (Seoul, Korea) 63(12)
    • • Misun Yun
      • Dooheon Son
      • Namhee Kim
      • Se Hee Lee
      • Eunbee Cho
      • Sanghyun Lim

    • PubMed: 41486934
    • DOI: 10.71150/jm.2511001

    6 Insights on

    • Improved Gut Microbiota Composition
    • Improved Liver Function
    • Improved Lipid Metabolism
    • Reduced Blood Glucose Levels
    • Reduced Hepatic Lipid Accumulation
    • Improved Glucose Metabolism

    • Low evidence
    • Animal Study

  • Modulation of Behavioral, Biochemical, Immunomodulatory, and Transcriptional Profiles by the Strain Limosilactobacillus fermentum U-21 in Combined Model of Parkinson's Disease in Wistar Rats.

    • 2025-12-31
    • International journal of molecular sciences 27(1)
    • • Diana A Reznikova
      • Olga B Bekker
      • Alla V Stavrovskaya
      • Dmitry N Voronkov
      • Andrei A Gerasimov
      • Anastasiia K Pavlova
      • Ivan A Potapov
      • Mikhail V Ivanov
      • Veronika S Letvinova
      • Maya V Odorskaya
      • Dilara A Mavletova
      • Aleksey A Vatlin
      • Sergey N Illarioshkin
      • Valery N Danilenko

    • PubMed: 41516320
    • DOI: 10.3390/ijms27010446

    1 Insight on

    • Reduced Behavioral Deficits in Parkinson's Disease Model

    • Low evidence
    • Rigorous Journal
    • Animal Study
• Undated – 42 supplement studies

  • Exploring neurotransmitter regulation following probiotic supplementation in adults with subthreshold depression: A secondary analysis of a randomized controlled trial.

    • 2025-12
    • RCT · n = 39
    • Nutrition (Burbank, Los Angeles County, Calif.) 140
    • • Pauline Dacaya
      • Katerina Sarapis
      • Renate Hall
      • Kanny Yim
      • Stephanie Resciniti
      • Antony Vinh
      • Quynh Nhu Dinh
      • Thy Truong
      • Marco Pane
      • Jessica R Biesiekierski
      • George Moschonis

    • PubMed: 40729791
    • DOI: 10.1016/j.nut.2025.112891

    2 Insights on

    • Increased Plasma Serotonin Levels
    • No Change in Plasma GABA Levels

    • High evidence

  • The effects of Bifidobacterium animalis subsp. lactis BLa80 on glycemic control and gut microbiota in patients with T2DM: a randomized, double-blind, placebo-controlled trial.

    • 2025-12
    • RCT · n = 80
    • Journal of diabetes and its complications 39(12)
    • • Chao Zhao
      • Xin Lu
      • Xiaoling Deng
      • Wenbo Xia
      • Tingting Sun
      • Di Huo
      • Lili Shi

    • PubMed: 41110348
    • DOI: 10.1016/j.jdiacomp.2025.109195

    3 Insights on

    • Increased HDL Cholesterol Levels
    • Reduced Fasting Blood Glucose Levels
    • Increased LDL Cholesterol Level

    • High evidence

  • Effects of vitamin and multiple micronutrient supplementation for pregnant and/or lactating women on maternal and infant nutritional status in low- and middle-income countries: a systematic review and meta-analysis.

    • 2025-12
    • Meta-Analysis
    • Advances in nutrition (Bethesda, Md.) 16(12)
    • • Sachin Shinde
      • Cara A Yelverton
      • Mashavu Yussuf
      • Lina Nurhussien
      • Dongqing Wang
      • Wafaie W Fawzi

    • PubMed: 40752545
    • DOI: 10.1016/j.advnut.2025.100487

    7 Insights on

    • Reduced Vitamin D Deficiency
    • Increased Vitamin A Concentration
    • Reduced Vitamin A Deficiency
    • Increased Infant Cord Blood Vitamin A Level
    • Improved Milk Vitamin A Concentration
    • Increased Serum Vitamin D Level
    • Increased Infant Cord Serum Vitamin D Concentration

    • High evidence

  • Short- and long-term effects of inhaled lavender essential oil on anxiety, fatigue, blood pressure, and sleep quality in middle-aged adults with hypertension: A randomized placebo-controlled pilot study.

    • 2025-12
    • RCT · n = 30
    • Complementary therapies in medicine 95
    • • Yi-Ren Wang
      • Ying-Chih Ho
      • Yueh-Chiao Yeh

    • PubMed: 41177368
    • DOI: 10.1016/j.ctim.2025.103296

    5 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Reduced Anxiety
    • Improved Sleep Quality
    • Reduced Fatigue

    • High evidence

  • The impact of probiotics on Helicobacter pylori eradication with bismuth quadruple therapy: A systematic review and meta-analysis.

    • 2025-12
    • Meta-Analysis
    • International journal of antimicrobial agents 66(6)
    • • Yu-Hao Liu
      • Ju Zhang
      • Deng-Hua Li
      • Yan-Peng Zhang
      • Jie Li
      • Qi-Qi Guo
      • Xiao-Jing Zhu
      • Yong-Quan Shi

    • PubMed: 40865583
    • DOI: 10.1016/j.ijantimicag.2025.107600

    1 Insight on

    • Improved H Pylori Eradication Rates

    • High evidence

  • Postbiotics as Emerging Therapeutics for Skin Wound Healing and Dermatological Care: Clinical Trends and Mechanistic Insights.

    • 2025-12
    • Review
    • International wound journal 22(12)
    • • Seyedeh-Sara Hashemi
      • Alireza Rafati
      • Shahin Roohinejad
      • Fatemeh Yaghoobi
      • Alireza Salehi

    • PubMed: 41381406
    • DOI: 10.1111/iwj.70799

    5 Insights on

    • Improved Wound Healing
    • Improved Skin Barrier Function
    • Reduced Inflammation
    • Improved Gut Barrier Function
    • Improved Tissue Regeneration

    • Low evidence

  • Different oligosaccharides and sodium caseinate glycosylated conjugates for the microencapsulation of Lactobacillus fermentum to improve stability and cholesterol-lowering activity.

    • 2025-12
    • International journal of biological macromolecules 334
    • • Chenglong Lv
      • Xiangfei Li
      • Jie Liu
      • Jiayan Gu
      • Fei Gao
      • Jing Sun
      • Xinyi Pang
      • Yingjian Lu

    • PubMed: 41271046
    • DOI: 10.1016/j.ijbiomac.2025.149167

    2 Insights on

    • Improved Cholesterol Levels
    • Improved Gastrointestinal Survival

    • Low evidence
    • Animal Study

  • The Effect of Ginger and Mint on Postoperative Nausea and Vomiting in Patients Undergoing Total Thyroidectomy.

    • 2025-12
    • RCT
    • Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 40(6)
    • • Sona Pashaei
      • Nuray Akyüz
      • Yeliz Emine Ersoy

    • PubMed: 40856681
    • DOI: 10.1016/j.jopan.2025.02.004

    3 Insights on

    • Reduced Pain Severity
    • Reduced Nausea Severity
    • Reduced Nausea and Vomiting Score

    • High evidence

  • A Scoping Review of Clinical Trials on the Efficacy of Curcumin and Its Formulations for Wound Healing.

    • 2025-12
    • Systematic Review · n = 920
    • Journal of cosmetic dermatology 24(12)
    • • Mohammad Mahdi Parvizi
      • Ali Arefkia
      • Yasamin Dehghan
      • Mohammad Ali Salimi
      • Negin Fazelzadeh Haghighi

    • PubMed: 41388841
    • DOI: 10.1111/jocd.70615

    1 Insight on

    • Improved Wound Healing

    • High evidence

  • Novel Application of Oral Postbiotics for Skin Condition in Healthy Middle-Aged Women: A Randomized, Double-Blind, and Placebo-Controlled Study.

    • 2025-12
    • RCT · n = 60
    • Journal of cosmetic dermatology 24(12)
    • • Jinko Sawashita
      • Shinichi Honda
      • Yuji Tominaga
      • Namiko Tomatsu
      • Jordi Espadaler-Mazo
      • Takahiro Ueda

    • PubMed: 41414786
    • DOI: 10.1111/jocd.70617

    7 Insights on

    • Reduced Gastrointestinal Symptoms
    • Improved Skin Hydration
    • Improved Skin Condition
    • Improved Skin Barrier Function
    • Improved Skin Moisture Retention
    • Improved Skin Elasticity
    • No Worsening of Gastrointestinal Symptoms

    • High evidence

  • A Systematic Review and Meta-Analysis of Randomized Controlled Trials on the Benefits of Using Lactobacillus Supplements as an Adjunct Treatment for Helicobacter pylori Eradication.

    • 2025-12
    • Meta-Analysis · n = 2,054
    • MicrobiologyOpen 14(6)
    • • Asma Azam
      • Muhammad Abdul Muqtadir Qureshi
      • Hafiz Shahbaz Zahoor
      • Syeda Malaika Raza
      • Muhammad Mohsin Khan
      • Umaimah Naeem
      • Syed Atif
      • Abdul Waheed

    • PubMed: 41327607
    • DOI: 10.1002/mbo3.70166

    6 Insights on

    • Reduced Abdominal Pain
    • Increased Helicobacter pylori Eradication Rate
    • Reduced Constipation
    • Reduced Diarrhea
    • Reduced Taste Disturbance Incidence
    • Reduced Vomiting

    • High evidence

  • Efficacy of Momordica charantia in glycaemic control and insulin resistance among patients with prediabetes and type 2 diabetes. A GRADE-adherent meta-analysis of randomised controlled trials.

    • 2025-12
    • Review
    • Metabolism open 28
    • • Sphesihle A L Mkhize
      • Wendy N Phoswa
      • Phikelelani S Ngubane
      • Kabelo Mokgalaboni

    • PubMed: 41280283
    • DOI: 10.1016/j.metop.2025.100407

    5 Insights on

    • Improved Insulin Sensitivity
    • Reduced Fasting Blood Glucose Levels
    • Reduced HbA1c Level
    • Reduced Fasting Insulin Level
    • Unchanged Beta Cell Function

    • Low evidence

  • Lactobacillus strains from sows improve swine appetite by reducing the pro-inflammatory cytokine concentrations.

    • 2025-12
    • Observational
    • Animal nutrition (Zhongguo xu mu shou yi xue hui) 23
    • • Shuang Li
      • Jie Zheng
      • Yang Zhao
      • Jiaqi He
      • Hao Liu
      • Wei Zhong
      • Yingyan Huang
      • Zhen Li
      • Min Yang
      • Xilun Zhao
      • Bin Feng
      • Lianqiang Che
      • Zhengfeng Fang
      • Jian Li
      • Shengyu Xu
      • Yan Lin
      • Xuemei Jiang
      • Lun Hua
      • Yong Zhuo
      • De Wu

    • PubMed: 41321534
    • DOI: 10.1016/j.aninu.2025.03.021

    3 Insights on

    • Reduced Pro-inflammatory Cytokine Levels
    • Increased GLP-1 Levels
    • Reduced GLP-1 Receptor Positive Cells in Colon

    • Low evidence

  • Efficacy of Emblica Officinalis and Curcumin Longa, Two Significant Herbal Antioxidants, in the Management of OSMF: A Comparative Cross-sectional Study.

    • 2025-12
    • Clinical Trial
    • Journal of pharmacy & bioallied sciences 17(Suppl 4)
    • • Annette M Bhambal
      • Parnavi Mishra
      • Sudhanshu Saxena
      • Palak Jain Choudhary
      • Akshay K Agarwal
      • Aparna Raj

    • PubMed: 41522910
    • DOI: 10.4103/jpbs.jpbs_1426_25

    1 Insight on

    • Reduced Oral Burning

    • Moderate evidence

  • The role of probiotics in modulating cariogenic bacteria and oral health outcomes: A systematic review and risk of bias assessment.

    • 2025-12
    • Review · n = 34
    • The Saudi dental journal 37(10-12)
    • • Rahayu Zulkapli
      • Faezah Sabirin
      • Anis Najihah Salleh
      • Nurul Zurain Fatiha Zulaidi
      • Iman Nabilah Abd Rahim
      • Muhammad Nazirul Mubin Aziz

    • PubMed: 41331162
    • DOI: 10.1007/s44445-025-00103-1

    5 Insights on

    • Reduced Streptococcus Mutans Levels
    • Reduced Cariogenic Bacteria
    • Improved Oral Health
    • Reduced Enamel Demineralization
    • Increased Salivary pH

    • Moderate evidence

  • The Impact of Essential Oils From Aromatic Plants on Microbial Dynamics and Nutrition in Lacto-Fermented Systems.

    • 2025-12
    • Review
    • Food science & nutrition 13(12)
    • • Ibrahim Canbey
      • Tulay Ozcan
      • Ozan Gurbuz

    • PubMed: 41426509
    • DOI: 10.1002/fsn3.70948

    1 Insight on

    • Improved Gastrointestinal Health

    • Low evidence

  • Dysbiosis and Therapeutic Modulation of the Gut Microbiota in Multiple Sclerosis: A Narrative Review.

    • 2025-12
    • Review
    • Health science reports 8(12)
    • • Mojtaba Memariani
      • Hamed Memariani

    • PubMed: 41341415
    • DOI: 10.1002/hsr2.71564

    3 Insights on

    • Improved Gut Microbiota Composition
    • Improved Multiple Sclerosis Symptoms
    • Modulated Multiple Sclerosis-Related Dysbiosis

    • Low evidence

  • Safety and efficacy of a feed additive consisting of viable cells of Lactobacillus acidophilusCNCM I-3231, Ligilactobacillus salivariusCNCM I-3233, Lactiplantibacillus plantarumCNCM I-3232, Lacticaseibacillus rhamnosusCNCM I-4427, and Bifidobacterium animalis subsp. lactis CNCM I-3993 (FlorEquilibre® Chien) for dogs (Wamine SAS).

    • 2025-12
    • Review
    • EFSA journal. European Food Safety Authority 23(12)
    • • Roberto Edoardo Villa
      • Giovanna Azimonti
      • Eleftherios Bonos
      • Henrik Christensen
      • Mojca Durjava
      • Birgit Dusemund
      • Ronette Gehring
      • Boet Glandorf
      • Maryline Kouba
      • Marta López-Alonso
      • Francesca Marcon
      • Carlo Nebbia
      • Alena Pechová
      • Miguel Prieto-Maradona
      • Ilen Röhe
      • Katerina Theodoridou
      • Giovanna Martelli
      • Baltasar Mayo
      • Maria Saarela
      • Montserrat Anguita
      • Nicole Bozzi Cionci
      • Rosella Brozzi
      • Matteo L Innocenti
      • Jordi Ortuño

    • PubMed: 41377166
    • DOI: 10.2903/j.efsa.2025.9794

    2 Insights on

    • Safety Concern in Target Species
    • No Conclusive Efficacy

    • Low evidence

  • Selenium status and supplementation in thyroid disorders: A narrative review of current evidence.

    • 2025-12
    • Review
    • Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 92
    • • Ye Htut Linn
      • Sohail Aziz
      • Shiueh Lian Mok

    • PubMed: 41206976
    • DOI: 10.1016/j.jtemb.2025.127799

    5 Insights on

    • Improved Quality of Life
    • Reduced Inflammatory Markers
    • Improved Antioxidant Capacity
    • Enhanced Hormone Normalization
    • Reduced Thyroid Autoantibody Level

    • Low evidence

  • Bifidobacterium animalis subsp. lactis genome resources and metabolite profiling at the strain level and their ability to alleviate anxiety-like behavior in a sleep-deprived mouse model.

    • 2025-12
    • Engineering microbiology 5(4)
    • • Yao-Kun Zhang
      • Liang Zhang
      • Xue Ni
      • Shu-Wen Zhang
      • Min-Zhi Jiang
      • Si-Lu Zhang
      • Guo-Xun Xiao
      • He Jiang
      • Ming-Xia Bi
      • Yu-Lin Wang
      • Chang Liu
      • Shuang-Jiang Liu

    • PubMed: 41982656
    • DOI: 10.1016/j.engmic.2025.100228

    4 Insights on

    • Reduced Inflammation
    • Increased Body Weight Gain
    • Reduced Anxiety-like Behavior
    • Improved Fatigue Resistance

    • Low evidence

  • Spatiotemporal dynamics of mucosa-associated Lactobacillus along the small intestine and its response to 2'-fucosyllactose and galacto-oligosaccharides in piglets.

    • 2025-12
    • RCT
    • Animal nutrition (Zhongguo xu mu shou yi xue hui) 23
    • • Wenlu Fan
      • Chunlong Mu
      • Xuan Li
      • Yanan Zhang
      • Kaifan Yu
      • Yong Su
      • Weiyun Zhu

    • PubMed: 41321508
    • DOI: 10.1016/j.aninu.2025.04.015

    1 Insight on

    • Increased Ileal Mucosal Colonization of Lactobacillus amylovorus

    • High evidence

  • Infant gut microbiota and functional foods: Opportunities for early health intervention.

    • 2025-12
    • Review
    • Clinical nutrition ESPEN 70
    • • Pourandokht Gholamipour-Shirazi
      • Azarmidokht Gholamipour-Shirazi

    • PubMed: 41197774
    • DOI: 10.1016/j.clnesp.2025.10.032

    1 Insight on

    • Reduced Incidence of Atopic Dermatitis

    • Low evidence

  • Comparison of the effects of Echium amoenum and Melissa officinalis on hypertension in stage 1 hypertensive patients: A randomized, triple-blind, three-arm clinical trial.

    • 2025-12
    • RCT · n = 105
    • Complementary therapies in medicine 95
    • • Melika Jafari Dehnayebi
      • Pouya Zeidy
      • Soheila Shamsikhani
      • Mehdi Salehi
      • Mehdi Safarabadi

    • PubMed: 41101745
    • DOI: 10.1016/j.ctim.2025.103266

    2 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure

    • High evidence
    • Large Human Trial

  • Probiotics and Their Antimicrobial Metabolites: A Collegial Strategy for Food Bio-Preservation - A Review.

    • 2025-12
    • Review
    • Food science & nutrition 13(12)
    • • Lingling Wang
      • Shuanshan Ren
      • Atique Ahmed Behan
      • Muhammad Asif Arain
      • Nissar Ahmed Ujjan
      • Dequan Zeng
      • Yufeng Li
      • Xingming Ma

    • PubMed: 41356233
    • DOI: 10.1002/fsn3.71318

    6 Insights on

    • Improved Gastrointestinal Health
    • Reduced Pathogen Growth
    • Reduced Microbial Load
    • Reduced Microbial Spoilage
    • Improved Food Preservation and Shelf-Life
    • Delayed Food Spoilage

    • Low evidence

  • Impact of L-carnitine supplementation on post-transplant outcomes in liver transplant candidates with sarcopenia: A randomized controlled open-label trial.

    • 2025-12
    • RCT · n = 18
    • Clinical nutrition ESPEN 70
    • • Marwa Abd El-Razek Salama
      • Elham Ahmed Hassan
      • Nahed A Makhlouf

    • PubMed: 40962224
    • DOI: 10.1016/j.clnesp.2025.09.008

    2 Insights on

    • Increased Platelet Count
    • Reduced Mortality Risk

    • High evidence

  • Surface modification of probiotics at single-cell resolution: Strategies, applications, and future directions in inflammatory bowel disease.

    • 2025-12
    • Review
    • Materials today. Bio 35
    • • Li Peng
      • Xinyu Wang
      • Yafen Wang
      • Jueshuo Guo
      • Jianhong Yang

    • PubMed: 41281648
    • DOI: 10.1016/j.mtbio.2025.102485

    4 Insights on

    • Improved Gastrointestinal Health
    • Reduced Intestinal Inflammation
    • Improved Gut Microbiota Balance
    • Improved Gut Barrier Function

    • Low evidence

  • Species-level enumeration of low-concentration lactic acid bacteria in breast milk.

    • 2025-12
    • Food chemistry. Molecular sciences 11
    • • Yue Sun
      • Qiming Li
      • Mengling Hu
      • You Wu
      • Yunchao Wa
      • Hai Lu
      • Shilong Jiang
      • Hui Wang
      • Qiaosi Wei
      • Yujun Huang
      • Ruixia Gu
      • Chenchen Zhang

    • PubMed: 40678022
    • DOI: 10.1016/j.fochms.2025.100269

    3 Insights on

    • Reduced Abdominal Pain Severity
    • Reduced Postprandial Fullness
    • Improved Defecation Condition

    • Low evidence

  • Probiotic Potential of Lacticaseibacillus casei Isolated From Traditional Dairy Products and Its Hepatoprotective Effects in STZ-Induced Diabetic Rats.

    • 2025-12
    • Clinical Trial
    • APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 133(12)
    • • Yousef Nami
      • Parsa Johari
      • Alireza Dehnad

    • PubMed: 41334666
    • DOI: 10.1111/apm.70112

    2 Insights on

    • Reduced Liver Enzyme Levels
    • Reduced Blood Glucose Levels

    • Low evidence
    • Animal Study

  • Ganoderma lucidum dietary fiber and lactobacillus fermentum CECT5716 alleviate constipation via regulation of gut barrier and microbiota.

    • 2025-12
    • International journal of biological macromolecules 333
    • • Caihong Wang
      • Qianyang Zhang
      • Chaozhi Wei
      • Yuanxiang Jin

    • PubMed: 41232882
    • DOI: 10.1016/j.ijbiomac.2025.149010

    4 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Colonic Inflammation
    • Increased Short-Chain Fatty Acid Production
    • Improved Constipation

    • Low evidence
    • Animal Study

  • Potential benefits of l-serine in children with GRIN2B loss-of-function variants: Randomized n-of-1 trials.

    • 2025-12
    • RCT · n = 3
    • Molecular genetics and metabolism 146(4)
    • • Bibiche den Hollander
      • Marieke Rothuizen-Lindenschot
      • Hoang Lan Le
      • Jennifer R Ramautar
      • Annelieke R Müller
      • Lisa Geertjens
      • Frédéric M Vaz
      • Agnies M van Eeghen
      • Martina C Cornel
      • Bart A W Jacobs
      • Hilgo Bruining
      • Peter M van de Ven
      • Marion M Brands
      • Clara D van Karnebeek

    • PubMed: 41265180
    • DOI: 10.1016/j.ymgme.2025.109268

    1 Insight on

    • Improved Performance Mastery

    • High evidence

  • Psyllium supplementation and lipid profiles: systematic review and dose-response meta-analysis of randomized controlled trials.

    • 2025-12
    • Review · n = 2,049
    • Genes & nutrition 20(1)
    • • Zeinab Gholami
      • Zamzam Paknahad

    • PubMed: 41366295
    • DOI: 10.1186/s12263-025-00786-5

    1 Insight on

    • Reduced Blood Cholesterol

    • High evidence

  • Vitamin supplementation in the treatment of optic neuritis: A systematic review and meta-analysis.

    • 2025-12
    • Meta-Analysis · n = 2,465
    • Multiple sclerosis and related disorders 104
    • • Patrick J Gaffney
      • Rajesh K Gupta

    • PubMed: 41124782
    • DOI: 10.1016/j.msard.2025.106797

    4 Insights on

    • Improved Retinal Nerve Fiber Layer Thickness
    • Improved Visual Acuity
    • Improved Foveal Sensitivity
    • Reduced Multiple Sclerosis Conversion

    • High evidence

  • The influence of pepper-derived compounds on blood pressure and heart rate: a systematic review and meta-analysis of randomized controlled trials.

    • 2026
    • Review
    • Food & function 17(11)
    • • Peng Cheng
      • Tianyu Liang
      • Kousalya Prabahar
      • Jiechao Hu
      • Weiling Ye

    • PubMed: 42148967
    • DOI: 10.1039/d6fo00419a

    3 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Reduced Heart Rate

    • Moderate evidence
    • Rigorous Journal

  • Blueberry anthocyanin supplementation shows favorable trends in glycemic control and alters the gut microbiota in type 2 diabetes patients: a pilot study.

    • 2026
    • Clinical Trial
    • Food & function 17(8)
    • • Xindi Hu
      • Lujing Xu
      • Ying Li
      • Xingyu Zhao
      • Yakun Xing
      • Jin Feng
      • Jiawei Zheng
      • Cheng Xue
      • Wuyang Huang
      • Wuyang Huang
      • Shan Lu

    • PubMed: 41915410
    • DOI: 10.1039/d5fo05613f

    1 Insight on

    • Reduced Fasting Blood Glucose Levels

    • High evidence
    • Rigorous Journal

  • Daily mango (Mangifera indica L.) consumption supplemented with probiotics differentially modulates inflammation and cognitive function in individuals with overweight or obesity: a placebo-controlled, double-blind, and randomized trial.

    • 2026
    • RCT
    • Food & function 17(2)
    • • Hyemee Kim
      • Kevin B Kiefer
      • Shannon E Schmidt-Combest
      • Giuliana Noratto
      • Shirley Arbizu
      • Maria Joselyn Castellon Chicas
      • Nicos C Georghiades
      • Steven E Riechman
      • Colin D Kay
      • Rodrigo San-Cristobal
      • Stephen T Talcott
      • Susanne U Mertens-Talcott

    • PubMed: 41410576
    • DOI: 10.1039/d5fo01687h

    3 Insights on

    • Improved Attention Span
    • Improved Cognitive Performance
    • Reduced TNF-alpha Level

    • High evidence
    • Rigorous Journal

  • A meta-analysis of the literature evaluating the impact of vitamin D on female fertility and ovarian reserve function.

    • 2026
    • Meta-Analysis
    • Revista da Escola de Enfermagem da U S P 60
    • • Shanfei Zhao
      • Wenling Zheng
      • Guanyun Long
      • Guanglin Liang

    • PubMed: 41670949
    • DOI: 10.1590/1980-220x-reeusp-2025-0382en

    3 Insights on

    • Increased Dominant Follicle Count
    • Increased Ovulation Rate
    • Increased Pregnancy Rate

    • High evidence

  • The relationships among nutrition, body composition, muscle strength and physical performance in patients with acromegaly.

    • 2026
    • Observational · n = 82
    • Archives of endocrinology and metabolism 70(4)
    • • Natália Nachbar Hupalowski
      • Claudia Pinheiro Sanches Rocha
      • Vicente F C Andrade
      • Cesar Luiz Boguszewski
      • Victoria Zeghbi Cochenski Borba

    • PubMed: 42155079
    • DOI: 10.20945/2359-4292-2026-0048

    5 Insights on

    • Improved Handgrip Strength
    • Increased Lean Mass
    • Improved Sit-to-Stand Performance
    • Improved Timed Up and Go Performance
    • Improved Short Physical Performance Battery Score

    • Moderate evidence

  • Polyphenol consumption and neurodegeneration risk: a systematic meta-analysis of randomized controlled trials bridging nutrition and cognitive health.

    • 2026
    • Meta-Analysis · n = 849
    • Food & function 17(3)
    • • Xiaomei Wang
      • Jiao Yang
      • Jiayuan Zhang
      • Gaihong Yu
      • Jian Zhu
      • Yingli Nie

    • PubMed: 41524705
    • DOI: 10.1039/d5fo05135e

    2 Insights on

    • Improved Global Cognition
    • Improved Domain-Specific Cognition

    • High evidence
    • Rigorous Journal

  • Effects of fish oil supplementation on biomarkers of vascular endothelial function in middle-aged and older adults: a randomized controlled trial.

    • 2026
    • RCT · n = 240
    • Food & function 17(3)
    • • Chunxia Quan
      • Wei Tang
      • Yuting Qin
      • Zhaoyang Nian
      • Zhongxia Li
      • Limei Mao

    • PubMed: 41568898
    • DOI: 10.1039/d5fo04037j

    6 Insights on

    • Reduced Monocyte Adhesion
    • Reduced Endothelin-1 Level
    • Reduced Oxidized Low-Density Lipoprotein Level
    • Reduced ICAM-1 Level
    • Increased Nitric Oxide Level
    • Improved Vasodilation

    • High evidence
    • Large Human Trial
    • Rigorous Journal

  • Unravelling the Link between Polyphenol Intake and the Risk of Digestive System Cancer: An Umbrella Review Using Meta-Analyses and Systematic Reviews.

    • 2026
    • Systematic Review
    • Expert reviews in molecular medicine 28
    • • Arezo Amjadi
      • Hamid Abbasi
      • Atefeh Tahavorgar
      • Mohammadreza Esfahanian
      • Mahdie Torkaman
      • Adel Shahrokhi Sardoo
      • Ali Erfanimanesh
      • Ali Shamsi-Goushki
      • Mohammad Esmail Akbari
      • Barbod Alhouei
      • Maryam Gholamalizadeh
      • Saeid Doaei

    • PubMed: 41502351
    • DOI: 10.1017/erm.2025.10027

    1 Insight on

    • Reduced Risk of Digestive System Cancer

    • High evidence

  • Effects of olive leaf polyphenols on blood lipid profiles and cardiovascular risk markers in healthy and at-risk populations: a narrative review.

    • 2026
    • Review
    • Food & function 17(8)
    • • Sanne L M van Stratum
      • Yala Stevens
      • Jogchum Plat

    • PubMed: 41878818
    • DOI: 10.1039/d5fo04678e

    4 Insights on

    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol
    • Reduced Inflammation
    • Reduced Blood Cholesterol

    • Moderate evidence
    • Rigorous Journal

  • The effect of vitamin C supplementation on blood pressure in adults: an umbrella review of meta-analyses of randomized clinical trials.

    • 2026
    • Meta-Analysis · n = 17
    • Food & function 17(6)
    • • Ali Kosari
      • Hossein Shahinfar
      • Kimia Rostampour
      • Seyedeh Ghazal Mirhosseini
      • Sepideh Soltani

    • PubMed: 41784995
    • DOI: 10.1039/d5fo03679h

    2 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure

    • High evidence
    • Rigorous Journal